lidocaine and Seizures studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

Excerpt	Relevance	Reference
"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments."	9.12	Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006)
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)."	9.11	A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004)
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years."	9.09	[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."	8.91	Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."	8.91	Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Lidocaine has a concentration-dependent effect on seizures."	8.80	Lidocaine and seizures. ( DeToledo, JC, 2000)
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs."	8.02	Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021)
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."	7.96	Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."	7.83	Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events."	7.81	Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015)
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010."	7.79	Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013)
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures."	7.78	Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."	7.78	Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"We report a case of neonatal seizures after lidocaine administration for circumcision."	7.74	Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007)
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures."	7.73	Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006)
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge."	7.72	Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004)
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002."	7.72	[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004)
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure."	7.71	Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002)
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures."	7.69	Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994)
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures."	7.69	[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997)
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine."	7.68	Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992)
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen."	7.68	Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."	7.68	Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine."	7.67	Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988)
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method."	7.67	Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987)
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures."	7.67	Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986)
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures."	7.66	The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981)
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia."	7.66	Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981)
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure."	7.66	Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978)
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome."	6.73	Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."	5.72	Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."	5.43	Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3."	5.43	Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016)
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy."	5.37	Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011)
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14."	5.36	Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010)
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ."	5.33	Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005)
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements."	5.32	Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004)
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity."	5.30	Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998)
"infusion of 1."	5.29	Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
"A lidocaine level was obtained at 4 h post-ingestion and was 0."	5.28	Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992)
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior."	5.27	Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984)
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy."	5.26	Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976)
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration."	5.25	Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975)
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies."	5.22	[Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022)
"One to seven seizures were recognized before starting CBZ or Lidocaine therapy, followed by complete cessation in 57 episodes and one or two recurrent seizures in five."	5.15	Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis. ( Komatsu, M; Kubota, T; Nakajima, M; Okumura, A; Shimakawa, S; Tanabe, T, 2011)
"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments."	5.12	Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006)
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)."	5.11	A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004)
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years."	5.09	[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999)
" The duration of motor and EEG seizures (means +/- SD) were 37 +/- 13 sec and 64 +/- 21 sec, 25 +/- 11 sec and 52 +/- 43 sec, 17 +/- 12 sec and 32 +/- 17 sec, 1 +/- 3 sec and 18 +/- 10 sec in the saline, lidocaine 50 mg, 100 mg, 200 mg groups, respectively."	5.08	Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity. ( Fu, W; Husain, MM; Stool, LA; White, PF, 1997)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."	4.91	Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."	4.91	Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Seizures have been reported with lidocaine at its lowest effective dose (1."	4.85	Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. ( Guay, J, 2009)
"Lidocaine has a concentration-dependent effect on seizures."	4.80	Lidocaine and seizures. ( DeToledo, JC, 2000)
"We describe a two-year-old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic-clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy."	4.12	Anesthetic considerations in Dravet syndrome. ( Corlette, S; Davidson, A; Howell, KB; Macdonald-Laurs, E, 2022)
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs."	4.02	Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021)
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."	3.96	Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures."	3.88	Transplacental lidocaine intoxication. ( Cools, F; Demeulemeester, V; Lefevere, J; Van Hautem, H, 2018)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."	3.83	Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
"High doses of lidocaine produce seizures and vasoconstriction."	3.83	Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine. ( Déciga-Campos, M; Librowski, T; López-Muñoz, FJ; Navarrete-Vázquez, G; Ortiz-Andrade, R; Sánchez-Recillas, A; Yañez-Pérez, V, 2016)
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events."	3.81	Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015)
" In experiment 2, both emulsified isoflurane and midazolam significantly suppressed lidocaine-induced tonic-clonic seizures."	3.80	Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats. ( Chen, X; Huang, H; Liu, J; Wang, X; Zhang, W; Zhou, C, 2014)
" We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity."	3.79	Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013)
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010."	3.79	Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013)
"We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ)."	3.79	Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine. ( Kobayashi, K; Kodani, N; Maniwa, S; Nakano, K; Ohtsuka, Y, 2013)
