ligustroflavone has been researched along with Osteoporosis* in 1 studies
1 other study(ies) available for ligustroflavone and Osteoporosis
| Article | Year |
|---|---|
Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist.
Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR). This study aimed to explore the potency of ligustroflavone as a CaSR antagonist and its protective effects against diabetic osteoporosis in mice. LF interacted well with the allosteric site of CaSR shown by molecular docking analysis, increased PTH release of primary parathyroid gland cells and suppressed extracellular calcium influx in HEK-293 cells. The serum level of PTH attained peak value at 2 Topics: Animals; Apigenin; Bone Density; Calcium; Cancellous Bone; Cells, Cultured; Diabetes Complications; Gene Expression; Glycosides; HEK293 Cells; Humans; Kidney; Ligustrum; Male; Mice, Inbred C57BL; Osteoporosis; Parathyroid Glands; Parathyroid Hormone; Receptors, Calcium-Sensing; Time Factors | 2019 |