lignans has been researched along with Uveitis* in 2 studies
2 other study(ies) available for lignans and Uveitis
| Article | Year |
|---|---|
Licarin A as a Novel Drug for Inflammatory Eye Diseases.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Chorioallantoic Membrane; Disease Models, Animal; Drug Discovery; Electroretinography; Eye Diseases; Inflammation; Intraocular Pressure; Intravitreal Injections; Lignans; Male; Rats; Rats, Wistar; Retinal Pigment Epithelium; Safety; Treatment Outcome; Uveitis | 2021 |
Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells.
We investigated the effects of matairesinol (MAT) in the experimental autoimmune uveitis (EAU), a classical animal model of uveitis. We found that treatment with MAT could alleviate intraocular inflammation of EAU. Notably, Th17 cells in eyes of EAU mice could be predominantly restrained by MAT. Furthermore, MAT could inhibit Th17 differentiation in vitro. In addition, MAT inhibited the signaling of MAPK and ROR-γt, a pivotal transcription factor for Th17 cell differentiation in vitro and in vivo. Taken together, these results suggested that MAT had immune-suppressive effects on autoimmune inflammation through Th17 cells. Topics: Animals; Autoimmune Diseases; Eye Proteins; Female; Freund's Adjuvant; Furans; Lignans; Mice; Mice, Inbred C57BL; Retinol-Binding Proteins; Th17 Cells; Uveitis | 2020 |