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures."	3.78	Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."	3.78	Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)."	3.76	Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010)
"The addition of a small dose of lignocaine to propofol during ECT treatment enhanced rather than reduced the quality of the seizures produced."	3.76	Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy. ( Lawford, J; Loo, C; MacPherson, RD; Mahon, M; Scott, D; Simpson, B, 2010)
"We report a case of neonatal seizures after lidocaine administration for circumcision."	3.74	Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007)
" Clinical features were hypotonia, pupillary mydriasis fixed to light, apnea, cyanosis and seizures."	3.74	[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases]. ( de la Gastine, B; Guillemin, MG; Guillois, B; Lelong-Boulouard, V; Pagès, H; Quedru-Aboane, J, 2008)
" Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death."	3.74	The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008)
"Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice."	3.73	Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics. ( Dohi, T; Kitayama, T; Morioka, N; Morita, K; Song, L, 2006)
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures."	3.73	Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006)
"The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice."	3.72	Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003)
"To evaluate the effect of GABA(B) receptor in drug-kindled seizures, the gene expression of GABA(B) receptor in cocaine- and lidocaine-kindled rats was examined in this study."	3.72	Up-regulation of GABA(B) receptor mRNA and protein in the hippocampus of cocaine- and lidocaine-kindled rats. ( Abel, MS; Dassow, MS; Li, J; Olinger, AB, 2003)
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge."	3.72	Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004)
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002."	3.72	[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004)
"In this study the effect of transient inhibition of the CA1 region of the dorsal hippocampus by lidocaine on amygdala kindling rate and amygdaloid kindled seizures was investigated."	3.71	Effect of transient hippocampal inhibition on amygdaloid kindled seizures and amygdaloid kindling rate. ( Alasvand Zarasvand, M; Fathollahi, Y; Mirnajafi-Zadeh, J; Mortazavi, M; Reza Palizvan, M, 2002)
"Lidocaine, a local anesthetic, produces seizures by unknown central mechanisms."	3.71	Thyroid hormones modify susceptibility to lidocaine-kindling in rats. ( Chambert, G; Pacheco-Rosado, J; Zamudio-Hernández, S, 2001)
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure."	3.71	Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002)
"The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice."	3.70	Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999)
" To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin."	3.70	Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999)
"Lidocaine is well known to have toxic effects on the central nervous system including the induction of electroencepharographic seizures and convulsions at high doses."	3.70	[Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition]. ( Ikeda, M; Maru, E; Shimada, M; Suzuki, H; Ueyama, T, 1999)
" We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats."	3.70	Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999)
"5- year-old girl with systemic lidocaine toxicity following treatment for postoperative bladder spasms."	3.70	Lidocaine toxicity secondary to postoperative bladder instillation in a pediatric patient. ( Cilento, BG; Clapp, CR; Poss, WB, 1999)
"Lidocaine induces electroencephalographic seizures and generalized convulsions at large doses."	3.70	A decrease in seizure susceptibility to lidocaine in kindled epileptic rats. ( Fujita, H; Maru, E; Ogiuchi, H; Shimada, M; Suzuki, H, 2000)
"An equal degree of acute hypertension induced by these three different vasopressors may play a role in reducing the threshold (plasma and brain lidocaine concentrations) as well as the cumulative convulsant doses associated with lidocaine-induced convulsions."	3.69	Effect of vasoconstrictive agents added to lidocaine on intravenous lidocaine-induced convulsions in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1995)
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures."	3.69	Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994)
"The present study examined the effects of daily treatment with a subconvulsant dose (50 mg/kg) of cocaine or lidocaine on susceptibility to seizures induced by cross-injections of the same dose of the other local anesthetic, and to seizures induced by pentylenetetrazol (PTZ) or N-methyl-DL-aspartate (NMDLA) in ddY mice."	3.69	One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1996)
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures."	3.69	[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997)
"The present study investigated the effect of dextromethorphan and 6,7-dinitroquinoxaline-2,3-dione (DNQX) pre-treatment on the development of cocaine- and lidocaine-induced seizures."	3.69	Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat. ( Abdel-Rahman, MS; Barat, SA, 1997)
"In newborn infants suffering from perinatal asphyxia seizures, lidocaine (LD) has proved to be an effective anticonvulsant."	3.69	Lidocaine pharmacokinetics and toxicity in newborn pigs. ( Haaland, K; Hoem, NO; Johannessen, SI; Satas, S; Sørensen, DR; Thoresen, M, 1997)
"We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures."	3.69	Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997)
"We report a case of lidocaine toxicity with seizures that appears to represent a drug interaction with amiodarone."	3.68	Amiodarone interaction with lidocaine. ( Imhoff, TE; Siegmund, JB; Wilson, JH, 1993)
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine."	3.68	Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992)
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen."	3.68	Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991)
"At doses of 30 or 40 mg/kg, lidocaine does not induce seizures or death."	3.68	Lidocaine potentiation of cocaine toxicity. ( Albertson, TE; Derlet, RW; Tharratt, RS, 1991)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."	3.68	Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"Thirteen newborn infants (five premature, eight full term) with severe seizures and not responding to phenobarbital and diazepam received a lidocaine (LD) infusion."	3.68	Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. ( Bodiou, C; Olive, G; Radvanyi-Bouvet, MF; Rey, E; Richard, MO; Torricelli, A; Walti, H, 1990)
"The concentrations of cyclic 3', 5'-guanosine monophosphate (cGMP) and cyclic 3', 5'-adenosine monophosphate (cAMP) in the cerebellar and cerebral cortex were measured during lidocaine infusion and during bicuculline-induced seizures in rats."	3.67	Cyclic nucleotides in rat brain during lidocaine infusion. ( Maekawa, T; Okuda, Y; Takeshita, H; Yamada, K, 1984)
"The influence of hyperkalemia on the central nervous system and cardiac toxicity of bupivacaine and lidocaine was studied in open-chested mechanically ventilated dogs."	3.67	The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. ( Avery, P; Redon, D; Rusy, B; Schaenzer, G, 1984)
"A case of a 2-year-old girl who survived grand mal seizures secondary to toxicity from massive subcutaneous administration of lidocaine is presented."	3.67	Lidocaine toxicity following subcutaneous administration. ( Alfano, SN; Leicht, MJ; Skiendzielewski, JJ, 1984)
"The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde."	3.67	Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989)
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine."	3.67	Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988)
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method."	3.67	Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987)
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures."	3.67	Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986)
"Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic."	3.66	Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980)
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures."	3.66	The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981)
"A case is reported of an infant who experienced seizures while being treated with a topical lidocaine 2% solution (Xylocaine 2% Viscous) for teething."	3.66	Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine. ( Caraccio, TR; Greensher, J; Miller, H; Mofenson, HC, 1983)
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia."	3.66	Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981)
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure."	3.66	Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978)
" Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally."	3.65	Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975)
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome."	2.73	Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007)
"Furthermore, we also assessed seizure duration using both the cuff method and two-lead electroencephalography."	2.70	The effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy. ( Inoue, T; Ogawa, R; Ogura, A; Shiga, T; Wajima, Z; Yoshikawa, T, 2002)
"Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit."	2.55	The use of phenobarbital and other anti-seizure drugs in newborns. ( El-Dib, M; Soul, JS, 2017)
"Current therapeutic options to treat neonatal seizures (i."	2.49	Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013)
"The patients developed a generalized seizure requiring endotracheal intubation but recovered fully with supportive care."	2.47	Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision. ( Belhadj, S; Ben Jaballah, N; Bouziri, A; Hamdi, A; Khaldi, A; Menif, K, 2011)
"Neonatal seizures continue to present a diagnostic and therapeutic challenge to paediatricians worldwide, and are a worrying sign for both parents and clinicians alike."	2.42	Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003)
" In this study, it was shown that the safe and effective net application dose of lidocaine for the surgery may be within the range of 127 to 260 mg."	2.39	Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy. ( Iga, T; Ito, K; Kaga, K; Kotaki, H; Mitomi, N; Sawada, Y; Tayama, N; Tezuka, K, 1996)
"Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted."	2.36	Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983)
"We provide additional evidence highlighting the importance of caution regarding lidocaine dosing due to the effect on seizure length in the ECT setting."	1.91	Does Lidocaine Shorten Seizure Duration in Electroconvulsive Therapy? ( Enguita-Germán, M; Enriquez, ÁSR; Fábrega, AM; Gil, JL; López-Ilundain, J; Martinez de Zabarte Moraza, E; Maughan, AR; Prados, AB; Rosquil, EU; Yoldi-Murillo, J, 2023)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."	1.72	Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"An epileptic seizure can trigger a headache during (ictal) or after (postictal) the termination of the event."	1.56	Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache. ( Burstein, R; Melo-Carrillo, A; Schain, AJ; Strassman, AM, 2020)
"A sudden loss of consciousness and tonic-clonic seizure was occurred after negative aspiration and test dose."	1.51	Tonic-clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery: A case report. ( Dong, J; Lu, F; Tian, J; Zhang, K, 2019)
"We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy."	1.46	Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017)
"Lidocaine plasma levels were in the toxic range at the time of the first seizure (18."	1.43	[Delayed convulsion after lidocaine instillation for bronchoscopy]. ( Gaïes, E; Jebabli, N; Klouz, A; Lakhal, M; Salouage, I; Trabelsi, S, 2016)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."	1.43	Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3."	1.43	Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016)
"Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems."	1.43	Local Anesthetics Systemic Toxicity. ( Jayanthi, R; Monica, K; Nasser, K, 2016)
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy."	1.37	Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011)
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14."	1.36	Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010)
" The onset of toxic manifestations (seizure, dysrhythmia, and cardiac arrest) was recorded, and then the doses of local anesthetics were calculated."	1.36	Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats. ( Bo, YL; Li, HB; Li, WZ; Wan, QX, 2010)
" Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < ."	1.36	Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity. ( Barcelos, KC; Cabral, AM; Furtado, DP; Haas, DA; Ramacciato, JC, 2010)
"One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole."	1.35	Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy. ( Baxter, C; Dart, C; Rainger, J; Vogelnest, Lj, 2009)
"Propranolol is a beta-adrenoceptor antagonist used clinically."	1.35	Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain. ( Asada, A; Hase, I; Nakamura, T; Oda, Y; Takahashi, R; Tanaka, K, 2008)
"Diazepam prevents lidocaine-induced seizures, but not neuronal damage in brain structures."	1.34	Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats. ( Blas-Valdivia, V; Cano-Europa, E; Hernández-García, A; Ortiz-Butrón, R, 2007)
"The severity of convulsions was assessed and scored as 1 = mild, 2 = moderate, and 3 = severe."	1.33	Effect of fentanyl on lidocaine-induced convulsions in mice. ( Cherng, CH; Wong, CS, 2005)
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ."	1.33	Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005)
"Diazepam was administered as the first-line drug on 157 of 177 occasions (88."	1.33	[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005)
"At the onset of convulsions, plasma concentrations of both total (B = 4."	1.32	The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. ( Asada, A; Funao, T; Oda, Y; Tanaka, K, 2003)
"Some electrographic seizures are generated intracortically."	1.32	Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures. ( Grenier, F; Steriade, M; Timofeev, I, 2004)
"The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode."	1.32	Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. ( Negoro, T; Okumura, A; Uemura, N; Watanabe, K, 2004)
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements."	1.32	Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004)
"Audiogenic seizures, a model of brainstem epilepsy, are characterized by a tonic phase (sustained muscular contraction fixing the limbs in a flexed or extended position) associated with a short cortical electroencephalogram flattening."	1.30	The amygdala is critical for seizure propagation from brainstem to forebrain. ( Danober, L; Hirsch, E; Marescaux, C; Maton, B; Nehlig, A; Pereira de Vasconcelos, A; Simler, S; Vergnes, M, 1997)
"The latency to convulsion and survival rate were significantly longer and higher, respectively, in the brain-injured group than in the sham-operated one."	1.30	Prior brain injury protects death from local anaesthetic-induced convulsion. ( Baba, H; Endoh, H; Fukuda, S; Kumagai, Y; Sato, K; Shimoji, K; Taga, K; Yamakura, T, 1997)
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity."	1.30	Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998)
"VNS significantly reduced seizure severities of control rats."	1.30	Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. ( Browning, RA; Clark, KB; Krahl, SE; Smith, DC, 1998)
"In contrast to the seizure activity and wide-spread neuronal degeneration following kainate treatment, injections of lidocaine did not produce neuronal death within three days."	1.30	Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain. ( Chae, HJ; Cho, SB; Gwag, BJ; Jin, BG; Kang, JS; Kim, HR; Won, SJ, 1999)
"Acute cocaine overdose can result in convulsions and death although the mechanisms associated with this toxicity are poorly understood."	1.29	Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. ( Katz, JL; Newman, AH; Nowak, G; Witkin, JM, 1993)
