ligustilide and Ovarian-Neoplasms

ligustilide has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for ligustilide and Ovarian-Neoplasms

Article	Year
Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 121 Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epigenetic level and its downstream antioxidant defense genesHeme oxygenase-1,NAD(P)H Quinone Dehydrogenase 1, UDP Glucuronosyltransferase Family 1 Member A1and Glutamate-Cysteine Ligase. NRF2 knockdown by siRNA resulted increased cell death by Z-Ligustilide in ovarian cancer cells. Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death. Topics: 4-Butyrolactone; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; NF-E2-Related Factor 2; Ovarian Neoplasms; Reactive Oxygen Species; Transcription, Genetic	2018

Article

Year

Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 121

Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epigenetic level and its downstream antioxidant defense genesHeme oxygenase-1,NAD(P)H Quinone Dehydrogenase 1, UDP Glucuronosyltransferase Family 1 Member A1and Glutamate-Cysteine Ligase. NRF2 knockdown by siRNA resulted increased cell death by Z-Ligustilide in ovarian cancer cells. Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death.

Topics: 4-Butyrolactone; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; NF-E2-Related Factor 2; Ovarian Neoplasms; Reactive Oxygen Species; Transcription, Genetic

2018