lidoflazine has been researched along with Heart Arrest in 12 studies
Lidoflazine: Coronary vasodilator with some antiarrhythmic action.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five hundred twenty patients with cardiac arrest who remained comatose after the restoration of spontaneous circulation were randomly assigned to receive three doses of lidoflazine, an experimental calcium-entry blocker, or a placebo and were followed for six months." | 9.07 | A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. ( , 1991) |
| "Five hundred twenty patients with cardiac arrest who remained comatose after the restoration of spontaneous circulation were randomly assigned to receive three doses of lidoflazine, an experimental calcium-entry blocker, or a placebo and were followed for six months." | 5.07 | A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. ( , 1991) |
| "To assess survival after cardiac arrest and to determine whether age is an independent determinant of late mortality or poor neurologic outcome." | 2.68 | Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The Brain Resuscitation Clinical Trial I and II Study Groups. ( Abramson, NS; Rogove, HJ; Safar, P; Sutton-Tyrrell, K, 1995) |
| "Different mechanisms of cardiac arrest, which cause different morphologic patterns of brain damage, may need different cerebral resuscitation treatments." | 1.30 | Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study. ( Arfors, K; Diven, W; Moossy, J; Rao, G; Ravi, C; Safar, P; Vaagenes, P, 1997) |
| "Animals subjected to cardiac arrest and resuscitation and standard intensive care (SIC) had LMWC iron levels of 37." | 1.27 | Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest. ( Aust, SD; Bialek, H; Evans, AT; Huang, RR; Indrieri, RJ; Jacobs, WA; Komara, J; Nayini, NR; White, BC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| White, BC | 2 |
| Winegar, CD | 1 |
| Jackson, RE | 1 |
| Joyce, KM | 1 |
| Vigor, DN | 1 |
| Hoehner, TJ | 1 |
| Krause, GS | 1 |
| Wilson, RF | 1 |
| Rogove, HJ | 1 |
| Safar, P | 2 |
| Sutton-Tyrrell, K | 2 |
| Abramson, NS | 1 |
| Shively, M | 1 |
| Norton, L | 1 |
| Mendez, K | 1 |
| Vaagenes, P | 1 |
| Moossy, J | 1 |
| Rao, G | 1 |
| Diven, W | 1 |
| Ravi, C | 1 |
| Arfors, K | 1 |
| Engler, RL | 1 |
| Snyder, JV | 1 |
| Kelsey, S | 1 |
| Abramson, N | 2 |
| Plum, F | 1 |
| Martin, GB | 1 |
| Nowak, RM | 1 |
| Carden, DL | 1 |
| Eisiminger, RA | 1 |
| Tomlanovich, MC | 1 |
| Nayini, NR | 1 |
| Aust, SD | 1 |
| Huang, RR | 1 |
| Indrieri, RJ | 1 |
| Evans, AT | 1 |
| Bialek, H | 1 |
| Jacobs, WA | 1 |
| Komara, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest : Prospective Study of Routine Care[NCT02849561] | 82 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Vasopressin, Epinephrine, and Corticosteroids for Inhospital Cardiac Arrest: A Multicenter Randomized Controlled Trial[NCT00729794] | Phase 3 | 300 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Effect of Stress-dose Steroids on Post-resuscitation Infectious (Septic) Complications After In-hospital Cardiac Arrest. Individual Patient Data-based Re-analysis of Synthesized Prior Randomized Clinical Trial Data[NCT02408939] | 191 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lidoflazine and Heart Arrest
| Article | Year |
|---|---|
Neurologic outcomes after cardiac resuscitation.
Topics: Brain Injuries; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Heart Arrest; Humans; Hypno | 1996 |
6 trials available for lidoflazine and Heart Arrest
| Article | Year |
|---|---|
Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The Brain Resuscitation Clinical Trial I and II Study Groups.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Coma; Double-Blind Method; Fema | 1995 |
A randomized clinical trial of calcium entry blocker administration to comatose survivors of cardiac arrest. Design, methods, and patient characteristics. The Brain Resuscitation Clinical Trial II Study Group.
Topics: Brain Damage, Chronic; Cardiopulmonary Resuscitation; Coma; Double-Blind Method; Heart Arrest; Human | 1991 |
A randomized clinical trial of calcium entry blocker administration to comatose survivors of cardiac arrest. Design, methods, and patient characteristics. The Brain Resuscitation Clinical Trial II Study Group.
Topics: Brain Damage, Chronic; Cardiopulmonary Resuscitation; Coma; Double-Blind Method; Heart Arrest; Human | 1991 |
A randomized clinical trial of calcium entry blocker administration to comatose survivors of cardiac arrest. Design, methods, and patient characteristics. The Brain Resuscitation Clinical Trial II Study Group.
Topics: Brain Damage, Chronic; Cardiopulmonary Resuscitation; Coma; Double-Blind Method; Heart Arrest; Human | 1991 |
A randomized clinical trial of calcium entry blocker administration to comatose survivors of cardiac arrest. Design, methods, and patient characteristics. The Brain Resuscitation Clinical Trial II Study Group.
Topics: Brain Damage, Chronic; Cardiopulmonary Resuscitation; Coma; Double-Blind Method; Heart Arrest; Human | 1991 |
Risk monitoring of randomized trials in emergency medicine: experience of the Brain Resuscitation Clinical Trial II.
Topics: Arrhythmias, Cardiac; Brain Diseases; Brain Injuries; Clinical Protocols; Clinical Trials as Topic; | 1991 |
A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest.
Topics: Brain Damage, Chronic; Calcium Channel Blockers; Coma; Drug Evaluation; Female; Follow-Up Studies; H | 1991 |
Vulnerability of the brain and heart after cardiac arrest.
Topics: Brain; Brain Damage, Chronic; Calcium Channel Blockers; Coma; Heart; Heart Arrest; Humans; Lidoflazi | 1991 |
Calcium blockers after cardiac arrest: history repeats itself.
Topics: Animals; Brain; Calcium Channel Blockers; Clinical Trials as Topic; Heart Arrest; Humans; Lidoflazin | 1985 |
5 other studies available for lidoflazine and Heart Arrest
| Article | Year |
|---|---|
Cerebral cortical perfusion during and following resuscitation from cardiac arrest in dogs.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium; Cell Membrane; Cerebral Cortex; Cerebrovascular Cir | 1983 |
Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study.
Topics: Animals; Asphyxia; Brain Ischemia; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Dogs; Fe | 1997 |
Lidoflazine in the treatment of comatose survivors of cardiac arrest.
Topics: Coma; Heart Arrest; Humans; Lidoflazine | 1991 |
Cardiopulmonary bypass vs CPR as treatment for prolonged canine cardiopulmonary arrest.
Topics: Animals; Blood Circulation; Cardiopulmonary Bypass; Central Nervous System Diseases; Dogs; Heart Arr | 1987 |
Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest.
Topics: Animals; Brain Ischemia; Deferoxamine; Dogs; Free Radicals; Heart Arrest; Iron Chelating Agents; Lid | 1985 |