lignans and Pituitary-Neoplasms

lignans has been researched along with Pituitary-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for lignans and Pituitary-Neoplasms

Article	Year
Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na Molecules (Basel, Switzerland), 2020, Jul-04, Volume: 25, Issue:13 Sesamin (SSM) and sesamolin (SesA) are the two major furofuran lignans of sesame oil and they have been previously noticed to exert various biological actions. However, their modulatory actions on different types of ionic currents in electrically excitable cells remain largely unresolved. The present experiments were undertaken to explore the possible perturbations of SSM and SesA on different types of ionic currents, e.g., voltage-gated Na Topics: Adenoma; Animals; Antioxidants; Dioxoles; Ion Channel Gating; Lignans; Pituitary Neoplasms; Potassium Channels, Voltage-Gated; Rats; Sesame Oil; Tumor Cells, Cultured; Voltage-Gated Sodium Channels	2020
Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. International journal of oncology, 2017, Volume: 50, Issue:4 Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects. In the present study, we examined the therapeutic effect of S. chinensis and its single compounds on hyperprolactinemia in the pituitary gland. In rat pituitary cells, PRL expression levels were examined using real-time PCR and western blot assay. Crude S. chinensis extract and its single compound, gomisin N, reduced mRNA and protein levels of PRL in GH3 cells. In addition, cell proliferation and PRL target gene expression in cells were modulated by S. chinensis. Similar to the in vitro experiments, crude S. chinensis extract and gomisin N reduced PRL levels in the pituitary and serum of immature female rats. These results show that S. chinensis and its single compound, gomisin N, are regulators of PRL production and may be candidates for treatment of hyperprolactinemia and prolactinoma. Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Female; Fruit; Gene Expression; Humans; Hyperprolactinemia; Lignans; Pituitary Gland; Pituitary Neoplasms; Plant Extracts; Polycyclic Compounds; Prolactin; Prolactinoma; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Schisandra	2017

Article

Year

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na

Molecules (Basel, Switzerland), 2020, Jul-04, Volume: 25, Issue:13

Sesamin (SSM) and sesamolin (SesA) are the two major furofuran lignans of sesame oil and they have been previously noticed to exert various biological actions. However, their modulatory actions on different types of ionic currents in electrically excitable cells remain largely unresolved. The present experiments were undertaken to explore the possible perturbations of SSM and SesA on different types of ionic currents, e.g., voltage-gated Na

Topics: Adenoma; Animals; Antioxidants; Dioxoles; Ion Channel Gating; Lignans; Pituitary Neoplasms; Potassium Channels, Voltage-Gated; Rats; Sesame Oil; Tumor Cells, Cultured; Voltage-Gated Sodium Channels

2020

Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat.

International journal of oncology, 2017, Volume: 50, Issue:4

Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects. In the present study, we examined the therapeutic effect of S. chinensis and its single compounds on hyperprolactinemia in the pituitary gland. In rat pituitary cells, PRL expression levels were examined using real-time PCR and western blot assay. Crude S. chinensis extract and its single compound, gomisin N, reduced mRNA and protein levels of PRL in GH3 cells. In addition, cell proliferation and PRL target gene expression in cells were modulated by S. chinensis. Similar to the in vitro experiments, crude S. chinensis extract and gomisin N reduced PRL levels in the pituitary and serum of immature female rats. These results show that S. chinensis and its single compound, gomisin N, are regulators of PRL production and may be candidates for treatment of hyperprolactinemia and prolactinoma.

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Female; Fruit; Gene Expression; Humans; Hyperprolactinemia; Lignans; Pituitary Gland; Pituitary Neoplasms; Plant Extracts; Polycyclic Compounds; Prolactin; Prolactinoma; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Schisandra

2017