lidocaine has been researched along with Trigeminal Neuralgia in 56 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was undertaken to investigate the clinical outcome of trigeminal nerve block with 10% lidocaine in the management of trigeminal neuralgia (TN)." | 9.13 | Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia. ( Chae, YJ; Han, KR; Kim, C; Kim, DW, 2008) |
| "Intranasal lidocaine 8% administered by a metered-dose spray produced prompt but temporary analgesia without serious adverse reactions in patients with second-division trigeminal neuralgia." | 9.12 | Intranasal lidocaine 8% spray for second-division trigeminal neuralgia. ( Hoka, S; Kanai, A; Kobayashi, M; Suzuki, A, 2006) |
| "This study investigated the long term effect of a peripheral sensory block using streptomycin sulphate on trigeminal neuralgia." | 9.07 | The effects of streptomycin/lidocaine block on trigeminal neuralgia: a double blind crossover placebo controlled study. ( Bittar, GT; Graff-Radford, SB, 1993) |
| "Seventeen patients with long-lasting idiopathic trigeminal neuralgia (ITN) were treated with either five, weekly peripheral streptomycin/lidocaine (S/L) or lidocaine alone injections, in a double blind controlled study." | 9.06 | Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial. ( Juniper, RP; Stajcić, Z; Todorović, L, 1990) |
| " Tocainide was alternatively with carbamazepine given to 12 patients with trigeminal neuralgia in a double-blind cross-over study for 2 weeks." | 9.06 | The analgesic effect of tocainide in trigeminal neuralgia. ( Lindblom, U; Lindström, P, 1987) |
| "Whether 5% lidocaine-medicated plaster (LMP) is a valuable therapeutic option for the treatment of trigeminal neuralgia (TN) is worth exploring." | 8.31 | Effectiveness, Safety, and Predictors of Response to 5% Lidocaine-Medicated Plaster for the Treatment of Patients With Trigeminal Neuralgia: A Retrospective Study. ( Luo, F; Meng, L; Xing, Y; Yu, B; Zhang, W; Zhao, C, 2023) |
| "Lidocaine aerosol sprayed on oral and/or nasal mucosa is beneficial for immediate pain relief in patients with acute trigeminal neuralgia exacerbations." | 8.31 | Lidocaine aerosol sprayed on oral and/or nasal mucosa for the rescue of acute trigeminal neuralgia exacerbations: A retrospective study. ( Luo, F; Shen, Y; Zhao, C; Zhou, X, 2023) |
| " We aimed to evaluate the clinical efficacy of triamcinolone and lidocaine injection for peripheral nerve branches in trigeminal neuralgia (TN) in terms of pain severity, pain frequency, and drug doses used." | 8.02 | Clinical effectiveness of peripheral nerve blocks with lidocaine and corticosteroid in patients with trigeminal neuralgia. ( Balta, S; Köknel Talu, G, 2021) |
| "Streptomycin sulphate dissolved in 2% lidocaine solution was deposited adjacent to peripheral branches of maxillary or mandibular nerves in 20 patients with idiopathic trigeminal neuralgia." | 7.67 | Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia. A preliminary report. ( Petrović, V; Sokolović, M; Stajcić, Z; Todorović, L, 1986) |
| " Adverse events will also be monitored throughout the study." | 7.01 | The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study. ( Fan, B; Liu, H; Luo, F; Meng, L; Shen, Y; Shrestha, N; Zhao, C, 2021) |
| "Chronic neurogenic facial pain is commonly resistant to treatment and is often the source of significant patient morbidity." | 6.69 | Chronic neurogenic facial pain: lack of response to intravenous phentolamine. ( Chaudry, A; Keith, DA; Maciewicz, RJ; Scrivani, SJ, 1999) |
| "Trigeminal neuralgia and cluster headache syndrome are complex pain conditions of the craniofacial region." | 6.39 | Use of streptomycin-lidocaine injections in the treatment of the cluster-tic syndrome. Clinical perspectives and a case report. ( Kreiner, M, 1996) |
| " In our study, we assess the safety and efficacy of lidocaine local anesthesia in the treatment of trigeminal neuralgia." | 5.51 | Cardiovascular response to Gasserian ganglion ablation on trigeminal neuralgia under local anesthesia: a retrospective single-blind case-control study. ( Huang, Y; Li, J; Ma, C; Tao, G; Zhao, D, 2022) |
| "Trigeminal neuralgia (TN) is a neuropathic pain condition affecting one or more branches of the trigeminal nerve." | 5.40 | Effect of 5% lidocaine medicated plaster on pain intensity and paroxysms in classical trigeminal neuralgia. ( Brugnoli, MP; Magrinelli, F; Polati, E; Schweiger, V; Tamburin, S; Zanette, G, 2014) |
