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lidocaine and Seizures

lidocaine has been researched along with Seizures in 352 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments."9.12Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006)
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)."9.11A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004)
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years."9.09[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."8.91Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."8.91Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Lidocaine has a concentration-dependent effect on seizures."8.80Lidocaine and seizures. ( DeToledo, JC, 2000)
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs."8.02Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021)
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."7.96Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."7.83Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events."7.81Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015)
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010."7.79Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013)
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures."7.78Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."7.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"We report a case of neonatal seizures after lidocaine administration for circumcision."7.74Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007)
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures."7.73Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006)
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge."7.72Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004)
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002."7.72[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004)
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure."7.71Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002)
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures."7.69Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994)
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures."7.69[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997)
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine."7.68Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992)
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen."7.68Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."7.68Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine."7.67Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988)
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method."7.67Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987)
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures."7.67Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986)
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures."7.66The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981)
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia."7.66Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981)
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure."7.66Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978)
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome."6.73Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."5.72Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."5.43Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3."5.43Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016)
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy."5.37Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011)
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14."5.36Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010)
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ."5.33Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005)
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements."5.32Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004)
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity."5.30Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998)
"infusion of 1."5.29Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
"A lidocaine level was obtained at 4 h post-ingestion and was 0."5.28Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992)
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior."5.27Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984)
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy."5.26Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976)
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration."5.25Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975)
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies."5.22[Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022)
"One to seven seizures were recognized before starting CBZ or Lidocaine therapy, followed by complete cessation in 57 episodes and one or two recurrent seizures in five."5.15Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis. ( Komatsu, M; Kubota, T; Nakajima, M; Okumura, A; Shimakawa, S; Tanabe, T, 2011)
"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments."5.12Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006)
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)."5.11A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004)
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years."5.09[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999)
" The duration of motor and EEG seizures (means +/- SD) were 37 +/- 13 sec and 64 +/- 21 sec, 25 +/- 11 sec and 52 +/- 43 sec, 17 +/- 12 sec and 32 +/- 17 sec, 1 +/- 3 sec and 18 +/- 10 sec in the saline, lidocaine 50 mg, 100 mg, 200 mg groups, respectively."5.08Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity. ( Fu, W; Husain, MM; Stool, LA; White, PF, 1997)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."4.91Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control."4.91Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015)
"Seizures have been reported with lidocaine at its lowest effective dose (1."4.85Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. ( Guay, J, 2009)
"Lidocaine has a concentration-dependent effect on seizures."4.80Lidocaine and seizures. ( DeToledo, JC, 2000)
"We describe a two-year-old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic-clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy."4.12Anesthetic considerations in Dravet syndrome. ( Corlette, S; Davidson, A; Howell, KB; Macdonald-Laurs, E, 2022)
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs."4.02Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021)
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."3.96Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures."3.88Transplacental lidocaine intoxication. ( Cools, F; Demeulemeester, V; Lefevere, J; Van Hautem, H, 2018)
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures."3.83Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016)
"High doses of lidocaine produce seizures and vasoconstriction."3.83Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine. ( Déciga-Campos, M; Librowski, T; López-Muñoz, FJ; Navarrete-Vázquez, G; Ortiz-Andrade, R; Sánchez-Recillas, A; Yañez-Pérez, V, 2016)
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events."3.81Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015)
" In experiment 2, both emulsified isoflurane and midazolam significantly suppressed lidocaine-induced tonic-clonic seizures."3.80Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats. ( Chen, X; Huang, H; Liu, J; Wang, X; Zhang, W; Zhou, C, 2014)
" We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity."3.79Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013)
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010."3.79Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013)
"We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ)."3.79Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine. ( Kobayashi, K; Kodani, N; Maniwa, S; Nakano, K; Ohtsuka, Y, 2013)
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures."3.78Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."3.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)."3.76Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010)
"The addition of a small dose of lignocaine to propofol during ECT treatment enhanced rather than reduced the quality of the seizures produced."3.76Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy. ( Lawford, J; Loo, C; MacPherson, RD; Mahon, M; Scott, D; Simpson, B, 2010)
"We report a case of neonatal seizures after lidocaine administration for circumcision."3.74Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007)
" Clinical features were hypotonia, pupillary mydriasis fixed to light, apnea, cyanosis and seizures."3.74[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases]. ( de la Gastine, B; Guillemin, MG; Guillois, B; Lelong-Boulouard, V; Pagès, H; Quedru-Aboane, J, 2008)
" Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death."3.74The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008)
"Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice."3.73Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics. ( Dohi, T; Kitayama, T; Morioka, N; Morita, K; Song, L, 2006)
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures."3.73Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006)
"The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice."3.72Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003)
"To evaluate the effect of GABA(B) receptor in drug-kindled seizures, the gene expression of GABA(B) receptor in cocaine- and lidocaine-kindled rats was examined in this study."3.72Up-regulation of GABA(B) receptor mRNA and protein in the hippocampus of cocaine- and lidocaine-kindled rats. ( Abel, MS; Dassow, MS; Li, J; Olinger, AB, 2003)
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge."3.72Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004)
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002."3.72[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004)
"In this study the effect of transient inhibition of the CA1 region of the dorsal hippocampus by lidocaine on amygdala kindling rate and amygdaloid kindled seizures was investigated."3.71Effect of transient hippocampal inhibition on amygdaloid kindled seizures and amygdaloid kindling rate. ( Alasvand Zarasvand, M; Fathollahi, Y; Mirnajafi-Zadeh, J; Mortazavi, M; Reza Palizvan, M, 2002)
"Lidocaine, a local anesthetic, produces seizures by unknown central mechanisms."3.71Thyroid hormones modify susceptibility to lidocaine-kindling in rats. ( Chambert, G; Pacheco-Rosado, J; Zamudio-Hernández, S, 2001)
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure."3.71Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002)
"The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice."3.70Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999)
" To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin."3.70Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999)
"Lidocaine is well known to have toxic effects on the central nervous system including the induction of electroencepharographic seizures and convulsions at high doses."3.70[Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition]. ( Ikeda, M; Maru, E; Shimada, M; Suzuki, H; Ueyama, T, 1999)
" We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats."3.70Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999)
"5- year-old girl with systemic lidocaine toxicity following treatment for postoperative bladder spasms."3.70Lidocaine toxicity secondary to postoperative bladder instillation in a pediatric patient. ( Cilento, BG; Clapp, CR; Poss, WB, 1999)
"Lidocaine induces electroencephalographic seizures and generalized convulsions at large doses."3.70A decrease in seizure susceptibility to lidocaine in kindled epileptic rats. ( Fujita, H; Maru, E; Ogiuchi, H; Shimada, M; Suzuki, H, 2000)
"An equal degree of acute hypertension induced by these three different vasopressors may play a role in reducing the threshold (plasma and brain lidocaine concentrations) as well as the cumulative convulsant doses associated with lidocaine-induced convulsions."3.69Effect of vasoconstrictive agents added to lidocaine on intravenous lidocaine-induced convulsions in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1995)
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures."3.69Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994)
"The present study examined the effects of daily treatment with a subconvulsant dose (50 mg/kg) of cocaine or lidocaine on susceptibility to seizures induced by cross-injections of the same dose of the other local anesthetic, and to seizures induced by pentylenetetrazol (PTZ) or N-methyl-DL-aspartate (NMDLA) in ddY mice."3.69One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1996)
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures."3.69[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997)
"The present study investigated the effect of dextromethorphan and 6,7-dinitroquinoxaline-2,3-dione (DNQX) pre-treatment on the development of cocaine- and lidocaine-induced seizures."3.69Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat. ( Abdel-Rahman, MS; Barat, SA, 1997)
"In newborn infants suffering from perinatal asphyxia seizures, lidocaine (LD) has proved to be an effective anticonvulsant."3.69Lidocaine pharmacokinetics and toxicity in newborn pigs. ( Haaland, K; Hoem, NO; Johannessen, SI; Satas, S; Sørensen, DR; Thoresen, M, 1997)
"We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures."3.69Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997)
"We report a case of lidocaine toxicity with seizures that appears to represent a drug interaction with amiodarone."3.68Amiodarone interaction with lidocaine. ( Imhoff, TE; Siegmund, JB; Wilson, JH, 1993)
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine."3.68Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992)
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen."3.68Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991)
"At doses of 30 or 40 mg/kg, lidocaine does not induce seizures or death."3.68Lidocaine potentiation of cocaine toxicity. ( Albertson, TE; Derlet, RW; Tharratt, RS, 1991)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."3.68Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"Thirteen newborn infants (five premature, eight full term) with severe seizures and not responding to phenobarbital and diazepam received a lidocaine (LD) infusion."3.68Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. ( Bodiou, C; Olive, G; Radvanyi-Bouvet, MF; Rey, E; Richard, MO; Torricelli, A; Walti, H, 1990)
"The concentrations of cyclic 3', 5'-guanosine monophosphate (cGMP) and cyclic 3', 5'-adenosine monophosphate (cAMP) in the cerebellar and cerebral cortex were measured during lidocaine infusion and during bicuculline-induced seizures in rats."3.67Cyclic nucleotides in rat brain during lidocaine infusion. ( Maekawa, T; Okuda, Y; Takeshita, H; Yamada, K, 1984)
"The influence of hyperkalemia on the central nervous system and cardiac toxicity of bupivacaine and lidocaine was studied in open-chested mechanically ventilated dogs."3.67The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. ( Avery, P; Redon, D; Rusy, B; Schaenzer, G, 1984)
"A case of a 2-year-old girl who survived grand mal seizures secondary to toxicity from massive subcutaneous administration of lidocaine is presented."3.67Lidocaine toxicity following subcutaneous administration. ( Alfano, SN; Leicht, MJ; Skiendzielewski, JJ, 1984)
"The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde."3.67Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989)
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine."3.67Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988)
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method."3.67Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987)
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures."3.67Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986)
"Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic."3.66Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980)
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures."3.66The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981)
"A case is reported of an infant who experienced seizures while being treated with a topical lidocaine 2% solution (Xylocaine 2% Viscous) for teething."3.66Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine. ( Caraccio, TR; Greensher, J; Miller, H; Mofenson, HC, 1983)
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia."3.66Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981)
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure."3.66Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978)
" Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally."3.65Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975)
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome."2.73Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007)
"Furthermore, we also assessed seizure duration using both the cuff method and two-lead electroencephalography."2.70The effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy. ( Inoue, T; Ogawa, R; Ogura, A; Shiga, T; Wajima, Z; Yoshikawa, T, 2002)
"Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit."2.55The use of phenobarbital and other anti-seizure drugs in newborns. ( El-Dib, M; Soul, JS, 2017)
"Current therapeutic options to treat neonatal seizures (i."2.49Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013)
"The patients developed a generalized seizure requiring endotracheal intubation but recovered fully with supportive care."2.47Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision. ( Belhadj, S; Ben Jaballah, N; Bouziri, A; Hamdi, A; Khaldi, A; Menif, K, 2011)
"Neonatal seizures continue to present a diagnostic and therapeutic challenge to paediatricians worldwide, and are a worrying sign for both parents and clinicians alike."2.42Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003)
" In this study, it was shown that the safe and effective net application dose of lidocaine for the surgery may be within the range of 127 to 260 mg."2.39Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy. ( Iga, T; Ito, K; Kaga, K; Kotaki, H; Mitomi, N; Sawada, Y; Tayama, N; Tezuka, K, 1996)
"Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted."2.36Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983)
"We provide additional evidence highlighting the importance of caution regarding lidocaine dosing due to the effect on seizure length in the ECT setting."1.91Does Lidocaine Shorten Seizure Duration in Electroconvulsive Therapy? ( Enguita-Germán, M; Enriquez, ÁSR; Fábrega, AM; Gil, JL; López-Ilundain, J; Martinez de Zabarte Moraza, E; Maughan, AR; Prados, AB; Rosquil, EU; Yoldi-Murillo, J, 2023)
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD."1.72Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022)
"An epileptic seizure can trigger a headache during (ictal) or after (postictal) the termination of the event."1.56Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache. ( Burstein, R; Melo-Carrillo, A; Schain, AJ; Strassman, AM, 2020)
"A sudden loss of consciousness and tonic-clonic seizure was occurred after negative aspiration and test dose."1.51Tonic-clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery: A case report. ( Dong, J; Lu, F; Tian, J; Zhang, K, 2019)
"We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy."1.46Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017)
"Lidocaine plasma levels were in the toxic range at the time of the first seizure (18."1.43[Delayed convulsion after lidocaine instillation for bronchoscopy]. ( Gaïes, E; Jebabli, N; Klouz, A; Lakhal, M; Salouage, I; Trabelsi, S, 2016)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."1.43Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3."1.43Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016)
"Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems."1.43Local Anesthetics Systemic Toxicity. ( Jayanthi, R; Monica, K; Nasser, K, 2016)
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy."1.37Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011)
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14."1.36Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010)
" The onset of toxic manifestations (seizure, dysrhythmia, and cardiac arrest) was recorded, and then the doses of local anesthetics were calculated."1.36Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats. ( Bo, YL; Li, HB; Li, WZ; Wan, QX, 2010)
" Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < ."1.36Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity. ( Barcelos, KC; Cabral, AM; Furtado, DP; Haas, DA; Ramacciato, JC, 2010)
"One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole."1.35Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy. ( Baxter, C; Dart, C; Rainger, J; Vogelnest, Lj, 2009)
"Propranolol is a beta-adrenoceptor antagonist used clinically."1.35Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain. ( Asada, A; Hase, I; Nakamura, T; Oda, Y; Takahashi, R; Tanaka, K, 2008)
"Diazepam prevents lidocaine-induced seizures, but not neuronal damage in brain structures."1.34Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats. ( Blas-Valdivia, V; Cano-Europa, E; Hernández-García, A; Ortiz-Butrón, R, 2007)
"The severity of convulsions was assessed and scored as 1 = mild, 2 = moderate, and 3 = severe."1.33Effect of fentanyl on lidocaine-induced convulsions in mice. ( Cherng, CH; Wong, CS, 2005)
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ."1.33Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005)
"Diazepam was administered as the first-line drug on 157 of 177 occasions (88."1.33[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005)
"At the onset of convulsions, plasma concentrations of both total (B = 4."1.32The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. ( Asada, A; Funao, T; Oda, Y; Tanaka, K, 2003)
"Some electrographic seizures are generated intracortically."1.32Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures. ( Grenier, F; Steriade, M; Timofeev, I, 2004)
"The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode."1.32Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. ( Negoro, T; Okumura, A; Uemura, N; Watanabe, K, 2004)
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements."1.32Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004)
"Audiogenic seizures, a model of brainstem epilepsy, are characterized by a tonic phase (sustained muscular contraction fixing the limbs in a flexed or extended position) associated with a short cortical electroencephalogram flattening."1.30The amygdala is critical for seizure propagation from brainstem to forebrain. ( Danober, L; Hirsch, E; Marescaux, C; Maton, B; Nehlig, A; Pereira de Vasconcelos, A; Simler, S; Vergnes, M, 1997)
"The latency to convulsion and survival rate were significantly longer and higher, respectively, in the brain-injured group than in the sham-operated one."1.30Prior brain injury protects death from local anaesthetic-induced convulsion. ( Baba, H; Endoh, H; Fukuda, S; Kumagai, Y; Sato, K; Shimoji, K; Taga, K; Yamakura, T, 1997)
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity."1.30Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998)
"VNS significantly reduced seizure severities of control rats."1.30Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. ( Browning, RA; Clark, KB; Krahl, SE; Smith, DC, 1998)
"In contrast to the seizure activity and wide-spread neuronal degeneration following kainate treatment, injections of lidocaine did not produce neuronal death within three days."1.30Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain. ( Chae, HJ; Cho, SB; Gwag, BJ; Jin, BG; Kang, JS; Kim, HR; Won, SJ, 1999)
"Acute cocaine overdose can result in convulsions and death although the mechanisms associated with this toxicity are poorly understood."1.29Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. ( Katz, JL; Newman, AH; Nowak, G; Witkin, JM, 1993)
"infusion of 1."1.29Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994)
"Pretreatment with clonidine changed neither cumulative convulsant doses (Group 1: 41."1.29Clonidine does not affect lidocaine seizure threshold in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1993)
"Pretreatment with diazepam alone increased both cumulative convulsant doses and plasma concentrations of lidocaine at the onset of convulsions."1.28Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. ( Arakawa, K; Benson, KT; Goto, H; Yokoyama, M, 1992)
"A lidocaine level was obtained at 4 h post-ingestion and was 0."1.28Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992)
"The incidence of lidocaine-induced convulsions was decreased by treatments with alpha-MPT and disulfiram, while that of PTZ was increased by either treatment."1.28Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions. ( Dohi, T; Takada, K; Tanaka, S; Tsujimoto, A; Yoshimura, Y, 1991)
"However, lidocaine-induced convulsions were enhanced by AOAA."1.28Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord. ( Kawaguchi, M; Ouchi, K; Sato, T; Sawaki, K, 1991)
"No ventricular arrhythmias were observed in this group."1.28Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. ( Arthur, GR; Covino, BG; Feldman, HS, 1989)
"While epinephrine enhanced lidocaine seizure activity and lethality by approximately 50%, midazolam almost completely prevented lidocaine-induced convulsions but had no significant effect on mortality."1.28Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats. ( Mito, RS; Torbiner, ML; Yagiela, JA, 1989)
"Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC."1.28Lidocaine treatment of neonatal convulsions, a therapeutic dilemma. ( Hynning, PA; Nergårdh, A; Wallin, A, 1989)
"With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine."1.27A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983)
""Clearing" of catecholamine-induced arrhythmias was not obtained in any of six dogs given tocainide and only in two out of six dogs given lidocaine."1.27Antiarrhythmic effects of tocainide and lidocaine in dogs. ( Aberg, G; Aberg, L; Fitzgerald, T; McCollom, K; Moller, R; Ronfeld, R, 1983)
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior."1.27Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984)
" These results suggest that the CNS is the primary target organ for the toxic effects of both highly lipid-soluble and highly protein-bound local anesthetics (i."1.27Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. ( Covino, BG; Feldman, HS; Giasi, R; Liu, PL; Patterson, MK, 1983)
"Lidocaine and phenytoin were relatively ineffective against convulsants that act on synaptic chloride channels via the GABA-ionophore receptor complex."1.27Anticonvulsive and convulsive effects of lidocaine: comparison with those of phenytoin, and implications for mechanism of action concepts. ( Javid, MJ; Stone, WE, 1988)
"At the time of the seizure both tocainide and lidocaine were well within their respective therapeutic ranges."1.27A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity? ( Covinsky, JO; Forrence, E; Mullen, C, 1986)
" The L group received lidocaine at a dosage of 0."1.27Effect on the seizure threshold in dogs of tocainide/lidocaine administration. ( Kaplan, RM; Paris, PM; Schuster, MR; Stewart, RD, 1987)
"The comparative pharmacokinetic properties of lidocaine, bupivacaine, etidocaine and mepivacaine were investigated in convulsing and non-convulsing dogs."1.27Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. ( Arthur, GR; Covino, BG; Feldman, HS, 1988)
"SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions."1.27General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988)
"This is the longest cardiac arrest in early pregnancy reported in the medical literature with normal maternal and fetal outcome."1.27Complete maternal and fetal recovery after prolonged cardiac arrest. ( Burke, TJ; Selden, BS, 1988)
"To induce convulsions 4."1.27The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics. ( Bokesch, PM; Castaneda, AR; Wilson, JM; Ziemer, G, 1987)
"The child had asystole and grand mal seizures associated with lidocaine serum concentration of 19."1.27Intravenous lidocaine overdosage in a child. ( Edgren, B; Gehrz, R; Tilelli, J, 1986)
"Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50."1.27Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. ( Kim, KC; Tasch, MD, 1986)
"No synchronized population bursting (seizures) was observed at any of the concentrations tested (10(-6)M to 10(-3)M)."1.27Lidocaine depresses synaptic activity in the rat hippocampal slice. ( Edmonds, HL; Reid, KH; Rigor, BM; Schurr, A; Spears, B; West, CA, 1986)
" Onset of electrical seizure activity occurred at about the same time in both groups and was defined as the central nervous system (CNS) toxic end point."1.27Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. ( Chadwick, HS, 1985)
"The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats."1.27Effect of cocaine and pentylenetetrazol on cortical kindling. ( Russell, RD; Stripling, JS, 1985)
"The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg ."1.26Studies on the post-ictal rise in seizure threshold. ( Cowen, PJ; Green, AR; Nutt, DJ, 1981)
"Lidocaine and procaine seizure thresholds were studied."1.26Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines. ( Ciarlone, AE, 1981)
"Lidocaine was administered using a constant rate infusion pump."1.26The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats. ( Mori, K; Oshima, E; Seo, N; Stevens, J, 1982)
"Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine."1.26Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981)
"The metabolic changes during lidocaine seizure were essentially the same as those observed in the seizure group in the first series."1.26Cerebral energy state and glycolytic metabolism during lidocaine infusion in the rat. ( Imamura, A; Maekawa, T; Oshibuchi, T; Takeshita, H, 1981)
" An identical sequence of toxic manifestations occurred in the adult, newborn, and fetus: convulsions, hypotension, respiratory arrest, and circulatory collapse."1.26Toxicity of lidocaine in adult, newborn, and fetal sheep. ( Bruce, SL; Covino, BG; Finster, M; Gutsche, BB; Morishima, HO; Pedersen, H; Sakuma, K; Stark, RI, 1981)
"The effect of drug-induced convulsions on kindling was studied in male Long-Evans rats."1.26Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol. ( Hendricks, C; Stripling, JS, 1981)
"The first seizure activity observed was tonic extension (TE) which occurred at an infused lidocaine dose of 12."1.26Cardiorespiratory and behavioral reactions to the lidocaine-induced convulsions in the dog. ( Gangarosa, LP; Hofman, WF; Jerram, DC, 1977)
"Excitation, coma, convulsions, tachycardia, mydriasis, nystagmus, and rubeosis of the face were the most important signs."1.26[Fenfluramin (ponderax) intoxications in children (author's transl)]. ( Krienke, EG; Mühlendahl, KE, 1978)
"Toxicities were compared by determining seizure dosages for each drug alone and then in a lidocaine-etidocaine-tetracaine mixture."1.26Central-nervous-system toxicity of local anesthetic mixtures in monkeys. ( Embro, WJ; Munson, ES; Paul, WL, 1977)
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy."1.26Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976)
"Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection."1.26Gestational differences in lidocaine toxicity in the fetal lamb. ( Benowitz, N; Heymann, MA; Rudolph, AM; Teramo, K, 1976)
"The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase."1.25Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975)
"Five patients died."1.25Tricyclic antidepressive poisoning with special reference to cardiac complications. ( Asmussen, I; Lunding, M; Serafimovski, N; Thorball, N, 1975)
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration."1.25Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975)

