linarin and Chemical-and-Drug-Induced-Liver-Injury

linarin has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 2 studies

Other Studies

2 other study(ies) available for linarin and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin. Molecules (Basel, Switzerland), 2019, Sep-13, Volume: 24, Issue:18 Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Disease Models, Animal; Galactosamine; Glycosides; Liver; Male; Plasma; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution	2019
Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway. Food & function, 2018, Apr-25, Volume: 9, Issue:4 Coptis chinensis inflorescence is traditionally used as tea and has been popular in the local market. C. chinensis inflorescence extract (CE) exhibits protective effects against carbon tetrachloride (CCl4)-induced damage, but the underlying mechanism remains unclear. The main chemicals of CE were detected, purified, and identified in this study. CE and linarin could reverse changes in cell viability, decrease alanine aminotransferase and aspartate transaminase levels, and reduce reactive oxygen species (ROS) generation induced by CCl4 in HepG2 cells. CE and linarin could also phosphorylate mitogen-activated protein kinases (MAPKs) and up-regulate Kelth-like ECH-associated protein (Keap1). The pathways of MAPKs and Keap1 lead to the separation of Keap1 and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Free Nrf2 transferred to the nucleus and enhanced the expression of phase II detoxification enzymes. This study provides a scientific basis for the use of C. chinensis inflorescence, which exhibits a hepatoprotective function, as a supplement in the food industry. Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Glycosides; Hep G2 Cells; Humans; Inflorescence; Kelch-Like ECH-Associated Protein 1; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; Protective Agents; Signal Transduction	2018

Article

Year

LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin.

Molecules (Basel, Switzerland), 2019, Sep-13, Volume: 24, Issue:18

Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Disease Models, Animal; Galactosamine; Glycosides; Liver; Male; Plasma; Rats; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution

2019

Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway.

Food & function, 2018, Apr-25, Volume: 9, Issue:4

Coptis chinensis inflorescence is traditionally used as tea and has been popular in the local market. C. chinensis inflorescence extract (CE) exhibits protective effects against carbon tetrachloride (CCl4)-induced damage, but the underlying mechanism remains unclear. The main chemicals of CE were detected, purified, and identified in this study. CE and linarin could reverse changes in cell viability, decrease alanine aminotransferase and aspartate transaminase levels, and reduce reactive oxygen species (ROS) generation induced by CCl4 in HepG2 cells. CE and linarin could also phosphorylate mitogen-activated protein kinases (MAPKs) and up-regulate Kelth-like ECH-associated protein (Keap1). The pathways of MAPKs and Keap1 lead to the separation of Keap1 and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Free Nrf2 transferred to the nucleus and enhanced the expression of phase II detoxification enzymes. This study provides a scientific basis for the use of C. chinensis inflorescence, which exhibits a hepatoprotective function, as a supplement in the food industry.

Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Glycosides; Hep G2 Cells; Humans; Inflorescence; Kelch-Like ECH-Associated Protein 1; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; Protective Agents; Signal Transduction

2018