lidocaine has been researched along with Sensation Disorders in 28 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Sensation Disorders: Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 9.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 5.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| " After undergoing resection for femoral chondrosarcoma under epidural anesthesia, the patient received a continuous infusion of epidural morphine for postoperative analgesia." | 3.70 | Perioperative stroke associated with postoperative epidural analgesia. ( Benesch, CG; Francisco, DR; Wu, CL, 2000) |
| "The study included data sets of annual sales of local anesthetics (from 1995 through 2007), 292 reports to the Danish Medicines Agency, Copenhagen, Denmark, of adverse reactions to local anesthetic drugs, and a clinical sample of 115 patients with NSD associated with local anesthetics." | 1.37 | Trigeminal nerve injury associated with injection of local anesthetics: needle lesion or neurotoxicity? ( Ersbøll, BK; Hillerup, S; Jensen, RH, 2011) |
| "The phenotype overlaps with that of attention deficit disorder, raising the possibility of subtypes of attention deficit disorder that have a peripheral sensory cause and novel forms of therapy." | 1.34 | Hypokalemic sensory overstimulation. ( Chapman, CA; Needleman, HL; Rogers, GF; Segal, MM, 2007) |
| "Following middle cerebral artery occlusion, rats received intensive enriched-rehabilitation (ER) of the impaired forelimb for 4 weeks." | 1.33 | Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats. ( Biernaskie, J; Corbett, D; Szymanska, A; Windle, V, 2005) |
| "The physical examination revealed the flaccid paraplegia and the disturbance of pain and touch sensation." | 1.29 | [Transient paraplegia following the epidural block]. ( Kabutan, K; Ono, J; Satou, K; Sugimoto, S; Taniguchi, M; Tsuji, F, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (60.71) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Z | 2 |
| Wang, J | 1 |
| Song, Z | 2 |
| Wang, Y | 1 |
| Cheng, Z | 1 |
| Guo, Q | 2 |
| Wang, E | 2 |
| Jian, Y | 1 |
| Wu, L | 2 |
| Chen, Y | 1 |
| Wang, R | 1 |
| Weng, Y | 1 |
| Sun, Z | 1 |
| Li, Y | 1 |
| Ochoa, N | 1 |
| Gogola, GR | 1 |
| Gorniak, SL | 1 |
| Mailis-Gagnon, A | 1 |
| Yegneswaran, B | 1 |
| Bharatwal, B | 1 |
| Krassioukov, AV | 1 |
| Hillerup, S | 1 |
| Jensen, RH | 1 |
| Ersbøll, BK | 1 |
| Henry, R | 1 |
| Morales, A | 1 |
| Biernaskie, J | 1 |
| Szymanska, A | 1 |
| Windle, V | 1 |
| Corbett, D | 1 |
| Rosén, B | 1 |
| Björkman, A | 1 |
| Lundborg, G | 1 |
| Segal, MM | 1 |
| Rogers, GF | 1 |
| Needleman, HL | 1 |
| Chapman, CA | 1 |
| Carpenter, RL | 1 |
| Hampl, KF | 2 |
| Schneider, MC | 2 |
| Ummenhofer, W | 1 |
| Drewe, J | 3 |
| Pogrel, MA | 1 |
| Bryan, J | 1 |
| Regezi, J | 1 |
| Beardsley, D | 1 |
| Holman, S | 1 |
| Gantt, R | 1 |
| Robinson, RA | 1 |
| Lindsey, J | 1 |
| Bazaral, M | 1 |
| Stewart, SF | 1 |
| Stevens, RA | 1 |
| Sakura, S | 2 |
| Bollen, AW | 2 |
| Ciriales, R | 2 |
| Drasner, K | 3 |
| Douglas, MJ | 1 |
| Nicholson, A | 1 |
| Chan, VW | 1 |
| Fukuda, H | 1 |
| Kasuda, H | 1 |
| Nemoto, K | 1 |
| Shimizu, R | 1 |
| Kabutan, K | 1 |
| Satou, K | 1 |
| Ono, J | 1 |
| Sugimoto, S | 1 |
| Tsuji, F | 1 |
| Taniguchi, M | 1 |
| Strebel, S | 1 |
| Frei, F | 1 |
| Rosow, CE | 1 |
| Erian, R | 1 |
| Hantler, C | 1 |
| Solomon, D | 1 |
| Pargger, H | 1 |
| Gut, J | 1 |
| Shenkman, Z | 1 |
| Findler, M | 1 |
| Lossos, A | 1 |
| Barak, S | 1 |
| Katz, J | 1 |
| Loo, CC | 1 |
| Irestedt, L | 1 |
| Takagi, A | 1 |
| Wu, CL | 1 |
| Francisco, DR | 1 |
| Benesch, CG | 1 |
| Matsuo, K | 1 |
| Honda, O | 1 |
| Yokokawa, N | 1 |
| Hiraga, K | 1 |
| Palkar, NV | 1 |
| Boudreaux, RC | 1 |
| Mankad, AV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726] | 120 participants (Actual) | Interventional | 2017-06-10 | Completed | |||
| A Phase IIb, Multi-center, Randomized, Double-blind, Placebo-controlled Study, With Open-label Follow on, to Evaluate the Efficacy, Safety and Tolerability of PSD502 in Subjects With Premature Ejaculation (PE)[NCT00556478] | Phase 2/Phase 3 | 256 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Effectiveness of Add-on Inhibitory Repetitive Transcranial Magnetic Stimulation Over the Contralesional Primary Motor Cortex in Subacute Stroke Patients With Severe Upper Limb Motor Impairment[NCT05505201] | 24 participants (Anticipated) | Interventional | 2022-11-11 | Recruiting | |||
| Single-dose Potassium Supplementation in ADHD Patients With Lidocaine Ineffectiveness[NCT03563573] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2018-07-01 | Enrolling by invitation | ||
