linsidomine has been researched along with Heart Failure in 2 studies
linsidomine: RN given refers to parent cpd; structure
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the hemodynamic effects of SIN-1, the active metabolite of the venodilator molsidomine, after acute as well as chronic intravenous administration, ten patients with exacerbation of chronic heart failure were studied." | 5.06 | Hemodynamic effects of SIN-1 in acute left heart failure. ( Degre, S; Depelchin, P; Ibrahim, TM; Jottrand, M; Sobolski, J; Unger, PH, 1989) |
| " The differences between aorto-caval fistula rats and sham operated rats were probably the result of increased basal EDRF-NO release in the former, since NO synthase blockade abolished the differences in both aortic cGMP and the dose-response curve to Sin-1." | 1.29 | Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure. ( Arnal, JF; Michel, JB; Schott, C; Stoclet, JC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnal, JF | 1 |
| Schott, C | 1 |
| Stoclet, JC | 1 |
| Michel, JB | 1 |
| Ibrahim, TM | 1 |
| Unger, PH | 1 |
| Sobolski, J | 1 |
| Depelchin, P | 1 |
| Jottrand, M | 1 |
| Degre, S | 1 |
1 trial available for linsidomine and Heart Failure
| Article | Year |
|---|---|
Hemodynamic effects of SIN-1 in acute left heart failure.
Topics: Aged; Dose-Response Relationship, Drug; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intr | 1989 |
1 other study available for linsidomine and Heart Failure
| Article | Year |
|---|---|
Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Calcimycin; Cyclic GMP; Disease Models, Animal; D | 1993 |