Research

Studies (352)

TimeframeStudies, this research(%)All Research%
pre-1990189 (53.69)18.7374
1990's57 (16.19)18.2507
2000's50 (14.20)29.6817
2010's47 (13.35)24.3611
2020's9 (2.56)2.80

Authors

AuthorsStudies
Kim, H2
Lee, I1
Son, WG1
Robinson, S1
Macdonald-Laurs, E1
Corlette, S1
Davidson, A1
Howell, KB1
Soto-Insuga, V1
González-Alguacil, E1
García-Peñas, JJ1
Stephenson, DT1
Thomas, N1
Korbely, R1
López-Ilundain, J1
Prados, AB1
Enriquez, ÁSR1
Enguita-Germán, M1
Rosquil, EU1
Gil, JL1
Fábrega, AM1
Martinez de Zabarte Moraza, E1
Maughan, AR1
Yoldi-Murillo, J1
Favié, LMA1
Huitema, ADR1
van den Broek, MPH1
Rademaker, CMA1
de Haan, TR1
van Straaten, HLM1
Simons, SHP1
Rijken, M1
Nuytemans, DHGM1
Egberts, TCG1
Groenendaal, F3
Lu, F1
Tian, J1
Dong, J1
Zhang, K1
Melo-Carrillo, A1
Schain, AJ1
Strassman, AM1
Burstein, R1
Santos, GFS1
Ferreira, LO1
Gerrits Mattos, B1
Fidelis, EJ1
de Souza, AS1
Batista, PS1
Manoel, CAF1
Cabral, DAC1
Jóia de Mello, V1
Favacho Lopes, DC1
Hamoy, M1
El-Dib, M1
Soul, JS1
Szadkowski, M1
Drapkin, Z1
Hewes, H1
Caravati, EM1
Plumb, J1
Lee, WK1
Bae, MI1
Choi, SH1
Min, KT1
Demeulemeester, V1
Van Hautem, H1
Cools, F1
Lefevere, J1
van Rooij, LG4
Hellström-Westas, L5
de Vries, LS5
Larson, A1
Stidham, T1
Banerji, S1
Kaufman, J1
Lundqvist, M2
Ågren, J2
Flink, R2
Wickström, R2
Nakano, K1
Kobayashi, K1
Maniwa, S1
Kodani, N1
Ohtsuka, Y1
Hakan, N1
Aydin, M1
Dilli, D1
Zenciroglu, A1
Okumus, N1
Tanawuttiwat, T1
Thisayakorn, P1
Viles-Gonzalez, JF1
Zhou, C1
Huang, H1
Liu, J1
Wang, X1
Chen, X1
Zhang, W1
Özer, AB1
Erhan, ÖL1
Bensghir, M1
Badou, N1
Houba, A1
Balkhi, H1
Haimeur, C1
Azendour, H1
Weeke, LC2
Schalkwijk, S1
Toet, MC4
van den Broek, MP4
Zeiler, FA2
Zeiler, KJ2
Teitelbaum, J2
Gillman, LM2
West, M2
Kazina, CJ2
Gaïes, E1
Jebabli, N1
Lakhal, M1
Klouz, A1
Salouage, I1
Trabelsi, S1
Boylan, GB2
Pressler, RM1
Chiu, KM1
Lu, CW1
Lee, MY1
Wang, MJ1
Lin, TY1
Wang, SJ1
Hoda, S1
O'Brien, J1
Gamble, J1
Déciga-Campos, M1
Navarrete-Vázquez, G1
López-Muñoz, FJ1
Librowski, T1
Sánchez-Recillas, A1
Yañez-Pérez, V1
Ortiz-Andrade, R1
Nicholas, E1
Thornton, MD1
Cho, YS1
Chung, BY1
Park, CW1
Kim, HO1
Jayanthi, R1
Nasser, K1
Monica, K1
Wang, XF1
Luo, XL1
Liu, WC1
Hou, BC1
Huang, J1
Zhan, YP1
Chen, SB1
Osman, BM1
Maga, JM1
Baquero, SM1
Wentlandt, M1
Morris, SC1
Mitchell, SH1
Kalimullah, EA1
Bryant, SM1
Brown, C1
Bachmann, G1
Ling, FW1
Rainger, J1
Baxter, C1
Vogelnest, Lj1
Dart, C1
Dror, M1
Baptiste, SL1
Tang, HM1
Kuzniecky, RI1
Devinsky, O1
French, JA1
Ludvig, N1
Guay, J1
Wan, QX1
Bo, YL1
Li, HB1
Li, WZ1
MacPherson, RD1
Lawford, J1
Simpson, B1
Mahon, M1
Scott, D1
Loo, C1
Tanabe, T3
Okumura, A3
Komatsu, M1
Kubota, T1
Nakajima, M1
Shimakawa, S2
Barcelos, KC1
Furtado, DP1
Ramacciato, JC1
Cabral, AM1
Haas, DA1
Nishiyama, T1
Komatsu, K1
Chakrabarti, R1
Topf, HG1
Schroth, M1
Huitema, AD1
van Hasselt, JG1
Egberts, TC1
Rademaker, CM2
Mishra, SK1
Subramanian, A1
Hemavathi, B1
Badhe, A1
Chung, SG1
Menif, K1
Khaldi, A1
Bouziri, A1
Hamdi, A1
Belhadj, S1
Ben Jaballah, N1
ter Weijden, E1
Ververs, FF1
Abdullah, MA1
Zeidan, A1
Landy, C1
Schaeffer, E1
Raynaud, L1
Favier, JC1
Plancade, D1
Jennekens, W1
Dankers, F1
Janssen, F1
Toet, M1
van der Aa, N1
Niemarkt, H1
van Pul, C1
de Vries, L1
Andriessen, P1
Ellis, LD1
Soanes, KH1
Bouwman, NA1
Morré, HH1
DeToledo, JC2
Minagar, A1
Lowe, MR1
Mirnajafi-Zadeh, J1
Mortazavi, M1
Fathollahi, Y1
Alasvand Zarasvand, M1
Reza Palizvan, M1
Wajima, Z1
Yoshikawa, T1
Ogura, A1
Shiga, T1
Inoue, T1
Ogawa, R1
Arai, S2
Morita, K4
Kitayama, S2
Kumagai, K1
Kumagai, M1
Kihira, K2
Dohi, T5
Rennie, JM1
Li, J1
Olinger, AB1
Dassow, MS1
Abel, MS2
Kempen, PM1
Rodins, K1
Hlavac, M1
Beckert, L1
Hutchinson, BR1
DUTTON, WA1
BERNHARD, CG1
BOHM, E2
KIRSTEIN, L2
WIESEL, T1
FLODMARK, S1
PETERSEN, I1
EEROLA, R1
TAULANIEMI, E1
CRONHOLM, B1
OTTOSSON, JO6
RAEVSKII, KS1
Mosovich, A1
Etchepareborda, J1
DEACOCK, AR1
SIMPSON, WT1
ANSELL, G1
ANSELL, A1
HARLEY, HR1
LAURENCE, KM1
SEAL, RM1
STEVENS, JH1
CAHILL, JF1
ALDOUS, JG1
WENNING, AS1
MORALES AGUILERA, A1
VAUGHANWILLIAMS, EM1
Funao, T1
Oda, Y3
Tanaka, K3
Asada, A3
Timofeev, I1
Grenier, F1
Steriade, M1
Uemura, N1
Negoro, T1
Watanabe, K2
Wolfe, TR1
Bernstone, T1
Moran, LR1
Hossain, T1
Insoft, RM1
Pacheco-Rosado, J2
Hernández-García, A2
Ortiz-Butrón, R2
Kato, T1
Hayakawa, F1
Sugiyama, N2
Hamano, S2
Mochizuki, M1
Tanaka, M2
Eto, Y2
Priya, V1
Dalal, K1
Sareen, R1
Cherng, CH1
Wong, CS1
Guler, G1
Erdogan, F1
Golgeli, A1
Akin, A1
Boyaci, A1
Ahmed, SU1
Vallejo, R1
Hord, ED1
Hamamoto, M1
Irifune, M1
Kawahara, M1
Yamashita, S1
Yoshinari, S1
Minamitani, M1
Hayakawa, M1
Kikuchi, K1
Bordes, M1
Cros, AM1
Malingré, MM1
Ververs, TF1
van Kesteren, C1
Kitayama, T1
Song, L1
Morioka, N1
Tsilosani, NA1
Nanobashvili, ZI1
Azikuri, GSh1
Bekaia, GL1
Dorf, E1
Kuntz, AF1
Kelsey, J1
Holstege, CP1
Takahashi, R2
Morishima, HO4
Inoue, K1
Dahle, JM1
Iserson, KV1
da Costa, JC1
Olsen, PC1
de Azeredo Siqueira, R1
de Frias Carvalho, V1
Serra, MF1
Alves, LA1
Faria, RX1
Xisto, DG1
Rocco, PR1
Cordeiro, RS1
Rodrigues E Silva, PM1
Martins, MA1
Trailović, SM1
Varagić, VM1
Rezvani, M1
Finkelstein, Y1
Verjee, Z1
Railton, C1
Koren, G1
Shany, E1
Benzaqen, O1
Watemberg, N1
Blas-Valdivia, V1
Cano-Europa, E1
Pagès, H1
de la Gastine, B1
Quedru-Aboane, J1
Guillemin, MG1
Lelong-Boulouard, V1
Guillois, B1
Takinami, Y1
Copeland, SE1
Ladd, LA1
Gu, XQ1
Mather, LE3
Nakamura, T1
Hase, I1
Englesson, S3
Akerman, B1
Aström, A1
Ross, S1
Telc, A1
De Jong, RH16
Wagman, IH5
Prince, DA1
Nutt, DJ1
Cowen, PJ1
Green, AR1
Vatashsky, E3
Aronson, HB3
Zaroura, S1
Stirt, JA1
Sullivan, SF1
Yamada, K1
Maekawa, T5
Okuda, Y1
Takeshita, H4
Oppenheimer, EY1
Rosman, NP1
Aberg, G1
Ronfeld, R1
Aberg, L1
Fitzgerald, T1
McCollom, K1
Moller, R1
Yoshimura, Y2
Ciarlone, AE1
Avery, P1
Redon, D1
Schaenzer, G1
Rusy, B1
Beilin, B1
Weinstock, M1
Post, RM4
Kennedy, C1
Shinohara, M1
Squillace, K1
Miyaoka, M1
Suda, S1
Ingvar, DH1
Sokoloff, L1
Kotelko, DM1
Shnider, SM1
Dailey, PA1
Brizgys, RV1
Levinson, G1
Shapiro, WA1
Koike, M1
Rosen, MA1
Antonelli, D1
Ben-Ami, M1
Weiss, Z1
Alfano, SN1
Leicht, MJ1
Skiendzielewski, JJ1
Wynn, RL1
McFarland, SA1
Meyer, EA1
Coffman, WB1
Mumford, R1
Squillace, KM1
Pert, A1
Sass, W1
Mofenson, HC1
Caraccio, TR1
Miller, H1
Greensher, J1
Liu, PL1
Feldman, HS4
Giasi, R1
Patterson, MK1
Covino, BG6
Kusek, JC1
Stripling, JS6
Ireland, D1
Rothstein, P1
Dornbusch, J1
Shaywitz, BA1
Nadkarni, AV1
Tondare, AS1
Seo, N1
Oshima, E1
Stevens, J1
Mori, K2
Sutter, M1
Pfenninger, J1
Bonin, JD4
Ronfeld, RA1
DeRosa, RA1
Oshibuchi, T1
Imamura, A1
Heavner, JE11
Amory, DW1
Hendricks, C2
Pedersen, H2
Finster, M3
Sakuma, K1
Bruce, SL1
Gutsche, BB1
Stark, RI1
Badui, E1
Garcia-Rubi, D1
Estañol, B1
Lloyd, BL1
Greenblatt, DJ1
Sakai, RI1
Lattin, JE1
Ingvar, M1
Shapiro, HM2
Brown, DL1
Ransom, DM1
Hall, JA1
Leicht, CH1
Schroeder, DR1
Offord, KP1
Siegmund, JB1
Wilson, JH1
Imhoff, TE1
Yokoyama, M4
Hirakawa, M3
Goto, H4
Kragh, J1
Seidelin, J1
Bolwig, TG1
Nakao, S1
Kurata, J1
Arai, T1
Murakawa, M1
Adachi, T1
Avramov, MN1
Yasuhara, O1
Tooyama, I1
Kimura, H1
Witkin, JM1
Newman, AH1
Nowak, G1
Katz, JL1
McFarlane, C2
Warner, DS4
Dexter, F2
Todd, MM4
Hartung, J1
Ying, H1
Weinberger, J1
Cottrell, JE1
Bruguerolle, B2
Emperaire, N2
Carney, DE1
Fortuna, A1
Fortuna, AO1
Berry, FR1
Endo, K1
Uchiyama, Y1
Takada, K2
Tsujimoto, A2
Sutherland, R1
Ueda, W1
Arakawa, K2
Kotaki, H1
Tayama, N1
Ito, K1
Mitomi, N1
Tezuka, K1
Kaga, K1
Sawada, Y1
Iga, T1
Kim, YJ1
Baker, MT1
Choi, WW3
Shimosato, K2
Watanabe, S2
Marley, RJ1
Saito, T1
Sata, Y1
Aihara, M1
Hatakeyama, K1
Hinohara, Y1
Kamiya, Y1
Shimoda, C1
Kanemura, H1
Nakazawa, S1
Barat, SA2
Abdel-Rahman, MS2
Hirsch, E1
Danober, L1
Simler, S1
Pereira de Vasconcelos, A1
Maton, B1
Nehlig, A1
Marescaux, C1
Vergnes, M1
Pantuck, AJ1
Goldsmith, JW1
Kuriyan, JB1
Weiss, RE1
Satas, S1
Johannessen, SI1
Hoem, NO1
Haaland, K1
Sørensen, DR1
Thoresen, M1
Endoh, H1
Kumagai, Y1
Baba, H1
Yamakura, T1
Taga, K1
Sato, K1
Fukuda, S1
Shimoji, K1
Fu, W1
Stool, LA1
White, PF1
Husain, MM1
Katsura, M1
Ohkuma, S1
Geraniotis, EG1
Lee, VC1
Moscicki, JC1
DiFazio, CA1
Avery, JK1
Krahl, SE1
Clark, KB1
Smith, DC1
Browning, RA1
Capron, F1
Perry, D1
Capolaghi, B1
Altenburg, SP1
Farah, MB1
Suzuki, S1
Yamashiro, K1
Tamai, H1
Sakurai, M1
Kanazawa, I1
Rosenberg, P1
Kim, DC1
Ueyama, T1
Maru, E2
Shimada, M2
Suzuki, H2
Ikeda, M1
Walker, BR1
Easton, A1
Gale, K1
Chae, HJ1
Kang, JS1
Cho, SB1
Jin, BG1
Won, SJ1
Gwag, BJ1
Kim, HR1
Sawaki, K2
Ohno, K1
Miyamoto, K1
Hirai, S1
Yazaki, K1
Kawaguchi, M2
Clapp, CR1
Poss, WB1
Cilento, BG1
Fujita, H1
Ogiuchi, H1
Rincon, E1
Baker, RL1
Iglesias, AJ1
Duarte, AM1
Kurt, M1
Bilge, SS1
Kukula, O1
Kesim, Y1
Celik, S1
Zamudio-Hernández, S1
Chambert, G1
Sawyer, RJ1
von Schroeder, H1
Hofman, WF1
Jerram, DC1
Gangarosa, LP1
Mühlendahl, KE1
Krienke, EG1
Slome, J1
Thompson, RG1
Aldrete, JA2
Matousek, M1
Konthikamee, W1
Sprecher, RL1
Moore, PA1
Munson, ES7
Paul, WL1
Embro, WJ1
Caron, M1
LeLorier, J1
Hanna, MK1
Blackburn, JG1
Ogilvie, RW1
Campbell, SL1
Lemmen, LJ1
Klassen, M1
Duiser, B1
Rosenbaum, KJ1
Sapthavichaikul, S1
Skovsted, P1
Kopanda, RT2
Verrill, PJ1
Ausinsch, B2
Malagodi, MH2
Contratti, V1
Amato, MG1
Bortone, AM1
Malagoli, MA1
Serafimovski, N1
Thorball, N1
Asmussen, I1
Lunding, M1
Raskin, NH1
Fishman, RA1
Tucker, WK1
Jalling, B1
Jain, PD1
Pandey, K1
Chandra, HK1
Lee, A1
Teramo, K1
Benowitz, N1
Heymann, MA1
Rudolph, AM1
Benson, KT1
Garrettson, LK1
McGee, EB1
McLeod, D1
Svenningsen, NW1
Westgren, U1
Rosén, I1
Lagerström, PO1
Bucklin, BA1
Chestnut, DH1
Yerzingatsian, KL1
Tanaka, S1
Ouchi, K1
Sato, T1
Monahan, DJ1
Derlet, RW1
Albertson, TE1
Tharratt, RS1
Arthur, GR4
Shokeir, O1
Code, WE1
Hertz, L1
Jonville, AP1
Barbier, P1
Blond, MH1
Boscq, M1
Autret, E1
Breteau, M1
Rey, E1
Radvanyi-Bouvet, MF1
Bodiou, C1
Richard, MO1
Torricelli, A1
Walti, H1
Olive, G1
de Fiebre, CM1
Ruth, JA1
Collins, AC1
Gramlich, CA1
Cunningham, MG1
Torbiner, ML1
Yagiela, JA1
Mito, RS1
Viel, E1
d'Athis, F1
Müller, M1
Schramek, J1
Uthman, BM1
Wilder, BJ1
Nancarrow, C2
Rutten, AJ2
Runciman, WB2
Carapetis, RJ1
McLean, CF1
Hipkins, SF1
Ilsley, AH1
Upton, RN1
Wallin, A1
Nergårdh, A1
Hynning, PA1
Pelter, MA1
Vollmer, TA1
Blum, RL1
Wamil, A1
Kleinrok, Z1
Lanier, WL1
Sharbrough, FW1
Michenfelder, JD1
Pottage, A1
Scott, DB1
Stone, WE1
Javid, MJ1
Forrence, E1
Covinsky, JO1
Mullen, C1
Schuster, MR1
Paris, PM1
Kaplan, RM1
Stewart, RD1
Vale, NB1
Leite, JR1
Hirotsu, I1
Kihara, T1
Nakamura, S1
Hattori, Y1
Hatta, M1
Kitakaze, Y1
Takahama, K1
Hashimoto, Y1
Miyata, T1
Ishihara, T1
Selden, BS1
Burke, TJ1
Hess, GP1
Walson, PD1
Dux, E1
Kloiber, O1
Hossmann, KA1
Siklós, L1
Sundaram, MB1
Bokesch, PM1
Castaneda, AR1
Ziemer, G1
Wilson, JM1
Yatscoff, RW1
Honcharik, N1
Tenenbein, M1
Edgren, B1
Tilelli, J1
Gehrz, R1
Tommasino, C1
Kim, KC1
Tasch, MD1
Schurr, A1
Spears, B1
Reid, KH1
West, CA1
Edmonds, HL1
Rigor, BM1
Parish, RC1
Moore, RT1
Gotz, VP1
Russell, RD2
Hiraoka, H1
Tsuji, A1
Chadwick, HS1
Regal, RE1
Flensted-Jensen, E1
Sandoe, E1
Tuttle, WW1
Elliott, HW1
Dereymaeker, A2
Sorel, L2
Dawkins, CJ1
De Oliveira, LF4
Bretas, AD1
Swan, HJ1
Robles, R1
Corbin, RW1
Huffman, RD1
Yim, GK1
Löfström, B2
Murmann, W1
Almirante, L1
Saccani-Guelfi, M1
Müller, H1
Sakabe, T2
Karlsson, E1
Collste, P1
Rawlins, MD1
Demetrescu, M2
Julien, RM2
Westphal, P1
Fink, BR1
Martucci, RW1
Gueyé, SN1
Dosseh, B1
Wale, N1
Jenkins, LC1
Gillis, RA1
Levine, FH1
Thibodeaux, H1
Raines, A1
Standaert, FG1
Blumer, J1
Strong, JM1
Atkinson, AJ1
Freund, G1
Gogolák, G1
Stumpf, C1
Tschakaloff, C1
Irstam, L1
Ishikawa, T1
Jorfeldt, L1
Pernow, B1
Persson, B1
Wahren, J1
Widman, B1
Hazra, J1
Paymaster, NJ1
Hill, TR1
Porciello, PI1
Zanini, S1
Poppi, A1
Smith, ER1
Duce, BR1
Gamstorp, I1
Bennett, CR1
Monheim, LM1
Ruskin, P1
Fleming, SA1
Olurin, O1
Ferngren, H1
Hellström, B1
Feinstein, MB1
Lenard, W1
Mathias, J1
Staniweski, JA1
Peng, AT1
Bufalo, J1
Blancato, LS1
Phansalkar, AG1
Kulkarni, SD1
Balwani, JH1
Rosenberg, FJ1
Cooke, WJ1
Wessinger, GD1
Southgate, PJ1
Borney, G1
Devoti, G1
Havers, L1
Price, J1
Hvidt, V1
Kühl, V1
Dobbs, EC2
Ross, NM1
Crampton, RS1
Ishida, R1
Adachi, S1
Kowa, Y1
Inniss, C1
Pearson, RE1
Salter, FJ1
Epstein, HM1
Sherline, DM1
Evans, JA1
Chastain, GM1
Phillips, JM1
Essman, WB1
de Magalhães Seabra, J1
Morera Marco, V1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Early Versus Late Deflation of Distal Tourniquet in Intravenous Regional Anesthesia With and Without Ketorolac in Hand & Forearm Surgery[NCT05234619]80 participants (Anticipated)Interventional2022-01-01Active, not recruiting
A Randomized Controlled Trial to Investigate the Efficacy of a Bier's Block Compared to a Mini-bier's Block in Patients Undergoing Hand Surgery[NCT03761329]280 participants (Actual)Interventional2018-11-12Completed
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]Phase 4144 participants (Anticipated)Interventional2019-04-05Recruiting
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538]100 participants (Anticipated)Interventional2023-04-30Not yet recruiting
Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785]Phase 2/Phase 380 participants (Anticipated)Interventional2021-11-15Recruiting
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964]550 participants (Actual)Interventional2009-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.27
Placebo-0.89