| Prevalence of Lidocaine Ineffectiveness in Those With Hard-to-treat ADHD[NCT04167189] | Early Phase 1 | 28 participants (Actual) | Interventional | 2018-01-20 | Completed | ||
| Reliability Testing of a Non-invasive, Pain-free, Taste-based Assessment Approach to Lidocaine Effectiveness[NCT03680885] | Early Phase 1 | 20 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Assessing the Frequency of Lidocaine Ineffectiveness in the General Population vs. Males With ADHD, and Females With ADHD, With or Without PMS[NCT03676725] | Early Phase 1 | 90 participants (Actual) | Interventional | 2019-08-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Summary of mean IELT at Baseline and at month 3 during double-blind treatment (NCT00556478)
Timeframe: 3 months
| Intervention | Seconds (Geometric Mean) |
|---|---|
| Double-Blind Active / Open-Label Active | 140.964 |
| Double-Blind Placebo / Open-Label Active | 49.615 |
"To evaluate efficacy of treatment with PSD502 compared with placebo in subjects with PE as measured by:~• change in mean IELT from baseline to during the 3 month double-blind treatment~Results provide are ratio (over the 3 months/baseline)." (NCT00556478)
Timeframe: Baseline to 3 Months
| Intervention | ratio (Geometric Mean) |
|---|---|
| Double-Blind Active / Open-Label Active | 4.607 |
| Double-Blind Placebo / Open-Label Active | 1.505 |
"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 1.~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 1 month
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Ejaculatory control | Distress | Sexual satisfaction | |
| Double-Blind Active / Open-Label Active | 5.7 | 2.5 | 5.1 |
| Double-Blind Placebo / Open-Label Active | 1.3 | 0.6 | 1.8 |
"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 2~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 2 months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Control | Satisfaction | Distress | |
| Double-Blind Active / Open-Label Active | 6.5 | 5.8 | 2.9 |
| Double-Blind Placebo / Open-Label Active | 1.4 | 1.3 | 0.7 |
"To Evaluate Efficacy of Treatment With PSD502 Compared With Placebo in Subjects With PE as measured by:~• changes in all 3 IPE domains from baseline to month 3~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: Baseline to 3 Months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Ejaculatory control | Sexual satisfaction | Distress | |
| Double-Blind Active / Open-Label Active | 7.2 | 6.6 | 3.5 |
| Double-Blind Placebo / Open-Label Active | 2.2 | 2.1 | 0.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the partner PEP at month 3. Proportion of partners with at least a 1 point category improvement in partner PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of partners (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 68.9 | 64.9 | 62.8 | 66.9 |
| Double-Blind Placebo / Open-Label Active | 40.8 | 50.0 | 32.9 | 50.0 |
Percentage of subjects with mean IELT > 1 minute and >2 minutes during the 3 months of double-blind treatment as measured by the proportion of subjects (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of subjects (Number) | |
|---|---|---|
| IELT > 1 minute | IELT > 2 minutes | |
| Double-Blind Active / Open-Label Active | 80.2 | 57.5 |
| Double-Blind Placebo / Open-Label Active | 37.8 | 14.6 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 1. Percentage of subjects with at least a 1 point category improvement in subject PEP domain scores at month 1. (NCT00556478)
Timeframe: 1 month
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 59.6 | 63.4 | 62.7 | 72.0 |
| Double-Blind Placebo / Open-Label Active | 23.5 | 27.2 | 33.3 | 51.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 2. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 2. (NCT00556478)
Timeframe: 2 months
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 67.5 | 70.1 | 69.4 | 75.8 |
| Double-Blind Placebo / Open-Label Active | 24.7 | 33.8 | 27.3 | 42.9 |
Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 3. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| Control | Distress | Sexual satisfaction | Interpersonal difficulty | |
| Double-Blind Active / Open-Label Active | 72.4 | 76.9 | 73.7 | 77.6 |
| Double-Blind Placebo / Open-Label Active | 24.1 | 36.7 | 36.7 | 59.5 |
1 review available for lidocaine and Sensation Disorders
| Article | Year |
|---|---|
[Toxic and adverse effects of local anesthetics/neuromuscular blocker: lidocaine, succinylcholine].