| " This study was undertaken to investigate the clinical outcome of trigeminal nerve block with 10% lidocaine in the management of trigeminal neuralgia (TN)." | 5.13 | Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia. ( Chae, YJ; Han, KR; Kim, C; Kim, DW, 2008) |
| "Intranasal lidocaine 8% administered by a metered-dose spray produced prompt but temporary analgesia without serious adverse reactions in patients with second-division trigeminal neuralgia." | 5.12 | Intranasal lidocaine 8% spray for second-division trigeminal neuralgia. ( Hoka, S; Kanai, A; Kobayashi, M; Suzuki, A, 2006) |
| "This study investigated the long term effect of a peripheral sensory block using streptomycin sulphate on trigeminal neuralgia." | 5.07 | The effects of streptomycin/lidocaine block on trigeminal neuralgia: a double blind crossover placebo controlled study. ( Bittar, GT; Graff-Radford, SB, 1993) |
| "Seventeen patients with long-lasting idiopathic trigeminal neuralgia (ITN) were treated with either five, weekly peripheral streptomycin/lidocaine (S/L) or lidocaine alone injections, in a double blind controlled study." | 5.06 | Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial. ( Juniper, RP; Stajcić, Z; Todorović, L, 1990) |
| " Tocainide was alternatively with carbamazepine given to 12 patients with trigeminal neuralgia in a double-blind cross-over study for 2 weeks." | 5.06 | The analgesic effect of tocainide in trigeminal neuralgia. ( Lindblom, U; Lindström, P, 1987) |
| "Whether 5% lidocaine-medicated plaster (LMP) is a valuable therapeutic option for the treatment of trigeminal neuralgia (TN) is worth exploring." | 4.31 | Effectiveness, Safety, and Predictors of Response to 5% Lidocaine-Medicated Plaster for the Treatment of Patients With Trigeminal Neuralgia: A Retrospective Study. ( Luo, F; Meng, L; Xing, Y; Yu, B; Zhang, W; Zhao, C, 2023) |
| "Lidocaine aerosol sprayed on oral and/or nasal mucosa is beneficial for immediate pain relief in patients with acute trigeminal neuralgia exacerbations." | 4.31 | Lidocaine aerosol sprayed on oral and/or nasal mucosa for the rescue of acute trigeminal neuralgia exacerbations: A retrospective study. ( Luo, F; Shen, Y; Zhao, C; Zhou, X, 2023) |
| " We aimed to evaluate the clinical efficacy of triamcinolone and lidocaine injection for peripheral nerve branches in trigeminal neuralgia (TN) in terms of pain severity, pain frequency, and drug doses used." | 4.02 | Clinical effectiveness of peripheral nerve blocks with lidocaine and corticosteroid in patients with trigeminal neuralgia. ( Balta, S; Köknel Talu, G, 2021) |
| "Intra-arterial lidocaine was administered to three patients with trigeminal neuralgia (35-year-old woman, 57-year-old man, and 34-year-old woman)." | 3.88 | Intra-arterial Modulation of the Trigeminal Nerve Ganglion in Patients with Refractory Trigeminal Neuralgia. ( Jadhav, V; Qureshi, AI; Raja, F; Saleem, MA; Wallery, SS, 2018) |
| "Streptomycin sulphate dissolved in 2% lidocaine solution was deposited adjacent to peripheral branches of maxillary or mandibular nerves in 20 patients with idiopathic trigeminal neuralgia." | 3.67 | Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia. A preliminary report. ( Petrović, V; Sokolović, M; Stajcić, Z; Todorović, L, 1986) |
| "Human trigeminal root evoked potentials have been recorded using signal averaging techniques during radiofrequency trigeminal rhizotomy and lidocaine blocks in patients with trigeminal neuralgia." | 3.67 | Human trigeminal root evoked potentials during differential retrogasserian thermal and chemical rhizotomy. ( Macon, JB; Poletti, CE, 1987) |
| " Adverse events will also be monitored throughout the study." | 3.01 | The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study. ( Fan, B; Liu, H; Luo, F; Meng, L; Shen, Y; Shrestha, N; Zhao, C, 2021) |
| "Chronic neurogenic facial pain is commonly resistant to treatment and is often the source of significant patient morbidity." | 2.69 | Chronic neurogenic facial pain: lack of response to intravenous phentolamine. ( Chaudry, A; Keith, DA; Maciewicz, RJ; Scrivani, SJ, 1999) |
| "Lidocaine is a local anaesthetic that is sometimes used on the skin to treat neuropathic pain." | 2.50 | Topical lidocaine for neuropathic pain in adults. ( Derry, S; Moore, RA; Quinlan, J; Wiffen, PJ, 2014) |
