lidocaine has been researched along with Seizures in 352 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Excerpt | Relevance | Reference |
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"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments." | 9.12 | Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006) |
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)." | 9.11 | A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004) |
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years." | 9.09 | [Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999) |
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control." | 8.91 | Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015) |
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control." | 8.91 | Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015) |
"Lidocaine has a concentration-dependent effect on seizures." | 8.80 | Lidocaine and seizures. ( DeToledo, JC, 2000) |
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs." | 8.02 | Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021) |
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants." | 7.96 | Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020) |
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 7.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events." | 7.81 | Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015) |
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010." | 7.79 | Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013) |
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures." | 7.78 | Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012) |
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 7.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
"We report a case of neonatal seizures after lidocaine administration for circumcision." | 7.74 | Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007) |
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures." | 7.73 | Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006) |
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge." | 7.72 | Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004) |
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002." | 7.72 | [Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004) |
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 7.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures." | 7.69 | Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994) |
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures." | 7.69 | [Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997) |
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine." | 7.68 | Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992) |
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen." | 7.68 | Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991) |
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 7.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine." | 7.67 | Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988) |
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method." | 7.67 | Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987) |
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures." | 7.67 | Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986) |
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures." | 7.66 | The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981) |
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia." | 7.66 | Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981) |
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure." | 7.66 | Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978) |
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome." | 6.73 | Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007) |
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 5.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint." | 5.43 | Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016) |
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 5.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy." | 5.37 | Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011) |
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14." | 5.36 | Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010) |
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ." | 5.33 | Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005) |
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements." | 5.32 | Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004) |
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity." | 5.30 | Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998) |
"infusion of 1." | 5.29 | Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994) |
"A lidocaine level was obtained at 4 h post-ingestion and was 0." | 5.28 | Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992) |
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 5.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy." | 5.26 | Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976) |
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 5.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
"One to seven seizures were recognized before starting CBZ or Lidocaine therapy, followed by complete cessation in 57 episodes and one or two recurrent seizures in five." | 5.15 | Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis. ( Komatsu, M; Kubota, T; Nakajima, M; Okumura, A; Shimakawa, S; Tanabe, T, 2011) |
"No cardiac arrhythmias were observed, and lidocaine was effective in 76% of the treatments." | 5.12 | Development of an optimal lidocaine infusion strategy for neonatal seizures. ( de Vries, LS; Malingré, MM; Rademaker, CM; Toet, MC; van Kesteren, C; Van Rooij, LG; Ververs, TF, 2006) |
"The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG)." | 5.11 | A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis. ( Hayakawa, F; Kato, T; Okumura, A; Tanabe, T; Watanabe, K, 2004) |
"Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years." | 5.09 | [Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]. ( Shimakawa, S; Suzuki, S; Tamai, H; Tanabe, T; Yamashiro, K, 1999) |
" The duration of motor and EEG seizures (means +/- SD) were 37 +/- 13 sec and 64 +/- 21 sec, 25 +/- 11 sec and 52 +/- 43 sec, 17 +/- 12 sec and 32 +/- 17 sec, 1 +/- 3 sec and 18 +/- 10 sec in the saline, lidocaine 50 mg, 100 mg, 200 mg groups, respectively." | 5.08 | Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity. ( Fu, W; Husain, MM; Stool, LA; White, PF, 1997) |
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in pediatrics for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control." | 4.91 | Lidocaine for Status Epilepticus in Pediatrics. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015) |
"Our goal was to perform a systematic review of the literature on the use of intravenous lidocaine in adults for status epilepticus (SE) and refractory status epilepticus (RSE) to determine its impact on seizure control." | 4.91 | Lidocaine for status epilepticus in adults. ( Gillman, LM; Kazina, CJ; Teitelbaum, J; West, M; Zeiler, FA; Zeiler, KJ, 2015) |
"Seizures have been reported with lidocaine at its lowest effective dose (1." | 4.85 | Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. ( Guay, J, 2009) |
"Lidocaine has a concentration-dependent effect on seizures." | 4.80 | Lidocaine and seizures. ( DeToledo, JC, 2000) |
"We describe a two-year-old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic-clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy." | 4.12 | Anesthetic considerations in Dravet syndrome. ( Corlette, S; Davidson, A; Howell, KB; Macdonald-Laurs, E, 2022) |
"In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs." | 4.02 | Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures. ( Batista, PS; Cabral, DAC; de Souza, AS; Favacho Lopes, DC; Ferreira, LO; Fidelis, EJ; Gerrits Mattos, B; Hamoy, M; Jóia de Mello, V; Manoel, CAF; Santos, GFS, 2021) |
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants." | 3.96 | Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020) |
"We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures." | 3.88 | Transplacental lidocaine intoxication. ( Cools, F; Demeulemeester, V; Lefevere, J; Van Hautem, H, 2018) |