Topics: Anesthetics, Local; Drug Interactions; Humans; Hypokalemia; Hypotension; Lidocaine; Muscle Rigidity; | 1999 |
6 trials available for lidocaine and Sensation Disorders
| Article | Year |
|---|---|
Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury.
Topics: Adult; Amobarbital; Anesthetics, Local; Female; Humans; Hypnotics and Sedatives; Injections, Intrave | 2009 |
Improved sensory relearning after nerve repair induced by selective temporary anaesthesia - a new concept in hand rehabilitation.
Topics: Adult; Aged; Anesthetics, Local; Double-Blind Method; Female; Forearm; Hand; Humans; Learning; Lidoc | 2006 |
Transient neurologic symptoms after spinal anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacain | 1995 |
Central nervous system symptoms after intravenous lignocaine: dose-response during pregnancy.
Topics: Abortion, Therapeutic; Anesthesia, Intravenous; Anesthesia, Obstetrical; Brain; Catheterization, Per | 1993 |
A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Female; Genitalia, Female; Humans; Incidence; Lidocai | 1996 |
[Effect of gargling the throat with Panaxylocaine as a lubricant for the laryngeal mask airway].
Topics: Anesthetics, Local; Breast Neoplasms; Female; Humans; Laryngeal Masks; Lidocaine; Lubrication; Middl | 2000 |
21 other studies available for lidocaine and Sensation Disorders
| Article | Year |
|---|---|
Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model.
Topics: Animals; Antagomirs; Disease Models, Animal; Down-Regulation; Lidocaine; Male; MicroRNAs; Myelin She | 2021 |
Sufentanil Alleviates Intrathecal Lidocaine Induced Prolonged Sensory and Motor Impairments but not the Spinal Histological Injury in Rats.
Topics: Activating Transcription Factor 3; Analgesics, Opioid; Anesthetics, Local; Animals; Dyskinesia, Drug | 2018 |
Contribution of tactile dysfunction to manual motor dysfunction in type II diabetes.
Topics: Aged; Analysis of Variance; Anesthetics, Local; Case-Control Studies; Diabetes Mellitus, Type 2; Fem | 2016 |
Trigeminal nerve injury associated with injection of local anesthetics: needle lesion or neurotoxicity?
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthetics, Local; Cartica | 2011 |
Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study.
Topics: Administration, Topical; Adult; Aerosols; Aged; Anesthetics, Local; Ejaculation; Erectile Dysfunctio | 2003 |
Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats.
Topics: Animals; Behavior, Animal; Brain Infarction; Brain Ischemia; Forelimb; Functional Laterality; Infarc | 2005 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hyperbaric lidocaine spinal anesthesia: do we need an alternative?
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Drug Monitoring; Humans; Lidocaine; Pain; Perip | 1995 |
Nerve damage associated with inferior alveolar nerve blocks.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Chorda Tympani Nerve; Dental Restoration, Perma | 1995 |
Transient neurologic deficit after spinal anesthesia: local anesthetic maldistribution with pencil point needles?
Topics: Adult; Anesthesia, Spinal; Coloring Agents; Equipment Design; Glucose; Humans; Indoles; Injections, | 1995 |
Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels.
Topics: Animals; Bupivacaine; Demyelinating Diseases; Dose-Response Relationship, Drug; Injections, Spinal; | 1995 |
Neurotoxicity of lidocaine--does it exist?
Topics: Adult; Anesthesia, Spinal; Animals; Humans; Lidocaine; Peripheral Nervous System Diseases; Sensation | 1995 |
Painless epidural haematoma.
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Bupivacaine; Fatal Outcome; Female; Hematoma, Epidura | 1994 |
Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat.
Topics: Anesthesia, Local; Anesthetics; Animals; Injections, Spinal; Lidocaine; Male; Rats; Rats, Sprague-Da | 1994 |
[Intravenous lidocaine in the treatment of post treatment neuropathy].
Topics: Administration, Oral; Aged; Diabetes Mellitus; Diabetic Neuropathies; Drug Therapy, Combination; Hum | 1994 |
[Transient paraplegia following the epidural block].
Topics: Adult; Analgesia, Epidural; Humans; Lidocaine; Male; Paraplegia; Sensation Disorders; Spinal Cord; S | 1994 |
Transient neurologic symptoms after spinal anesthesia.
Topics: Anesthesia, Spinal; Anesthetics, Local; Confounding Factors, Epidemiologic; Humans; Incidence; Lidoc | 1996 |
Permanent neurologic deficit after inferior alveolar nerve block: a case report.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Ataxia; Cranial Nerve Diseases; Facial Paralysis; Gai | 1996 |
Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: a review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anesthesia, Spinal; Anesthetics, Local; Cauda Equina | 1999 |
Perioperative stroke associated with postoperative epidural analgesia.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Arm; Cerebr | 2000 |
Accidental total spinal block: a complication of an epidural test dose.
Topics: Accidents; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Aphonia; Female; Humans; Lidocaine; | 1992 |