lignans and Hepatoblastoma

lignans has been researched along with Hepatoblastoma* in 1 studies

Other Studies

1 other study(ies) available for lignans and Hepatoblastoma

Article	Year
Arctigenin induces apoptosis in human hepatoblastoma cells. Pediatric surgery international, 2019, Volume: 35, Issue:6 Arctigenin has been shown to have anti-tumor effects in various types of cancers. This study was conducted to verify these effects in the human-derived hepatoblastoma cell line, HUH-6 clone 5 (hereinafter, HUH-6).. Arctigenin was added to cultured HUH-6 cells, and cellular activity was evaluated by MTS assay. To determine the relationship between reduced cellular activity and apoptosis, we measured the activities of caspase 3/7, 8, and 9 and conducted flow cytometry with Annexin V/PI staining.. We found that arctigenin has anti-tumor effects in HUH-6 cells in a concentration-dependent manner. Arctigenin may have exerted its anti-tumor effect by inducing apoptosis via TNFR1, which recruits Complex IIa to activate caspase 8 and 3/7. These results may be useful for developing therapeutic agents for hepatoblastoma. Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cells, Cultured; Furans; Hepatoblastoma; Humans; Lignans; Liver Neoplasms	2019

Article

Year

Arctigenin induces apoptosis in human hepatoblastoma cells.

Pediatric surgery international, 2019, Volume: 35, Issue:6

Arctigenin has been shown to have anti-tumor effects in various types of cancers. This study was conducted to verify these effects in the human-derived hepatoblastoma cell line, HUH-6 clone 5 (hereinafter, HUH-6).. Arctigenin was added to cultured HUH-6 cells, and cellular activity was evaluated by MTS assay. To determine the relationship between reduced cellular activity and apoptosis, we measured the activities of caspase 3/7, 8, and 9 and conducted flow cytometry with Annexin V/PI staining.. We found that arctigenin has anti-tumor effects in HUH-6 cells in a concentration-dependent manner. Arctigenin may have exerted its anti-tumor effect by inducing apoptosis via TNFR1, which recruits Complex IIa to activate caspase 8 and 3/7. These results may be useful for developing therapeutic agents for hepatoblastoma.

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cells, Cultured; Furans; Hepatoblastoma; Humans; Lignans; Liver Neoplasms

2019