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.57
Placebo0.16

Change in Cognitive Function From Baseline

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery

Interventionunits on a scale (Mean)
Lidocaine0.09
Placebo0.07

Change in Cognitive Function From Baseline Characterized as Continuous Cognitive Change

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

Interventionunits on a scale (Mean)
Lidocaine0.07
Placebo0.07

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine6.3
Placebo6.96

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-10.98
Placebo-11.67

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.07

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.04

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.02
Placebo-0.02

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.04
Placebo-0.01

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.71
Placebo-1.16

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine1.23
Placebo-0.49

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.20
Placebo0.03

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.95
Placebo1.59

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-6.70
Placebo-6.39

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-7.12
Placebo-6.31

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.39
Placebo-1.48

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-0.67
Placebo-0.8

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.46
Placebo-1.02

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-3
Placebo-3.21

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.15
Placebo-0.31

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine2.46
Placebo2.1

Count of Participants With a Decline of Greater Than or Equal to One Standard Deviation in One or More of Five Cognitive Domain Scores Reported as a Dichotomous Post-operative Cognitive Deficit (POCD) Outcome

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

InterventionParticipants (Count of Participants)
Lidocaine87
Placebo83

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year

,
Interventionunits on a scale (Mean)
1 year Change Work Activities1 year Change General health perception
Lidocaine-1.37-0.28
Placebo-1.42-0.43

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks

,
Interventionunits on a scale (Mean)
6-Week Change Work activities6-Week Change General health perception
Lidocaine2.71-0.004
Placebo3-0.03

Transcerebral Activation Gradient of Platelet-neutrophil Conjugates

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.150.02-0.73-0.10
Placebo-0.43-0.73-0.400.19

Transcerebral Activation Gradients of Monocytes

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-4.22-2.46-0.341.21
Placebo-0.041.832.640.54

Transcerebral Activation Gradients of Neutrophils

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-2.020.560.581.04
Placebo-0.080.171.19-0.68

Transcerebral Activation Gradients of Platelets

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.030.030.330.37
Placebo0.350.430.050.27

Reviews

19 reviews available for lidocaine and Seizures

ArticleYear
[Paediatric status epilepticus].
    Revista de neurologia, 2022, 10-16, Volume: 75, Issue:8

    Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide;

2022
The use of phenobarbital and other anti-seizure drugs in newborns.
    Seminars in fetal & neonatal medicine, 2017, Volume: 22, Issue:5

    Topics: Anticonvulsants; Fructose; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Midazolam; Phen

2017
Treatment of neonatal seizures.
    Seminars in fetal & neonatal medicine, 2013, Volume: 18, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo

2013
Lidocaine for Status Epilepticus in Pediatrics.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2015, Volume: 42, Issue:6

    Topics: Anticonvulsants; Humans; Lidocaine; Pediatrics; Phenytoin; Prospective Studies; Seizures; Status Epi

2015
Lidocaine for status epilepticus in adults.
    Seizure, 2015, Volume: 31

    Topics: Adult; Anticonvulsants; Humans; Lidocaine; Seizures; Status Epilepticus

2015
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:8

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela

2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:8

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela

2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:8

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela

2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:8

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela

2009
Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision.
    Fetal and pediatric pathology, 2011, Volume: 30, Issue:6

    Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Injections, Subcutaneous; L

2011
Neonatal seizures and their treatment.
    Current opinion in neurology, 2003, Volume: 16, Issue:2

    Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas

2003
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.
    Journal of emergency nursing, 2004, Volume: 30, Issue:2

    Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio

2004
[Inhalation induction with sevoflurane in paediatrics: what is new?].
    Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:4

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Drug Synergism;

2006
Aminophylline.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:8

    Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransfo

1981
Seizures and seizure-like states in the child: an approach to emergency management.
    Emergency medicine clinics of North America, 1983, Volume: 1, Issue:1

    Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans

1983
Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy.
    Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:2

    Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Female; Humans; Laryngoscopy; Lidocaine; M

1996
Lidocaine and seizures.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:3

    Topics: Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Humans; Lidocaine; Seizures

2000
Cocaine, kindling, and psychosis.
    The American journal of psychiatry, 1976, Volume: 133, Issue:6

    Topics: Amphetamine; Cocaine; Drug Tolerance; Electric Stimulation; Epilepsy, Temporal Lobe; Humans; Lidocai

1976
Neurologic disorders in renal failure (first of two parts).
    The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3

    Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc

1976
An analysis of the complications of extradural and caudal block.
    Anaesthesia, 1969, Volume: 24, Issue:4

    Topics: Adult; Aged; Anesthesia, Spinal; Back Pain; Blood Pressure; Catheterization; Dura Mater; Epinephrine

1969
Aspects of the pharmacology of local anaesthetic agents.
    British journal of anaesthesia, 1970, Volume: 42, Issue:3

    Topics: Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood Pressure; Central Nervous System; Epine

1970
Acute and chronic toxicity of local anaesthetics.
    Canadian Anaesthetists' Society journal, 1973, Volume: 20, Issue:1

    Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Brain; Cats; Diazepam; Drug Hypersensitivity;

1973

Trials

8 trials available for lidocaine and Seizures

ArticleYear
Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis.
    Brain & development, 2011, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Anesthetics, Local; Anticonvulsants; Carbamazepine; Child; Electroencephalography

2011
The effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Blood Pressure; Cross-Over Studies; Depressive D

2002
A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis.
    Brain & development, 2004, Volume: 26, Issue:8

    Topics: Administration, Cutaneous; Anti-Arrhythmia Agents; Anticonvulsants; Child, Preschool; Dose-Response

2004
Development of an optimal lidocaine infusion strategy for neonatal seizures.
    European journal of pediatrics, 2006, Volume: 165, Issue:9

    Topics: Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Fol

2006
Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures.
    Journal of child neurology, 2007, Volume: 22, Issue:3

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Dose-Response Relationship, D

2007
Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity.
    Journal of clinical anesthesia, 1997, Volume: 9, Issue:8

    Topics: Aged; Aged, 80 and over; Anesthesia; Anesthetics, Local; Blood Pressure; Cross-Over Studies; Double-

1997
[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood].
    No to hattatsu = Brain and development, 1999, Volume: 31, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intrav

1999
Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.
    Journal of the neurological sciences, 1999, Jan-15, Volume: 162, Issue:2

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; M

1999

Other Studies

325 other studies available for lidocaine and Seizures

ArticleYear
Tonic-clonic seizure in a dog following suspected intra-arterial administration of lidocaine.
    Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:2

    Topics: Animals; Dog Diseases; Dogs; Lidocaine; Seizures

2022
Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine.
    The American journal of emergency medicine, 2022, Volume: 55

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Drug Overdose; Fema

2022
Anesthetic considerations in Dravet syndrome.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:10

    Topics: Anesthetics; Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Epileptic Syndromes

2022
Early-onset neonatal seizures: lidocaine toxicity as a rare differential diagnosis to hypoxic ischaemic encephalopathy.
    BMJ case reports, 2023, Mar-23, Volume: 16, Issue:3

    Topics: Anticonvulsants; Diagnosis, Differential; Electroencephalography; Female; Humans; Hypoxia-Ischemia,

2023
Does Lidocaine Shorten Seizure Duration in Electroconvulsive Therapy?
    Pharmacopsychiatry, 2023, Volume: 56, Issue:5

    Topics: Cohort Studies; Electroconvulsive Therapy; Humans; Lidocaine; Propofol; Retrospective Studies; Seizu

2023
Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen.
    British journal of clinical pharmacology, 2020, Volume: 86, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Seizures

2020
Tonic-clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery: A case report.
    Medicine, 2019, Volume: 98, Issue:48

    Topics: Adult; Anesthetics, Local; Autonomic Nerve Block; Humans; Intraoperative Complications; Lidocaine; M

2019
Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 07-01, Volume: 40, Issue:27

    Topics: Anesthetics, Local; Animals; Central Nervous System; Electroencephalography; Female; Headache; Lidoc

2020
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.
    Brain and behavior, 2021, Volume: 11, Issue:2

    Topics: Animals; Anticonvulsants; Lidocaine; Male; Rats; Rats, Wistar; Seizures; Status Epilepticus

2021
A Teenager With Seizures and Cardiac Arrest After Drug Overdose: Are We Numb to the Danger?
    Pediatric emergency care, 2017, Volume: 33, Issue:9

    Topics: Adolescent; Anesthetics, Local; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Fatal Outc

2017
Accidental intracerebral injection and seizure during scalp nerve blocks for awake craniotomy in a previously craniotomized patient -a case report.
    Korean journal of anesthesiology, 2018, Volume: 71, Issue:6

    Topics: Adult; Anesthetics, Local; Brain; Craniotomy; Humans; Injections; Lidocaine; Male; Medication Errors

2018
Transplacental lidocaine intoxication.
    Journal of neonatal-perinatal medicine, 2018, Volume: 11, Issue:4

    Topics: Adult; Anesthesia, Obstetrical; Apnea; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Li

2018
Seizures and methemoglobinemia in an infant after excessive EMLA application.
    Pediatric emergency care, 2013, Volume: 29, Issue:3

    Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Infant; Lidoca

2013
Efficacy and safety of lidocaine for treatment of neonatal seizures.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:9

    Topics: Cohort Studies; Electroencephalography; Female; Follow-Up Studies; Gestational Age; Humans; Infant,

2013
Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:3

    Topics: Anesthetics, Local; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Tonic-C

2013
Lidocaine should only be used in neonatal seizures that do not respond to first-generation AEDs.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:11

    Topics: Female; Humans; Lidocaine; Male; Seizures

2013
Adverse effects following lidocaine treatment are limited with current dosing regimens.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:11

    Topics: Female; Humans; Lidocaine; Male; Seizures

2013
LAST (local anesthetic systemic toxicity) but not least: systemic lidocaine toxicity during cardiac intervention.
    The Journal of invasive cardiology, 2014, Volume: 26, Issue:1

    Topics: Anesthetics, Local; Cardiomyopathies; Cardiopulmonary Resuscitation; Defibrillators, Implantable; Do

2014
Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats.
    Anesthesia and analgesia, 2014, Volume: 118, Issue:2

    Topics: Anesthesia, Conduction; Anesthetics, Inhalation; Anesthetics, Local; Animals; Cognition; Dose-Respon

2014
Systemic toxicity to local anesthesia in an infant undergoing circumcision.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2014, Volume: 26, Issue:1

    Topics: Anesthetics, Local; Circumcision, Male; Diagnosis, Differential; Humans; Infant; Lidocaine; Male; Se

2014
Convulsions during cataract surgery under peribulbar anesthesia: a case report.
    Journal of medical case reports, 2014, Jun-23, Volume: 8

    Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cataract Extraction; Humans; Injections; L

2014
Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors.
    Neonatology, 2015, Volume: 108, Issue:2

    Topics: Anticonvulsants; Birth Weight; Bradycardia; Databases, Factual; Female; Gestational Age; Heart Rate;

2015
[Delayed convulsion after lidocaine instillation for bronchoscopy].
    Revue des maladies respiratoires, 2016, Volume: 33, Issue:5

    Topics: Aged; Anesthesia, Local; Bronchiolitis Obliterans; Bronchoscopy; Female; Humans; Instillation, Drug;

2016
Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants.
    Epilepsia, 2016, Volume: 57, Issue:2

    Topics: Anticonvulsants; Central Nervous System Infections; Cohort Studies; Electroencephalography; Female;

2016
Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats.
    Neuroreport, 2016, May-04, Volume: 27, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; CA3 Region, Hippocampal; Cell Death; Encephalitis; Kainic Acid; L

2016
Intractable seizures in a toddler after application of an over-the-counter local anesthetic cream.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-04, Volume: 188, Issue:14

    Topics: Administration, Cutaneous; Anesthetics, Local; Bandages; Burns; Drug Overdose; Emergency Service, Ho

2016
Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine.
    Life sciences, 2016, Jun-15, Volume: 155

    Topics: Anesthetics, Local; Animals; Anti-Anxiety Agents; Cardiovascular System; Guinea Pigs; Hypnotics and

2016
Lidocaine Toxicity During Attempted Epistaxis Cautery.
    The Journal of emergency medicine, 2016, Volume: 51, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Bradycardia; Cautery; Epistaxis; Humans; Lidocaine; Male; Sei

2016
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
    Pediatric dermatology, 2016, Volume: 33, Issue:5

    Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Dermatitis, Atopic; Female; Humans; L

2016
Local Anesthetics Systemic Toxicity.
    The Journal of the Association of Physicians of India, 2016, Volume: 64, Issue:3

    Topics: Administration, Intravenous; Adult; Anesthetics, Local; Diazepam; Female; Humans; Lidocaine; Male; M

2016
Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine.
    Medicine, 2016, Volume: 95, Issue:43

    Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Dexmedet

2016
Case report: management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia.
    Journal of clinical anesthesia, 2016, Volume: 35

    Topics: Anaphylaxis; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Arthroplasty, Replace

2016
Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:5

    Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Anticonvulsants; Diuretics; Electrocardiography; Emergenc

2017
Case files of the medical toxicology fellowship at the toxikon consortium in Chicago: cocaine-associated wide-complex dysrhythmias and cardiac arrest - treatment nuances and controversies.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2008, Volume: 4, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Anticonvulsants; Antidotes; Arrhythmias, Cardiac; Charcoal; Coca

2008
Differential diagnosis of seizure associated with topical lidocaine in a patient with vestibulodynia.
    Journal of lower genital tract disease, 2009, Volume: 13, Issue:1

    Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Lidocaine; Mid

2009
Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy.
    Australian veterinary journal, 2009, Volume: 87, Issue:5

    Topics: Anesthetics, Local; Animals; Biopsy; Dermatitis, Atopic; Dog Diseases; Dogs; Drug Interactions; Fata

2009
Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent.
    Laboratory animals, 2010, Volume: 44, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Bacterial Agents; Ceftriaxone; Injections, Intramuscular; Injectio

2010
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
    Neuroscience letters, 2010, Jan-29, Volume: 469, Issue:3

    Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob

2010
Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats.
    Chinese medical journal, 2010, Jan-05, Volume: 123, Issue:1

    Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Cardiovascular System; Central Nervous Sy

2010
Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy.
    Journal of affective disorders, 2010, Volume: 126, Issue:1-2

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Blood Pressure; Drug Therapy, Combination; Electroconv

2010
Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity.
    Anesthesia progress, 2010,Fall, Volume: 57, Issue:3

    Topics: Anesthetics, Local; Animals; Carbon Dioxide; Carticaine; Dose-Response Relationship, Drug; Lidocaine

2010
Local anesthetic toxicity in interscalene block: clinical series.
    Minerva anestesiologica, 2010, Volume: 76, Issue:12

    Topics: Aged; Amides; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Female; Humans; Lidocaine; Mal

2010
Low dose lidocaine for refractory seizures in preterm neonates.
    Indian journal of pediatrics, 2011, Volume: 78, Issue:5

    Topics: Anesthetics, Local; Drug Administration Schedule; Humans; Infant, Newborn; Infant, Premature; Infant

2011
Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures.
    Clinical pharmacokinetics, 2011, Volume: 50, Issue:7

    Topics: Anticonvulsants; Arrhythmias, Cardiac; Clinical Protocols; Drug Monitoring; Female; Gestational Age;

2011
Convulsion and cardiorespiratory collapse with first epidural test dose.
    Journal of anesthesia, 2011, Volume: 25, Issue:4

    Topics: Adult; Analgesia, Epidural; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Seizures

2011
Convulsion caused by a lidocaine test in cervical transforaminal epidural steroid injection.
    PM & R : the journal of injury, function, and rehabilitation, 2011, Volume: 3, Issue:7

    Topics: Anesthetics, Local; Contrast Media; Female; Humans; Injections, Epidural; Injections, Spinal; Iopami

2011
Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jan-15, Volume: 881-882

    Topics: Animals; Cattle; Chromatography, Liquid; Drug Monitoring; Humans; Infant, Newborn; Lidocaine; Linear

2012
Epidural test dose and tachycardia.
    Journal of anesthesia, 2012, Volume: 26, Issue:3

    Topics: Analgesia, Epidural; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Seizures

2012
Convulsions after normal dose of lidocaine: a probable drug interaction.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Adrenergic alpha-Agonists; Aged; Anesthetics, Local; Anti-Arrhythmia Agents; Atrial Fibrillation; Br

2012
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:6

    Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy;

2012
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
    Behavioural brain research, 2012, Aug-01, Volume: 233, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Ada

2012
Lidocaine-induced seizure during carotid endarterectomy.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013, Volume: 124, Issue:7

    Topics: Aged; Anesthetics, Local; Constriction, Pathologic; Electroencephalography; Endarterectomy, Carotid;

2013
Lidocaine-induced seizures in patients with history of epilepsy: effect of antiepileptic drugs.
    Anesthesiology, 2002, Volume: 97, Issue:3

    Topics: Adult; Anesthetics, Local; Anticonvulsants; Diabetes Complications; Electroencephalography; Epilepsi

2002
Effect of transient hippocampal inhibition on amygdaloid kindled seizures and amygdaloid kindling rate.
    Brain research, 2002, Nov-08, Volume: 954, Issue:2

    Topics: Amygdala; Animals; Hippocampus; Kindling, Neurologic; Lidocaine; Male; Rats; Rats, Sprague-Dawley; S

2002
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
    Brain research, 2003, Feb-21, Volume: 964, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Brain; Brain Chemistry; Citalopram; Cocai

2003
Up-regulation of GABA(B) receptor mRNA and protein in the hippocampus of cocaine- and lidocaine-kindled rats.
    Neuroscience, 2003, Volume: 118, Issue:2

    Topics: Animals; Behavior, Animal; Blotting, Western; Cocaine; Dose-Response Relationship, Drug; Hippocampus

2003
Lidocaine administration, seizures, and causality.
    Anesthesiology, 2003, Volume: 98, Issue:5

    Topics: Adult; Anesthetics, Local; Anticonvulsants; Epilepsy; Female; Humans; Lidocaine; Seizures

2003
Lignocaine neurotoxicity following fibre-optic bronchoscopy.
    The New Zealand medical journal, 2003, Jul-11, Volume: 116, Issue:1177

    Topics: Aged; Anesthetics, Local; Bronchoscopy; Fiber Optic Technology; Humans; Lidocaine; Male; Seizures

2003
Lignocaine neurotoxicity.
    The New Zealand medical journal, 2003, Jul-25, Volume: 116, Issue:1178

    Topics: Anesthetics, Local; Bronchoscopy; Lidocaine; Seizures

2003
Convulsions following pudendal block by lignocaine.
    Lancet (London, England), 1955, Dec-31, Volume: 269, Issue:6905

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Conduction; Anesthetics; Anesthetics, L

1955
The difference in action on normal and convulsive cortical activity between a local anaesthetic (lidocaine) and barbiturates.
    Archives internationales de pharmacodynamie et de therapie, 1956, Dec-01, Volume: 108, Issue:3-4

    Topics: Anesthesia, Local; Anesthetics, Local; Barbiturates; Lidocaine; Pentobarbital; Phenobarbital; Seizur

1956
Effect of lidocaine (xylocaine) on seizure and interseizure electroencephalograms in epileptics.
    A.M.A. archives of neurology and psychiatry, 1959, Volume: 81, Issue:5

    Topics: Electroencephalography; Epilepsy; Humans; Lidocaine; Seizures

1959
[Toxic effects of xylocaine].
    Duodecim; laaketieteellinen aikakauskirja, 1960, Volume: 76

    Topics: Humans; Lidocaine; Seizures

1960
Experimental studies of the therapeutic action of electroconvulsive therapy in endogenous depression. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
    Acta psychiatrica Scandinavica. Supplementum, 1960, Volume: 35, Issue:145

    Topics: Convulsive Therapy; Depression; Depressive Disorder; Electric Stimulation; Electroconvulsive Therapy

1960
Seizure characteristics and therapeutic efficiency in electroconvulsive therapy: an analysis of the antidepressive efficiency of grand mal and lidocaine-modified seizures.
    The Journal of nervous and mental disease, 1962, Volume: 135

    Topics: Antidepressive Agents; Electroconvulsive Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Lidocain

1962
[The comparative anticonvulsive properties of trimecaine and xylocaine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1962, Volume: 54

    Topics: Anesthetics; Anesthetics, Local; Lidocaine; Seizures; Trimecaine

1962
THE EFFECT OF XYLOCAINE UPON THE BURSTS OF PAROXYSMAL ACTIVITY IN THE E.E.G. OF EPILEPTICS.
    Acta neurologica Scandinavica, 1964, Volume: 40, Issue:1

    Topics: Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Lidocaine; Phar

1964
FATAL REACTIONS TO LIGNOCAINE.
    Anaesthesia, 1964, Volume: 19

    Topics: Humans; Lidocaine; Positive-Pressure Respiration; Seizures; Succinylcholine; Thiopental; Toxicology

1964
MEDICAL EMERGENCIES IN THE X-RAY DEPARTMENT PREVENTION AND TREATMENT.
    The British journal of radiology, 1964, Volume: 37

    Topics: Anesthesia; Anesthetics; Anesthetics, Local; Angioedema; Barium Sulfate; Contrast Media; Drug Hypers

1964
FATAL CEREBRAL ANOXIA FOLLOWING THE USE OF LIGNOCAINE SPRAY FOR BRONCHOSCOPY. A CASE REPORT.
    British journal of anaesthesia, 1965, Volume: 37

    Topics: Anesthesia; Anesthesiology; Bronchoscopy; Child; Humans; Hypoxia, Brain; Iatrogenic Disease; Lidocai

1965
THE RELATION BETWEEN ACUTE TOXICITY AND CRITICAL RATE OF DISPOSAL OF SEVERAL LOCAL ANESTHETICS.
    Canadian journal of physiology and pharmacology, 1965, Volume: 43

    Topics: Anesthetics; Anesthetics, Local; Blood; Lidocaine; Metabolism; Procaine; Propoxycaine; Rabbits; Rese

1965
THE ACTION OF PRONETHALOL ON SPINAL REFLEXES.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Anesthetics; Anesthetics, Local; Blood Pressure; Electrophysiology; Electroshock; Ethanolamines; Gui

1965
Experimental studies of electroencephalographic changes following electroconvulsive therapy: the role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
    Acta psychiatrica Scandinavica. Supplementum, 1960, Volume: 35, Issue:145

    Topics: Convulsive Therapy; Electric Stimulation; Electricity; Electroconvulsive Therapy; Electroencephalogr

1960
Effect of lidocaine and procaine on the electroshock seizure threshold, with a comparison of the effects of phenytoin and phenobarbital.
    Acta psychiatrica Scandinavica. Supplementum, 1960, Volume: 35, Issue:145

    Topics: Convulsive Therapy; Electroconvulsive Therapy; Electroshock; Humans; Hydantoins; Lidocaine; Phenobar

1960
Effect of lidocaine on the seizure discharge in electroconvulsive therapy.
    Acta psychiatrica Scandinavica. Supplementum, 1960, Volume: 35, Issue:145

    Topics: Convulsive Therapy; Electroconvulsive Therapy; Humans; Lidocaine; Patient Discharge; Seizures

1960
Experimental studies of memory impairment after electroconvulsive therapy. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
    Acta psychiatrica Scandinavica. Supplementum, 1960, Volume: 35, Issue:145

    Topics: Convulsive Therapy; Electric Stimulation; Electroconvulsive Therapy; Humans; Lidocaine; Memory; Memo

1960
The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Anesthetics, Local; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Gas Anal

2003
Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures.
    Journal of neurophysiology, 2004, Volume: 92, Issue:2

    Topics: Action Potentials; Anesthetics, Local; Animals; Calcium Channels; Cats; Cerebral Cortex; Cesium; Che

2004
Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis.
    Brain & development, 2004, Volume: 26, Issue:3

    Topics: Anesthetics, Local; Anticonvulsants; Bromazepam; Child, Preschool; Diazepam; Female; Gastroenteritis

2004
Neonatal seizures following lidocaine administration for elective circumcision.
    Journal of perinatology : official journal of the California Perinatal Association, 2004, Volume: 24, Issue:6

    Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Male;

2004
Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats.
    Neuroscience letters, 2004, Sep-02, Volume: 367, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Disease Susceptibility; Female; Hypothyroidism; Kindling, Ne

2004
[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion].
    No to hattatsu = Brain and development, 2004, Volume: 36, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous

2004
Convulsions with intraurethral instillation of lignocaine.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:1

    Topics: Adult; Anesthetics, Local; Anticonvulsants; Diazepam; Humans; Lidocaine; Male; Rectal Neoplasms; Sei

2005
Effect of fentanyl on lidocaine-induced convulsions in mice.
    Pharmacology, 2005, Volume: 75, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Injections, Intraperitoneal; Li

2005
Ketamine reduces lidocaine-induced seizures in mice.
    The International journal of neuroscience, 2005, Volume: 115, Issue:8

    Topics: Anesthetics, Local; Animals; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamin

2005
Seizures after a Bier block with clonidine and lidocaine: is clonidine really the culprit?
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Clonidine; Drug Interactions; Humans; Lidoca

2005
Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.
    Brain research, 2005, Sep-28, Volume: 1057, Issue:1-2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid

2005
[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children].
    No to hattatsu = Brain and development, 2005, Volume: 37, Issue:5

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female

2005
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.
    Brain research, 2006, Jun-22, Volume: 1096, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Behavior, Animal; Brain Chemistry; Cocain

2006
[Effect of lidocaine and lidocaine with adrenaline on development of cerebral seizures].
    Georgian medical news, 2006, Issue:134

    Topics: Animals; Brain; Drug Combinations; Electrodes, Implanted; Epinephrine; Lidocaine; Male; Rats; Rats,

2006
Lidocaine-induced altered mental status and seizure after hematoma block.
    The Journal of emergency medicine, 2006, Volume: 31, Issue:3

    Topics: Aged, 80 and over; Anesthetics, Local; Female; Fracture Fixation; Hematoma; Humans; Injections, Intr

2006
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Animals; Brain; Central Nervous System; Drug Synergism; Epinephrine; Extracellular Fluid; Infusions,

2006
ED treatment of brainstem anesthesia after retrobulbar block.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:1

    Topics: Aged; Anesthetics, Local; Brain Stem; Humans; Lidocaine; Male; Nerve Block; Seizures

2007
JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats.
    The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:1

    Topics: Anesthetics; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Cell Line; Histamine; Leukocy

2007
The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine.
    Veterinary research communications, 2007, Volume: 31, Issue:7

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Antiparasitic Agents; Convulsants; Dose-Response Relat

2007
Generalized seizures following topical lidocaine administration during circumcision: establishing causation.
    Paediatric drugs, 2007, Volume: 9, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Circumcision, Male; Dose-Response Relationship, Drug; D

2007
Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats.
    Life sciences, 2007, Aug-02, Volume: 81, Issue:8

    Topics: Amygdala; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Calcium; Cell Count; Cell Size; Diazepam

2007
[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2008, Volume: 37, Issue:4

    Topics: Anesthesia, Obstetrical; Anesthetics, Local; Apnea; Female; Humans; Infant, Newborn; Lidocaine; Male

2008
[Case of serious lidocaine intoxication].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:4

    Topics: Anesthetics, Local; Atropine; Brachial Plexus; Cardiac Pacing, Artificial; Diazepam; Heart Arrest; H

2008
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:5

    Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca

2008
Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:5

    Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anticonvulsants; Brain; Dose-Response Rela

2008
Intravenous toxicity--subjective symptoms and acid-base influences on the toxicity of local anaesthetic agents.
    Acta anaesthesiologica Scandinavica. Supplementum, 1966, Volume: 25

    Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Bicarbonates; Carbon Dioxide; Cell Membrane; Dog

1966
Studies on the absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:4

    Topics: Anesthetics, Local; Animals; Brain; Carbon Isotopes; Cats; Female; Kidney; Lidocaine; Liver; Lung; M

1966
Effect of carbon dioxide on the cortical seizure threshold to lidocaine.
    Experimental neurology, 1967, Volume: 17, Issue:2