"To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 3.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
"High doses of lidocaine produce seizures and vasoconstriction." | 3.83 | Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine. ( Déciga-Campos, M; Librowski, T; López-Muñoz, FJ; Navarrete-Vázquez, G; Ortiz-Andrade, R; Sánchez-Recillas, A; Yañez-Pérez, V, 2016) |
"Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events." | 3.81 | Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors. ( de Vries, LS; Schalkwijk, S; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2015) |
" In experiment 2, both emulsified isoflurane and midazolam significantly suppressed lidocaine-induced tonic-clonic seizures." | 3.80 | Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats. ( Chen, X; Huang, H; Liu, J; Wang, X; Zhang, W; Zhou, C, 2014) |
" We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity." | 3.79 | Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013) |
"In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010." | 3.79 | Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013) |
"We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ)." | 3.79 | Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine. ( Kobayashi, K; Kodani, N; Maniwa, S; Nakano, K; Ohtsuka, Y, 2013) |
"A fast liquid chromatography-tandem mass spectrometry with electrospray ionization method was developed and validated for simultaneous quantification of lidocaine and its active metabolite MEGX in 10 μL of plasma of neonates with seizures." | 3.78 | Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures. ( ter Weijden, E; van den Broek, MP; Ververs, FF, 2012) |
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 3.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
"This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)." | 3.76 | Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010) |
"The addition of a small dose of lignocaine to propofol during ECT treatment enhanced rather than reduced the quality of the seizures produced." | 3.76 | Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy. ( Lawford, J; Loo, C; MacPherson, RD; Mahon, M; Scott, D; Simpson, B, 2010) |
"We report a case of neonatal seizures after lidocaine administration for circumcision." | 3.74 | Generalized seizures following topical lidocaine administration during circumcision: establishing causation. ( Finkelstein, Y; Koren, G; Railton, C; Rezvani, M; Verjee, Z, 2007) |
" Clinical features were hypotonia, pupillary mydriasis fixed to light, apnea, cyanosis and seizures." | 3.74 | [Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases]. ( de la Gastine, B; Guillemin, MG; Guillois, B; Lelong-Boulouard, V; Pagès, H; Quedru-Aboane, J, 2008) |
" Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death." | 3.74 | The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008) |
"Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice." | 3.73 | Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics. ( Dohi, T; Kitayama, T; Morioka, N; Morita, K; Song, L, 2006) |
"Hematoma blocks with lidocaine are routinely utilized in the Emergency Department to allow reduction of Colles' fractures." | 3.73 | Lidocaine-induced altered mental status and seizure after hematoma block. ( Dorf, E; Holstege, CP; Kelsey, J; Kuntz, AF, 2006) |
"The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice." | 3.72 | Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003) |
"To evaluate the effect of GABA(B) receptor in drug-kindled seizures, the gene expression of GABA(B) receptor in cocaine- and lidocaine-kindled rats was examined in this study." | 3.72 | Up-regulation of GABA(B) receptor mRNA and protein in the hippocampus of cocaine- and lidocaine-kindled rats. ( Abel, MS; Dassow, MS; Li, J; Olinger, AB, 2003) |
"We report a case of a 25-day old, former 34-week gestation male newborn who experienced neonatal seizures following administration of subcutaneous lidocaine for regional anesthesia during an elective circumcision prior to discharge." | 3.72 | Neonatal seizures following lidocaine administration for elective circumcision. ( Hossain, T; Insoft, RM; Moran, LR, 2004) |
"We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002." | 3.72 | [Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion]. ( Eto, Y; Hamano, S; Mochizuki, M; Sugiyama, N; Tanaka, M, 2004) |
"In this study the effect of transient inhibition of the CA1 region of the dorsal hippocampus by lidocaine on amygdala kindling rate and amygdaloid kindled seizures was investigated." | 3.71 | Effect of transient hippocampal inhibition on amygdaloid kindled seizures and amygdaloid kindling rate. ( Alasvand Zarasvand, M; Fathollahi, Y; Mirnajafi-Zadeh, J; Mortazavi, M; Reza Palizvan, M, 2002) |
"Lidocaine, a local anesthetic, produces seizures by unknown central mechanisms." | 3.71 | Thyroid hormones modify susceptibility to lidocaine-kindling in rats. ( Chambert, G; Pacheco-Rosado, J; Zamudio-Hernández, S, 2001) |
"This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 3.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
"The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice." | 3.70 | Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999) |
" To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin." | 3.70 | Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999) |
"Lidocaine is well known to have toxic effects on the central nervous system including the induction of electroencepharographic seizures and convulsions at high doses." | 3.70 | [Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition]. ( Ikeda, M; Maru, E; Shimada, M; Suzuki, H; Ueyama, T, 1999) |
" We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
"5- year-old girl with systemic lidocaine toxicity following treatment for postoperative bladder spasms." | 3.70 | Lidocaine toxicity secondary to postoperative bladder instillation in a pediatric patient. ( Cilento, BG; Clapp, CR; Poss, WB, 1999) |
"Lidocaine induces electroencephalographic seizures and generalized convulsions at large doses." | 3.70 | A decrease in seizure susceptibility to lidocaine in kindled epileptic rats. ( Fujita, H; Maru, E; Ogiuchi, H; Shimada, M; Suzuki, H, 2000) |
"An equal degree of acute hypertension induced by these three different vasopressors may play a role in reducing the threshold (plasma and brain lidocaine concentrations) as well as the cumulative convulsant doses associated with lidocaine-induced convulsions." | 3.69 | Effect of vasoconstrictive agents added to lidocaine on intravenous lidocaine-induced convulsions in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1995) |
"Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures." | 3.69 | Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats. ( Cottrell, JE; Hartung, J; Weinberger, J; Ying, H, 1994) |
"The present study examined the effects of daily treatment with a subconvulsant dose (50 mg/kg) of cocaine or lidocaine on susceptibility to seizures induced by cross-injections of the same dose of the other local anesthetic, and to seizures induced by pentylenetetrazol (PTZ) or N-methyl-DL-aspartate (NMDLA) in ddY mice." | 3.69 | One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1996) |
"Intravenous drip infusions of lidocaine (IDIL; 1-5 mg/kg/h) were performed in ten patients with intractable seizures." | 3.69 | [Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures]. ( Aihara, M; Hatakeyama, K; Hinohara, Y; Kamiya, Y; Kanemura, H; Nakazawa, S; Sata, Y; Shimoda, C, 1997) |
"The present study investigated the effect of dextromethorphan and 6,7-dinitroquinoxaline-2,3-dione (DNQX) pre-treatment on the development of cocaine- and lidocaine-induced seizures." | 3.69 | Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat. ( Abdel-Rahman, MS; Barat, SA, 1997) |
"In newborn infants suffering from perinatal asphyxia seizures, lidocaine (LD) has proved to be an effective anticonvulsant." | 3.69 | Lidocaine pharmacokinetics and toxicity in newborn pigs. ( Haaland, K; Hoem, NO; Johannessen, SI; Satas, S; Sørensen, DR; Thoresen, M, 1997) |
"We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures." | 3.69 | Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997) |