"infusion of 1."	1.29	Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
"Pretreatment with clonidine changed neither cumulative convulsant doses (Group 1: 41."	1.29	Clonidine does not affect lidocaine seizure threshold in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1993)
"Pretreatment with diazepam alone increased both cumulative convulsant doses and plasma concentrations of lidocaine at the onset of convulsions."	1.28	Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. ( Arakawa, K; Benson, KT; Goto, H; Yokoyama, M, 1992)
"A lidocaine level was obtained at 4 h post-ingestion and was 0."	1.28	Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992)
"The incidence of lidocaine-induced convulsions was decreased by treatments with alpha-MPT and disulfiram, while that of PTZ was increased by either treatment."	1.28	Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions. ( Dohi, T; Takada, K; Tanaka, S; Tsujimoto, A; Yoshimura, Y, 1991)
"However, lidocaine-induced convulsions were enhanced by AOAA."	1.28	Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord. ( Kawaguchi, M; Ouchi, K; Sato, T; Sawaki, K, 1991)
"No ventricular arrhythmias were observed in this group."	1.28	Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. ( Arthur, GR; Covino, BG; Feldman, HS, 1989)
"While epinephrine enhanced lidocaine seizure activity and lethality by approximately 50%, midazolam almost completely prevented lidocaine-induced convulsions but had no significant effect on mortality."	1.28	Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats. ( Mito, RS; Torbiner, ML; Yagiela, JA, 1989)
"Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC."	1.28	Lidocaine treatment of neonatal convulsions, a therapeutic dilemma. ( Hynning, PA; Nergårdh, A; Wallin, A, 1989)
"With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine."	1.27	A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983)
""Clearing" of catecholamine-induced arrhythmias was not obtained in any of six dogs given tocainide and only in two out of six dogs given lidocaine."	1.27	Antiarrhythmic effects of tocainide and lidocaine in dogs. ( Aberg, G; Aberg, L; Fitzgerald, T; McCollom, K; Moller, R; Ronfeld, R, 1983)
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior."	1.27	Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984)
" These results suggest that the CNS is the primary target organ for the toxic effects of both highly lipid-soluble and highly protein-bound local anesthetics (i."	1.27	Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. ( Covino, BG; Feldman, HS; Giasi, R; Liu, PL; Patterson, MK, 1983)
"Lidocaine and phenytoin were relatively ineffective against convulsants that act on synaptic chloride channels via the GABA-ionophore receptor complex."	1.27	Anticonvulsive and convulsive effects of lidocaine: comparison with those of phenytoin, and implications for mechanism of action concepts. ( Javid, MJ; Stone, WE, 1988)
"At the time of the seizure both tocainide and lidocaine were well within their respective therapeutic ranges."	1.27	A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity? ( Covinsky, JO; Forrence, E; Mullen, C, 1986)
" The L group received lidocaine at a dosage of 0."	1.27	Effect on the seizure threshold in dogs of tocainide/lidocaine administration. ( Kaplan, RM; Paris, PM; Schuster, MR; Stewart, RD, 1987)
"The comparative pharmacokinetic properties of lidocaine, bupivacaine, etidocaine and mepivacaine were investigated in convulsing and non-convulsing dogs."	1.27	Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. ( Arthur, GR; Covino, BG; Feldman, HS, 1988)
"SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions."	1.27	General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988)
"This is the longest cardiac arrest in early pregnancy reported in the medical literature with normal maternal and fetal outcome."	1.27	Complete maternal and fetal recovery after prolonged cardiac arrest. ( Burke, TJ; Selden, BS, 1988)
"To induce convulsions 4."	1.27	The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics. ( Bokesch, PM; Castaneda, AR; Wilson, JM; Ziemer, G, 1987)
"The child had asystole and grand mal seizures associated with lidocaine serum concentration of 19."	1.27	Intravenous lidocaine overdosage in a child. ( Edgren, B; Gehrz, R; Tilelli, J, 1986)
"Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50."	1.27	Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. ( Kim, KC; Tasch, MD, 1986)
"No synchronized population bursting (seizures) was observed at any of the concentrations tested (10(-6)M to 10(-3)M)."	1.27	Lidocaine depresses synaptic activity in the rat hippocampal slice. ( Edmonds, HL; Reid, KH; Rigor, BM; Schurr, A; Spears, B; West, CA, 1986)
" Onset of electrical seizure activity occurred at about the same time in both groups and was defined as the central nervous system (CNS) toxic end point."	1.27	Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. ( Chadwick, HS, 1985)
"The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats."	1.27	Effect of cocaine and pentylenetetrazol on cortical kindling. ( Russell, RD; Stripling, JS, 1985)
"The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg ."	1.26	Studies on the post-ictal rise in seizure threshold. ( Cowen, PJ; Green, AR; Nutt, DJ, 1981)
"Lidocaine and procaine seizure thresholds were studied."	1.26	Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines. ( Ciarlone, AE, 1981)
"Lidocaine was administered using a constant rate infusion pump."	1.26	The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats. ( Mori, K; Oshima, E; Seo, N; Stevens, J, 1982)
"Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine."	1.26	Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981)
"The metabolic changes during lidocaine seizure were essentially the same as those observed in the seizure group in the first series."	1.26	Cerebral energy state and glycolytic metabolism during lidocaine infusion in the rat. ( Imamura, A; Maekawa, T; Oshibuchi, T; Takeshita, H, 1981)
" An identical sequence of toxic manifestations occurred in the adult, newborn, and fetus: convulsions, hypotension, respiratory arrest, and circulatory collapse."	1.26	Toxicity of lidocaine in adult, newborn, and fetal sheep. ( Bruce, SL; Covino, BG; Finster, M; Gutsche, BB; Morishima, HO; Pedersen, H; Sakuma, K; Stark, RI, 1981)
"The effect of drug-induced convulsions on kindling was studied in male Long-Evans rats."	1.26	Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol. ( Hendricks, C; Stripling, JS, 1981)
"The first seizure activity observed was tonic extension (TE) which occurred at an infused lidocaine dose of 12."	1.26	Cardiorespiratory and behavioral reactions to the lidocaine-induced convulsions in the dog. ( Gangarosa, LP; Hofman, WF; Jerram, DC, 1977)
"Excitation, coma, convulsions, tachycardia, mydriasis, nystagmus, and rubeosis of the face were the most important signs."	1.26	[Fenfluramin (ponderax) intoxications in children (author's transl)]. ( Krienke, EG; Mühlendahl, KE, 1978)
"Toxicities were compared by determining seizure dosages for each drug alone and then in a lidocaine-etidocaine-tetracaine mixture."	1.26	Central-nervous-system toxicity of local anesthetic mixtures in monkeys. ( Embro, WJ; Munson, ES; Paul, WL, 1977)
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy."	1.26	Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976)
"Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection."	1.26	Gestational differences in lidocaine toxicity in the fetal lamb. ( Benowitz, N; Heymann, MA; Rudolph, AM; Teramo, K, 1976)
"The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase."	1.25	Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975)
"Five patients died."	1.25	Tricyclic antidepressive poisoning with special reference to cardiac complications. ( Asmussen, I; Lunding, M; Serafimovski, N; Thorball, N, 1975)
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration."	1.25	Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975)