| "Paroxysmal hemicrania is experienced as headache attacks with pain and accompanying symptoms similar to those of cluster headaches." | 2.47 | [Paroxysmal hemicrania and SUNCT]. ( Göbel, C; Göbel, H; Heinze, A, 2011) |
| "Trigeminal neuralgia and cluster headache syndrome are complex pain conditions of the craniofacial region." | 2.39 | Use of streptomycin-lidocaine injections in the treatment of the cluster-tic syndrome. Clinical perspectives and a case report. ( Kreiner, M, 1996) |
| "Neuropathic orofacial pain disorders are frequently managed with topical or systemic medications that carry a risk of dangerous side effects such as drowsiness, disorientation, and/or physical addiction." | 1.72 | Oral appliances in the management of neuropathic orofacial pain: A retrospective case series. ( Bavarian, R; Khawaja, SN; Treister, NS, 2022) |
| "The results showed that CCI-ION induced hyperalgesia, which was attenuated by lidocaine or carbamazepine, developed anxiety-like behavior, which was reduced only by midazolam, and displayed a reduced number of 50-kHz calls, compared to sham." | 1.72 | Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs. ( Araya, EI; Baggio, DF; Chichorro, JG; Koren, LO; Schwarting, RKW, 2022) |
| "Localized neuropathic pain (LNP) is a subgroup of neuropathic pain characterized by consistent and circumscribed area(s) of maximum pain, associated with negative or positive sensory signs and/or spontaneous symptoms characteristic of NP." | 1.48 | Efficacy of lidocaine 5% medicated plaster (VERSATIS®) in patients with localized neuropathic pain poorly responsive to pharmacological therapy. ( Chinellato, E; Del Balzo, G; Martini, A; Parolini, M; Picelli, A; Polati, E; Schweiger, V; Tamburin, S; Zanzotti, M, 2018) |
| "However, if the intractable pain is limited to a certain branch, the patient may also benefit from a peripheral and nerve-targeted interventional approach." | 1.46 | Management of isolated infraorbital neuralgia by ultrasound-guided infraorbital nerve block with combination of steroid and local anesthetic. ( Aribogan, A; Cok, OY; Deniz, S; Eker, HE; Oguzkurt, L, 2017) |
| "Trigeminal neuralgia (TN) is a neuropathic pain condition affecting one or more branches of the trigeminal nerve." | 1.40 | Effect of 5% lidocaine medicated plaster on pain intensity and paroxysms in classical trigeminal neuralgia. ( Brugnoli, MP; Magrinelli, F; Polati, E; Schweiger, V; Tamburin, S; Zanette, G, 2014) |
| "The treatment of neuropathic pain is a medical challenge." | 1.40 | [Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain]. ( Chiarlone, R; Fogliardi, A; Intelligente, F; Irace, C; Lanzilotta, M; Lattanzi, S; Palomba, R; Provinciali, L; Storelli, E; Zampi, M, 2014) |
| "Chronic pain is often a symptom after local anaesthetic-induced nerve injury." | 1.36 | Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010) |
| "All Lidocaine injections were given with 20 mg Depo-medrol and the same injection technique and location were used for all the procedures." | 1.36 | Adverse effect profile of lidocaine injections for occipital nerve block in occipital neuralgia. ( Sahai-Srivastava, S; Subhani, D, 2010) |
| "Facial pain has many causes, including idiopathic factors, trigeminal neuralgia, dental problems, temporomandibular joint disorders, cranial abnormalities, and infections." | 1.35 | A case of facial myofascial pain syndrome presenting as trigeminal neuralgia. ( Chang, SH; Choi, SU; Lee, HW; Lee, SI; Lim, HJ; Shin, HW; Yoon, SZ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (23.21) | 18.7374 |
| 1990's | 8 (14.29) | 18.2507 |
| 2000's | 6 (10.71) | 29.6817 |
| 2010's | 22 (39.29) | 24.3611 |
| 2020's | 7 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Balta, S | 1 |
| Köknel Talu, G | 1 |
| Araya, EI | 1 |
| Baggio, DF | 1 |
| Koren, LO | 1 |
| Schwarting, RKW | 1 |
| Chichorro, JG | 1 |
| Zhao, D | 1 |
| Li, J | 1 |
| Ma, C | 1 |
| Huang, Y | 1 |
| Tao, G | 1 |
| Yu, B | 1 |
| Zhang, W | 1 |
| Zhao, C | 3 |
| Xing, Y | 1 |
| Meng, L | 2 |
| Luo, F | 3 |
| Zhou, X | 1 |
| Shen, Y | 2 |
| Bavarian, R | 1 |
| Khawaja, SN | 1 |
| Treister, NS | 1 |
| Shrestha, N | 1 |
| Liu, H | 1 |
| Fan, B | 1 |
| Qureshi, AI | 2 |
| Saleem, MA | 2 |
| Jadhav, V | 1 |
| Wallery, SS | 2 |
| Raja, F | 2 |
| Martini, A | 1 |
| Del Balzo, G | 1 |
| Schweiger, V | 2 |
| Zanzotti, M | 1 |
| Picelli, A | 1 |
| Parolini, M | 1 |
| Chinellato, E | 1 |
| Tamburin, S | 2 |
| Polati, E | 2 |
| Naseem, N | 1 |
| Perloff, MD | 1 |
