linsidomine has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
linsidomine: RN given refers to parent cpd; structure
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reactive astrogliosis and dysfunctional transporters for L-glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS pathology." | 1.35 | Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis. ( Beart, PM; Nagley, P; O'Shea, RD; Wallis, N; Zagami, CJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zagami, CJ | 1 |
| Beart, PM | 1 |
| Wallis, N | 1 |
| Nagley, P | 1 |
| O'Shea, RD | 1 |
| Kupershmidt, L | 1 |
| Weinreb, O | 1 |
| Amit, T | 1 |
| Mandel, S | 1 |
| Carri, MT | 1 |
| Youdim, MB | 1 |
| Aguirre, T | 1 |
| Van Den Bosch, L | 1 |
| Goetschalckx, K | 1 |
| Tilkin, P | 1 |
| Mathijs, G | 1 |
| Cassiman, JJ | 1 |
| Robberecht, W | 1 |
3 other studies available for linsidomine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Astrocytes; Cell Survival; Cells, Cultu | 2009 |
Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Different | 2009 |
Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress.
Topics: Amyotrophic Lateral Sclerosis; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Human | 1998 |