linopirdine has been researched along with Seizures in 4 studies
linopirdine: acetylcholine releasing drug
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In BFNC, seizures begin shortly after birth, and spontaneously remit in the first few months of life." | 1.34 | K+ M-current regulates the transition to seizures in immature and adult hippocampus. ( Johnson, BN; Qiu, C; Tallent, MK, 2007) |
| "Szt1 mouse seizure thresholds were significantly reduced relative to B6 littermates in the minimal clonic, minimal tonic hindlimb extension, and partial psychomotor seizure models." | 1.32 | Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. ( Frankel, WN; Otto, JF; White, HS; Wilcox, KS; Yang, Y, 2004) |
| "Benign familial neonatal convulsions (BFNC), a hereditary epilepsy, occurs specifically in newborns and remits spontaneously after this period." | 1.31 | Impaired M-current and neuronal excitability. ( Kamata, A; Kaneko, S; Murakami, T; Okada, M; Wada, K; Zhu, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maslarova, A | 1 |
| Salar, S | 1 |
| Lapilover, E | 1 |
| Friedman, A | 1 |
| Veh, RW | 1 |
| Heinemann, U | 1 |
| Okada, M | 1 |
| Wada, K | 1 |
| Kamata, A | 1 |
| Murakami, T | 1 |
| Zhu, G | 1 |
| Kaneko, S | 1 |
| Otto, JF | 1 |
| Yang, Y | 1 |
| Frankel, WN | 1 |
| Wilcox, KS | 1 |
| White, HS | 1 |
| Qiu, C | 1 |
| Johnson, BN | 1 |
| Tallent, MK | 1 |
4 other studies available for linopirdine and Seizures
| Article | Year |
|---|---|
Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels.
Topics: Acetylcholine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Entorhinal Cortex; Evoke | 2013 |
Impaired M-current and neuronal excitability.
Topics: Age Factors; Animals; Bicuculline; Central Nervous System; Data Interpretation, Statistical; Electro | 2002 |
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Electroshock; Female; Genetic Predispo | 2004 |
K+ M-current regulates the transition to seizures in immature and adult hippocampus.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsy, Benign Ne | 2007 |