lignans and Substance-Withdrawal-Syndrome

To investigate the chemical constituents of active components of Saururus chinensis on anti-nicotine withdrawal symptoms.. Various column chromatography were used in the isolation and purification, and physiochemical constant determination and spectral analysis were adopted to determine the chemical structures.. Six chemical compounds were isolated from the active part of anti-withdrawal symptoms, and were identified as 4'-hydroxyl-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan (1) ,3-(2-nitroethyl)-1-methoxyindole(2), elemicin (3), erythro-(7R, 8S) - (-) - (3,4,5-trimethoxy-7-hydroxy-1'-allyl-3', 5'-dimethoxy)-8-O-4'-neolignan (4), 3,4,5-trimethoxy-phenylacrylaldehyde (5) and dibutyl phthalate (6).. Compound 1 is a novel lignan, compounds 2 - 6 are firstly isolated from this plant.

Topics: Lignans; Nicotine; Phytochemicals; Plants, Medicinal; Saururaceae; Substance Withdrawal Syndrome