    Topics: Amygdala; Animals; Apnea; Blood Pressure Determination; Brain; Carbon Dioxide; Cats; Cerebral Cortex

1967
Studies on the post-ictal rise in seizure threshold.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane

1981
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions.
    Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Dr

1983
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
    Israel journal of medical sciences, 1983, Volume: 19, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizure

1983
Cyclic nucleotides in rat brain during lidocaine infusion.
    Acta anaesthesiologica Scandinavica, 1984, Volume: 28, Issue:1

    Topics: Animals; Bicuculline; Cerebellar Cortex; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Electroencephalogr

1984
Antiarrhythmic effects of tocainide and lidocaine in dogs.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catecholamines; Coronary Disease; Dogs; Heart

1983
[Mechanisms of local anesthetic-induced convulsions. The relation to brain catecholamines].
    Hiroshima Daigaku shigaku zasshi. The Journal of Hiroshima University Dental Society, 1984, Volume: 16, Issue:2

    Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Dihydroxypheny

1984
Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines.
    Journal of dental research, 1981, Volume: 60, Issue:2

    Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Dopamine; Droxidopa; Fenclonin

1981
The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine.
    Anesthesiology, 1984, Volume: 61, Issue:2

    Topics: Animals; Bupivacaine; Cardiac Output; Dogs; Electrocardiography; Electroencephalography; Female; Hea

1984
Oral flunitrazepam in the prevention of local anaesthetic-induced convulsions in mice.
    Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:6

    Topics: Administration, Oral; Anesthetics, Local; Animals; Bupivacaine; Flunitrazepam; Lidocaine; Male; Mice

1984
Metabolic and behavioral consequences of lidocaine-kindled seizures.
    Brain research, 1984, Dec-24, Volume: 324, Issue:2

    Topics: Aggression; Amygdala; Animals; Electroshock; Glucose; Humans; Lidocaine; Limbic System; Male; Pentyl

1984
Bupivacaine-induced cardiac arrhythmias in sheep.
    Anesthesiology, 1984, Volume: 60, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Electrocardiography; Fem

1984
Sinus standstill following accidental lidocaine overdose.
    American heart journal, 1984, Volume: 107, Issue:5 Pt 1

    Topics: Aged; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Seizures

1984
Lidocaine toxicity following subcutaneous administration.
    Annals of emergency medicine, 1984, Volume: 13, Issue:6

    Topics: Child, Preschool; Diagnosis, Differential; Emergencies; Female; Humans; Injections, Subcutaneous; Li

1984
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
    Pharmacology and therapeutics in dentistry, 1980, Volume: 5, Issue:1-2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain

1980
The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures.
    Psychopharmacology, 1981, Volume: 72, Issue:2

    Topics: Amygdala; Animals; Apomorphine; Cocaine; Electric Stimulation; Humans; Lidocaine; Male; Motor Activi

1981
Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine.
    Clinical pediatrics, 1983, Volume: 22, Issue:3

    Topics: Anesthesia, Local; Gingiva; Humans; Infant; Lidocaine; Male; Seizures; Tooth Eruption

1983
Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:4

    Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Cats; Central Nervo

1983
Lidocaine metabolism and toxicity: a laboratory experiment for dental students.
    Journal of dental education, 1980, Volume: 44, Issue:4

    Topics: Anesthesia, Dental; Anesthesiology; Animals; Carbon Tetrachloride; Lidocaine; Liver; Male; Phenobarb

1980
Role of nasal air flow in convulsions induced by lidocaine in the rat.
    Experimental neurology, 1982, Volume: 76, Issue:1

    Topics: Animals; Electrodes, Implanted; Lidocaine; Male; Olfactory Bulb; Pentylenetetrazole; Pulmonary Venti

1982
Prolonged seizures associated with the use of viscous lidocaine.
    The Journal of pediatrics, 1982, Volume: 101, Issue:3

    Topics: Absorption; Administration, Oral; Child, Preschool; Female; Humans; Infant; Lidocaine; Male; Seizure

1982
Localized clonic convulsions after spinal anesthesia with lidocaine and epinephrine.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:11

    Topics: Anesthesia, Spinal; Epinephrine; Female; Humans; Hydatidiform Mole; Hysterectomy; Lidocaine; Middle

1982
The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats.
    Anesthesiology, 1982, Volume: 57, Issue:6

    Topics: Animals; Behavior, Animal; Brain; Cats; Dose-Response Relationship, Drug; Electroencephalography; Fe

1982
[Adult respiratory distress syndrome (ARDS) after poisoning by local anesthetics].
    Schweizerische medizinische Wochenschrift, 1982, Nov-20, Volume: 112, Issue:47

    Topics: Arrhythmias, Cardiac; Child, Preschool; Dibucaine; Female; Humans; Intracranial Pressure; Lidocaine;

1982
Deaths from local anesthetic-induced convulsions in mice.
    Anesthesia and analgesia, 1980, Volume: 59, Issue:6

    Topics: Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Female; Injections, Intr

1980
Benzodiazepines protect mice from local anesthetic convulsions and deaths.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:6

    Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female;

1981
Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:1

    Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Cats; Dose-Response Relationship, Drug; El

1982
Cerebral energy state and glycolytic metabolism during lidocaine infusion in the rat.
    Anesthesiology, 1981, Volume: 54, Issue:4

    Topics: Animals; Blood Pressure; Brain; Electroencephalography; Energy Metabolism; Glycolysis; Infusions, Pa

1981
Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia.
    Anesthesiology, 1981, Volume: 54, Issue:5

    Topics: Anesthesia; Animals; Brain Diseases; Cats; Enflurane; Female; Lidocaine; Male; Pentylenetetrazole; S

1981
Effect of cocaine and lidocaine on the expression of kindled seizures in the rat.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:3

    Topics: Animals; Behavior, Animal; Cerebral Cortex; Cocaine; Electric Stimulation; Lidocaine; Male; Olfactor

1981
Toxicity of lidocaine in adult, newborn, and fetal sheep.
    Anesthesiology, 1981, Volume: 55, Issue:1

    Topics: Animals; Animals, Newborn; Cardiovascular System; Central Nervous System; Female; Fetus; Hypotension

1981
Inadvertent massive lidocaine overdose causing temporary complete heart block in myocardial infarction.
    American heart journal, 1981, Volume: 102, Issue:4

    Topics: Adult; Electrocardiography; Electrophysiology; Heart Block; Hemodynamics; Humans; Lidocaine; Male; M

1981
Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:5

    Topics: Animals; Behavior, Animal; Cocaine; Electric Stimulation; Kindling, Neurologic; Lidocaine; Male; Olf

1981
Neuropsychiatric sequelae of pharmacotherapy of cardiac arrhythmias and hypertension.
    Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:6

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Brain; Drug Interactions; Gua

1981
Lidocaine ingestion.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:3

    Topics: Diazepam; Female; Humans; Infant; Lidocaine; Respiratory Insufficiency; Seizures

1980
Toxicity of local anesthetic mixtures.
    Toxicology and applied pharmacology, 1980, Volume: 54, Issue:3

    Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice

1980
Selective metabolic activation of the hippocampus during lidocaine-induced pre-seizure activity.
    Anesthesiology, 1981, Volume: 54, Issue:1

    Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Female;

1981
Mixtures of local anesthetics are no more toxic than the parent drugs.
    Anesthesiology, 1981, Volume: 54, Issue:3

    Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice

1981
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:2

    Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br

1995
Amiodarone interaction with lidocaine.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:4

    Topics: Aged; Amiodarone; Drug Interactions; Humans; Infusions, Intravenous; Lidocaine; Male; Seizures

1993
Effect of vasoconstrictive agents added to lidocaine on intravenous lidocaine-induced convulsions in rats.
    Anesthesiology, 1995, Volume: 82, Issue:2

    Topics: Acute Disease; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Dose-Response Relationshi

1995
Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock).
    Psychopharmacology, 1993, Volume: 111, Issue:4

    Topics: Animals; Convulsants; Electroshock; Lidocaine; Male; Rats; Rats, Wistar; Regression Analysis; Seizur

1993
Lignocaine-induced convulsion does not induce c-fos protein (c-Fos) in rat hippocampus.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:8

    Topics: Animals; Electroencephalography; Hippocampus; Immunohistochemistry; Lidocaine; Male; Proto-Oncogene

1994
Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cocaine; Dopamine

1993
Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:4

    Topics: Animals; Electroencephalography; Excitatory Amino Acid Antagonists; Halothane; Lidocaine; Male; Pipe

1994
Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats.
    Journal of neurosurgical anesthesiology, 1994, Volume: 6, Issue:4

    Topics: Animals; Anticonvulsants; Blood Pressure; Dose-Response Relationship, Drug; Electroencephalography;

1994
Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:7

    Topics: Animals; Circadian Rhythm; Drug Interactions; Flumazenil; Lidocaine; Male; Mice; Seizures

1993
Alterations in t-butylbicyclophosphorothionate binding in the brains of lidocaine-kindled rats.
    Metabolic brain disease, 1993, Volume: 8, Issue:4

    Topics: Animals; Autoradiography; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compou

1993
Convulsion during lignocaine infiltration.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:4

    Topics: Anesthesia, Epidural; Female; Humans; Lidocaine; Seizures

1993
Clonidine does not affect lidocaine seizure threshold in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:12

    Topics: Animals; Blood Pressure; Carbon Dioxide; Clonidine; Dose-Response Relationship, Drug; Heart Rate; He

1993
Fit with finger block.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Fingers; Hand; Humans; Lidocaine; Nerve Block; Seizures

1993
Involvement of brain serotonergic function in lidocaine-induced convulsions in mice.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electric Stimulation; Lidocaine; Male; Mice; N

1993
Fit with finger block.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Anxiety; Fingers; Humans; Lidocaine; Nerve Block; Seizures; Syncope

1993
Modification of intravenous lidocaine-induced convulsions by epinephrine in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:3

    Topics: Animals; Blood Glucose; Blood Pressure; Brain Chemistry; Dose-Response Relationship, Drug; Drug Inte

1993
The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:6

    Topics: Animals; Anticonvulsants; Blood Pressure; Body Temperature; Brain; Carbon Dioxide; Convulsants; Elec

1996
One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine.
    Annals of the New York Academy of Sciences, 1996, Oct-31, Volume: 801

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cocaine; Drug Tolerance; Lidocaine; Male; Mice

1996
[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures].
    No to hattatsu = Brain and development, 1997, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Lidocain

1997
Cocaine and lidocaine in combination are synergistic convulsants.
    Brain research, 1996, Dec-02, Volume: 742, Issue:1-2

    Topics: Animals; Cocaine; Drug Synergism; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Seizures

1996
The amygdala is critical for seizure propagation from brainstem to forebrain.
    Neuroscience, 1997, Volume: 77, Issue:4

    Topics: Acoustic Stimulation; Amygdala; Anesthetics, Local; Animals; Brain Stem; Carbon Radioisotopes; Deoxy

1997
Seizures after ureteral stone manipulation with lidocaine.
    The Journal of urology, 1997, Volume: 157, Issue:6

    Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Seizures; Ureteral Calculi

1997
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat.
    Brain research, 1997, May-09, Volume: 756, Issue:1-2

    Topics: Anesthetics, Local; Animals; Cocaine; Dextromethorphan; Excitatory Amino Acid Antagonists; Incidence

1997
Lidocaine pharmacokinetics and toxicity in newborn pigs.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Anticonvulsants; Awareness; Brain; Dose-

1997
Prior brain injury protects death from local anaesthetic-induced convulsion.
    Brain research, 1997, Aug-29, Volume: 767, Issue:1

    Topics: Anesthetics, Local; Animals; Brain Injuries; Lidocaine; Male; Mice; Reaction Time; Seizures; Surviva

1997
Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine.
    Brain research, 1997, Nov-14, Volume: 775, Issue:1-2

    Topics: Animals; Brain Chemistry; Cocaine; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Dr

1997
Re: Seizures after ureteral stone manipulation with lidocaine.
    The Journal of urology, 1998, Volume: 159, Issue:3

    Topics: Anesthetics, Local; Humans; Lidocaine; Seizures; Ureteral Calculi; Urinary Catheterization

1998
Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:3

    Topics: Anesthetics, Local; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Heart Rate; Hydrogen-

1998
Routine procedure--bad outcome.
    Tennessee medicine : journal of the Tennessee Medical Association, 1998, Volume: 91, Issue:7

    Topics: Aged; Anesthetics, Local; Bradycardia; Brain Diseases; Bronchoscopy; Drug Overdose; Heart Arrest; Hu

1998
Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation.
    Epilepsia, 1998, Volume: 39, Issue:7

    Topics: Animals; Electric Stimulation Therapy; Electroshock; Female; Hydroxydopamines; Lidocaine; Locus Coer

1998
[Convulsive crisis and methemoglobinemia after the application of anesthetic cream].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1998, Volume: 5, Issue:7

    Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Eczema; Female; Humans; Lidocaine; Lido

1998
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
    Pharmacology & toxicology, 1999, Volume: 84, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe

1999
Propofol for lidocaine-induced seizures.
    Anesthesia and analgesia, 1999, Volume: 88, Issue:5

    Topics: Anesthetics, Local; Anticonvulsants; Humans; Lidocaine; Propofol; Seizures

1999
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
    Brain research, 1999, Jun-12, Volume: 831, Issue:1-2

    Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pent

1999
[Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:7

    Topics: Action Potentials; Anesthetics, Local; Animals; Dentate Gyrus; gamma-Aminobutyric Acid; Lidocaine; M

1999
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
    Epilepsia, 1999, Volume: 40, Issue:8

    Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists

1999
Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain.
    Research communications in molecular pathology and pharmacology, 1999, Volume: 104, Issue:1

    Topics: Animals; Brain; Gene Expression Regulation; In Situ Hybridization; Injections, Intraperitoneal; Lido

1999
Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Brain; Drug Synergism; Lidocaine; Mal

2000
Lidocaine toxicity secondary to postoperative bladder instillation in a pediatric patient.
    Urology, 1999, Volume: 53, Issue:6

    Topics: Administration, Intravesical; Anesthetics; Child, Preschool; Female; Humans; Lidocaine; Postoperativ

1999
A decrease in seizure susceptibility to lidocaine in kindled epileptic rats.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:5

    Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electroencephalography; Kindling, Neurologic; L

2000
CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum.
    Pediatric emergency care, 2000, Volume: 16, Issue:4

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Central Nervous System; Female;

2000
The role of nitrergic system in lidocaine-induced convulsion in the mouse.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:1

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Arginine; Diazepam; Enzyme Inhibitors; Lidocaine; Male