"We report a case of lidocaine toxicity with seizures that appears to represent a drug interaction with amiodarone." | 3.68 | Amiodarone interaction with lidocaine. ( Imhoff, TE; Siegmund, JB; Wilson, JH, 1993) |
"Although altered effects of various anesthetics have been demonstrated during pregnancy, published studies have incompletely defined potential pregnancy-induced changes in the central nervous system toxicity of lidocaine." | 3.68 | Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat. ( Bucklin, BA; Chestnut, DH; Choi, WW; Todd, MM; Warner, DS, 1992) |
"The effects of acute changes in plasma magnesium concentration on the threshold for lidocaine-induced seizures were evaluated in mechanically ventilated rats receiving 70% nitrous oxide and 30% oxygen." | 3.68 | Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat. ( Choi, WW; Monahan, DJ; Todd, MM; Warner, DS, 1991) |
"At doses of 30 or 40 mg/kg, lidocaine does not induce seizures or death." | 3.68 | Lidocaine potentiation of cocaine toxicity. ( Albertson, TE; Derlet, RW; Tharratt, RS, 1991) |
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 3.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
"Thirteen newborn infants (five premature, eight full term) with severe seizures and not responding to phenobarbital and diazepam received a lidocaine (LD) infusion." | 3.68 | Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. ( Bodiou, C; Olive, G; Radvanyi-Bouvet, MF; Rey, E; Richard, MO; Torricelli, A; Walti, H, 1990) |
"The concentrations of cyclic 3', 5'-guanosine monophosphate (cGMP) and cyclic 3', 5'-adenosine monophosphate (cAMP) in the cerebellar and cerebral cortex were measured during lidocaine infusion and during bicuculline-induced seizures in rats." | 3.67 | Cyclic nucleotides in rat brain during lidocaine infusion. ( Maekawa, T; Okuda, Y; Takeshita, H; Yamada, K, 1984) |
"The influence of hyperkalemia on the central nervous system and cardiac toxicity of bupivacaine and lidocaine was studied in open-chested mechanically ventilated dogs." | 3.67 | The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. ( Avery, P; Redon, D; Rusy, B; Schaenzer, G, 1984) |
"A case of a 2-year-old girl who survived grand mal seizures secondary to toxicity from massive subcutaneous administration of lidocaine is presented." | 3.67 | Lidocaine toxicity following subcutaneous administration. ( Alfano, SN; Leicht, MJ; Skiendzielewski, JJ, 1984) |
"The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde." | 3.67 | Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989) |
"We present the cases of two children with lidocaine-induced seizures resulting from the use of oral viscous lidocaine." | 3.67 | Seizures secondary to oral viscous lidocaine. ( Hess, GP; Walson, PD, 1988) |
"The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method." | 3.67 | Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. ( Dux, E; Hossmann, KA; Kloiber, O; Siklós, L, 1987) |
"Neurophysiologic and local cerebral metabolic mapping techniques indicate that seizures associated with lidocaine toxicity originate in subcortical brain structures." | 3.67 | Local cerebral blood flow during lidocaine-induced seizures in rats. ( Maekawa, T; Shapiro, HM; Tommasino, C, 1986) |
"Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
" Eighteen days following completion of amygdala kindling, kindled animals were more sensitive to lidocaine-induced convulsions; 88% of kindled animals, but only 24% of the implanted sham-stimulated controls, had seizures." | 3.66 | The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. ( Pert, A; Post, RM; Sass, W; Squillace, KM, 1981) |
"A case is reported of an infant who experienced seizures while being treated with a topical lidocaine 2% solution (Xylocaine 2% Viscous) for teething." | 3.66 | Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine. ( Caraccio, TR; Greensher, J; Miller, H; Mofenson, HC, 1983) |
"Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia." | 3.66 | Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981) |
" Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure." | 3.66 | Sympathetic nervous system response to lidocaine induced seizures in cats. ( Rosenbaum, KJ; Sapthavichaikul, S; Skovsted, P, 1978) |
" Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally." | 3.65 | Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975) |
"Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome." | 2.73 | Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007) |
"Furthermore, we also assessed seizure duration using both the cuff method and two-lead electroencephalography." | 2.70 | The effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy. ( Inoue, T; Ogawa, R; Ogura, A; Shiga, T; Wajima, Z; Yoshikawa, T, 2002) |
"Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit." | 2.55 | The use of phenobarbital and other anti-seizure drugs in newborns. ( El-Dib, M; Soul, JS, 2017) |
"Current therapeutic options to treat neonatal seizures (i." | 2.49 | Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013) |
"The patients developed a generalized seizure requiring endotracheal intubation but recovered fully with supportive care." | 2.47 | Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision. ( Belhadj, S; Ben Jaballah, N; Bouziri, A; Hamdi, A; Khaldi, A; Menif, K, 2011) |
"Neonatal seizures continue to present a diagnostic and therapeutic challenge to paediatricians worldwide, and are a worrying sign for both parents and clinicians alike." | 2.42 | Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003) |
" In this study, it was shown that the safe and effective net application dose of lidocaine for the surgery may be within the range of 127 to 260 mg." | 2.39 | Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy. ( Iga, T; Ito, K; Kaga, K; Kotaki, H; Mitomi, N; Sawada, Y; Tayama, N; Tezuka, K, 1996) |
"Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
"We provide additional evidence highlighting the importance of caution regarding lidocaine dosing due to the effect on seizure length in the ECT setting." | 1.91 | Does Lidocaine Shorten Seizure Duration in Electroconvulsive Therapy? ( Enguita-Germán, M; Enriquez, ÁSR; Fábrega, AM; Gil, JL; López-Ilundain, J; Martinez de Zabarte Moraza, E; Maughan, AR; Prados, AB; Rosquil, EU; Yoldi-Murillo, J, 2023) |
"Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 1.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
"An epileptic seizure can trigger a headache during (ictal) or after (postictal) the termination of the event." | 1.56 | Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache. ( Burstein, R; Melo-Carrillo, A; Schain, AJ; Strassman, AM, 2020) |
"A sudden loss of consciousness and tonic-clonic seizure was occurred after negative aspiration and test dose." | 1.51 | Tonic-clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery: A case report. ( Dong, J; Lu, F; Tian, J; Zhang, K, 2019) |
"We present a case of seizure activity in a woman in whom EKG led to a diagnosis of intermittent monomorphic and polymorphic ventricular tachycardia (torsades de pointes), highlighting the need for careful consideration of alternative causes of seizures, even in patients with known epilepsy." | 1.46 | Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity. ( Mitchell, SH; Morris, SC; Wentlandt, M, 2017) |
"Lidocaine plasma levels were in the toxic range at the time of the first seizure (18." | 1.43 | [Delayed convulsion after lidocaine instillation for bronchoscopy]. ( Gaïes, E; Jebabli, N; Klouz, A; Lakhal, M; Salouage, I; Trabelsi, S, 2016) |
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint." | 1.43 | Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016) |
"We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 1.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
"Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems." | 1.43 | Local Anesthetics Systemic Toxicity. ( Jayanthi, R; Monica, K; Nasser, K, 2016) |
"Lidocaine has been shown to be an effective anticonvulsant for the treatment of neonatal seizures that persist in spite of first-line anticonvulsant therapy." | 1.37 | Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures. ( de Vries, LS; Egberts, TC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG, 2011) |
