lignans and Esophageal-Squamous-Cell-Carcinoma

lignans has been researched along with Esophageal-Squamous-Cell-Carcinoma* in 2 studies

Other Studies

2 other study(ies) available for lignans and Esophageal-Squamous-Cell-Carcinoma

Article	Year
Sesamin exerts anti-tumor activity in esophageal squamous cell carcinoma via inhibition of TRIM44 and NF-κB signaling. Chemical biology & drug design, 2022, Volume: 99, Issue:1 Tripartite motif-containing 44 (TRIM44) is known to play an oncogenic role in multiple human cancers, including esophageal cancer. Sesamin possesses potent anti-inflammatory and anti-cancer properties for various cancers. This study is designed to unravel the biological functions of sesamin and TRIM44 in esophageal cancer. TRIM44 expression in esophageal squamous cell cancer (ESCC) cell lines and tissues was determined by RT-qPCR assay and Western blot. The effects of sesamin and TRIM44 on ESCC cell growth in vivo and in vitro were assessed by the mouse model and CCK-8 assay, respectively. We found that TRIM44 was significantly upregulated in ESCC cell lines and tissues when compared to their counterparts. Sesamin treatment or depletion of TRIM44 markedly reduced ESCC cell proliferation. The nuclear factor kappa B (NF-κB) and toll-like receptor 4 (TLR4) signaling pathway may be involved in sesamin-mediated TRIM44 suppression. Finally, we showed that oral administration of sesamin dramatically inhibited tumor growth or ESCC in nude mice. Our results suggest that sesamin exerts anti-tumor activity in ESCC via inhibition of NF-κB signaling pathway, demonstrating its potential for the treatment of esophageal cancer. Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dioxoles; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Intracellular Signaling Peptides and Proteins; Lignans; Mice; Mice, Nude; NF-kappa B; Signal Transduction; Transplantation, Heterologous; Tripartite Motif Proteins	2022
Deoxypodophyllotoxin, a Lignan from International journal of molecular sciences, 2020, Sep-18, Volume: 21, Issue:18 Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drugs, Chinese Herbal; ErbB Receptors; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species	2020

Article

Year

Sesamin exerts anti-tumor activity in esophageal squamous cell carcinoma via inhibition of TRIM44 and NF-κB signaling.

Chemical biology & drug design, 2022, Volume: 99, Issue:1

Tripartite motif-containing 44 (TRIM44) is known to play an oncogenic role in multiple human cancers, including esophageal cancer. Sesamin possesses potent anti-inflammatory and anti-cancer properties for various cancers. This study is designed to unravel the biological functions of sesamin and TRIM44 in esophageal cancer. TRIM44 expression in esophageal squamous cell cancer (ESCC) cell lines and tissues was determined by RT-qPCR assay and Western blot. The effects of sesamin and TRIM44 on ESCC cell growth in vivo and in vitro were assessed by the mouse model and CCK-8 assay, respectively. We found that TRIM44 was significantly upregulated in ESCC cell lines and tissues when compared to their counterparts. Sesamin treatment or depletion of TRIM44 markedly reduced ESCC cell proliferation. The nuclear factor kappa B (NF-κB) and toll-like receptor 4 (TLR4) signaling pathway may be involved in sesamin-mediated TRIM44 suppression. Finally, we showed that oral administration of sesamin dramatically inhibited tumor growth or ESCC in nude mice. Our results suggest that sesamin exerts anti-tumor activity in ESCC via inhibition of NF-κB signaling pathway, demonstrating its potential for the treatment of esophageal cancer.

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dioxoles; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Intracellular Signaling Peptides and Proteins; Lignans; Mice; Mice, Nude; NF-kappa B; Signal Transduction; Transplantation, Heterologous; Tripartite Motif Proteins

2022

Deoxypodophyllotoxin, a Lignan from

International journal of molecular sciences, 2020, Sep-18, Volume: 21, Issue:18

Topics: Antineoplastic Agents, Phytogenic; Apiaceae; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drugs, Chinese Herbal; ErbB Receptors; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Podophyllotoxin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species

2020