linagliptin has been researched along with Retinal-Neovascularization* in 1 studies
1 other study(ies) available for linagliptin and Retinal-Neovascularization
| Article | Year |
|---|---|
Anti-angiogenic effects of the DPP-4 inhibitor linagliptin via inhibition of VEGFR signalling in the mouse model of oxygen-induced retinopathy.
Linagliptin has protective effects on the retinal neurovascular unit but, in proliferative retinopathy, dipeptidyl peptidase 4 (DPP-4) inhibition could be detrimental. The aim of this study was to assess the effect of linagliptin on ischaemia-induced neovascularisation of the retina.. Systemic treatment with linagliptin demonstrated GLP-1R-independent anti-angiogenic effects mediated by an inhibition of VEGF receptor downstream signalling. The specific effects of linagliptin on diabetic retinopathy are of potential benefit for individuals with diabetes, independent of metabolic effects. Topics: Animals; Diabetic Retinopathy; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Linagliptin; Male; Mice; Mice, Inbred C57BL; Oxygen; Retina; Retinal Neovascularization; Signal Transduction; Vascular Endothelial Growth Factor A | 2018 |