"7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14." | 1.36 | Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent. ( Dror, M, 2010) |
" The onset of toxic manifestations (seizure, dysrhythmia, and cardiac arrest) was recorded, and then the doses of local anesthetics were calculated." | 1.36 | Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats. ( Bo, YL; Li, HB; Li, WZ; Wan, QX, 2010) |
" Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < ." | 1.36 | Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity. ( Barcelos, KC; Cabral, AM; Furtado, DP; Haas, DA; Ramacciato, JC, 2010) |
"One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole." | 1.35 | Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy. ( Baxter, C; Dart, C; Rainger, J; Vogelnest, Lj, 2009) |
"Propranolol is a beta-adrenoceptor antagonist used clinically." | 1.35 | Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain. ( Asada, A; Hase, I; Nakamura, T; Oda, Y; Takahashi, R; Tanaka, K, 2008) |
"Diazepam prevents lidocaine-induced seizures, but not neuronal damage in brain structures." | 1.34 | Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats. ( Blas-Valdivia, V; Cano-Europa, E; Hernández-García, A; Ortiz-Butrón, R, 2007) |
"The severity of convulsions was assessed and scored as 1 = mild, 2 = moderate, and 3 = severe." | 1.33 | Effect of fentanyl on lidocaine-induced convulsions in mice. ( Cherng, CH; Wong, CS, 2005) |
"Generalized tonic-clonic convulsions were seen in 8 mice and deep sedation was seen in 7 mice in Group 2 (p < ." | 1.33 | Ketamine reduces lidocaine-induced seizures in mice. ( Akin, A; Boyaci, A; Erdogan, F; Golgeli, A; Guler, G, 2005) |
"Diazepam was administered as the first-line drug on 157 of 177 occasions (88." | 1.33 | [Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005) |
"At the onset of convulsions, plasma concentrations of both total (B = 4." | 1.32 | The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. ( Asada, A; Funao, T; Oda, Y; Tanaka, K, 2003) |
"Some electrographic seizures are generated intracortically." | 1.32 | Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures. ( Grenier, F; Steriade, M; Timofeev, I, 2004) |
"The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode." | 1.32 | Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. ( Negoro, T; Okumura, A; Uemura, N; Watanabe, K, 2004) |
"The seizures were usually present in the form of tonic attacks of fore and hind limbs, followed by intermittent clonic movements." | 1.32 | Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats. ( Hernández-García, A; Ortiz-Butrón, R; Pacheco-Rosado, J, 2004) |
"Audiogenic seizures, a model of brainstem epilepsy, are characterized by a tonic phase (sustained muscular contraction fixing the limbs in a flexed or extended position) associated with a short cortical electroencephalogram flattening." | 1.30 | The amygdala is critical for seizure propagation from brainstem to forebrain. ( Danober, L; Hirsch, E; Marescaux, C; Maton, B; Nehlig, A; Pereira de Vasconcelos, A; Simler, S; Vergnes, M, 1997) |
"The latency to convulsion and survival rate were significantly longer and higher, respectively, in the brain-injured group than in the sham-operated one." | 1.30 | Prior brain injury protects death from local anaesthetic-induced convulsion. ( Baba, H; Endoh, H; Fukuda, S; Kumagai, Y; Sato, K; Shimoji, K; Taga, K; Yamakura, T, 1997) |
"The lidocaine infusion was then started, and systemic lidocaine levels were obtained at the onset of EEG seizure activity." | 1.30 | Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats. ( DiFazio, CA; Lee, VC; Moscicki, JC, 1998) |
"VNS significantly reduced seizure severities of control rats." | 1.30 | Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. ( Browning, RA; Clark, KB; Krahl, SE; Smith, DC, 1998) |
"In contrast to the seizure activity and wide-spread neuronal degeneration following kainate treatment, injections of lidocaine did not produce neuronal death within three days." | 1.30 | Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain. ( Chae, HJ; Cho, SB; Gwag, BJ; Jin, BG; Kang, JS; Kim, HR; Won, SJ, 1999) |
"Acute cocaine overdose can result in convulsions and death although the mechanisms associated with this toxicity are poorly understood." | 1.29 | Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. ( Katz, JL; Newman, AH; Nowak, G; Witkin, JM, 1993) |
"infusion of 1." | 1.29 | Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. ( Dexter, F; McFarlane, C; Todd, MM; Warner, DS, 1994) |
"Pretreatment with clonidine changed neither cumulative convulsant doses (Group 1: 41." | 1.29 | Clonidine does not affect lidocaine seizure threshold in rats. ( Goto, H; Hirakawa, M; Yokoyama, M, 1993) |
"Pretreatment with diazepam alone increased both cumulative convulsant doses and plasma concentrations of lidocaine at the onset of convulsions." | 1.28 | Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. ( Arakawa, K; Benson, KT; Goto, H; Yokoyama, M, 1992) |
"A lidocaine level was obtained at 4 h post-ingestion and was 0." | 1.28 | Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992) |
"The incidence of lidocaine-induced convulsions was decreased by treatments with alpha-MPT and disulfiram, while that of PTZ was increased by either treatment." | 1.28 | Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions. ( Dohi, T; Takada, K; Tanaka, S; Tsujimoto, A; Yoshimura, Y, 1991) |
"However, lidocaine-induced convulsions were enhanced by AOAA." | 1.28 | Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord. ( Kawaguchi, M; Ouchi, K; Sato, T; Sawaki, K, 1991) |
"No ventricular arrhythmias were observed in this group." | 1.28 | Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. ( Arthur, GR; Covino, BG; Feldman, HS, 1989) |
"While epinephrine enhanced lidocaine seizure activity and lethality by approximately 50%, midazolam almost completely prevented lidocaine-induced convulsions but had no significant effect on mortality." | 1.28 | Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats. ( Mito, RS; Torbiner, ML; Yagiela, JA, 1989) |
"Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC." | 1.28 | Lidocaine treatment of neonatal convulsions, a therapeutic dilemma. ( Hynning, PA; Nergårdh, A; Wallin, A, 1989) |
"With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine." | 1.27 | A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983) |
""Clearing" of catecholamine-induced arrhythmias was not obtained in any of six dogs given tocainide and only in two out of six dogs given lidocaine." | 1.27 | Antiarrhythmic effects of tocainide and lidocaine in dogs. ( Aberg, G; Aberg, L; Fitzgerald, T; McCollom, K; Moller, R; Ronfeld, R, 1983) |
"Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 1.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
" These results suggest that the CNS is the primary target organ for the toxic effects of both highly lipid-soluble and highly protein-bound local anesthetics (i." | 1.27 | Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. ( Covino, BG; Feldman, HS; Giasi, R; Liu, PL; Patterson, MK, 1983) |
"Lidocaine and phenytoin were relatively ineffective against convulsants that act on synaptic chloride channels via the GABA-ionophore receptor complex." | 1.27 | Anticonvulsive and convulsive effects of lidocaine: comparison with those of phenytoin, and implications for mechanism of action concepts. ( Javid, MJ; Stone, WE, 1988) |
"At the time of the seizure both tocainide and lidocaine were well within their respective therapeutic ranges." | 1.27 | A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity? ( Covinsky, JO; Forrence, E; Mullen, C, 1986) |
" The L group received lidocaine at a dosage of 0." | 1.27 | Effect on the seizure threshold in dogs of tocainide/lidocaine administration. ( Kaplan, RM; Paris, PM; Schuster, MR; Stewart, RD, 1987) |
"The comparative pharmacokinetic properties of lidocaine, bupivacaine, etidocaine and mepivacaine were investigated in convulsing and non-convulsing dogs." | 1.27 | Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. ( Arthur, GR; Covino, BG; Feldman, HS, 1988) |
"SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions." | 1.27 | General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988) |
