linsidomine has been researched along with Multiple Sclerosis in 2 studies
linsidomine: RN given refers to parent cpd; structure
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative diseases." | 7.71 | Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. ( Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV, 2002) |
| "Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative diseases." | 3.71 | Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. ( Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scott, GS | 1 |
| Spitsin, SV | 1 |
| Kean, RB | 1 |
| Mikheeva, T | 1 |
| Koprowski, H | 1 |
| Hooper, DC | 1 |
| López-Moratalla, N | 1 |
| González, A | 1 |
| Aymerich, MS | 1 |
| López-Zabalza, MJ | 1 |
| Pío, R | 1 |
| de Castro, P | 1 |
| Santiago, E | 1 |
2 other studies available for linsidomine and Multiple Sclerosis
| Article | Year |
|---|---|
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluat | 2002 |
Monocyte inducible nitric oxide synthase in multiple sclerosis: regulatory role of nitric oxide.
Topics: Amino Acid Sequence; Flow Cytometry; HLA-DR Antigens; Humans; Immunohistochemistry; Immunophenotypin | 1997 |