Research

Studies (352)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Change in Center for Epidemiological Studies Depression Scale (CES-D)

Timeframe	Studies, this research(%)	All Research%
pre-1990	189 (53.69)	18.7374
1990's	57 (16.19)	18.2507
2000's	50 (14.20)	29.6817
2010's	47 (13.35)	24.3611
2020's	9 (2.56)	2.80

Authors	Studies
Kim, H	2
Lee, I	1
Son, WG	1
Robinson, S	1
Macdonald-Laurs, E	1
Corlette, S	1
Davidson, A	1
Howell, KB	1
Soto-Insuga, V	1
González-Alguacil, E	1
García-Peñas, JJ	1
Stephenson, DT	1
Thomas, N	1
Korbely, R	1
López-Ilundain, J	1
Prados, AB	1
Enriquez, ÁSR	1
Enguita-Germán, M	1
Rosquil, EU	1
Gil, JL	1
Fábrega, AM	1
Martinez de Zabarte Moraza, E	1
Maughan, AR	1
Yoldi-Murillo, J	1
Favié, LMA	1
Huitema, ADR	1
van den Broek, MPH	1
Rademaker, CMA	1
de Haan, TR	1
van Straaten, HLM	1
Simons, SHP	1
Rijken, M	1
Nuytemans, DHGM	1
Egberts, TCG	1
Groenendaal, F	3
Lu, F	1
Tian, J	1
Dong, J	1
Zhang, K	1
Melo-Carrillo, A	1
Schain, AJ	1
Strassman, AM	1
Burstein, R	1
Santos, GFS	1
Ferreira, LO	1
Gerrits Mattos, B	1
Fidelis, EJ	1
de Souza, AS	1
Batista, PS	1
Manoel, CAF	1
Cabral, DAC	1
Jóia de Mello, V	1
Favacho Lopes, DC	1
Hamoy, M	1
El-Dib, M	1
Soul, JS	1
Szadkowski, M	1
Drapkin, Z	1
Hewes, H	1
Caravati, EM	1
Plumb, J	1
Lee, WK	1
Bae, MI	1
Choi, SH	1
Min, KT	1
Demeulemeester, V	1
Van Hautem, H	1
Cools, F	1
Lefevere, J	1
van Rooij, LG	4
Hellström-Westas, L	5
de Vries, LS	5
Larson, A	1
Stidham, T	1
Banerji, S	1
Kaufman, J	1
Lundqvist, M	2
Ågren, J	2
Flink, R	2
Wickström, R	2
Nakano, K	1
Kobayashi, K	1
Maniwa, S	1
Kodani, N	1
Ohtsuka, Y	1
Hakan, N	1
Aydin, M	1
Dilli, D	1
Zenciroglu, A	1
Okumus, N	1
Tanawuttiwat, T	1
Thisayakorn, P	1
Viles-Gonzalez, JF	1
Zhou, C	1
Huang, H	1
Liu, J	1
Wang, X	1
Chen, X	1
Zhang, W	1
Özer, AB	1
Erhan, ÖL	1
Bensghir, M	1
Badou, N	1
Houba, A	1
Balkhi, H	1
Haimeur, C	1
Azendour, H	1
Weeke, LC	2
Schalkwijk, S	1
Toet, MC	4
van den Broek, MP	4
Zeiler, FA	2
Zeiler, KJ	2
Teitelbaum, J	2
Gillman, LM	2
West, M	2
Kazina, CJ	2
Gaïes, E	1
Jebabli, N	1
Lakhal, M	1
Klouz, A	1
Salouage, I	1
Trabelsi, S	1
Boylan, GB	2
Pressler, RM	1
Chiu, KM	1
Lu, CW	1
Lee, MY	1
Wang, MJ	1
Lin, TY	1
Wang, SJ	1
Hoda, S	1
O'Brien, J	1
Gamble, J	1
Déciga-Campos, M	1
Navarrete-Vázquez, G	1
López-Muñoz, FJ	1
Librowski, T	1
Sánchez-Recillas, A	1
Yañez-Pérez, V	1
Ortiz-Andrade, R	1
Nicholas, E	1
Thornton, MD	1
Cho, YS	1
Chung, BY	1
Park, CW	1
Kim, HO	1
Jayanthi, R	1
Nasser, K	1
Monica, K	1
Wang, XF	1
Luo, XL	1
Liu, WC	1
Hou, BC	1
Huang, J	1
Zhan, YP	1
Chen, SB	1
Osman, BM	1
Maga, JM	1
Baquero, SM	1
Wentlandt, M	1
Morris, SC	1
Mitchell, SH	1
Kalimullah, EA	1
Bryant, SM	1
Brown, C	1
Bachmann, G	1
Ling, FW	1
Rainger, J	1
Baxter, C	1
Vogelnest, Lj	1
Dart, C	1
Dror, M	1
Baptiste, SL	1
Tang, HM	1
Kuzniecky, RI	1
Devinsky, O	1
French, JA	1
Ludvig, N	1
Guay, J	1
Wan, QX	1
Bo, YL	1
Li, HB	1
Li, WZ	1
MacPherson, RD	1
Lawford, J	1
Simpson, B	1
Mahon, M	1
Scott, D	1
Loo, C	1
Tanabe, T	3
Okumura, A	3
Komatsu, M	1
Kubota, T	1
Nakajima, M	1
Shimakawa, S	2
Barcelos, KC	1
Furtado, DP	1
Ramacciato, JC	1
Cabral, AM	1
Haas, DA	1
Nishiyama, T	1
Komatsu, K	1
Chakrabarti, R	1
Topf, HG	1
Schroth, M	1
Huitema, AD	1
van Hasselt, JG	1
Egberts, TC	1
Rademaker, CM	2
Mishra, SK	1
Subramanian, A	1
Hemavathi, B	1
Badhe, A	1
Chung, SG	1
Menif, K	1
Khaldi, A	1
Bouziri, A	1
Hamdi, A	1
Belhadj, S	1
Ben Jaballah, N	1
ter Weijden, E	1
Ververs, FF	1
Abdullah, MA	1
Zeidan, A	1
Landy, C	1
Schaeffer, E	1
Raynaud, L	1
Favier, JC	1
Plancade, D	1
Jennekens, W	1
Dankers, F	1
Janssen, F	1
Toet, M	1
van der Aa, N	1
Niemarkt, H	1
van Pul, C	1