"This is the longest cardiac arrest in early pregnancy reported in the medical literature with normal maternal and fetal outcome." | 1.27 | Complete maternal and fetal recovery after prolonged cardiac arrest. ( Burke, TJ; Selden, BS, 1988) |
"To induce convulsions 4." | 1.27 | The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics. ( Bokesch, PM; Castaneda, AR; Wilson, JM; Ziemer, G, 1987) |
"The child had asystole and grand mal seizures associated with lidocaine serum concentration of 19." | 1.27 | Intravenous lidocaine overdosage in a child. ( Edgren, B; Gehrz, R; Tilelli, J, 1986) |
"Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50." | 1.27 | Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. ( Kim, KC; Tasch, MD, 1986) |
"No synchronized population bursting (seizures) was observed at any of the concentrations tested (10(-6)M to 10(-3)M)." | 1.27 | Lidocaine depresses synaptic activity in the rat hippocampal slice. ( Edmonds, HL; Reid, KH; Rigor, BM; Schurr, A; Spears, B; West, CA, 1986) |
" Onset of electrical seizure activity occurred at about the same time in both groups and was defined as the central nervous system (CNS) toxic end point." | 1.27 | Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. ( Chadwick, HS, 1985) |
"The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats." | 1.27 | Effect of cocaine and pentylenetetrazol on cortical kindling. ( Russell, RD; Stripling, JS, 1985) |
"The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg ." | 1.26 | Studies on the post-ictal rise in seizure threshold. ( Cowen, PJ; Green, AR; Nutt, DJ, 1981) |
"Lidocaine and procaine seizure thresholds were studied." | 1.26 | Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines. ( Ciarlone, AE, 1981) |
"Lidocaine was administered using a constant rate infusion pump." | 1.26 | The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats. ( Mori, K; Oshima, E; Seo, N; Stevens, J, 1982) |
"Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine." | 1.26 | Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981) |
"The metabolic changes during lidocaine seizure were essentially the same as those observed in the seizure group in the first series." | 1.26 | Cerebral energy state and glycolytic metabolism during lidocaine infusion in the rat. ( Imamura, A; Maekawa, T; Oshibuchi, T; Takeshita, H, 1981) |
" An identical sequence of toxic manifestations occurred in the adult, newborn, and fetus: convulsions, hypotension, respiratory arrest, and circulatory collapse." | 1.26 | Toxicity of lidocaine in adult, newborn, and fetal sheep. ( Bruce, SL; Covino, BG; Finster, M; Gutsche, BB; Morishima, HO; Pedersen, H; Sakuma, K; Stark, RI, 1981) |
"The effect of drug-induced convulsions on kindling was studied in male Long-Evans rats." | 1.26 | Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol. ( Hendricks, C; Stripling, JS, 1981) |
"The first seizure activity observed was tonic extension (TE) which occurred at an infused lidocaine dose of 12." | 1.26 | Cardiorespiratory and behavioral reactions to the lidocaine-induced convulsions in the dog. ( Gangarosa, LP; Hofman, WF; Jerram, DC, 1977) |
"Excitation, coma, convulsions, tachycardia, mydriasis, nystagmus, and rubeosis of the face were the most important signs." | 1.26 | [Fenfluramin (ponderax) intoxications in children (author's transl)]. ( Krienke, EG; Mühlendahl, KE, 1978) |
"Toxicities were compared by determining seizure dosages for each drug alone and then in a lidocaine-etidocaine-tetracaine mixture." | 1.26 | Central-nervous-system toxicity of local anesthetic mixtures in monkeys. ( Embro, WJ; Munson, ES; Paul, WL, 1977) |
"Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy." | 1.26 | Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976) |
"Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection." | 1.26 | Gestational differences in lidocaine toxicity in the fetal lamb. ( Benowitz, N; Heymann, MA; Rudolph, AM; Teramo, K, 1976) |
"The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase." | 1.25 | Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975) |
"Five patients died." | 1.25 | Tricyclic antidepressive poisoning with special reference to cardiac complications. ( Asmussen, I; Lunding, M; Serafimovski, N; Thorball, N, 1975) |
" For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 1.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 189 (53.69) | 18.7374 |
1990's | 57 (16.19) | 18.2507 |
2000's | 50 (14.20) | 29.6817 |
2010's | 47 (13.35) | 24.3611 |
2020's | 9 (2.56) | 2.80 |
Authors | Studies |
---|---|
Kim, H | 2 |
Lee, I | 1 |
Son, WG | 1 |
Robinson, S | 1 |
Macdonald-Laurs, E | 1 |
Corlette, S | 1 |
Davidson, A | 1 |
Howell, KB | 1 |
Soto-Insuga, V | 1 |
González-Alguacil, E | 1 |
García-Peñas, JJ | 1 |
Stephenson, DT | 1 |
Thomas, N | 1 |
Korbely, R | 1 |
López-Ilundain, J | 1 |
Prados, AB | 1 |
Enriquez, ÁSR | 1 |
Enguita-Germán, M | 1 |
Rosquil, EU | 1 |
Gil, JL | 1 |
Fábrega, AM | 1 |
Martinez de Zabarte Moraza, E | 1 |
Maughan, AR | 1 |
Yoldi-Murillo, J | 1 |
Favié, LMA | 1 |
Huitema, ADR | 1 |
van den Broek, MPH | 1 |
Rademaker, CMA | 1 |
de Haan, TR | 1 |
van Straaten, HLM | 1 |
Simons, SHP | 1 |
Rijken, M | 1 |
Nuytemans, DHGM | 1 |
Egberts, TCG | 1 |
Groenendaal, F | 3 |
Lu, F | 1 |
Tian, J | 1 |
Dong, J | 1 |
Zhang, K | 1 |
Melo-Carrillo, A | 1 |
Schain, AJ | 1 |
Strassman, AM | 1 |
Burstein, R | 1 |
Santos, GFS | 1 |
Ferreira, LO | 1 |
Gerrits Mattos, B | 1 |
Fidelis, EJ | 1 |
de Souza, AS | 1 |
Batista, PS | 1 |
Manoel, CAF | 1 |
Cabral, DAC | 1 |
Jóia de Mello, V | 1 |
Favacho Lopes, DC | 1 |
Hamoy, M | 1 |
El-Dib, M | 1 |
Soul, JS | 1 |
Szadkowski, M | 1 |
Drapkin, Z | 1 |
Hewes, H | 1 |
Caravati, EM | 1 |
Plumb, J | 1 |
Lee, WK | 1 |
Bae, MI | 1 |
Choi, SH | 1 |
Min, KT | 1 |
Demeulemeester, V | 1 |
Van Hautem, H | 1 |
Cools, F | 1 |
Lefevere, J | 1 |
van Rooij, LG | 4 |
Hellström-Westas, L | 5 |
de Vries, LS | 5 |
Larson, A | 1 |
Stidham, T | 1 |
Banerji, S | 1 |
Kaufman, J | 1 |
Lundqvist, M | 2 |
Ågren, J | 2 |
Flink, R | 2 |
Wickström, R | 2 |
Nakano, K | 1 |
Kobayashi, K | 1 |
Maniwa, S | 1 |
Kodani, N | 1 |
Ohtsuka, Y | 1 |
Hakan, N | 1 |
Aydin, M | 1 |
Dilli, D | 1 |
Zenciroglu, A | 1 |
Okumus, N | 1 |
Tanawuttiwat, T | 1 |
Thisayakorn, P | 1 |
Viles-Gonzalez, JF | 1 |
Zhou, C | 1 |
Huang, H | 1 |
Liu, J | 1 |
Wang, X | 1 |
Chen, X | 1 |
Zhang, W | 1 |
Özer, AB | 1 |
Erhan, ÖL | 1 |
Bensghir, M | 1 |
Badou, N | 1 |
Houba, A | 1 |
Balkhi, H | 1 |
Haimeur, C | 1 |
Azendour, H | 1 |
Weeke, LC | 2 |
Schalkwijk, S | 1 |
Toet, MC | 4 |
van den Broek, MP | 4 |
Zeiler, FA | 2 |
Zeiler, KJ | 2 |
Teitelbaum, J | 2 |
Gillman, LM | 2 |
West, M | 2 |
Kazina, CJ | 2 |
Gaïes, E | 1 |
Jebabli, N | 1 |
Lakhal, M | 1 |
Klouz, A | 1 |
Salouage, I | 1 |
Trabelsi, S | 1 |
Boylan, GB | 2 |
Pressler, RM | 1 |
Chiu, KM | 1 |
Lu, CW | 1 |
Lee, MY | 1 |
Wang, MJ | 1 |
Lin, TY | 1 |
Wang, SJ | 1 |
Hoda, S | 1 |
O'Brien, J | 1 |
Gamble, J | 1 |
Déciga-Campos, M | 1 |
Navarrete-Vázquez, G | 1 |
López-Muñoz, FJ | 1 |
Librowski, T | 1 |
Sánchez-Recillas, A | 1 |
Yañez-Pérez, V | 1 |
Ortiz-Andrade, R | 1 |
Nicholas, E | 1 |
Thornton, MD | 1 |
Cho, YS | 1 |
Chung, BY | 1 |
Park, CW | 1 |
Kim, HO | 1 |
Jayanthi, R | 1 |
Nasser, K | 1 |
Monica, K | 1 |
Wang, XF | 1 |
Luo, XL | 1 |
Liu, WC | 1 |
Hou, BC | 1 |
Huang, J | 1 |
Zhan, YP | 1 |
Chen, SB | 1 |
Osman, BM | 1 |
Maga, JM | 1 |
Baquero, SM | 1 |
Wentlandt, M | 1 |
Morris, SC | 1 |
Mitchell, SH | 1 |
Kalimullah, EA | 1 |
Bryant, SM | 1 |
Brown, C | 1 |
Bachmann, G | 1 |
Ling, FW | 1 |
Rainger, J | 1 |
Baxter, C | 1 |
Vogelnest, Lj | 1 |
Dart, C | 1 |
Dror, M | 1 |
Baptiste, SL | 1 |
Tang, HM | 1 |
Kuzniecky, RI | 1 |
Devinsky, O | 1 |
French, JA | 1 |
Ludvig, N | 1 |
Guay, J | 1 |
Wan, QX | 1 |
Bo, YL | 1 |
Li, HB | 1 |
Li, WZ | 1 |
MacPherson, RD | 1 |
Lawford, J | 1 |
Simpson, B | 1 |
Mahon, M | 1 |
Scott, D | 1 |
Loo, C | 1 |
Tanabe, T | 3 |
Okumura, A | 3 |
Komatsu, M | 1 |
Kubota, T | 1 |
Nakajima, M | 1 |
Shimakawa, S | 2 |
Barcelos, KC | 1 |
Furtado, DP | 1 |
Ramacciato, JC | 1 |
Cabral, AM | 1 |
Haas, DA | 1 |
Nishiyama, T | 1 |
Komatsu, K | 1 |
Chakrabarti, R | 1 |
Topf, HG | 1 |
Schroth, M | 1 |
Huitema, AD | 1 |
van Hasselt, JG | 1 |
Egberts, TC | 1 |
Rademaker, CM | 2 |