2001
Thyroid hormones modify susceptibility to lidocaine-kindling in rats.
    Life sciences, 2001, Oct-19, Volume: 69, Issue:22

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Kindling, Neurologic; Lidocaine; Models, Animal;

2001
Temporary bilateral blindness after acute lidocaine toxicity.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:1

    Topics: Acute Disease; Adult; Anesthetics, Local; Blindness; Female; Fractures, Bone; GABA Modulators; Hand

2002
Cardiorespiratory and behavioral reactions to the lidocaine-induced convulsions in the dog.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 16, Issue:4

    Topics: Animals; Blood Pressure; Body Temperature; Body Weight; Carbon Dioxide; Dogs; Female; Heart Rate; He

1977
[Fenfluramin (ponderax) intoxications in children (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1978, Volume: 126, Issue:10

    Topics: Adolescent; Adrenergic beta-Antagonists; Anticonvulsants; Child, Preschool; Chlorpromazine; Coma; El

1978
Death after paracervical block.
    Lancet (London, England), 1977, Jan-29, Volume: 1, Issue:8005

    Topics: Abortion, Induced; Cervix Uteri; Female; Humans; Lidocaine; Nerve Block; Pregnancy; Respiratory Insu

1977
Interaction between local anesthetics and analeptic drugs.
    Southern medical journal, 1975, Volume: 68, Issue:2

    Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai

1975
Central nervous system effects of local anaesthetic agents.
    British journal of anaesthesia, 1975, Volume: 47 suppl

    Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides;

1975
Effects of acute and chronic administration of methylphenidate on lidocaine convulsions in mice.
    Archives of oral biology, 1978, Volume: 23, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Lidocaine; Male; Methylphenidate; Mice

1978
Central-nervous-system toxicity of local anesthetic mixtures in monkeys.
    Anesthesiology, 1977, Volume: 46, Issue:3

    Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Brain; Drug Co

1977
Potentiation of lidocaine toxicity by pentobarbital in the dog.
    Toxicology and applied pharmacology, 1979, Volume: 51, Issue:3

    Topics: Animals; Blood Pressure; Dogs; Drug Synergism; Electrocardiography; Female; Lidocaine; Male; Pentoba

1979
The effects of lidocaine on hyperoxic seizure activity in the rat.
    Experimental neurology, 1978, Volume: 58, Issue:3

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperbaric Oxygenation; L

1978
Intravenous lidocaine in the treatment of convulsions.
    JAMA, 1978, May-12, Volume: 239, Issue:19

    Topics: Adolescent; Adult; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Seizures

1978
Sympathetic nervous system response to lidocaine induced seizures in cats.
    Acta anaesthesiologica Scandinavica, 1978, Volume: 22, Issue:5

    Topics: Animals; Blood Pressure; Cats; Electroencephalography; Ganglia, Autonomic; Injections, Intravenous;

1978
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
    The Practitioner, 1975, Volume: 214, Issue:1281

    Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Dise

1975
Diazepam in the prophylaxis of lignocaine seizures.
    British journal of anaesthesia, 1976, Volume: 48, Issue:4

    Topics: Acid-Base Equilibrium; Animals; Behavior, Animal; Carbon Dioxide; Diazepam; Haplorhini; Lidocaine; M

1976
[Personal experience with retrograde intravenous loco-regional anesthesia].
    Minerva anestesiologica, 1977, Volume: 43, Issue:3

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Body Image; Extremities; Humans; Lidocaine; Percept

1977
Local anesthetic convulsions in cats with limbic brain seizure foci.
    Proceedings of the Western Pharmacology Society, 1977, Volume: 20

    Topics: Amygdala; Animals; Cats; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; El

1977
Tricyclic antidepressive poisoning with special reference to cardiac complications.
    Acta anaesthesiologica Scandinavica. Supplementum, 1975, Volume: 57

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; Child, Presc

1975
Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.
    Anesthesiology, 1975, Volume: 42, Issue:4

    Topics: Acetanilides; Acid-Base Equilibrium; Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Anima

1975
Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:3

    Topics: Administration, Oral; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; I

1975
Diazepam prophylaxis for lignocaine induced convulsions.
    Anaesthesia and intensive care, 1975, Volume: 3, Issue:4

    Topics: Animals; Diazepam; Gait; Injections, Intraperitoneal; Lidocaine; Phenobarbital; Rats; Seizures; Wake

1975
Progressive behavioral changes during chronic lidocaine administration: relationship to kindling.
    Life sciences, 1975, Sep-15, Volume: 17, Issue:6

    Topics: Animals; Coprophagia; Feeding Behavior; Humans; Lidocaine; Limbic System; Male; Rats; Seizures; Time

1975
Gestational differences in lidocaine toxicity in the fetal lamb.
    Anesthesiology, 1976, Volume: 44, Issue:2

    Topics: Animals; Blood Pressure; Cerebellar Cortex; Female; Femoral Artery; Fetal Diseases; Fetus; Gestation

1976
Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Animals; Anticonvulsants; Bicarbonates; Blood Pressure; Carbon Dioxide; Convulsants; Diazepam; Dose-

1992
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
    Life sciences, 1992, Volume: 51, Issue:25

    Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic

1992
Rapid onset of seizures following aspiration of viscous lidocaine.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:3

    Topics: Drainage, Postural; Extracorporeal Membrane Oxygenation; Female; Humans; Inappropriate ADH Syndrome;

1992
Fit with finger block.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:3

    Topics: Adult; Fingers; Humans; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Seizures

1992
Lidocaine for treatment of severe seizures in newborn infants. II. Blood concentrations of lidocaine and metabolites during intravenous infusion.
    Acta paediatrica (Oslo, Norway : 1992), 1992, Volume: 81, Issue:1

    Topics: Electroencephalography; Humans; Infant, Newborn; Infusions, Intravenous; Lidocaine; Seizures

1992
Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:1

    Topics: Animals; Brain; Female; Hemodynamics; Infusions, Intravenous; Lidocaine; Male; Pregnancy; Rats; Rats

1992
The dosage of dilute lignocaine for the infiltration technique of local analgesia.
    Annals of the Royal College of Surgeons of England, 1991, Volume: 73, Issue:4

    Topics: Adult; Anesthesia, Local; Drug Administration Schedule; Epinephrine; Humans; Injections, Intra-Arter

1991
Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:1

    Topics: Animals; Brain Chemistry; Catecholamines; Lidocaine; Male; Mice; Mice, Inbred Strains; Neurons; Pent

1991
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:3

    Topics: Aminooxyacetic Acid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyr

1991
Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat.
    American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:2

    Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography;

1991
Lidocaine potentiation of cocaine toxicity.
    Annals of emergency medicine, 1991, Volume: 20, Issue:2

    Topics: Animals; Cocaine; Drug Synergism; Lidocaine; Male; Rats; Rats, Inbred Strains; Seizures

1991
Pregnancy does not alter lidocaine toxicity.
    American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:5

    Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn

1990
Does inhibition of K+ transport in glial cells by local anaesthetics contribute to seizures?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:4 Pt 2

    Topics: Anesthetics, Local; Animals; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Globus P

1990
Accidental lidocaine overdosage in an infant.
    Journal of toxicology. Clinical toxicology, 1990, Volume: 28, Issue:1

    Topics: Drug Overdose; Hemodynamics; Humans; Infant, Newborn; Injections, Intravenous; Lidocaine; Male; Medi

1990
Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:4

    Topics: Diazepam; Humans; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Lidocaine; Seizures

1990
Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:6

    Topics: Amides; Animals; Arrhythmias, Cardiac; Bupivacaine; Carbon Dioxide; Dogs; Dose-Response Relationship

1989
Differential sensitivity of long-sleep and short-sleep mice to high doses of cocaine.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4

    Topics: Animals; Body Temperature; Cocaine; Dopamine; Dose-Response Relationship, Drug; Female; Heart Rate;

1989
Effect of cocaine and lidocaine on the development of kindled seizures.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:2

    Topics: Animals; Cocaine; Electric Stimulation; Kindling, Neurologic; Lidocaine; Male; Rats; Seizures

1989
Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:6

    Topics: Animals; Drug Interactions; Epinephrine; Injections, Intraperitoneal; Injections, Intravenous; Lidoc

1989
[Total spinal anesthesia complicating peridural anesthesia].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8, Issue:2

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Coma; Humans; Lidocaine; Male; Middle Aged; Seizures; Spee

1989
Combined application of propranolol and local anesthetics: enhanced anticonvulsant action.
    Biomedica biochimica acta, 1989, Volume: 48, Issue:4

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Lidocaine;

1989
Emergency management of seizures: an overview.
    Epilepsia, 1989, Volume: 30 Suppl 2

    Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epileptic

1989
Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:3

    Topics: Amides; Anesthetics, Local; Animals; Brain; Bupivacaine; Cause of Death; Hemodynamics; Infusions, In

1989
Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:3

    Topics: Acid-Base Equilibrium; Amides; Anesthetics, Local; Animals; Bupivacaine; Hemodynamics; Injections, I

1989
Lidocaine treatment of neonatal convulsions, a therapeutic dilemma.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:6

    Topics: Female; Half-Life; Humans; Infant, Newborn; Infusions, Parenteral; Lidocaine; Male; Seizures; Status

1989
Seizure-like reaction associated with subcutaneous lidocaine injection.
    Clinical pharmacy, 1989, Volume: 8, Issue:11

    Topics: Aged; Female; Humans; Injections, Subcutaneous; Lidocaine; Seizures

1989
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1988, Volume: 43

    Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol

1988
Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats.
    British journal of anaesthesia, 1988, Volume: 60, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Atracurium; Cats; Electroencephalography; Halothane; Lidocaine; Pan

1988
Safety of "topical" lignocaine.
    Lancet (London, England), 1988, Apr-30, Volume: 1, Issue:8592

    Topics: Administration, Rectal; Humans; Infant; Lidocaine; Seizures

1988
Anticonvulsive and convulsive effects of lidocaine: comparison with those of phenytoin, and implications for mechanism of action concepts.
    Neurological research, 1988, Volume: 10, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Lidocaine; Male; Mice; Mice

1988
A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity?
    Drug intelligence & clinical pharmacy, 1986, Volume: 20, Issue:1

    Topics: Aged; Drug Synergism; Drug Therapy, Combination; Humans; Lidocaine; Male; Seizures; Substance Withdr

1986
Effect on the seizure threshold in dogs of tocainide/lidocaine administration.
    Annals of emergency medicine, 1987, Volume: 16, Issue:7

    Topics: Animals; Dogs; Drug Interactions; Female; Lidocaine; Seizures; Tocainide

1987
Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation.
    Psychopharmacology, 1988, Volume: 94, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Mice; Pentylenetetrazole; Seizures; Sleep

1988
Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions.
    Acta anaesthesiologica Scandinavica, 1988, Volume: 32, Issue:7

    Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Etidocaine; Lidocaine; Male; Mepivacaine; Seizures

1988
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Ne

1988
Complete maternal and fetal recovery after prolonged cardiac arrest.
    Annals of emergency medicine, 1988, Volume: 17, Issue:4

    Topics: Adult; Female; Heart Arrest; Humans; Infant, Newborn; Lidocaine; Medication Errors; Pregnancy; Pregn

1988
Seizures secondary to oral viscous lidocaine.
    Annals of emergency medicine, 1988, Volume: 17, Issue:7

    Topics: Administration, Oral; Female; Humans; Infant; Lidocaine; Male; Seizures; Stomatitis, Herpetic; Tooth

1988
Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study.
    Acta biologica Hungarica, 1987, Volume: 38, Issue:2

    Topics: Animals; Calcium; Electron Probe Microanalysis; Female; Hippocampus; Histocytochemistry; Lidocaine;

1987
Seizures after intraurethral instillation of lidocaine.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Aug-01, Volume: 137, Issue:3

    Topics: Administration, Topical; Aged; Aged, 80 and over; Cystoscopy; Humans; Lidocaine; Male; Petrolatum; S

1987
The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics.
    Anesthesiology, 1987, Volume: 67, Issue:5

    Topics: Animals; Heart Septal Defects; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Seizures;

1987
Systemic absorption of intraurethral lidocaine.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Dec-01, Volume: 137, Issue:11

    Topics: Absorption; Aged; Humans; Lidocaine; Male; Seizures

1987
Intravenous lidocaine overdosage in a child.
    Journal of toxicology. Clinical toxicology, 1986, Volume: 24, Issue:1

    Topics: Child; Dopamine; Glucagon; Half-Life; Humans; Hypotension; Isoproterenol; Kinetics; Lidocaine; Liver

1986
Local cerebral blood flow during lidocaine-induced seizures in rats.
    Anesthesiology, 1986, Volume: 64, Issue:6

    Topics: Animals; Basal Metabolism; Cerebrovascular Circulation; Electroencephalography; Female; Lidocaine; R

1986
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:8

    Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Inte

1986
Lidocaine depresses synaptic activity in the rat hippocampal slice.
    Anesthesiology, 1986, Volume: 64, Issue:4

    Topics: Animals; Depression, Chemical; Hippocampus; In Vitro Techniques; Lidocaine; Male; Rats; Rats, Inbred

1986
Seizures following oral lidocaine for esophageal anesthesia.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:3

    Topics: Aged; Anesthesia, Local; Esophagus; Humans; Lidocaine; Male; Middle Aged; Seizures

1985
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:3

    Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol;

1985
Bupivacaine toxicity in pregnant and nonpregnant ewes.
    Anesthesiology, 1985, Volume: 63, Issue:2

    Topics: Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Female; Fetus; H

1985
Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats.
    Anesthesiology, 1985, Volume: 63, Issue:4

    Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Bupivacaine; Cats; Electrocardiography; Electroence

1985
Comment: Lidocaine seizures.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:9

    Topics: Humans; Lidocaine; Risk; Seizures

1985
Effect of cocaine and pentylenetetrazol on cortical kindling.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:4

    Topics: Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Infusions, Parenteral; Kindling, Neurologic

1985
Lidocaine (Xylocaine) as an anti-arrhythmic agent.
    The Medical letter on drugs and therapeutics, 1971, Jan-08, Volume: 13, Issue:1

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Hea

1971
Drug-induced convulsions. Report from Boston Collaborative Drug Surveillance Program.
    Lancet (London, England), 1972, Sep-30, Volume: 2, Issue:7779

    Topics: Chlorpromazine; Ephedrine; Female; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Is

1972
Lidocaine as an antiarrhythmic Experience in 68 patients.
    Acta medica Scandinavica, 1969, Volume: 185, Issue:4

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Card

1969
Diazepam prevents and aborts lidocaine convulsions in monkeys.
    Anesthesiology, 1974, Volume: 41, Issue:3

    Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Injections,

1974
Electrographic and behavioral study of convulsants in the cat.
    Anesthesiology, 1969, Volume: 30, Issue:1

    Topics: 4-Aminobenzoic Acid; Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Brain; Cats; Electroen

