lidoflazine has been researched along with Brain Ischemia in 7 studies
Lidoflazine: Coronary vasodilator with some antiarrhythmic action.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate the effects of the calcium entry blocker lidoflazine on neurologic outcome in primates following an episode of global brain ischemia, 12 pigtail monkeys (Macaca nemestrina) were subjected to 17 min of complete cerebral ischemia, followed by 48 h of intensive care treatment and daily neurologic evaluations for 96 h." | 7.67 | Lidoflazine does not improve neurologic outcome when administered after complete cerebral ischemia in primates. ( Fleischer, JE; Lanier, WL; Michenfelder, JD; Milde, JH, 1987) |
| "This study tested the hypothesis that lidoflazine, a calcium entry blocking drug, will improve post-ischemic neurologic outcome when administered after a period of complete cerebral ischemia, and that the improvement in outcome is related to an increase in post-ischemic cerebral blood flow (CBF)." | 7.67 | Effect of lidoflazine on cerebral blood flow and neurologic outcome when administered after complete cerebral ischemia in dogs. ( Fleischer, JE; Lanier, WL; Michenfelder, JD; Milde, JH, 1987) |
| "In order to investigate the effects of the calcium entry blocker lidoflazine on neurologic outcome in primates following an episode of global brain ischemia, 12 pigtail monkeys (Macaca nemestrina) were subjected to 17 min of complete cerebral ischemia, followed by 48 h of intensive care treatment and daily neurologic evaluations for 96 h." | 3.67 | Lidoflazine does not improve neurologic outcome when administered after complete cerebral ischemia in primates. ( Fleischer, JE; Lanier, WL; Michenfelder, JD; Milde, JH, 1987) |
| "This study tested the hypothesis that lidoflazine, a calcium entry blocking drug, will improve post-ischemic neurologic outcome when administered after a period of complete cerebral ischemia, and that the improvement in outcome is related to an increase in post-ischemic cerebral blood flow (CBF)." | 3.67 | Effect of lidoflazine on cerebral blood flow and neurologic outcome when administered after complete cerebral ischemia in dogs. ( Fleischer, JE; Lanier, WL; Michenfelder, JD; Milde, JH, 1987) |
| "Different mechanisms of cardiac arrest, which cause different morphologic patterns of brain damage, may need different cerebral resuscitation treatments." | 1.30 | Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study. ( Arfors, K; Diven, W; Moossy, J; Rao, G; Ravi, C; Safar, P; Vaagenes, P, 1997) |
| "Animals subjected to cardiac arrest and resuscitation and standard intensive care (SIC) had LMWC iron levels of 37." | 1.27 | Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest. ( Aust, SD; Bialek, H; Evans, AT; Huang, RR; Indrieri, RJ; Jacobs, WA; Komara, J; Nayini, NR; White, BC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaagenes, P | 2 |
| Cantadore, R | 1 |
| Safar, P | 2 |
| Moossy, J | 2 |
| Rao, G | 2 |
| Diven, W | 2 |
| Alexander, H | 1 |
| Stezoski, W | 1 |
| Ravi, C | 1 |
| Arfors, K | 1 |
| Alps, BJ | 1 |
| Calder, C | 1 |
| Hass, WK | 1 |
| Wilson, AD | 1 |
| Lyden, PD | 1 |
| Zivin, JA | 1 |
| Kochhar, A | 1 |
| Mazzarella, V | 1 |
| Fleischer, JE | 2 |
| Lanier, WL | 2 |
| Milde, JH | 2 |
| Michenfelder, JD | 2 |
| Nayini, NR | 1 |
| White, BC | 1 |
| Aust, SD | 1 |
| Huang, RR | 1 |
| Indrieri, RJ | 1 |
| Evans, AT | 1 |
| Bialek, H | 1 |
| Jacobs, WA | 1 |
| Komara, J | 1 |
7 other studies available for lidoflazine and Brain Ischemia
| Article | Year |
|---|---|
Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs.
Topics: Animals; Blood Pressure; Brain Ischemia; Cardiac Output; Dogs; Drug Evaluation, Preclinical; Electro | 1984 |
Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study.
Topics: Animals; Asphyxia; Brain Ischemia; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Dogs; Fe | 1997 |
Comparative protective effects of nicardipine, flunarizine, lidoflazine and nimodipine against ischaemic injury in the hippocampus of the Mongolian gerbil.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Female; Flunarizine; | 1988 |
Effects of calcium channel blockers on neurologic outcome after focal ischemia in rabbits.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Lidoflazine; Nervous System; Nicardipine; Nimodip | 1988 |
Lidoflazine does not improve neurologic outcome when administered after complete cerebral ischemia in primates.
Topics: Animals; Brain Ischemia; Female; Hemodynamics; Lidoflazine; Macaca nemestrina; Male; Neurologic Exam | 1987 |
Effect of lidoflazine on cerebral blood flow and neurologic outcome when administered after complete cerebral ischemia in dogs.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dogs; Lidoflazine; Oxygen Consumption; | 1987 |
Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest.
Topics: Animals; Brain Ischemia; Deferoxamine; Dogs; Free Radicals; Heart Arrest; Iron Chelating Agents; Lid | 1985 |