| Chung, JS | 1 |
| Steinberg, DI | 1 |
| Roses, S | 1 |
| Arai, YC | 1 |
| Hatakeyama, N | 1 |
| Nishihara, M | 1 |
| Ikeuchi, M | 1 |
| Kurisuno, M | 1 |
| Ikemoto, T | 1 |
| Niki, Y | 1 |
| Kanai, A | 2 |
| Hoshi, K | 1 |
| Okamoto, H | 1 |
| Chaudhry, P | 1 |
| Friedman, DI | 1 |
| Derry, S | 1 |
| Wiffen, PJ | 1 |
| Moore, RA | 1 |
| Quinlan, J | 1 |
| Magrinelli, F | 1 |
| Brugnoli, MP | 1 |
| Zanette, G | 1 |
| Provinciali, L | 1 |
| Lattanzi, S | 1 |
| Chiarlone, R | 1 |
| Fogliardi, A | 1 |
| Intelligente, F | 1 |
| Irace, C | 1 |
| Lanzilotta, M | 1 |
| Palomba, R | 1 |
| Storelli, E | 1 |
| Zampi, M | 1 |
| Di Stani, F | 1 |
| Ojango, C | 1 |
| Dugoni, D | 1 |
| Di Lorenzo, L | 1 |
| Masala, S | 1 |
| Delfini, R | 1 |
| Bruti, G | 1 |
| Simonetti, G | 1 |
| Piovesan, EJ | 1 |
| Ruggeri, AG | 1 |
| Xu, M | 1 |
| Chen, P | 1 |
| Zhu, X | 1 |
| Wang, CZ | 1 |
| Huang, J | 1 |
| Ni, Z | 1 |
| Finch, P | 1 |
| Cok, OY | 1 |
| Deniz, S | 1 |
| Eker, HE | 1 |
| Oguzkurt, L | 1 |
| Aribogan, A | 1 |
| Yoon, SZ | 1 |
| Lee, SI | 1 |
| Choi, SU | 1 |
| Shin, HW | 1 |
| Lee, HW | 1 |
| Lim, HJ | 1 |
| Chang, SH | 1 |
| Sahai-Srivastava, S | 1 |
| Subhani, D | 1 |
| Renton, T | 2 |
| Adey-Viscuso, D | 1 |
| Meechan, JG | 1 |
| Yilmaz, Z | 2 |
| Candido, KD | 1 |
| Germanovich, A | 1 |
| Ghaly, RF | 1 |
| Gorelick, GH | 1 |
| Knezevic, NN | 1 |
| Göbel, H | 1 |
| Göbel, C | 1 |
| Heinze, A | 1 |
| Chigurupati, K | 1 |
| Vemuri, NN | 1 |
| Velivela, SR | 1 |
| Mastan, SS | 1 |
| Thotakura, AK | 1 |
| Galer, BS | 1 |
| MCNEILL, RA | 1 |
| LAHAUT, J | 1 |
| CIOCATTO, E | 1 |
| ZAFFIRI, O | 1 |
| Lin, M | 1 |
| Suzuki, A | 1 |
| Kobayashi, M | 1 |
| Hoka, S | 1 |
| Wheeler, DW | 1 |
| Han, KR | 1 |
| Kim, C | 1 |
| Chae, YJ | 1 |
| Kim, DW | 1 |
| Maxwell, RE | 1 |
| Chindia, ML | 1 |
| Ng'ang'a, PM | 1 |
| Dominguez, J | 1 |
| Lobato, RD | 1 |
| Rivas, JJ | 1 |
| Gargallo, MC | 1 |
| Castells, V | 1 |
| Gozalo, A | 1 |
| Sarabia, R | 1 |
| Bittar, GT | 1 |
| Graff-Radford, SB | 1 |
| Kreiner, M | 1 |
| Peterson, JN | 1 |
| Schames, J | 1 |
| Schames, M | 1 |
| King, E | 1 |
| Stajcić, Z | 3 |
| Todorović, L | 3 |
| Scrivani, SJ | 1 |
| Chaudry, A | 1 |
| Maciewicz, RJ | 1 |
| Keith, DA | 1 |
| Juniper, RP | 1 |
| Lindström, P | 1 |
| Lindblom, U | 1 |
| Sokolović, M | 1 |
| Petrović, V | 1 |
| Macon, JB | 1 |
| Poletti, CE | 1 |
| Mason, DA | 1 |
| Struzak-Wysokinska, M | 1 |
| Leanderson, R | 1 |
| Persson, A | 1 |
| Maritano, M | 1 |
| Marchisio, O | 1 |
| Ghilardi, F | 1 |
| Bobrow, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Effect Evaluation of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia[NCT06129071] | 10 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | |||
| The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia[NCT04570293] | Phase 4 | 226 participants (Actual) | Interventional | 2021-05-01 | Completed | ||
| Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726] | 120 participants (Actual) | Interventional | 2017-06-10 | Completed | |||
| Use of the Tx360 Nasal Applicator for Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Migraine: A Double-blind Placebo-controlled Study[NCT01709708] | Phase 4 | 41 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma[NCT02838758] | Phase 1 | 10 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of acute medications used during Treatment period (6 weeks) and Follow-Up (4 weeks) (Group A vs. Group B). (NCT01709708)
Timeframe: 10 Weeks
| Intervention | Number of medications used (Mean) |
|---|---|
| Marcaine | 29.3 |
| Saline | 47.4 |
Number of adverse events over the entire length of study (Group A vs. Group B). (NCT01709708)
Timeframe: 34 weeks
| Intervention | Number of Adverse Events (Mean) |
|---|---|
| Marcaine | 7.67 |
| Saline | 5.29 |
Compare percentage change in Numeric Rating Scale (NRS) score from Before Procedure to 15-Minutes, Before Procedure to 30-Minutes, Before Procedure to 24-Hours After Procedure for all 12 treatments (Mean of all 12 treatments for each timepoint, comparing Group A to Group B). NRS is a likert scale ranging from 0-10 with 0 being no pain and 10 being worst possible pain. (NCT01709708)
Timeframe: 15 Minutes Post Treatment, 30 minutes Post Treatment and 24 hours Post Treatment, assessed up to 6 weeks
| Intervention | percentage of change (Mean) | ||
|---|---|---|---|
| 15 Minutes Post Treatment | 30 Minutes Post Treatment | 24 Hours Post Treatment | |