1969
Lack of depression of the cortical neurons activity by topical anesthetics in the rabbit.
    European neurology, 1969, Volume: 2, Issue:6

    Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Animals; Cerebral Cortex; Cortical Spreading Depression; Di

1969
Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice.
    European journal of pharmacology, 1974, Volume: 29, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fen

1974
Cooperative study on cardiac catheterization. Complications involving the nervous system.
    Circulation, 1968, Volume: 37, Issue:5 Suppl

    Topics: Adolescent; Adult; Angiocardiography; Cardiac Catheterization; Central Nervous System Diseases; Chil

1968
Central actions of lidocaine--synaptic transmission.
    Anesthesiology, 1969, Volume: 30, Issue:1

    Topics: Action Potentials; Anesthesia, Endotracheal; Animals; Blood Pressure; Cats; Halothane; Injections, I

1969
Local anesthetic seizures.
    Anesthesiology, 1969, Volume: 30, Issue:1

    Topics: Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Brain; Cats; Lidocaine; Reflex, Monosynapti

1969
Effects of diphenylaminoethanol and lidocaine on central inhibition.
    International journal of neuropharmacology, 1969, Volume: 8, Issue:3

    Topics: Action Potentials; Amino Alcohols; Animals; Cats; Central Nervous System; Cerebellum; Decerebrate St

1969
Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:10

    Topics: Amino Alcohols; Animals; Atropine; Bradycardia; Central Nervous System; Drug Synergism; Ethers; Hear

1966
Experimental epilepsy and blood-brain barrier.
    Epilepsia, 1967, Volume: 8, Issue:3

    Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Cerebral Cortex

1967
[A severe complication of stellatum blockade].
    HNO, 1969, Volume: 17, Issue:10

    Topics: Autonomic Nerve Block; Ganglionic Blockers; Humans; Lidocaine; Male; Middle Aged; Procaine; Seizures

1969
Diazepam blocks cerebral metabolic and circulatory responses to local anesthetic-induced seizures.
    Anesthesiology, 1974, Volume: 41, Issue:4

    Topics: Anesthesia, Local; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Elec

1974
Plasma levels of lidocaine during combined treatment with phenytoin and procainamide.
    European journal of clinical pharmacology, 1974, Oct-04, Volume: 7, Issue:6

    Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Pressu

1974
Local anesthesia and experimental epilepsy.
    Epilepsia, 1974, Volume: 15, Issue:2

    Topics: Animals; Benzocaine; Cats; Disease Models, Animal; Female; Lidocaine; Male; Procaine; Seizures; Time

1974
5-Hydroxytryptophan intensifies local anesthetic-induced convulsions.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 207, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Drug Synergism

1974
Dental care of epileptics.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Anesthesia, Dental; Dental Caries; Dentistry; Dentures; Epilepsy; Gingival Hyperplasia; Humans; Hyda

1972
Diazepam treatment of local anesthetic-induced seizures.
    Anesthesiology, 1972, Volume: 37, Issue:5

    Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Bupivacaine; Diazepam; Dose-Response Relationship,

1972
Bupivacaine and lignocaine induced seizures in rhesus monkeys.
    British journal of anaesthesia, 1972, Volume: 44, Issue:10

    Topics: Animals; Behavior, Animal; Blood; Bupivacaine; Carbon Dioxide; Consciousness; Electroencephalography

1972
Elevation of lidocaine seizure threshold by gallamine in rhesus monkeys.
    Archives of neurology, 1973, Volume: 28, Issue:5

    Topics: Animals; Blood Gas Analysis; Brain; Dose-Response Relationship, Drug; Electroencephalography; Gallam

1973
[Complications of local anesthesia using lignocaine].
    Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1972, Volume: 17, Issue:2

    Topics: Adult; Anesthesia, Local; Central Nervous System Diseases; Child; Coma; Developing Countries; Female

1972
Site of action of diazepam in the prevention of lidocaine induced seizure activity in cats.
    Canadian Anaesthetists' Society journal, 1973, Volume: 20, Issue:2

    Topics: Amygdala; Animals; Brain; Cats; Caudate Nucleus; Diazepam; Hippocampus; Lidocaine; Limbic System; Me

1973
Comparison of methyllidocaine and lidocaine on arrhythmias produced by coronary occlusion in the dog.
    Circulation, 1973, Volume: 47, Issue:4

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brain; Coronary Disease;

1973
The convulsant potency of lidocaine and its N-dealkylated metabolites.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 186, Issue:1

    Topics: Acetanilides; Amines; Animals; Behavior, Animal; Dealkylation; Dose-Response Relationship, Drug; Dru

1973
The prevention of ethanol withdrawal seizures in mice by lidocaine.
    Neurology, 1973, Volume: 23, Issue:1

    Topics: Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hum

1973
[Anticonvulsive effect of clonazepam and Ro 8-4192 on penicillin and lidocaine induced convulsions].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:4

    Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Benzazepines; Cerebral Cortex; Electroencepha

1973
Diazepam and lidocaine-induced cardiovascular changes.
    Anesthesiology, 1973, Volume: 39, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Diazepam; Drug Interactions; Electrocardiograph

1973
Side effects of water-soluble contrast media in lumbar myelography.
    Acta radiologica: diagnosis, 1973, Volume: 14, Issue:6

    Topics: Anesthesia, Spinal; Diazepam; Female; Headache; Humans; Hyperesthesia; Hypotension; Iothalamic Acid;

1973
Convulsions induced by local anaesthetic: time course of diazepam prophylaxis.
    Canadian Anaesthetists' Society journal, 1974, Volume: 21, Issue:2

    Topics: Anesthesia, Intravenous; Anesthesia, Local; Animals; Cats; Diazepam; Dose-Response Relationship, Dru

1974
The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram.
    Anesthesiology, 1974, Volume: 40, Issue:5

    Topics: Analysis of Variance; Animals; Blood Glucose; Blood Specimen Collection; Brain; Carbon Dioxide; Cere

1974
A "neutral" local anesthetic for reasearch in experimental epilepsy.
    T.-I.-T. journal of life sciences, 1974, Volume: 4, Issue:1

    Topics: Anesthetics, Local; Animals; Benzocaine; Cats; Cerebral Cortex; Electric Stimulation; Evoked Potenti

1974
The effect of local anaesthetics on the central circulation and respiration in man and dog.
    Acta anaesthesiologica Scandinavica, 1968, Volume: 12, Issue:4

    Topics: Anesthetics, Local; Animals; Blood Circulation; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs

1968
Diazepam prevents local anesthetic seizures.
    Anesthesiology, 1971, Volume: 34, Issue:6

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Circulation; Brain; Cats; Diazepam; Electroence

1971
The effects of intravenous lidocaine on optic evoked potentials in light and darkness.
    Anesthesiology, 1971, Volume: 35, Issue:4

    Topics: Anesthesia; Animals; Barbiturates; Blood Pressure; Cats; Darkness; Electric Stimulation; Electrocard

1971
Electrical seizure activity produced by Xylocaine and Citanest.
    Acta anaesthesiologica Scandinavica. Supplementum, 1965, Volume: 16

    Topics: Anesthetics, Local; Animals; Dogs; Electric Stimulation; Electroencephalography; Hippocampus; Lidoca

1965
Acid-base changes during lidocaine induced seizures in Macaca mulatta.
    Archives of neurology, 1969, Volume: 20, Issue:4

    Topics: Acid-Base Equilibrium; Amygdala; Animals; Behavior, Animal; Body Weight; Caudate Nucleus; Electroenc

1969
Local anesthetic seizure prevention: diazepam versus pentobarbital.
    Anesthesiology, 1972, Volume: 36, Issue:5

    Topics: Anesthesia, Local; Animals; Arousal; Cats; Central Nervous System; Diazepam; Electroencephalography;

1972
Nitrous oxide elevates local anesthetic seizure threshold.
    Experimental neurology, 1972, Volume: 35, Issue:3

    Topics: Anesthetics, Local; Animals; Cats; Electrodes, Implanted; Electroencephalography; Injections, Intrav

1972
[Comparison of 2 modern antiarrhythmic drugs: lidocaine and diphenylhydantoin].
    Giornale italiano di cardiologia, 1972, Volume: 2, Issue:4

    Topics: Arrhythmias, Cardiac; Brain; Chronic Disease; Hemodynamics; Humans; Hypotension; Lidocaine; Necrosis

1972
Effects of nitrous oxide on the lidocaine seizure threshold and diazepam protection.
    Anesthesiology, 1972, Volume: 37, Issue:3

    Topics: Anesthesia, Local; Animals; Cats; Diazepam; Drug Interactions; Electroencephalography; Lidocaine; Ni

1972
The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:3

    Topics: Acetanilides; Administration, Oral; Animals; Arrhythmias, Cardiac; Blood Pressure; Chloroform; Dogs;

1971
[Anticonvulsants. 5. Treatment of convulsions in the neonatal period].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Phe

1971
Effectiveness of various doses of premedicating drugs used for dental procedures in altering toxicity of procaine and lidocaine.
    Pharmacology and therapeutics in dentistry, 1971, Volume: 1, Issue:4

    Topics: Dental Care; Drug Synergism; Lidocaine; Meperidine; Preanesthetic Medication; Procaine; Promethazine

1971
Safety and usefulness of intravenous regional anaesthesia.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Anemia, Sickle Cell; Anesthesia, Conduction; Anesthesia, Intravenous; Child; Child, Preschool; Diabe

1969
Teething troubles.
    British medical journal, 1970, Apr-11, Volume: 2, Issue:5701

    Topics: Diarrhea, Infantile; Female; Fever; Humans; Infant; Lidocaine; Male; Seizures; Tooth Eruption

1970
Cortical blindness following convulsions and fever in Nigerian children.
    Pediatrics, 1970, Volume: 46, Issue:1

    Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor

1970
[Drugs and children. 1. Treatment of seizures in children].
    Lakartidningen, 1970, Apr-13, Volume: 67

    Topics: Adolescent; Barbiturates; Child; Child, Preschool; Chloral Hydrate; Diazepam; Electroencephalography

1970
The antagonism of local anesthetic induced convulsions by the benzodiazepine derivative diazepam.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 187, Issue:1

    Topics: Animals; Cats; Diazepam; Drug Antagonism; Electroencephalography; Electromyography; Female; Lidocain

1970
The effects of inhalation anaesthetic agents on convulsant (LD-50) doses of local anaesthetics in the rat.
    Canadian Anaesthetists' Society journal, 1970, Volume: 17, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Local; Animals; Cardiovascular System; Drug Antagonism; Drug Sy

1970
Rare complication during stellate ganglion block: a case report.
    Canadian Anaesthetists' Society journal, 1970, Volume: 17, Issue:6

    Topics: Adult; Anesthesia, Intravenous; Anesthesia, Local; Central Nervous System; Female; Humans; Injection

1970
Influence of some antiarrhythmic agents on electrically induced convulsive seizures in rats.
    Indian journal of physiology and pharmacology, 1970, Jul-03, Volume: 14, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Chloroquine; Electroshock; Female; Lidocaine; Male

1970
The effect of central nervous system depressants on the tolerance to local anesthetic solutions.
    International surgery, 1971, Volume: 55, Issue:2

    Topics: Anesthetics, Local; Animals; Barbiturates; Chlorpromazine; Drug Synergism; Lidocaine; Male; Meperidi

1971
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 191, Issue:2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocai

1971
[Use of lidocaine in an unusual case of ventricular fibrillation].
    Minerva medica, 1971, Jul-21, Volume: 62, Issue:57

    Topics: Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Female; Humans; Lidocaine; Middle Aged;

1971
[203. The dangers of local anesthesia].
    Langenbecks Archiv fur Chirurgie, 1967, Volume: 319

    Topics: Adult; Anesthetics, Local; Epinephrine; Female; Heart Arrest; Humans; Infant; Lidocaine; Male; Mepiv

1967
[Stellate block. A case with a rare complication].
    Ugeskrift for laeger, 1967, Dec-28, Volume: 129, Issue:52

    Topics: Autonomic Nerve Block; Barbiturates; Diazepam; Humans; Lidocaine; Male; Middle Aged; Seizures; Stell

1967
Convulsive properties of the anilide-derived local anesthetic drugs.
    Journal of oral therapeutics and pharmacology, 1968, Volume: 4, Issue:6

    Topics: Animals; Epinephrine; Lidocaine; Mepivacaine; Prilocaine; Rats; Seizures

1968
EEG evaluation of lidocaine convulsions.
    JAMA, 1968, Sep-09, Volume: 205, Issue:11

    Topics: Electroencephalography; Humans; Lidocaine; Seizures; Tachycardia

1968
[Studies on the central action, and use as an epidural anesthetic, of a new local anesthetic, 2'-methyl-2-methyl-2-n-propylaminopropionanilide (LA-012)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1968, Nov-20, Volume: 64, Issue:6

    Topics: Anesthesia, Spinal; Anesthetics, Local; Anilides; Animals; Arousal; Central Nervous System; Electric

1968
Lidocaine vs parabens as convulsants.
    JAMA, 1968, Dec-16, Volume: 206, Issue:12

    Topics: Humans; Lidocaine; Parabens; Respiratory Insufficiency; Seizures

1968
Single-injection caudal anesthesia in obstetrics.
    Obstetrics and gynecology, 1969, Volume: 33, Issue:4

    Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Female; Fetus; Humans; Infant, Newborn; Lidocaine;

1969
The use of local anesthetic agents in obstetrics.
    Southern medical journal, 1969, Volume: 62, Issue:5

    Topics: Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Delivery, Obstetric; Female;

1969
Xylocaine induced protection against electrically induced convulsions in mice.
    Archives internationales de pharmacodynamie et de therapie, 1965, Volume: 157, Issue:1

    Topics: Animals; Electroconvulsive Therapy; Lidocaine; Mice; Seizures

1965
Convulsive properties of four local anesthetic preparations.
    Journal of oral therapeutics and pharmacology, 1966, Volume: 3, Issue:3

    Topics: Aminobenzoates; Anesthetics, Local; Animals; Benzoates; Epinephrine; Female; Lidocaine; Male; Pentyl

1966
[Apropos of a case of convulsions after local anesthesia].
    Revista espanola de anestesiologia, 1966, Volume: 13, Issue:1

    Topics: Anesthesia, Local; Humans; Lidocaine; Seizures

1966
[Incidents and accidents related to the intravenous use of xylocaine for the purpose of general anesthesia, and the method of their prevention and treatment].
    Revista espanola de anestesiologia, 1966, Volume: 13, Issue:3

    Topics: Anesthesia, General; Anesthesia, Intravenous; Humans; Hypotension; Lidocaine; Respiratory Insufficie

1966