lignans and Lipid-Metabolism-Disorders

Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia plants, has been widely studied for its beneficial effects on several chronic diseases. Accumulating studies have revealed that honokiol displays a potential therapeutic effect on alcoholic liver disease. In this study, the protective activity of honokiol on alcoholic liver disease was confirmed due to its significant inhibitory activity on the expression levels of inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1

Topics: Animals; Cytokines; Interleukin-1beta; Interleukin-6; Lignans; Lipid Metabolism; Lipid Metabolism Disorders; Liver; Liver Diseases, Alcoholic; Mice; NF-kappa B; PPAR alpha; Sterols; Tumor Necrosis Factor-alpha