ligustilide and Glioblastoma

ligustilide has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for ligustilide and Glioblastoma

Article	Year
The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells. PloS one, 2013, Volume: 8, Issue:6 Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardio-vascular diseases and ischemic brain injury. Recently, LIG has been connected to Glioblastoma multiforme (GBM) because of its structural similarity to 3-n-alkyphthalide (NBP), which is specifically cytotoxic to GBM cells. Hence, we investigated LIG's effect on GBM T98G cells. The study shows that LIG can significantly reduce T98G cells' migration in a dose-dependent manner. Furthermore, the attenuation of cellular mobility can be linked to the activity of the Rho GTPases (RhoA, Rac1 and Cdc42), the three critical molecular switches governing cytoskeleton remodeling; thus, regulating cell migration. LIG significantly reduces the expression of RhoA and affects in a milder manner the expression of Cdc42 and Rac1. Topics: 4-Butyrolactone; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cytoskeleton; Glioblastoma; Humans; Neoplasm Proteins; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein	2013

Article

Year

The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells.

PloS one, 2013, Volume: 8, Issue:6

Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardio-vascular diseases and ischemic brain injury. Recently, LIG has been connected to Glioblastoma multiforme (GBM) because of its structural similarity to 3-n-alkyphthalide (NBP), which is specifically cytotoxic to GBM cells. Hence, we investigated LIG's effect on GBM T98G cells. The study shows that LIG can significantly reduce T98G cells' migration in a dose-dependent manner. Furthermore, the attenuation of cellular mobility can be linked to the activity of the Rho GTPases (RhoA, Rac1 and Cdc42), the three critical molecular switches governing cytoskeleton remodeling; thus, regulating cell migration. LIG significantly reduces the expression of RhoA and affects in a milder manner the expression of Cdc42 and Rac1.

Topics: 4-Butyrolactone; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cytoskeleton; Glioblastoma; Humans; Neoplasm Proteins; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein

2013