| Marcaine | -23.3 | -27.7 | -15.5 |
| Saline | -4.31 | -5.41 | 13.5 |
"Total Headache Impact Test (HIT-6) scores Pre-Treatment at Visit 2 vs. Post-Treatment (following final treatment), and at 1-Month Post-Treatment (Group A vs. Group B). HIT-6 is a series of 6 likert scale questions ranging from 1 to 5 with 1 being never and 5 being always. The HIT-6 answer options are weighted as follows: Never (1) = 6 points each, Rarely (2) = 9 points each, Sometimes (3) = 10 points each, Very often (4) = 11 points each, Always (5) = 13 points each. The total score for the HIT-6 ranges from 36 (subject answers all 6 questions as Never) to 78 subject answers all 6 questions as Always), with higher total scores indicating more impact than lower scores, i.e., headaches cause greater impact on the subject's life." (NCT01709708)
Timeframe: 10 Weeks
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Pre-Treatment | Post-Treatment | 1-Month Post-Treatment | |
| Marcaine | 64.36 | 59.85 | 59.23 |
| Saline | 64 | 62.5 | 61.92 |
Compare change in the number of migraine headache days per month reported in Baseline Period Diary vs. Treatment Period Diary vs. Post-Treatment Period Diary. (NCT01709708)
Timeframe: 12 Weeks
| Intervention | Migraine headache days per month (Mean) | ||
|---|---|---|---|
| Baseline | Treatment | Post Treatment | |
| Marcaine | 15.0 | 12.3 | 10.8 |
| Saline | 15.8 | 12.2 | 11.3 |
Compare Modified Pain Characteristic Questionnaire scores Before Procedure vs. 24-Hour After Procedure, Before Procedure vs. 1-Month Follow Up, and Before Procedure vs. 6-Month Follow Up (Mean of all 12 treatments for each timepoint, comparing Group A to Group B). The modified pain characteristic questionnaire is a series of 11 questions on a likert scale ranging from 0 to 10 with 0 being no pain or does not interfere and 10 being worst pain or completely interferes. Percentage questions range from 0 to 100. (NCT01709708)
Timeframe: Before Treatment, 24 Hours After Treatment, 1 Month Post Treatment, and 6 Months Post Treatment
| Intervention | units on a scale (Mean) | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Worst Pain Question: Before Treatment | Worst Pain Question: 24 Hours After Treatment | Worst Pain Question: 1 Month Post Treatment | Worst Pain Question: 6 Months Post Treatment | Least Pain Question: Before Treatment | Least Pain Question: 24 Hours After Treatment | Least Pain Question: 1 Month Post Treatment | Least Pain Question: 6 Months Post Treatment | Average Pain Question: Before Treatment | Average Pain Question: 24 Hours After Treatment | Average Pain Question: 1 Month Post Treatment | Average Pain Question: 6 Months Post Treatment | Percent Relief Question: Before Treatment | Percent Relief Question: 24 Hours After Treatment | Percent Relief Question: 1 Month Post Treatment | Percent Relief Question: 6 Months Post Treatment | General Activity Question: Before Treatment | General Activity Question: 24 Hours After Treatmen | General Activity Question: 1 Month Post Treatment | General Activity Question: 6 Months Post Treatment | Mood Interference Question: Before Treatment | Mood Interference Question: 24 Hours After Treatme | Mood Interference Question: 1 Month Post Treatment | Mood Interference Question: 6 Months Post Treatmen | Walking Ability Question: Before Treatment | Walking Ability Question: 24 Hours After Treatment | Walking Ability Question: 1 Month Post Treatment | Walking Ability Question: 6 Months Post Treatment | Normal Work Question: Before Treatment | Normal Work Question: 24 Hours After Treatment | Normal Work Question: 1 Month Post Treatment | Normal Work Question: 6 Months Post Treatment | Relationships Question: Before Treatment | Relationships Question: 24 Hours After Treatment | Relationships Question: 1 Month Post Treatment | Relationships Question: 6 Months Post Treatment | Sleep Interference Question: Before Treatment | Sleep Interfere Question: 24 Hours After Treatment | Sleep Interferenc Question: 1 Month Post Treatment | Sleep Interference Question: 6 Months Post Treatme | Enjoyment Question: Before Treatment | Enjoyment Question: 24 Hours After Treatment | Enjoyment Question: 1 Month Post Treatment | Enjoyment Question: 6 Months Post Treatment | |
| Marcaine | 4.75 | 4.36 | 4.56 | 4.27 | 2.01 | 1.77 | 1.88 | 1.68 | 3.39 | 3.07 | 3.36 | 2.86 | 41.3 | 46.0 | 46.3 | 34.7 | 2.49 | 2.31 | 2.64 | 2.68 | 2.57 | 2.42 | 2.96 | 3.18 | 0.63 | 0.54 | 0.80 | 0.45 | 2.53 | 2.21 | 2.52 | 2.59 | 2.00 | 1.96 | 2.36 | 2.05 | 2.29 | 1.89 | 1.92 | 1.55 | 2.81 | 2.58 | 2.64 | 3.18 |