de Vries, L	1
Andriessen, P	1
Ellis, LD	1
Soanes, KH	1
Bouwman, NA	1
Morré, HH	1
DeToledo, JC	2
Minagar, A	1
Lowe, MR	1
Mirnajafi-Zadeh, J	1
Mortazavi, M	1
Fathollahi, Y	1
Alasvand Zarasvand, M	1
Reza Palizvan, M	1
Wajima, Z	1
Yoshikawa, T	1
Ogura, A	1
Shiga, T	1
Inoue, T	1
Ogawa, R	1
Arai, S	2
Morita, K	4
Kitayama, S	2
Kumagai, K	1
Kumagai, M	1
Kihira, K	2
Dohi, T	5
Rennie, JM	1
Li, J	1
Olinger, AB	1
Dassow, MS	1
Abel, MS	2
Kempen, PM	1
Rodins, K	1
Hlavac, M	1
Beckert, L	1
Hutchinson, BR	1
DUTTON, WA	1
BERNHARD, CG	1
BOHM, E	2
KIRSTEIN, L	2
WIESEL, T	1
FLODMARK, S	1
PETERSEN, I	1
EEROLA, R	1
TAULANIEMI, E	1
CRONHOLM, B	1
OTTOSSON, JO	6
RAEVSKII, KS	1
Mosovich, A	1
Etchepareborda, J	1
DEACOCK, AR	1
SIMPSON, WT	1
ANSELL, G	1
ANSELL, A	1
HARLEY, HR	1
LAURENCE, KM	1
SEAL, RM	1
STEVENS, JH	1
CAHILL, JF	1
ALDOUS, JG	1
WENNING, AS	1
MORALES AGUILERA, A	1
VAUGHANWILLIAMS, EM	1
Funao, T	1
Oda, Y	3
Tanaka, K	3
Asada, A	3
Timofeev, I	1
Grenier, F	1
Steriade, M	1
Uemura, N	1
Negoro, T	1
Watanabe, K	2
Wolfe, TR	1
Bernstone, T	1
Moran, LR	1
Hossain, T	1
Insoft, RM	1
Pacheco-Rosado, J	2
Hernández-García, A	2
Ortiz-Butrón, R	2
Kato, T	1
Hayakawa, F	1
Sugiyama, N	2
Hamano, S	2
Mochizuki, M	1
Tanaka, M	2
Eto, Y	2
Priya, V	1
Dalal, K	1
Sareen, R	1
Cherng, CH	1
Wong, CS	1
Guler, G	1
Erdogan, F	1
Golgeli, A	1
Akin, A	1
Boyaci, A	1
Ahmed, SU	1
Vallejo, R	1
Hord, ED	1
Hamamoto, M	1
Irifune, M	1
Kawahara, M	1
Yamashita, S	1
Yoshinari, S	1
Minamitani, M	1
Hayakawa, M	1
Kikuchi, K	1
Bordes, M	1
Cros, AM	1
Malingré, MM	1
Ververs, TF	1
van Kesteren, C	1
Kitayama, T	1
Song, L	1
Morioka, N	1
Tsilosani, NA	1
Nanobashvili, ZI	1
Azikuri, GSh	1
Bekaia, GL	1
Dorf, E	1
Kuntz, AF	1
Kelsey, J	1
Holstege, CP	1
Takahashi, R	2
Morishima, HO	4
Inoue, K	1
Dahle, JM	1
Iserson, KV	1
da Costa, JC	1
Olsen, PC	1
de Azeredo Siqueira, R	1
de Frias Carvalho, V	1
Serra, MF	1
Alves, LA	1
Faria, RX	1
Xisto, DG	1
Rocco, PR	1
Cordeiro, RS	1
Rodrigues E Silva, PM	1
Martins, MA	1
Trailović, SM	1
Varagić, VM	1
Rezvani, M	1
Finkelstein, Y	1
Verjee, Z	1
Railton, C	1
Koren, G	1
Shany, E	1
Benzaqen, O	1
Watemberg, N	1
Blas-Valdivia, V	1
Cano-Europa, E	1
Pagès, H	1
de la Gastine, B	1
Quedru-Aboane, J	1
Guillemin, MG	1
Lelong-Boulouard, V	1
Guillois, B	1
Takinami, Y	1
Copeland, SE	1
Ladd, LA	1
Gu, XQ	1
Mather, LE	3
Nakamura, T	1
Hase, I	1
Englesson, S	3
Akerman, B	1
Aström, A	1
Ross, S	1
Telc, A	1
De Jong, RH	16
Wagman, IH	5
Prince, DA	1
Nutt, DJ	1
Cowen, PJ	1
Green, AR	1
Vatashsky, E	3
Aronson, HB	3
Zaroura, S	1
Stirt, JA	1
Sullivan, SF	1
Yamada, K	1
Maekawa, T	5
Okuda, Y	1
Takeshita, H	4
Oppenheimer, EY	1
Rosman, NP	1
Aberg, G	1
Ronfeld, R	1
Aberg, L	1
Fitzgerald, T	1
McCollom, K	1
Moller, R	1
Yoshimura, Y	2
Ciarlone, AE	1
Avery, P	1
Redon, D	1
Schaenzer, G	1
Rusy, B	1
Beilin, B	1
Weinstock, M	1
Post, RM	4
Kennedy, C	1
Shinohara, M	1
Squillace, K	1
Miyaoka, M	1
Suda, S	1
Ingvar, DH	1
Sokoloff, L	1
Kotelko, DM	1
Shnider, SM	1
Dailey, PA	1
Brizgys, RV	1
Levinson, G	1
Shapiro, WA	1
Koike, M	1
Rosen, MA	1
Antonelli, D	1
Ben-Ami, M	1
Weiss, Z	1
Alfano, SN	1
Leicht, MJ	1
Skiendzielewski, JJ	1
Wynn, RL	1
McFarland, SA	1
Meyer, EA	1
Coffman, WB	1
Mumford, R	1
Squillace, KM	1
Pert, A	1
Sass, W	1
Mofenson, HC	1
Caraccio, TR	1
Miller, H	1
Greensher, J	1
Liu, PL	1
Feldman, HS	4
Giasi, R	1
Patterson, MK	1
Covino, BG	6
Kusek, JC	1
Stripling, JS	6
Ireland, D	1
Rothstein, P	1
Dornbusch, J	1
Shaywitz, BA	1
Nadkarni, AV	1
Tondare, AS	1
Seo, N	1
Oshima, E	1
Stevens, J	1
Mori, K	2
Sutter, M	1
Pfenninger, J	1
Bonin, JD	4
Ronfeld, RA	1
DeRosa, RA	1
Oshibuchi, T	1
Imamura, A	1
Heavner, JE	11

