lignans has been researched along with Renal-Insufficiency--Chronic* in 2 studies
2 other study(ies) available for lignans and Renal-Insufficiency--Chronic
| Article | Year |
|---|---|
(+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.
The progression of chronic kidney disease (CKD) increases the risks of cardiovascular morbidity and end-stage kidney disease. Indoxyl sulfate (IS), which is derived from dietary l-tryptophan by the action of bacterial l-tryptophan indole-lyase (TIL) in the gut, serves as a uremic toxin that exacerbates CKD-related kidney disorder. A mouse model previously showed that inhibition of TIL by 2-aza-l-tyrosine effectively reduced the plasma IS level, causing the recovery of renal damage. In this study, we found that (+)-sesamin and related lignans, which occur abundantly in sesame seeds, inhibit intestinal bacteria TILs. Kinetic studies revealed that (+)-sesamin and sesamol competitively inhibited Escherichia coli TIL (EcTIL) with K Topics: Benzodioxoles; Dioxoles; Enzyme Inhibitors; Gastrointestinal Microbiome; Kinetics; Lignans; Molecular Docking Simulation; Phenols; Renal Insufficiency, Chronic; Sesamum; Tryptophanase | 2022 |
Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis.
Topics: Acetylation; Animals; Biphenyl Compounds; Down-Regulation; Epithelial Cells; Fibrosis; Gene Ontology; Humans; Kidney Tubules; Lignans; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Peptide Fragments; Pyruvate Dehydrogenase Complex; Renal Insufficiency, Chronic; RNA, Messenger; Sirtuin 3; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2021 |