lidocaine has been researched along with Sex Disorders in 23 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Provoked vestibulodynia is the most common subtype of chronic vulvar pain." | 3.01 | Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2021) |
| "Provoked vestibulodynia (PVD) is a highly prevalent and debilitating condition yet its management relies mainly on non-empirically validated interventions." | 2.82 | Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Morin, M | 2 |
| Dumoulin, C | 2 |
| Bergeron, S | 2 |
| Mayrand, MH | 2 |
| Khalifé, S | 2 |
| Waddell, G | 2 |
| Dubois, MF | 2 |
| Gallo, L | 1 |
| Dinsmore, WW | 3 |
| Wyllie, MG | 3 |
| Porst, H | 1 |
| McCarty, EJ | 1 |
| Hellstrom, WJ | 4 |
| Carson, C | 1 |
| Wyllie, M | 2 |
| Xin, ZC | 1 |
| Zhu, YC | 1 |
| Yuan, YM | 1 |
| Cui, WS | 1 |
| Jin, Z | 1 |
| Li, WR | 1 |
| Liu, T | 1 |
| Serefoglu, EC | 1 |
| Saitz, TR | 1 |
| Chen, J | 1 |
| Mabjeesh, NJ | 1 |
| Matzkin, H | 1 |
| Greenstein, A | 1 |
| Henry, R | 1 |
| Morales, A | 1 |
| Busato, W | 1 |
| Galindo, CC | 1 |
| Metin, A | 1 |
| Kayigil, O | 1 |
| Ahmed, SI | 1 |
| Atan, A | 2 |
| Basar, MM | 2 |
| Tuncel, A | 1 |
| Ferhat, M | 1 |
| Agras, K | 1 |
| Tekdogan, U | 1 |
| Hackett, G | 1 |
| Goldmeier, D | 1 |
| Waldinger, M | 1 |
| Dean, J | 1 |
| Wright, P | 1 |
| Callander, M | 1 |
| Wylie, K | 1 |
| Novak, C | 1 |
| Keywood, C | 1 |
| Heath, P | 1 |
| Gurkan, L | 1 |
| Oommen, M | 1 |
| Mercado, MG | 1 |
| Kimmer, SL | 1 |
| Holman, JR | 1 |
| Wanserski, G | 1 |
| Lo, V | 1 |
| Aydoğanli, L | 1 |
| de Morsier, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Telerehabilitation in Chronic Pelvic Pain[NCT05698355] | 43 participants (Anticipated) | Interventional | 2023-01-16 | Recruiting | |||
| Efficacy of Treatments for Provoked Vestivulodynia : a Randomised Clinical Trial Comparing Multimodal Physiotherapy Treatments to Topical Lidocaine[NCT01455350] | 212 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| Research and Clinical Value of New Classification for Premature Ejaculation:Multi-Center Research[NCT02572037] | 568 participants (Actual) | Observational | 2015-10-31 | Completed | |||
| A Phase IIb, Multi-center, Randomized, Double-blind, Placebo-controlled Study, With Open-label Follow on, to Evaluate the Efficacy, Safety and Tolerability of PSD502 in Subjects With Premature Ejaculation (PE)[NCT00556478] | Phase 2/Phase 3 | 256 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Evaluation of the Safety and Effectiveness of the vPatch Device for the Management and Treatment of Premature Ejaculation[NCT03942367] | 59 participants (Actual) | Interventional | 2019-09-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Summary of mean IELT at Baseline and at month 3 during double-blind treatment (NCT00556478)
Timeframe: 3 months
| Intervention | Seconds (Geometric Mean) |
|---|---|
| Double-Blind Active / Open-Label Active | 140.964 |
| Double-Blind Placebo / Open-Label Active | 49.615 |
"To evaluate efficacy of treatment with PSD502 compared with placebo in subjects with PE as measured by:~• change in mean IELT from baseline to during the 3 month double-blind treatment~Results provide are ratio (over the 3 months/baseline)." (NCT00556478)
Timeframe: Baseline to 3 Months
| Intervention | ratio (Geometric Mean) |
|---|---|
| Double-Blind Active / Open-Label Active | 4.607 |
| Double-Blind Placebo / Open-Label Active | 1.505 |
"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 1.~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 1 month
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Ejaculatory control | Distress | Sexual satisfaction | |
| Double-Blind Active / Open-Label Active | 5.7 | 2.5 | 5.1 |
| Double-Blind Placebo / Open-Label Active | 1.3 | 0.6 | 1.8 |
"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 2~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 2 months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Control | Satisfaction | Distress | |
| Double-Blind Active / Open-Label Active | 6.5 | 5.8 | 2.9 |
| Double-Blind Placebo / Open-Label Active | 1.4 | 1.3 | 0.7 |
"To Evaluate Efficacy of Treatment With PSD502 Compared With Placebo in Subjects With PE as measured by:~• changes in all 3 IPE domains from baseline to month 3~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: Baseline to 3 Months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Ejaculatory control | Sexual satisfaction | Distress | |
| Double-Blind Active / Open-Label Active | 7.2 | 6.6 | 3.5 |
| Double-Blind Placebo / Open-Label Active | 2.2 | 2.1 | 0.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the partner PEP at month 3. Proportion of partners with at least a 1 point category improvement in partner PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of partners (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 68.9 | 64.9 | 62.8 | 66.9 |
| Double-Blind Placebo / Open-Label Active | 40.8 | 50.0 | 32.9 | 50.0 |
Percentage of subjects with mean IELT > 1 minute and >2 minutes during the 3 months of double-blind treatment as measured by the proportion of subjects (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of subjects (Number) | |
|---|---|---|
| IELT > 1 minute | IELT > 2 minutes | |
| Double-Blind Active / Open-Label Active | 80.2 | 57.5 |
| Double-Blind Placebo / Open-Label Active | 37.8 | 14.6 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 1. Percentage of subjects with at least a 1 point category improvement in subject PEP domain scores at month 1. (NCT00556478)
Timeframe: 1 month
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 59.6 | 63.4 | 62.7 | 72.0 |
| Double-Blind Placebo / Open-Label Active | 23.5 | 27.2 | 33.3 | 51.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 2. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 2. (NCT00556478)
Timeframe: 2 months
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 67.5 | 70.1 | 69.4 | 75.8 |
| Double-Blind Placebo / Open-Label Active | 24.7 | 33.8 | 27.3 | 42.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 3. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 72.4 | 76.9 | 73.7 | 77.6 |
| Double-Blind Placebo / Open-Label Active | 24.1 | 36.7 | 36.7 | 59.5 |
9 reviews available for lidocaine and Sex Disorders
| Article | Year |
|---|---|
[Premature ejaculation].
