lignans and Osteoarthritis--Knee

lignans has been researched along with Osteoarthritis--Knee* in 1 studies

Other Studies

1 other study(ies) available for lignans and Osteoarthritis--Knee

Article	Year
Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway. Oncotarget, 2016, Dec-13, Volume: 7, Issue:50 Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway. Topics: Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Heme Oxygenase-1; Humans; Interleukin-1beta; Lignans; Matrix Metalloproteinases, Secreted; Middle Aged; NF-E2-Related Factor 2; NF-KappaB Inhibitor alpha; Nitric Oxide; Osteoarthritis, Knee; Phosphorylation; RNA Interference; Signal Transduction; Transcription Factor RelA; Transfection	2016

Article

Year

Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway.

Oncotarget, 2016, Dec-13, Volume: 7, Issue:50

Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.

Topics: Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Heme Oxygenase-1; Humans; Interleukin-1beta; Lignans; Matrix Metalloproteinases, Secreted; Middle Aged; NF-E2-Related Factor 2; NF-KappaB Inhibitor alpha; Nitric Oxide; Osteoarthritis, Knee; Phosphorylation; RNA Interference; Signal Transduction; Transcription Factor RelA; Transfection

2016