Trial	Phase	Enrollment	Study Type	Start Date	Status
Early Versus Late Deflation of Distal Tourniquet in Intravenous Regional Anesthesia With and Without Ketorolac in Hand & Forearm Surgery[NCT05234619]		80 participants (Anticipated)	Interventional	2022-01-01	Active, not recruiting
A Randomized Controlled Trial to Investigate the Efficacy of a Bier's Block Compared to a Mini-bier's Block in Patients Undergoing Hand Surgery[NCT03761329]		280 participants (Actual)	Interventional	2018-11-12	Completed
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]	Phase 4	144 participants (Anticipated)	Interventional	2019-04-05	Recruiting
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538]		100 participants (Anticipated)	Interventional	2023-04-30	Not yet recruiting
Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785]	Phase 2/Phase 3	80 participants (Anticipated)	Interventional	2021-11-15	Recruiting
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964]		550 participants (Actual)	Interventional	2009-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year

Change in Center for Epidemiological Studies Depression Scale (CES-D)

Intervention	units on a scale (Mean)
Lidocaine	-1.27
Placebo	-0.89

Change in Cognitive Function From Baseline

Intervention	units on a scale (Mean)
Lidocaine	0.57
Placebo	0.16

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery

Change in Cognitive Function From Baseline Characterized as Continuous Cognitive Change

Intervention	units on a scale (Mean)
Lidocaine	0.09
Placebo	0.07

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

Change in Duke Activity Status Index (DASI)

Intervention	units on a scale (Mean)
Lidocaine	0.07
Placebo	0.07

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year

Change in Duke Activity Status Index (DASI)

Intervention	units on a scale (Mean)
Lidocaine	6.3
Placebo	6.96

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

Intervention	units on a scale (Mean)
Lidocaine	-10.98
Placebo	-11.67

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

Intervention	units on a scale (Mean)
Lidocaine	0.05
Placebo	0.07

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

Intervention	units on a scale (Mean)
Lidocaine	0.05
Placebo	0.04

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

Intervention	units on a scale (Mean)
Lidocaine	0.02
Placebo	-0.02

Change in Perceived Social Support

Intervention	units on a scale (Mean)
Lidocaine	0.04
Placebo	-0.01

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year

Change in Perceived Social Support

Intervention	units on a scale (Mean)
Lidocaine	0.71
Placebo	-1.16

Change in Social Activity

Intervention	units on a scale (Mean)
Lidocaine	1.23
Placebo	-0.49

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year

Change in Social Activity

Intervention	units on a scale (Mean)
Lidocaine	-0.20
Placebo	0.03

Change in Spielberger State Anxiety Inventory (STAI)

Intervention	units on a scale (Mean)
Lidocaine	0.95
Placebo	1.59

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year

Change in Spielberger State Anxiety Inventory (STAI)

Intervention	units on a scale (Mean)
Lidocaine	-6.70
Placebo	-6.39

Change in Symptom Limitations

Intervention	units on a scale (Mean)
Lidocaine	-7.12
Placebo	-6.31

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year

Change in Symptom Limitations

Intervention	units on a scale (Mean)
Lidocaine	-1.39
Placebo	-1.48

Change in the Cognitive Difficulties Scale

Intervention	units on a scale (Mean)
Lidocaine	-0.67
Placebo	-0.8

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year

Change in the Cognitive Difficulties Scale

Intervention	units on a scale (Mean)
Lidocaine	-0.46
Placebo	-1.02

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

Intervention	units on a scale (Mean)
Lidocaine	-3
Placebo	-3.21

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

Intervention	units on a scale (Mean)
Lidocaine	-0.15
Placebo	-0.31

Count of Participants With a Decline of Greater Than or Equal to One Standard Deviation in One or More of Five Cognitive Domain Scores Reported as a Dichotomous Post-operative Cognitive Deficit (POCD) Outcome