Topics: Anesthetics, Local; Benzylamines; Ejaculation; Humans; Lidocaine; Male; Marital Therapy; Naphthalene | 2009 |
Premature ejaculation: treatment update.
Topics: Administration, Oral; Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Benzylamin | 2010 |
The link between penile hypersensitivity and premature ejaculation.
Topics: Administration, Topical; Anesthetics, Local; Case-Control Studies; Clinical Trials as Topic; Coitus; | 2011 |
Available and future therapies for premature ejaculation.
Topics: Animals; Benzylamines; Drug Therapy, Combination; Drugs, Investigational; Ejaculation; Evidence-Base | 2010 |
Update on treatments for premature ejaculation.
Topics: Analgesics, Opioid; Anesthetics, Local; Benzylamines; Ejaculation; Humans; Lidocaine; Lidocaine, Pri | 2011 |
Current therapeutic strategies for premature ejaculation and future perspectives.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antidepressive Agents; Drug Combinations; Ejaculat | 2011 |
New insights on premature ejaculation: a review of definition, classification, prevalence and treatment.
Topics: Animals; Benzylamines; Coitus; Humans; Lidocaine; Male; Naphthalenes; Piperazines; Premature Ejacula | 2012 |
Premature ejaculation: current and future treatments.
Topics: Anesthetics, Local; Behavior Therapy; Clomipramine; Ejaculation; Humans; Lidocaine; Male; Prilocaine | 2008 |
It's been a long time coming, but that's good.
Topics: Ejaculation; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Prilocaine; Serotonin | 2008 |
8 trials available for lidocaine and Sex Disorders
| Article | Year |
|---|---|
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods.
Topics: Academic Medical Centers; Administration, Topical; Adult; Anesthetics, Local; Anxiety; Catastrophiza | 2016 |
PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Coitus; Double-Blind Method; Drug Combinat | 2009 |
Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthetics, Local; Anxiety; Coitus; Double-Blind | 2010 |
Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Ejac | 2004 |
Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation.
Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Therapy, Combination; Ejaculation; Humans; | 2006 |
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin | 2007 |
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin | 2007 |
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin | 2007 |
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin | 2007 |
Comparison of the efficacy of fluoxetine alone vs. fluoxetine plus local lidocaine ointment in the treatment of premature ejaculation.
Topics: Administration, Topical; Adult; Ejaculation; Fluoxetine; Humans; Lidocaine; Male; Middle Aged; Ointm | 2000 |
6 other studies available for lidocaine and Sex Disorders
| Article | Year |
|---|---|
Patients affected by premature ejaculation due to glans hypersensitivity refuse circumcision as a potential definite treatment for their problem.
Topics: Adult; Anesthetics, Local; Circumcision, Male; Humans; Hypersensitivity; Lidocaine; Male; Penis; Pre | 2014 |
Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation.
Topics: Administration, Topical; Adolescent; Adult; Drug Therapy, Combination; Ejaculation; Humans; Lidocain | 2003 |
Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study.
Topics: Administration, Topical; Adult; Aerosols; Aged; Anesthetics, Local; Ejaculation; Erectile Dysfunctio | 2003 |
Does lidocaine ointment addition increase fluoxetine efficacy in the same group of patients with premature ejaculation?
Topics: Administration, Oral; Administration, Topical; Adult; Anesthetics, Local; Drug Therapy, Combination; | 2005 |
Clinical inquiries. What's the best drug treatment for premature ejaculation?
Topics: Anesthetics, Local; Antidepressive Agents; Clomipramine; Ejaculation; Fluoxetine; Humans; Lidocaine; | 2008 |
[Traumatic intervertebral disk disorders. A study of 31 new cases].
Topics: Adult; Back Pain; Female; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Lidocaine; | 1971 |