Mishra, SK | 1 |
Subramanian, A | 1 |
Hemavathi, B | 1 |
Badhe, A | 1 |
Chung, SG | 1 |
Menif, K | 1 |
Khaldi, A | 1 |
Bouziri, A | 1 |
Hamdi, A | 1 |
Belhadj, S | 1 |
Ben Jaballah, N | 1 |
ter Weijden, E | 1 |
Ververs, FF | 1 |
Abdullah, MA | 1 |
Zeidan, A | 1 |
Landy, C | 1 |
Schaeffer, E | 1 |
Raynaud, L | 1 |
Favier, JC | 1 |
Plancade, D | 1 |
Jennekens, W | 1 |
Dankers, F | 1 |
Janssen, F | 1 |
Toet, M | 1 |
van der Aa, N | 1 |
Niemarkt, H | 1 |
van Pul, C | 1 |
de Vries, L | 1 |
Andriessen, P | 1 |
Ellis, LD | 1 |
Soanes, KH | 1 |
Bouwman, NA | 1 |
Morré, HH | 1 |
DeToledo, JC | 2 |
Minagar, A | 1 |
Lowe, MR | 1 |
Mirnajafi-Zadeh, J | 1 |
Mortazavi, M | 1 |
Fathollahi, Y | 1 |
Alasvand Zarasvand, M | 1 |
Reza Palizvan, M | 1 |
Wajima, Z | 1 |
Yoshikawa, T | 1 |
Ogura, A | 1 |
Shiga, T | 1 |
Inoue, T | 1 |
Ogawa, R | 1 |
Arai, S | 2 |
Morita, K | 4 |
Kitayama, S | 2 |
Kumagai, K | 1 |
Kumagai, M | 1 |
Kihira, K | 2 |
Dohi, T | 5 |
Rennie, JM | 1 |
Li, J | 1 |
Olinger, AB | 1 |
Dassow, MS | 1 |
Abel, MS | 2 |
Kempen, PM | 1 |
Rodins, K | 1 |
Hlavac, M | 1 |
Beckert, L | 1 |
Hutchinson, BR | 1 |
DUTTON, WA | 1 |
BERNHARD, CG | 1 |
BOHM, E | 2 |
KIRSTEIN, L | 2 |
WIESEL, T | 1 |
FLODMARK, S | 1 |
PETERSEN, I | 1 |
EEROLA, R | 1 |
TAULANIEMI, E | 1 |
CRONHOLM, B | 1 |
OTTOSSON, JO | 6 |
RAEVSKII, KS | 1 |
Mosovich, A | 1 |
Etchepareborda, J | 1 |
DEACOCK, AR | 1 |
SIMPSON, WT | 1 |
ANSELL, G | 1 |
ANSELL, A | 1 |
HARLEY, HR | 1 |
LAURENCE, KM | 1 |
SEAL, RM | 1 |
STEVENS, JH | 1 |
CAHILL, JF | 1 |
ALDOUS, JG | 1 |
WENNING, AS | 1 |
MORALES AGUILERA, A | 1 |
VAUGHANWILLIAMS, EM | 1 |
Funao, T | 1 |
Oda, Y | 3 |
Tanaka, K | 3 |
Asada, A | 3 |
Timofeev, I | 1 |
Grenier, F | 1 |
Steriade, M | 1 |
Uemura, N | 1 |
Negoro, T | 1 |
Watanabe, K | 2 |
Wolfe, TR | 1 |
Bernstone, T | 1 |
Moran, LR | 1 |
Hossain, T | 1 |
Insoft, RM | 1 |
Pacheco-Rosado, J | 2 |
Hernández-García, A | 2 |
Ortiz-Butrón, R | 2 |
Kato, T | 1 |
Hayakawa, F | 1 |
Sugiyama, N | 2 |
Hamano, S | 2 |
Mochizuki, M | 1 |
Tanaka, M | 2 |
Eto, Y | 2 |
Priya, V | 1 |
Dalal, K | 1 |
Sareen, R | 1 |
Cherng, CH | 1 |
Wong, CS | 1 |
Guler, G | 1 |
Erdogan, F | 1 |
Golgeli, A | 1 |
Akin, A | 1 |
Boyaci, A | 1 |
Ahmed, SU | 1 |
Vallejo, R | 1 |
Hord, ED | 1 |
Hamamoto, M | 1 |
Irifune, M | 1 |
Kawahara, M | 1 |
Yamashita, S | 1 |
Yoshinari, S | 1 |
Minamitani, M | 1 |
Hayakawa, M | 1 |
Kikuchi, K | 1 |
Bordes, M | 1 |
Cros, AM | 1 |
Malingré, MM | 1 |
Ververs, TF | 1 |
van Kesteren, C | 1 |
Kitayama, T | 1 |
Song, L | 1 |
Morioka, N | 1 |
Tsilosani, NA | 1 |
Nanobashvili, ZI | 1 |
Azikuri, GSh | 1 |
Bekaia, GL | 1 |
Dorf, E | 1 |
Kuntz, AF | 1 |
Kelsey, J | 1 |
Holstege, CP | 1 |
Takahashi, R | 2 |
Morishima, HO | 4 |
Inoue, K | 1 |
Dahle, JM | 1 |
Iserson, KV | 1 |
da Costa, JC | 1 |
Olsen, PC | 1 |
de Azeredo Siqueira, R | 1 |
de Frias Carvalho, V | 1 |
Serra, MF | 1 |
Alves, LA | 1 |
Faria, RX | 1 |
Xisto, DG | 1 |
Rocco, PR | 1 |
Cordeiro, RS | 1 |
Rodrigues E Silva, PM | 1 |
Martins, MA | 1 |
Trailović, SM | 1 |
Varagić, VM | 1 |
Rezvani, M | 1 |
Finkelstein, Y | 1 |
Verjee, Z | 1 |
Railton, C | 1 |
Koren, G | 1 |
Shany, E | 1 |
Benzaqen, O | 1 |
Watemberg, N | 1 |
Blas-Valdivia, V | 1 |
Cano-Europa, E | 1 |
Pagès, H | 1 |
de la Gastine, B | 1 |
Quedru-Aboane, J | 1 |
Guillemin, MG | 1 |
Lelong-Boulouard, V | 1 |
Guillois, B | 1 |
Takinami, Y | 1 |
Copeland, SE | 1 |
Ladd, LA | 1 |
Gu, XQ | 1 |
Mather, LE | 3 |
Nakamura, T | 1 |
Hase, I | 1 |
Englesson, S | 3 |
Akerman, B | 1 |
Aström, A | 1 |
Ross, S | 1 |
Telc, A | 1 |
De Jong, RH | 16 |
Wagman, IH | 5 |
Prince, DA | 1 |
Nutt, DJ | 1 |
Cowen, PJ | 1 |
Green, AR | 1 |
Vatashsky, E | 3 |
Aronson, HB | 3 |
Zaroura, S | 1 |
Stirt, JA | 1 |
Sullivan, SF | 1 |
Yamada, K | 1 |
Maekawa, T | 5 |
Okuda, Y | 1 |
Takeshita, H | 4 |
Oppenheimer, EY | 1 |
Rosman, NP | 1 |
Aberg, G | 1 |
Ronfeld, R | 1 |
Aberg, L | 1 |
Fitzgerald, T | 1 |
McCollom, K | 1 |
Moller, R | 1 |
Yoshimura, Y | 2 |
Ciarlone, AE | 1 |
Avery, P | 1 |
Redon, D | 1 |
Schaenzer, G | 1 |
Rusy, B | 1 |
Beilin, B | 1 |
Weinstock, M | 1 |
Post, RM | 4 |
Kennedy, C | 1 |
Shinohara, M | 1 |
Squillace, K | 1 |
Miyaoka, M | 1 |
Suda, S | 1 |
Ingvar, DH | 1 |
Sokoloff, L | 1 |
Kotelko, DM | 1 |
Shnider, SM | 1 |
Dailey, PA | 1 |
Brizgys, RV | 1 |
Levinson, G | 1 |
Shapiro, WA | 1 |
Koike, M | 1 |
Rosen, MA | 1 |
Antonelli, D | 1 |
Ben-Ami, M | 1 |
Weiss, Z | 1 |
Alfano, SN | 1 |
Leicht, MJ | 1 |
Skiendzielewski, JJ | 1 |
Wynn, RL | 1 |
McFarland, SA | 1 |
Meyer, EA | 1 |
Coffman, WB | 1 |
Mumford, R | 1 |
Squillace, KM | 1 |
Pert, A | 1 |
Sass, W | 1 |
Mofenson, HC | 1 |
Caraccio, TR | 1 |
Miller, H | 1 |
Greensher, J | 1 |
Liu, PL | 1 |
Feldman, HS | 4 |
Giasi, R | 1 |
Patterson, MK | 1 |
Covino, BG | 6 |
Kusek, JC | 1 |
Stripling, JS | 6 |
Ireland, D | 1 |
Rothstein, P | 1 |
Dornbusch, J | 1 |
Shaywitz, BA | 1 |
Nadkarni, AV | 1 |
Tondare, AS | 1 |
Seo, N | 1 |
Oshima, E | 1 |
Stevens, J | 1 |
Mori, K | 2 |
Sutter, M | 1 |
Pfenninger, J | 1 |
Bonin, JD | 4 |
Ronfeld, RA | 1 |
DeRosa, RA | 1 |
Oshibuchi, T | 1 |
Imamura, A | 1 |
Heavner, JE | 11 |
Amory, DW | 1 |
Hendricks, C | 2 |
Pedersen, H | 2 |
Finster, M | 3 |
Sakuma, K | 1 |
Bruce, SL | 1 |
Gutsche, BB | 1 |
Stark, RI | 1 |
Badui, E | 1 |
Garcia-Rubi, D | 1 |
Estañol, B | 1 |
Lloyd, BL | 1 |
Greenblatt, DJ | 1 |
Sakai, RI | 1 |
Lattin, JE | 1 |
Ingvar, M | 1 |
Shapiro, HM | 2 |
Brown, DL | 1 |
Ransom, DM | 1 |
Hall, JA | 1 |
Leicht, CH | 1 |
Schroeder, DR | 1 |
Offord, KP | 1 |
Siegmund, JB | 1 |
Wilson, JH | 1 |
Imhoff, TE | 1 |
Yokoyama, M | 4 |
Hirakawa, M | 3 |
Goto, H | 4 |
Kragh, J | 1 |
Seidelin, J | 1 |
Bolwig, TG | 1 |
Nakao, S | 1 |
Kurata, J | 1 |
Arai, T | 1 |
Murakawa, M | 1 |
Adachi, T | 1 |
Avramov, MN | 1 |
Yasuhara, O | 1 |
Tooyama, I | 1 |
Kimura, H | 1 |
Witkin, JM | 1 |
Newman, AH | 1 |
Nowak, G | 1 |
Katz, JL | 1 |
McFarlane, C | 2 |
Warner, DS | 4 |
Dexter, F | 2 |
Todd, MM | 4 |
Hartung, J | 1 |
Ying, H | 1 |
Weinberger, J | 1 |
Cottrell, JE | 1 |
Bruguerolle, B | 2 |
Emperaire, N | 2 |
Carney, DE | 1 |
Fortuna, A | 1 |
Fortuna, AO | 1 |
Berry, FR | 1 |
Endo, K | 1 |
Uchiyama, Y | 1 |
Takada, K | 2 |
Tsujimoto, A | 2 |
Sutherland, R | 1 |
Ueda, W | 1 |
Arakawa, K | 2 |
Kotaki, H | 1 |
Tayama, N | 1 |
Ito, K | 1 |
Mitomi, N | 1 |
Tezuka, K | 1 |
Kaga, K | 1 |
Sawada, Y | 1 |
Iga, T | 1 |
Kim, YJ | 1 |
Baker, MT | 1 |
Choi, WW | 3 |
Shimosato, K | 2 |
Watanabe, S | 2 |
Marley, RJ | 1 |
Saito, T | 1 |
Sata, Y | 1 |
Aihara, M | 1 |
Hatakeyama, K | 1 |
Hinohara, Y | 1 |
Kamiya, Y | 1 |
Shimoda, C | 1 |
Kanemura, H | 1 |
Nakazawa, S | 1 |
Barat, SA | 2 |
Abdel-Rahman, MS | 2 |
Hirsch, E | 1 |
Danober, L | 1 |
Simler, S | 1 |
Pereira de Vasconcelos, A | 1 |
Maton, B | 1 |
Nehlig, A | 1 |
Marescaux, C | 1 |
Vergnes, M | 1 |
Pantuck, AJ | 1 |
Goldsmith, JW | 1 |
Kuriyan, JB | 1 |
Weiss, RE | 1 |
Satas, S | 1 |
Johannessen, SI | 1 |
Hoem, NO | 1 |
Haaland, K | 1 |
Sørensen, DR | 1 |
Thoresen, M | 1 |
Endoh, H | 1 |
Kumagai, Y | 1 |
Baba, H | 1 |
Yamakura, T | 1 |
Taga, K | 1 |
Sato, K | 1 |
Fukuda, S | 1 |
Shimoji, K | 1 |
Fu, W | 1 |
Stool, LA | 1 |
White, PF | 1 |
Husain, MM | 1 |
Katsura, M | 1 |
Ohkuma, S | 1 |
Geraniotis, EG | 1 |
Lee, VC | 1 |
Moscicki, JC | 1 |
DiFazio, CA | 1 |
Avery, JK | 1 |
Krahl, SE | 1 |
Clark, KB | 1 |
Smith, DC | 1 |
Browning, RA | 1 |
Capron, F | 1 |
Perry, D | 1 |
Capolaghi, B | 1 |
Altenburg, SP | 1 |
Farah, MB | 1 |
Suzuki, S | 1 |
Yamashiro, K | 1 |
Tamai, H | 1 |
Sakurai, M | 1 |
Kanazawa, I | 1 |
Rosenberg, P | 1 |
Kim, DC | 1 |
Ueyama, T | 1 |
Maru, E | 2 |
Shimada, M | 2 |
Suzuki, H | 2 |
Ikeda, M | 1 |
Walker, BR | 1 |
Easton, A | 1 |
Gale, K | 1 |
Chae, HJ | 1 |
Kang, JS | 1 |
Cho, SB | 1 |
Jin, BG | 1 |
Won, SJ | 1 |
Gwag, BJ | 1 |
Kim, HR | 1 |
Sawaki, K | 2 |
Ohno, K | 1 |
Miyamoto, K | 1 |
Hirai, S | 1 |
Yazaki, K | 1 |
Kawaguchi, M | 2 |
Clapp, CR | 1 |
Poss, WB | 1 |
Cilento, BG | 1 |
Fujita, H | 1 |
Ogiuchi, H | 1 |
Rincon, E | 1 |
Baker, RL | 1 |
Iglesias, AJ | 1 |
Duarte, AM | 1 |
Kurt, M | 1 |
Bilge, SS | 1 |
Kukula, O | 1 |
Kesim, Y | 1 |
Celik, S | 1 |
Zamudio-Hernández, S | 1 |
Chambert, G | 1 |
Sawyer, RJ | 1 |
von Schroeder, H | 1 |
Hofman, WF | 1 |
Jerram, DC | 1 |
Gangarosa, LP | 1 |
Mühlendahl, KE | 1 |
Krienke, EG | 1 |
Slome, J | 1 |
Thompson, RG | 1 |
Aldrete, JA | 2 |
