lignans has been researched along with Zika-Virus-Infection* in 2 studies
2 other study(ies) available for lignans and Zika-Virus-Infection
| Article | Year |
|---|---|
Untargeted-based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir.
This study describes the molecular profile and the potential antiviral activity of extracts from Phyllanthus brasiliensis, a plant widely found in the Brazilian Amazon. The research aims to shed light on the potential use of this species as a natural antiviral agent.. The extracts were analysed using liquid chromatography-mass spectrometry (LC-MS) system, a potent analytical technique to discover drug candidates. In the meantime, in vitro antiviral assays were performed against Mayaro, Oropouche, Chikungunya, and Zika viruses. In addition, the antiviral activity of annotated compounds was predicted by in silico methods.. Overall, 44 compounds were annotated in this study. The results revealed that P. brasiliensis has a high content of fatty acids, flavones, flavan-3-ols, and lignans. Furthermore, in vitro assays revealed potent antiviral activity against different arboviruses, especially lignan-rich extracts against Zika virus (ZIKV), as follows: methanolic extract from bark (MEB) [effective concentration for 50% of the cells (EC. Phyllanthus brasiliensis extracts contain metabolites that could be a new kick-off point for the discovery of candidates for antiviral drug development, with lignans becoming a promising trend for further virology research. Topics: Antiviral Agents; Lignans; Phyllanthus; Plant Extracts; Zika Virus; Zika Virus Infection | 2023 |
Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus.
Flaviviruses such as Zika cause sporadic pandemic outbreaks worldwide. There is an urgent need for anti-Zika virus (ZIKV) drugs to prevent mother-to-child transmission of ZIKV, new infections in high-risk populations, and the infection of medical personnel in ZIKV-affected areas.. These investigations revealed that DGP inhibits ZIKV infection in vitro and in vivo.. The small molecule DGP has great potential for preclinical studies and the ability to inhibit ZIKV infection in humans. Topics: Animals; Antiviral Agents; Benzodioxoles; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Endosomes; Flavivirus; Glycosylation; Humans; Lignans; Mice; Mice, Knockout; Microbial Sensitivity Tests; Molecular Structure; Molecular Weight; Receptor, Interferon alpha-beta; Vero Cells; Zika Virus; Zika Virus Infection | 2019 |