linsidomine has been researched along with Coronary Disease in 19 studies
linsidomine: RN given refers to parent cpd; structure
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1)." | 9.07 | Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency. ( Degré, S; Gaertner, W; Ostrowski, J; Sennesael, J; Stolear, JC; Unger, P; Verbeelen, D; von Hattingberg, HM, 1993) |
| "Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1)." | 5.07 | Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency. ( Degré, S; Gaertner, W; Ostrowski, J; Sennesael, J; Stolear, JC; Unger, P; Verbeelen, D; von Hattingberg, HM, 1993) |
| "The pharmacokinetics of molsidomine were investigated in the plasma and urine of healthy male volunteers and patients with coronary heart disease after intravenous and/or oral administration of different galenic dosage forms of molsidomine." | 3.67 | Pharmacokinetics of molsidomine in humans. ( Ostrowski, J; Resag, K, 1985) |
| "Treatment with linsidomine and molsidomine was associated with a modest improvement in the long-term angiographic result after angioplasty but had no effect on clinical outcome." | 2.68 | Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem. ( Bassand, JP; Battaglia, S; Béard, T; Bertrand, B; Bertrand, ME; Boschat, J; Coste, P; Crochet, PD; Desveaux, B; Drobinski, G; Dubois-Randé, JL; Finet, G; Giraud, T; Grollier, G; Juillière, Y; Juliard, JM; Lablanche, JM; Le Breton, H; Leclercq, F; Letac, B; Livarek, B; Lusson, JR; Metzger, JP; Quiret, JC; Virot, P, 1997) |
| "In 28 patients with unstable angina pectoris biplane coronary angiography was performed in the acute stage." | 2.65 | [Dynamics of critical stenosis in patients with unstable angina pectoris]. ( Karsch, KR; Niemczyk, P; Seipel, L; Voelker, W, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 13 (68.42) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karsch, KR | 1 |
| Niemczyk, P | 1 |
| Voelker, W | 1 |
| Seipel, L | 1 |
| Schulz, W | 1 |
| Wendt, T | 1 |
| Scherer, D | 1 |
| Kober, G | 2 |
| Dubois-Rande, JL | 2 |
| Dupouy, P | 1 |
| Geschwind, H | 1 |
| Castaigne, A | 1 |
| Adnot, S | 1 |
| Kenny, D | 1 |
| Coughlan, MG | 1 |
| Kampine, JP | 1 |
| Montgomery, RR | 1 |
| Bosnjak, ZJ | 1 |
| Warltier, DC | 1 |
| Hug, J | 1 |
| Hasenfuss, G | 1 |
| Wollschläger, H | 1 |
| Just, HJ | 1 |
| Bonzel, T | 1 |
| Münzel, T | 1 |
| Kurz, S | 1 |
| Heitzer, T | 1 |
| Luhmann, C | 1 |
| Just, H | 1 |
| Ferguson, JJ | 1 |
| Bender, M | 1 |
| Vallbracht, C | 1 |
| Sievert, H | 1 |
| Klepzig, H | 1 |
| Sennesael, J | 1 |
| Verbeelen, D | 1 |
| Degré, S | 1 |
| Unger, P | 1 |
| Stolear, JC | 1 |
| Ostrowski, J | 2 |
| von Hattingberg, HM | 1 |
| Gaertner, W | 1 |
| Jost, S | 3 |
| Sturm, M | 1 |
| Hausmann, D | 1 |
| Lippolt, P | 1 |
| Lichtlen, PR | 2 |
| Lablanche, JM | 1 |
| Grollier, G | 1 |
| Lusson, JR | 1 |
| Bassand, JP | 1 |
| Drobinski, G | 1 |
| Bertrand, B | 1 |
| Battaglia, S | 1 |
| Desveaux, B | 1 |
| Juillière, Y | 1 |
| Juliard, JM | 1 |
| Metzger, JP | 1 |
| Coste, P | 1 |
| Quiret, JC | 1 |
| Crochet, PD | 1 |
| Letac, B | 1 |
| Boschat, J | 1 |
| Virot, P | 1 |
| Finet, G | 1 |
| Le Breton, H | 1 |
| Livarek, B | 1 |
| Leclercq, F | 1 |
| Béard, T | 1 |
| Giraud, T | 1 |
| Bertrand, ME | 1 |
| Feld, S | 1 |
| Smalling, RW | 1 |
| Vrolix, M | 1 |
| Piessens, J | 1 |
| De Geest, H | 1 |
| Rafflenbeul, W | 2 |
| Reil, GH | 1 |
| Gulba, D | 2 |
| Knop, I | 2 |
| Hecker, H | 2 |
| Darius, H | 2 |
| Erbel, R | 1 |
| Rupprecht, HJ | 1 |
| Pop, T | 1 |
| Meyer, J | 2 |
| Reil, G | 1 |
| Auricchio, A | 1 |
| Frombach, R | 1 |
| Lichtlen, P | 1 |
| Erbel, E | 1 |
| Schmucker, B | 1 |
| Reusch, U | 1 |
| Serruys, PW | 1 |
| Deckers, JW | 1 |
| Luijten, HE | 1 |
| Reiber, JH | 1 |
| Tijssen, JG | 1 |
| Chadha, D | 1 |
| Hugenholtz, PG | 1 |
| Resag, K | 1 |
8 trials available for linsidomine and Coronary Disease
| Article | Year |
|---|---|
[Dynamics of critical stenosis in patients with unstable angina pectoris].