Matousek, M | 1 |
Konthikamee, W | 1 |
Sprecher, RL | 1 |
Moore, PA | 1 |
Munson, ES | 7 |
Paul, WL | 1 |
Embro, WJ | 1 |
Caron, M | 1 |
LeLorier, J | 1 |
Hanna, MK | 1 |
Blackburn, JG | 1 |
Ogilvie, RW | 1 |
Campbell, SL | 1 |
Lemmen, LJ | 1 |
Klassen, M | 1 |
Duiser, B | 1 |
Rosenbaum, KJ | 1 |
Sapthavichaikul, S | 1 |
Skovsted, P | 1 |
Kopanda, RT | 2 |
Verrill, PJ | 1 |
Ausinsch, B | 2 |
Malagodi, MH | 2 |
Contratti, V | 1 |
Amato, MG | 1 |
Bortone, AM | 1 |
Malagoli, MA | 1 |
Serafimovski, N | 1 |
Thorball, N | 1 |
Asmussen, I | 1 |
Lunding, M | 1 |
Raskin, NH | 1 |
Fishman, RA | 1 |
Tucker, WK | 1 |
Jalling, B | 1 |
Jain, PD | 1 |
Pandey, K | 1 |
Chandra, HK | 1 |
Lee, A | 1 |
Teramo, K | 1 |
Benowitz, N | 1 |
Heymann, MA | 1 |
Rudolph, AM | 1 |
Benson, KT | 1 |
Garrettson, LK | 1 |
McGee, EB | 1 |
McLeod, D | 1 |
Svenningsen, NW | 1 |
Westgren, U | 1 |
Rosén, I | 1 |
Lagerström, PO | 1 |
Bucklin, BA | 1 |
Chestnut, DH | 1 |
Yerzingatsian, KL | 1 |
Tanaka, S | 1 |
Ouchi, K | 1 |
Sato, T | 1 |
Monahan, DJ | 1 |
Derlet, RW | 1 |
Albertson, TE | 1 |
Tharratt, RS | 1 |
Arthur, GR | 4 |
Shokeir, O | 1 |
Code, WE | 1 |
Hertz, L | 1 |
Jonville, AP | 1 |
Barbier, P | 1 |
Blond, MH | 1 |
Boscq, M | 1 |
Autret, E | 1 |
Breteau, M | 1 |
Rey, E | 1 |
Radvanyi-Bouvet, MF | 1 |
Bodiou, C | 1 |
Richard, MO | 1 |
Torricelli, A | 1 |
Walti, H | 1 |
Olive, G | 1 |
de Fiebre, CM | 1 |
Ruth, JA | 1 |
Collins, AC | 1 |
Gramlich, CA | 1 |
Cunningham, MG | 1 |
Torbiner, ML | 1 |
Yagiela, JA | 1 |
Mito, RS | 1 |
Viel, E | 1 |
d'Athis, F | 1 |
Müller, M | 1 |
Schramek, J | 1 |
Uthman, BM | 1 |
Wilder, BJ | 1 |
Nancarrow, C | 2 |
Rutten, AJ | 2 |
Runciman, WB | 2 |
Carapetis, RJ | 1 |
McLean, CF | 1 |
Hipkins, SF | 1 |
Ilsley, AH | 1 |
Upton, RN | 1 |
Wallin, A | 1 |
Nergårdh, A | 1 |
Hynning, PA | 1 |
Pelter, MA | 1 |
Vollmer, TA | 1 |
Blum, RL | 1 |
Wamil, A | 1 |
Kleinrok, Z | 1 |
Lanier, WL | 1 |
Sharbrough, FW | 1 |
Michenfelder, JD | 1 |
Pottage, A | 1 |
Scott, DB | 1 |
Stone, WE | 1 |
Javid, MJ | 1 |
Forrence, E | 1 |
Covinsky, JO | 1 |
Mullen, C | 1 |
Schuster, MR | 1 |
Paris, PM | 1 |
Kaplan, RM | 1 |
Stewart, RD | 1 |
Vale, NB | 1 |
Leite, JR | 1 |
Hirotsu, I | 1 |
Kihara, T | 1 |
Nakamura, S | 1 |
Hattori, Y | 1 |
Hatta, M | 1 |
Kitakaze, Y | 1 |
Takahama, K | 1 |
Hashimoto, Y | 1 |
Miyata, T | 1 |
Ishihara, T | 1 |
Selden, BS | 1 |
Burke, TJ | 1 |
Hess, GP | 1 |
Walson, PD | 1 |
Dux, E | 1 |
Kloiber, O | 1 |
Hossmann, KA | 1 |
Siklós, L | 1 |
Sundaram, MB | 1 |
Bokesch, PM | 1 |
Castaneda, AR | 1 |
Ziemer, G | 1 |
Wilson, JM | 1 |
Yatscoff, RW | 1 |
Honcharik, N | 1 |
Tenenbein, M | 1 |
Edgren, B | 1 |
Tilelli, J | 1 |
Gehrz, R | 1 |
Tommasino, C | 1 |
Kim, KC | 1 |
Tasch, MD | 1 |
Schurr, A | 1 |
Spears, B | 1 |
Reid, KH | 1 |
West, CA | 1 |
Edmonds, HL | 1 |
Rigor, BM | 1 |
Parish, RC | 1 |
Moore, RT | 1 |
Gotz, VP | 1 |
Russell, RD | 2 |
Hiraoka, H | 1 |
Tsuji, A | 1 |
Chadwick, HS | 1 |
Regal, RE | 1 |
Flensted-Jensen, E | 1 |
Sandoe, E | 1 |
Tuttle, WW | 1 |
Elliott, HW | 1 |
Dereymaeker, A | 2 |
Sorel, L | 2 |
Dawkins, CJ | 1 |
De Oliveira, LF | 4 |
Bretas, AD | 1 |
Swan, HJ | 1 |
Robles, R | 1 |
Corbin, RW | 1 |
Huffman, RD | 1 |
Yim, GK | 1 |
Löfström, B | 2 |
Murmann, W | 1 |
Almirante, L | 1 |
Saccani-Guelfi, M | 1 |
Müller, H | 1 |
Sakabe, T | 2 |
Karlsson, E | 1 |
Collste, P | 1 |
Rawlins, MD | 1 |
Demetrescu, M | 2 |
Julien, RM | 2 |
Westphal, P | 1 |
Fink, BR | 1 |
Martucci, RW | 1 |
Gueyé, SN | 1 |
Dosseh, B | 1 |
Wale, N | 1 |
Jenkins, LC | 1 |
Gillis, RA | 1 |
Levine, FH | 1 |
Thibodeaux, H | 1 |
Raines, A | 1 |
Standaert, FG | 1 |
Blumer, J | 1 |
Strong, JM | 1 |
Atkinson, AJ | 1 |
Freund, G | 1 |
Gogolák, G | 1 |
Stumpf, C | 1 |
Tschakaloff, C | 1 |
Irstam, L | 1 |
Ishikawa, T | 1 |
Jorfeldt, L | 1 |
Pernow, B | 1 |
Persson, B | 1 |
Wahren, J | 1 |
Widman, B | 1 |
Hazra, J | 1 |
Paymaster, NJ | 1 |
Hill, TR | 1 |
Porciello, PI | 1 |
Zanini, S | 1 |
Poppi, A | 1 |
Smith, ER | 1 |
Duce, BR | 1 |
Gamstorp, I | 1 |
Bennett, CR | 1 |
Monheim, LM | 1 |
Ruskin, P | 1 |
Fleming, SA | 1 |
Olurin, O | 1 |
Ferngren, H | 1 |
Hellström, B | 1 |
Feinstein, MB | 1 |
Lenard, W | 1 |
Mathias, J | 1 |
Staniweski, JA | 1 |
Peng, AT | 1 |
Bufalo, J | 1 |
Blancato, LS | 1 |
Phansalkar, AG | 1 |
Kulkarni, SD | 1 |
Balwani, JH | 1 |
Rosenberg, FJ | 1 |
Cooke, WJ | 1 |
Wessinger, GD | 1 |
Southgate, PJ | 1 |
Borney, G | 1 |
Devoti, G | 1 |
Havers, L | 1 |
Price, J | 1 |
Hvidt, V | 1 |
Kühl, V | 1 |
Dobbs, EC | 2 |
Ross, NM | 1 |
Crampton, RS | 1 |
Ishida, R | 1 |
Adachi, S | 1 |
Kowa, Y | 1 |
Inniss, C | 1 |
Pearson, RE | 1 |
Salter, FJ | 1 |
Epstein, HM | 1 |
Sherline, DM | 1 |
Evans, JA | 1 |
Chastain, GM | 1 |
Phillips, JM | 1 |
Essman, WB | 1 |
de Magalhães Seabra, J | 1 |
Morera Marco, V | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Early Versus Late Deflation of Distal Tourniquet in Intravenous Regional Anesthesia With and Without Ketorolac in Hand & Forearm Surgery[NCT05234619] | 80 participants (Anticipated) | Interventional | 2022-01-01 | Active, not recruiting | |||
A Randomized Controlled Trial to Investigate the Efficacy of a Bier's Block Compared to a Mini-bier's Block in Patients Undergoing Hand Surgery[NCT03761329] | 280 participants (Actual) | Interventional | 2018-11-12 | Completed | |||
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538] | 100 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964] | 550 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -1.27 |
Placebo | -0.89 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.57 |
Placebo | 0.16 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.09 |
Placebo | 0.07 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.07 |
Placebo | 0.07 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 6.3 |
Placebo | 6.96 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -10.98 |
Placebo | -11.67 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.05 |
Placebo | 0.07 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.05 |
Placebo | 0.04 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.02 |
Placebo | -0.02 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.04 |
Placebo | -0.01 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.71 |
Placebo | -1.16 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 1.23 |
Placebo | -0.49 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.20 |
Placebo | 0.03 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.95 |
Placebo | 1.59 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -6.70 |
Placebo | -6.39 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -7.12 |
Placebo | -6.31 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -1.39 |
Placebo | -1.48 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.67 |
Placebo | -0.8 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.46 |
Placebo | -1.02 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -3 |
Placebo | -3.21 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.15 |
Placebo | -0.31 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 2.46 |
Placebo | 2.1 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
Intervention | Participants (Count of Participants) |
---|---|
Lidocaine | 87 |
Placebo | 83 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) | |
---|---|---|
1 year Change Work Activities | 1 year Change General health perception | |
Lidocaine | -1.37 | -0.28 |
Placebo | -1.42 | -0.43 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) | |
---|---|---|
6-Week Change Work activities | 6-Week Change General health perception | |
Lidocaine | 2.71 | -0.004 |
Placebo | 3 | -0.03 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -0.15 | 0.02 | -0.73 | -0.10 |
Placebo | -0.43 | -0.73 | -0.40 | 0.19 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -4.22 | -2.46 | -0.34 | 1.21 |
Placebo | -0.04 | 1.83 | 2.64 | 0.54 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -2.02 | 0.56 | 0.58 | 1.04 |
Placebo | -0.08 | 0.17 | 1.19 | -0.68 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -0.03 | 0.03 | 0.33 | 0.37 |
Placebo | 0.35 | 0.43 | 0.05 | 0.27 |
19 reviews available for lidocaine and Seizures
Article | Year |
---|---|
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
The use of phenobarbital and other anti-seizure drugs in newborns.
