linsidomine has been researched along with Heart Disease, Ischemic in 11 studies
linsidomine: RN given refers to parent cpd; structure
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of myocardial ischemia (30 min) and reperfusion were measured in mice, with assays of myocardial apoptosis, superoxide production, NOx and nitrotyrosine content, and myocardial infarct size." | 3.73 | Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress. ( Christopher, TA; Coletti, C; Gao, E; Hu, A; Koch, W; Lopez, BL; Ma, XL; Tao, L; Wang, Y, 2006) |
| "We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model." | 3.69 | The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion. ( Fung, KP; Wu, J; Wu, TW; Zeng, LH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, L | 2 |
| Gao, E | 2 |
| Hu, A | 1 |
| Coletti, C | 1 |
| Wang, Y | 1 |
| Christopher, TA | 1 |
| Lopez, BL | 1 |
| Koch, W | 2 |
| Ma, XL | 2 |
| Jiao, X | 1 |
| Lau, WB | 1 |
| Yuan, Y | 1 |
| Lopez, B | 1 |
| Christopher, T | 1 |
| RamachandraRao, SP | 1 |
| Williams, W | 1 |
| Southan, G | 1 |
| Sharma, K | 1 |
| Barnes, CS | 1 |
| Coker, SJ | 1 |
| Vacheron, A | 1 |
| de Vernejoul, P | 1 |
| Richard, V | 4 |
| Kaeffer, N | 3 |
| Tron, C | 2 |
| Thuillez, C | 4 |
| Fung, KP | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Wu, J | 1 |
| Kober, G | 1 |
| Bender, M | 1 |
| Vallbracht, C | 1 |
| Sievert, H | 1 |
| Klepzig, H | 1 |
| Blanc, T | 1 |
| François, A | 1 |
| Lallemand, F | 2 |
| Henry, JP | 2 |
| Czarnowska, E | 1 |
| Karwatowska-Prokopczuk, E | 1 |
| Laude, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for linsidomine and Heart Disease, Ischemic
| Article | Year |
|---|---|
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electro | 1993 |
10 other studies available for linsidomine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nit | 2006 |
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiotonic Agents; Cyclic N-Oxides; Free Radical Scave | 2006 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynam | 1995 |
[Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion].
Topics: Adult; Aged; Aged, 80 and over; Exercise Test; Female; Heart; Humans; Injections, Intravenous; Male; | 1994 |
Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Coronary Vessels; Endothelium, Vascular; Male; Molsido | 1994 |
The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Heart; Molsidomine; Myocardial Ischemia; My | 1994 |
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Coronary Vessels; Disease Models, Animal; Endothel | 1995 |
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats.
Topics: Acetylcholine; Animals; Chronic Disease; Coronary Circulation; Coronary Vessels; Endothelium, Vascul | 1996 |
Role of oxygen free radicals in cardiocyte injury in the reperfused rat heart.
Topics: Animals; Endothelium; Free Radical Scavengers; Glycocalyx; Heart; Male; Molsidomine; Myocardial Isch | 1996 |
Evidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Coronary Vessels; Endothelium, Vascular; Enzyme Inhi | 2000 |