| Saline | 6.15 | 6.16 | 5.64 | 5.88 | 2.50 | 2.43 | 2.64 | 2.88 | 4.33 | 4.27 | 3.91 | 4.00 | 29.2 | 29.8 | 21.0 | 18.6 | 3.50 | 3.64 | 3.91 | 4.00 | 3.78 | 4.19 | 3.82 | 5.71 | 1.27 | 1.24 | 0.55 | 0.43 | 3.49 | 3.63 | 3.45 | 3.71 | 3.47 | 3.90 | 3.09 | 3.86 | 2.68 | 2.85 | 2.55 | 3.14 | 3.12 | 3.34 | 3.09 | 4.00 |
Compare Numeric Rating Scale (NRS) scores Before Procedure,15-Minute Post Treatment, 30-Minutes Post Treatment, 24-Hour Post Treatment for all 12 treatments (Marcaine vs. Saline). NRS is a likert scale ranging from 0-10 with 0 being no pain and 10 being worst possible pain. For each individual time point, all 12 treatments were averaged for that time point and a single value was used for comparison between the two groups. (NCT01709708)
Timeframe: 6 Weeks
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Before Procedure | 15 Minutes Post Treatment | 30 Minutes Post Treatment | 24 Hours Post Treatment | |
| Marcaine | 3.18 | 2.53 | 2.41 | 2.85 |
| Saline | 3.78 | 3.51 | 3.45 | 4.20 |
Satisfaction scores Visit 2 vs. following treatment (Treatment 12) and at 1-Month Post-Treatment (Group A vs. Group B). Satisfaction scores are a likert scale ranging from 1 to 5 with 1 being complete dissatisfaction and 5 being complete satisfaction. (NCT01709708)
Timeframe: 10 Weeks
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 2 | Following treatment (Treatment 12) | 1-Month Post-Treatment | |
| Marcaine | 3.52 | 3.55 | 3.57 |
| Saline | 3.00 | 2.50 | 2.64 |
Compare 24-Hour After Procedure Patient's Global Impression of Change (PGIC) score for 12 treatments (Mean of all 12 treatments for each timepoint, comparing Group A to Group B). PGIC is a likert scale ranging from 1 to 7 with 1 being very much improved and 7 being very much worse. (NCT01709708)
Timeframe: 30 minutes Post Treatment and 24 hours Post Treatment, assessed up to 6 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 30 Minutes Post Treatment | 24 Hours Post Treatment | |
| Marcaine | 3.00 | 3.08 |
| Saline | 3.72 | 3.88 |
3 reviews available for lidocaine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Topical lidocaine for neuropathic pain in adults.
Topics: Adult; Anesthetics, Local; Humans; Lidocaine; Neuralgia; Neuralgia, Postherpetic; Pain, Postoperativ | 2014 |
[Paroxysmal hemicrania and SUNCT].
Topics: Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Child; Cl | 2011 |
Use of streptomycin-lidocaine injections in the treatment of the cluster-tic syndrome. Clinical perspectives and a case report.
Topics: Aged; Anesthetics, Local; Cholinergic Agents; Cluster Headache; Drug Combinations; Female; Humans; I | 1996 |
10 trials available for lidocaine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Cardiovascular response to Gasserian ganglion ablation on trigeminal neuralgia under local anesthesia: a retrospective single-blind case-control study.
Topics: Anesthesia, Local; Case-Control Studies; Humans; Lidocaine; Retrospective Studies; Single-Blind Meth | 2022 |
The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study.
Topics: Double-Blind Method; Humans; Lidocaine; Randomized Controlled Trials as Topic; Treatment Outcome; Tr | 2021 |
Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; Humans | 2014 |
Combination of pharmacotherapy and lidocaine analgesic block of the peripheral trigeminal branches for trigeminal neuralgia: a pilot study.
Topics: Aged; Analgesics; Anesthetics, Local; Combined Modality Therapy; Female; Humans; Lidocaine; Male; Mi | 2015 |
Intranasal lidocaine 8% spray for second-division trigeminal neuralgia.
Topics: Administration, Intranasal; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Cross-Over | 2006 |
Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Female; Humans; Lidocaine; Male; Middle Aged; Nerve Blo | 2008 |
The effects of streptomycin/lidocaine block on trigeminal neuralgia: a double blind crossover placebo controlled study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Pain Me | 1993 |
Chronic neurogenic facial pain: lack of response to intravenous phentolamine.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Anesthetics, Local; Causalgia; Chronic Disease; Facial Pa | 1999 |
Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; | 1990 |
The analgesic effect of tocainide in trigeminal neuralgia.
