lignans and Pneumonia--Viral

To study anti-influenza virus effect of Arctigenin in vivo.. The influences on lung index, death rate of mice infected by influenza virus were observed in the mice infected with virus from nose.. Experiments in vivo showed that Arctigenin at the concentration of 100 microg/kg and 10 microg/kg for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus. Arctigenin at the concentration of 100 microg/kg prolonged the survival time of mice infected with influenza virus.. Arctigenin may be effective on treating influenza.

Topics: Animals; Antiviral Agents; Arctium; Drugs, Chinese Herbal; Female; Furans; Influenza A virus; Lignans; Lung; Male; Mice; Organ Size; Pneumonia, Viral; Ribavirin