Intervention	units on a scale (Mean)
Lidocaine	2.46
Placebo	2.1

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

Change in Study 36-Item Short Form Health Survey (SF-36)

Intervention	Participants (Count of Participants)
Lidocaine	87
Placebo	83

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year

Change in Study 36-Item Short Form Health Survey (SF-36)

Intervention	units on a scale (Mean)
	1 year Change Work Activities	1 year Change General health perception
Lidocaine	-1.37	-0.28
Placebo	-1.42	-0.43

Transcerebral Activation Gradient of Platelet-neutrophil Conjugates

Intervention	units on a scale (Mean)
	6-Week Change Work activities	6-Week Change General health perception
Lidocaine	2.71	-0.004
Placebo	3	-0.03

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

Transcerebral Activation Gradients of Monocytes

Intervention	Mean linear fluorescence intensity-MLFI (Mean)
	Baseline	Cross-clamp removal	End of Bypass	6 hours post cross-clamp removal
Lidocaine	-0.15	0.02	-0.73	-0.10
Placebo	-0.43	-0.73	-0.40	0.19

Transcerebral Activation Gradients of Neutrophils

Intervention	Mean linear fluorescence intensity-MLFI (Mean)
	Baseline	Cross-clamp removal	End of Bypass	6 hours post cross-clamp removal
Lidocaine	-4.22	-2.46	-0.34	1.21
Placebo	-0.04	1.83	2.64	0.54

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

Transcerebral Activation Gradients of Platelets

Article	Year
[Paediatric status epilepticus]. Revista de neurologia, 2022, 10-16, Volume: 75, Issue:8 Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide;	2022
The use of phenobarbital and other anti-seizure drugs in newborns. Seminars in fetal & neonatal medicine, 2017, Volume: 22, Issue:5 Topics: Anticonvulsants; Fructose; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Midazolam; Phen	2017
Treatment of neonatal seizures. Seminars in fetal & neonatal medicine, 2013, Volume: 18, Issue:4 Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo	2013
Lidocaine for Status Epilepticus in Pediatrics. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2015, Volume: 42, Issue:6 Topics: Anticonvulsants; Humans; Lidocaine; Pediatrics; Phenytoin; Prospective Studies; Seizures; Status Epi	2015
Lidocaine for status epilepticus in adults. Seizure, 2015, Volume: 31 Topics: Adult; Anticonvulsants; Humans; Lidocaine; Seizures; Status Epilepticus	2015
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision. Fetal and pediatric pathology, 2011, Volume: 30, Issue:6 Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Injections, Subcutaneous; L	2011
Neonatal seizures and their treatment. Current opinion in neurology, 2003, Volume: 16, Issue:2 Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas	2003
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases. Journal of emergency nursing, 2004, Volume: 30, Issue:2 Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio	2004
[Inhalation induction with sevoflurane in paediatrics: what is new?]. Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:4 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Drug Synergism;	2006
Aminophylline. Anesthesia and analgesia, 1981, Volume: 60, Issue:8 Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransfo	1981
Seizures and seizure-like states in the child: an approach to emergency management. Emergency medicine clinics of North America, 1983, Volume: 1, Issue:1 Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans	1983
Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy. Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:2 Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Female; Humans; Laryngoscopy; Lidocaine; M	1996
Lidocaine and seizures. Therapeutic drug monitoring, 2000, Volume: 22, Issue:3 Topics: Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Humans; Lidocaine; Seizures	2000
Cocaine, kindling, and psychosis. The American journal of psychiatry, 1976, Volume: 133, Issue:6 Topics: Amphetamine; Cocaine; Drug Tolerance; Electric Stimulation; Epilepsy, Temporal Lobe; Humans; Lidocai	1976
Neurologic disorders in renal failure (first of two parts). The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3 Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc	1976
An analysis of the complications of extradural and caudal block. Anaesthesia, 1969, Volume: 24, Issue:4 Topics: Adult; Aged; Anesthesia, Spinal; Back Pain; Blood Pressure; Catheterization; Dura Mater; Epinephrine	1969
Aspects of the pharmacology of local anaesthetic agents. British journal of anaesthesia, 1970, Volume: 42, Issue:3 Topics: Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood Pressure; Central Nervous System; Epine	1970
Acute and chronic toxicity of local anaesthetics. Canadian Anaesthetists' Society journal, 1973, Volume: 20, Issue:1 Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Brain; Cats; Diazepam; Drug Hypersensitivity;	1973

lidocaine and Seizures

Research Excerpts

Research

Studies (352)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Change in Center for Epidemiological Studies Depression Scale (CES-D)

Change in Center for Epidemiological Studies Depression Scale (CES-D)

Change in Cognitive Function From Baseline

Change in Cognitive Function From Baseline Characterized as Continuous Cognitive Change

Change in Duke Activity Status Index (DASI)

Change in Duke Activity Status Index (DASI)

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

Change in Perceived Social Support

Change in Perceived Social Support

Change in Social Activity

Change in Social Activity

Change in Spielberger State Anxiety Inventory (STAI)

Change in Spielberger State Anxiety Inventory (STAI)

Change in Symptom Limitations

Change in Symptom Limitations

Change in the Cognitive Difficulties Scale

Change in the Cognitive Difficulties Scale

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

Count of Participants With a Decline of Greater Than or Equal to One Standard Deviation in One or More of Five Cognitive Domain Scores Reported as a Dichotomous Post-operative Cognitive Deficit (POCD) Outcome

Change in Study 36-Item Short Form Health Survey (SF-36)

Change in Study 36-Item Short Form Health Survey (SF-36)

Transcerebral Activation Gradient of Platelet-neutrophil Conjugates

Transcerebral Activation Gradients of Monocytes

Transcerebral Activation Gradients of Neutrophils

Transcerebral Activation Gradients of Platelets

Reviews

Trials

Other Studies