lignans has been researched along with Atrophy* in 2 studies
2 other study(ies) available for lignans and Atrophy
| Article | Year |
|---|---|
Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase-2 Activation in Copper/Zinc Superoxide Dismutase-Deficient Mice.
Aging is characterized by accumulation of chronic and irreversible oxidative damage, chronic inflammation, and organ dysfunction. Superoxide dismutase (SOD) serves as a major enzyme for cellular superoxide radical metabolism and physiologically regulates cellular redox balance throughout the body. Copper/zinc superoxide dismutase-deficient (SOD1 Topics: Animals; Atrophy; Biopsy, Needle; Blotting, Western; Copper; Forkhead Box Protein O3; Furans; Immunohistochemistry; Lignans; Matrix Metalloproteinase 2; Mice; Mice, Hairless; Polymerase Chain Reaction; Skin Aging; Superoxide Dismutase; Superoxide Dismutase-1; Treatment Outcome | 2019 |
Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons.
Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome of Eleutherococcus senticosus) were shown to have protective effects on the regeneration of neurites and the reconstruction of synapses in rat cultured cortical neurons damaged by amyloid β (Aβ)(25-35), and eleutheroside B was one of the active constituents. In this study, a comprehensive evaluation of constituents was conducted to explore active components from Siberian ginseng which can protect against neuritic atrophy induced by Aβ(25-35) in cultured rat cortical neurons. The ethyl acetate, n-butanol and water fractions from the methanol extract of Siberian ginseng showed protective effects against Aβ-induced neuritic atrophy. Twelve compounds were isolated from the active fractions and identified. Among them, eleutheroside B, eleutheroside E and isofraxidin showed obvious protective effects against Aβ(25-35)-induced atrophies of axons and dendrites at 1 and 10 μM. Topics: Amyloid beta-Peptides; Animals; Atrophy; Axons; Benzaldehydes; Cells, Cultured; Cerebral Cortex; Coumarins; Dendrites; Eleutherococcus; Fatty Acids; Female; Glucosides; Lignans; Magnetic Resonance Spectroscopy; Neurites; Neurons; Phenylpropionates; Plant Extracts; Pregnancy; Rats; Rats, Sprague-Dawley; Sitosterols; Spectrometry, Mass, Electrospray Ionization; Stigmasterol | 2011 |