Topics: Angina Pectoris; Angina, Unstable; Coronary Angiography; Coronary Circulation; Coronary Disease; Hem | 1984 |
[Diameter changes of epicardial coronary arteries and coronary stenoses after intracoronary application of SIN 1, a molsidomine metabolite].
Topics: Coronary Disease; Coronary Vessels; Double-Blind Method; Humans; Injections, Intra-Arterial; Molsido | 1983 |
[Coronary dilatation after intracoronary administration of SIN-1 and intravenous molsidomine administration].
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Double-Blind | 1994 |
Meeting highlights: nitric oxide donors.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Diltiazem; Humans; Isosorbide Dinitrate; Molsidomi | 1994 |
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electro | 1993 |
Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Coronary Disease; Drug Admi | 1993 |
Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Disease; Coronary Vessels; Dilt | 1997 |
[Acute and chronic effects of molsidomine in therapeutic coronary angioplasty].
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Delayed-Action Preparations; | 1990 |
11 other studies available for linsidomine and Coronary Disease
| Article | Year |
|---|---|
Intracoronary linsidomine abolishes acetylcholine-induced vasoconstriction of epicardial coronary arteries.
Topics: Acetylcholine; Coronary Circulation; Coronary Disease; Coronary Vessels; Dose-Response Relationship, | 1993 |
Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor.
Topics: Animals; Arginine; Blood Flow Velocity; Calcimycin; Cells, Cultured; Coronary Circulation; Coronary | 1994 |
[Effects of intravenous administration of nitroglycerin and SIN-1 or molsidomine on epicardial arterial diameter in patients with stable coronary heart disease].
Topics: Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedu | 1994 |
Standardization of coronary vasomotor tone with intracoronary nitroglycerin.
Topics: Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Coronary Angiography; Coronary Disea | 1996 |
Gastroepiploic bypass graft stenting.
Topics: Angina, Unstable; Arteries; Coronary Artery Bypass; Coronary Disease; Graft Occlusion, Vascular; Hum | 1999 |
Torsades de pointes after intracoronary papaverine.
Topics: Angioplasty, Balloon, Coronary; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Electro | 1991 |
Reproducible uniform coronary vasomotor tone with nitrocompounds: prerequisite of quantitative coronary angiographic trials.
Topics: Angiography; Coronary Angiography; Coronary Disease; Female; Humans; Image Interpretation, Computer- | 1990 |
Coronary vasodilation with nitrocompounds--is there a maximum?
Topics: Administration, Sublingual; Adult; Aged; Coronary Circulation; Coronary Disease; Dose-Response Relat | 1989 |
[Anti-ischemic effects of SIN-1, a molsidomine metabolite, during coronary angioplasty and antiplatelet effects in humans].
Topics: Adenosine Triphosphate; Administration, Oral; Angioplasty, Balloon; Coronary Disease; Coronary Vesse | 1988 |
Long-acting coronary vasodilatory action of the molsidomine metabolite Sin 1: a quantitative angiographic study.
Topics: Coronary Angiography; Coronary Disease; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsid | 1987 |
Pharmacokinetics of molsidomine in humans.
Topics: Animals; Biological Availability; Coronary Disease; Dogs; Half-Life; Humans; Kinetics; Molsidomine; | 1985 |