Topics: Adult; Aged; Carbamazepine; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Tocai | 1987 |
43 other studies available for lidocaine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Clinical effectiveness of peripheral nerve blocks with lidocaine and corticosteroid in patients with trigeminal neuralgia.
Topics: Adrenal Cortex Hormones; Humans; Lidocaine; Peripheral Nerves; Retrospective Studies; Treatment Outc | 2021 |
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs.
Topics: Analgesics; Animals; Carbamazepine; Hyperalgesia; Lidocaine; Male; Midazolam; Neuralgia; Rats; Trige | 2022 |
Effectiveness, Safety, and Predictors of Response to 5% Lidocaine-Medicated Plaster for the Treatment of Patients With Trigeminal Neuralgia: A Retrospective Study.
Topics: Humans; Lidocaine; Pain Management; Retrospective Studies; Treatment Outcome; Trigeminal Neuralgia | 2023 |
Lidocaine aerosol sprayed on oral and/or nasal mucosa for the rescue of acute trigeminal neuralgia exacerbations: A retrospective study.
Topics: Aerosols; Humans; Lidocaine; Nasal Mucosa; Pain; Retrospective Studies; Treatment Outcome; Trigemina | 2023 |
Oral appliances in the management of neuropathic orofacial pain: A retrospective case series.
Topics: Facial Pain; Humans; Lidocaine; Neuralgia; Retrospective Studies; Trigeminal Neuralgia | 2022 |
Intra-arterial Modulation of the Trigeminal Nerve Ganglion in Patients with Refractory Trigeminal Neuralgia.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Male; Middle Aged; Treatment Outcome; Trigemin | 2018 |
Efficacy of lidocaine 5% medicated plaster (VERSATIS®) in patients with localized neuropathic pain poorly responsive to pharmacological therapy.
Topics: Aged; Analgesics; Anesthetics, Local; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; E | 2018 |
Electrophysiological Monitoring During Percutaneous Trigeminal Nerve Ganglion Block.
Topics: Anesthetics, Local; Blinking; Bupivacaine; Electrophysiological Phenomena; Humans; Lidocaine; Monito | 2019 |
Urgent care peripheral nerve blocks for refractory trigeminal neuralgia.
Topics: Ambulatory Care; Anesthetics, Local; Bupivacaine; Humans; Lidocaine; Nerve Block; Outpatient Clinics | 2018 |
Review: In trigeminal neuralgia, carbamazepine, botulinum toxin type A, or lidocaine improve response rate vs placebo.
Topics: Botulinum Toxins, Type A; Carbamazepine; Humans; Lidocaine; Network Meta-Analysis; Trigeminal Neural | 2018 |
Neuralgia and Myself.
Topics: Administration, Intranasal; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Carbamazepine; Fema | 2019 |
Intravenous lidocaine and magnesium for management of intractable trigeminal neuralgia: a case series of nine patients.
Topics: Aged; Aged, 80 and over; Female; Humans; Lidocaine; Magnesium Compounds; Male; Middle Aged; Trigemin | 2013 |
Intravenous lidocaine treatment in classical trigeminal neuralgia with concomitant persistent facial pain.
Topics: Aged; Anesthetics, Local; Facial Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Trigeminal | 2014 |
Effect of 5% lidocaine medicated plaster on pain intensity and paroxysms in classical trigeminal neuralgia.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Lidocaine; Neuralgia; Trigeminal Neural | 2014 |
[Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain].
Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Blood Vessel Prosthesis Implantation; Br | 2014 |
Efficacy of intravenous lidocaine and magnesium in intractable trigeminal neuralgia: A preliminary report.
Topics: Administration, Intravenous; Aged; Analgesics, Non-Narcotic; Female; Hospitalization; Humans; Lidoca | 2016 |
Gasserian Ganglion and Retrobulbar Nerve Block in the Treatment of Ophthalmic Postherpetic Neuralgia: A Case Report.
Topics: Aged, 80 and over; Analgesics; Anesthetics, Local; Female; Follow-Up Studies; Humans; Lidocaine; Ner | 2017 |
Management of isolated infraorbital neuralgia by ultrasound-guided infraorbital nerve block with combination of steroid and local anesthetic.
Topics: Anesthetics, Local; Dexamethasone; Drug Therapy, Combination; Glucocorticoids; Humans; Lidocaine; Ma | 2017 |
A case of facial myofascial pain syndrome presenting as trigeminal neuralgia.
Topics: Aged, 80 and over; Anesthetics, Local; Diagnosis, Differential; Facial Muscles; Facial Pain; Female; | 2009 |
Adverse effect profile of lidocaine injections for occipital nerve block in occipital neuralgia.
Topics: Adult; Aged; Cohort Studies; Female; Headache; Humans; Injections, Intra-Arterial; Lidocaine; Male; | 2010 |
Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections.
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Chin; Cranial Nerve Injuries; Female; Gingiva; H | 2010 |
Case report: computed tomography scan-guided Gasserian ganglion injection of dexamethasone and lidocaine for the treatment of recalcitrant pain associated with herpes simplex type 1 infection of the ophthalmic division of the trigeminal nerve.
Topics: Adolescent; Dexamethasone; Follow-Up Studies; Herpes Simplex; Herpesvirus 1, Human; Humans; Lidocain | 2011 |
Managing iatrogenic trigeminal nerve injury: a case series and review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anastomosis, Surgical; Anesthetics, Local; Cognitive Beh | 2012 |
Topical lidocaine to suppress trigemino-cardiac reflex.
Topics: Administration, Topical; Aged; Anesthesia, Intravenous; Anesthetics, Local; Craniotomy; Female; Huma | 2013 |
Effectiveness and safety of lidocaine patch 5%.
Topics: Administration, Topical; Anesthetics, Local; Herpesviridae Infections; Humans; Lidocaine; Neuralgia; | 2002 |
TRAUMATIC NASAL NEURALGIA AND ITS TREATMENT.
Topics: Facial Injuries; Humans; Lidocaine; Neuralgia; Nose; Ophthalmic Nerve; Trigeminal Neuralgia | 1963 |
[APROPOS OF THE TREATMENT OF TRIGEMINAL NEURALGIA].
Topics: Administration, Topical; Humans; Lidocaine; Prednisolone; Trigeminal Neuralgia | 1963 |
[APROPOS OF THE TREATMENT OF TRIGEMINAL NEURALGIA].
Topics: Anesthesia; Anesthesia, Conduction; Anesthesiology; Drug Therapy; Geriatrics; Heart Rate; Humans; Hy | 1964 |
[GRAVE INCIDENTS OF ACUTE INTOXICATION DUE TO XYLOCAINE IN THE COURSE OF BLOCK OF GASSER'S GANGLION].
Topics: Anesthesia; Anesthesia, Conduction; Anesthesiology; Humans; Iatrogenic Disease; Lidocaine; Toxicolog | 1965 |
Therapeutic effects of the point-injection therapy on primary trigeminal neuralgia--an observation of 103 cases.
Topics: Acupuncture Points; Acupuncture Therapy; Adult; Aged; Female; Follow-Up Studies; Humans; Injections; | 2003 |
Lidocaine intranasal spray for treatment of trigeminal neuralgia.
Topics: Administration, Intranasal; Anesthetics, Local; Humans; Lidocaine; Trigeminal Neuralgia | 2007 |
Surgical control of chronic migrainous neuralgia by trigeminal ganglio-rhizolysis.
Topics: Adult; Chronic Disease; Ergotamine; Humans; Lidocaine; Lithium; Male; Methysergide; Middle Aged; Mig | 1982 |
Alcohol injection in the management of paroxysmal trigeminal neuralgia: a report of six cases.
Topics: Adult; Aged; Ethanol; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Nerve Block; | 1994 |
Changes in systemic blood pressure and cardiac rhythm induced by therapeutic compression of the trigeminal ganglion.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Local; Blood Pressure; Catecholamines; Catheterization | 1994 |
Sphenopalatine ganglion block: a safe and easy method for the management of orofacial pain.
Topics: Acute Disease; Administration, Intranasal; Anesthetics, Local; Autonomic Nerve Block; Chronic Diseas | 1995 |
Blocks of the foramen rotundum and the oval foramen: a reappraisal of extraoral maxillary and mandibular nerve injections.
Topics: Anesthetics, Local; Epinephrine; Glycerol; Humans; Injections; Lidocaine; Mandible; Mandibular Nerve | 1997 |
Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia. A preliminary report.
Topics: Adult; Aged; Drug Combinations; Female; Humans; Injections; Lidocaine; Male; Mandibular Nerve; Maxil | 1986 |
Human trigeminal root evoked potentials during differential retrogasserian thermal and chemical rhizotomy.
Topics: Evoked Potentials; Facial Neuralgia; Humans; Hyperthermia, Induced; Lidocaine; Nerve Block; Reaction | 1987 |
Peripheral neurectomy in the treatment of trigeminal neuralgia of the second and third divisions.
Topics: Denervation; Female; Humans; Lidocaine; Male; Mandibular Nerve; Maxillary Nerve; Middle Aged; Recurr | 1972 |
[Personal experiences with the treatment of trigeminal neuralgia].
Topics: Humans; Lidocaine; Nerve Block; Trigeminal Neuralgia | 1974 |
The effect of trigeminal nerve block on the articulatory EMG activity of facial muscles.
Topics: Anesthesia; Electromyography; Facial Muscles; Female; Humans; Lidocaine; Male; Speech; Trigeminal Ne | 1972 |
[Atypical neurovascular pains in the head. Relation between sphygmographic charges caused by anesthetic block and the antalgic effect].
Topics: Adult; Aged; Anesthesia, Conduction; Cerebrovascular Circulation; Epinephrine; Facial Neuralgia; Fem | 1967 |
Anesthesiology and trigeminal neuralgia.
Topics: Anesthesia, Conduction; Ethanol; Humans; Injections; Lidocaine; Procaine; Time Factors; Trigeminal N | 1969 |