Topics: Anticonvulsants; Fructose; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Midazolam; Phen | 2017 |
Treatment of neonatal seizures.
Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo | 2013 |
Lidocaine for Status Epilepticus in Pediatrics.
Topics: Anticonvulsants; Humans; Lidocaine; Pediatrics; Phenytoin; Prospective Studies; Seizures; Status Epi | 2015 |
Lidocaine for status epilepticus in adults.
Topics: Adult; Anticonvulsants; Humans; Lidocaine; Seizures; Status Epilepticus | 2015 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Injections, Subcutaneous; L | 2011 |
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas | 2003 |
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.
Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio | 2004 |
[Inhalation induction with sevoflurane in paediatrics: what is new?].
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Drug Synergism; | 2006 |
Aminophylline.
Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransfo | 1981 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Safe and effective topical application dose of lidocaine for surgery with laryngomicroscopy.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Female; Humans; Laryngoscopy; Lidocaine; M | 1996 |
Lidocaine and seizures.
Topics: Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Humans; Lidocaine; Seizures | 2000 |
Cocaine, kindling, and psychosis.
Topics: Amphetamine; Cocaine; Drug Tolerance; Electric Stimulation; Epilepsy, Temporal Lobe; Humans; Lidocai | 1976 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
An analysis of the complications of extradural and caudal block.
Topics: Adult; Aged; Anesthesia, Spinal; Back Pain; Blood Pressure; Catheterization; Dura Mater; Epinephrine | 1969 |
Aspects of the pharmacology of local anaesthetic agents.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood Pressure; Central Nervous System; Epine | 1970 |
Acute and chronic toxicity of local anaesthetics.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Brain; Cats; Diazepam; Drug Hypersensitivity; | 1973 |
8 trials available for lidocaine and Seizures
Article | Year |
---|---|
Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis.
Topics: Adolescent; Adult; Anesthetics, Local; Anticonvulsants; Carbamazepine; Child; Electroencephalography | 2011 |
The effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Blood Pressure; Cross-Over Studies; Depressive D | 2002 |
A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis.
Topics: Administration, Cutaneous; Anti-Arrhythmia Agents; Anticonvulsants; Child, Preschool; Dose-Response | 2004 |
Development of an optimal lidocaine infusion strategy for neonatal seizures.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Fol | 2006 |
Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Dose-Response Relationship, D | 2007 |
Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity.
Topics: Aged; Aged, 80 and over; Anesthesia; Anesthetics, Local; Blood Pressure; Cross-Over Studies; Double- | 1997 |
[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood].
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intrav | 1999 |
Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; M | 1999 |
325 other studies available for lidocaine and Seizures
Article | Year |
---|---|
Tonic-clonic seizure in a dog following suspected intra-arterial administration of lidocaine.
Topics: Animals; Dog Diseases; Dogs; Lidocaine; Seizures | 2022 |
Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Drug Overdose; Fema | 2022 |
Anesthetic considerations in Dravet syndrome.
Topics: Anesthetics; Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Epileptic Syndromes | 2022 |
Early-onset neonatal seizures: lidocaine toxicity as a rare differential diagnosis to hypoxic ischaemic encephalopathy.
Topics: Anticonvulsants; Diagnosis, Differential; Electroencephalography; Female; Humans; Hypoxia-Ischemia, | 2023 |
Does Lidocaine Shorten Seizure Duration in Electroconvulsive Therapy?
Topics: Cohort Studies; Electroconvulsive Therapy; Humans; Lidocaine; Propofol; Retrospective Studies; Seizu | 2023 |
Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen.
Topics: Anticonvulsants; Epilepsy; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Seizures | 2020 |
Tonic-clonic seizure during the ultrasound-guided stellate ganglion block because of an injection into an unrecognized variant vertebral artery: A case report.
Topics: Adult; Anesthetics, Local; Autonomic Nerve Block; Humans; Intraoperative Complications; Lidocaine; M | 2019 |
Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache.
Topics: Anesthetics, Local; Animals; Central Nervous System; Electroencephalography; Female; Headache; Lidoc | 2020 |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine-induced seizures.
Topics: Animals; Anticonvulsants; Lidocaine; Male; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2021 |
A Teenager With Seizures and Cardiac Arrest After Drug Overdose: Are We Numb to the Danger?
Topics: Adolescent; Anesthetics, Local; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Fatal Outc | 2017 |
Accidental intracerebral injection and seizure during scalp nerve blocks for awake craniotomy in a previously craniotomized patient -a case report.
Topics: Adult; Anesthetics, Local; Brain; Craniotomy; Humans; Injections; Lidocaine; Male; Medication Errors | 2018 |
Transplacental lidocaine intoxication.
Topics: Adult; Anesthesia, Obstetrical; Apnea; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Li | 2018 |
Seizures and methemoglobinemia in an infant after excessive EMLA application.
Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Infant; Lidoca | 2013 |
Efficacy and safety of lidocaine for treatment of neonatal seizures.
Topics: Cohort Studies; Electroencephalography; Female; Follow-Up Studies; Gestational Age; Humans; Infant, | 2013 |
Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine.
Topics: Anesthetics, Local; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Tonic-C | 2013 |
Lidocaine should only be used in neonatal seizures that do not respond to first-generation AEDs.
Topics: Female; Humans; Lidocaine; Male; Seizures | 2013 |
Adverse effects following lidocaine treatment are limited with current dosing regimens.
Topics: Female; Humans; Lidocaine; Male; Seizures | 2013 |
LAST (local anesthetic systemic toxicity) but not least: systemic lidocaine toxicity during cardiac intervention.
Topics: Anesthetics, Local; Cardiomyopathies; Cardiopulmonary Resuscitation; Defibrillators, Implantable; Do | 2014 |
Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats.
Topics: Anesthesia, Conduction; Anesthetics, Inhalation; Anesthetics, Local; Animals; Cognition; Dose-Respon | 2014 |
Systemic toxicity to local anesthesia in an infant undergoing circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Diagnosis, Differential; Humans; Infant; Lidocaine; Male; Se | 2014 |
Convulsions during cataract surgery under peribulbar anesthesia: a case report.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cataract Extraction; Humans; Injections; L | 2014 |
Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors.
Topics: Anticonvulsants; Birth Weight; Bradycardia; Databases, Factual; Female; Gestational Age; Heart Rate; | 2015 |
[Delayed convulsion after lidocaine instillation for bronchoscopy].
Topics: Aged; Anesthesia, Local; Bronchiolitis Obliterans; Bronchoscopy; Female; Humans; Instillation, Drug; | 2016 |
Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants.
Topics: Anticonvulsants; Central Nervous System Infections; Cohort Studies; Electroencephalography; Female; | 2016 |
Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats.
Topics: Animals; Anti-Inflammatory Agents; CA3 Region, Hippocampal; Cell Death; Encephalitis; Kainic Acid; L | 2016 |
Intractable seizures in a toddler after application of an over-the-counter local anesthetic cream.
Topics: Administration, Cutaneous; Anesthetics, Local; Bandages; Burns; Drug Overdose; Emergency Service, Ho | 2016 |
Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analogue of lidocaine.
Topics: Anesthetics, Local; Animals; Anti-Anxiety Agents; Cardiovascular System; Guinea Pigs; Hypnotics and | 2016 |
Lidocaine Toxicity During Attempted Epistaxis Cautery.
Topics: Anesthesia, Local; Anesthetics, Local; Bradycardia; Cautery; Epistaxis; Humans; Lidocaine; Male; Sei | 2016 |
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Dermatitis, Atopic; Female; Humans; L | 2016 |
Local Anesthetics Systemic Toxicity.
Topics: Administration, Intravenous; Adult; Anesthetics, Local; Diazepam; Female; Humans; Lidocaine; Male; M | 2016 |
Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Dexmedet | 2016 |
Case report: management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia.
Topics: Anaphylaxis; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Arthroplasty, Replace | 2016 |
Ventricular tachycardia and prolonged QT interval presenting as seizure-like activity.
Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Anticonvulsants; Diuretics; Electrocardiography; Emergenc | 2017 |
Case files of the medical toxicology fellowship at the toxikon consortium in Chicago: cocaine-associated wide-complex dysrhythmias and cardiac arrest - treatment nuances and controversies.
Topics: Amiodarone; Anti-Arrhythmia Agents; Anticonvulsants; Antidotes; Arrhythmias, Cardiac; Charcoal; Coca | 2008 |
Differential diagnosis of seizure associated with topical lidocaine in a patient with vestibulodynia.
Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Lidocaine; Mid | 2009 |
Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy.
Topics: Anesthetics, Local; Animals; Biopsy; Dermatitis, Atopic; Dog Diseases; Dogs; Drug Interactions; Fata | 2009 |
Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent.
Topics: Anesthetics, Local; Animals; Anti-Bacterial Agents; Ceftriaxone; Injections, Intramuscular; Injectio | 2010 |
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob | 2010 |
Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Cardiovascular System; Central Nervous Sy | 2010 |
Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Blood Pressure; Drug Therapy, Combination; Electroconv | 2010 |
Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity.
Topics: Anesthetics, Local; Animals; Carbon Dioxide; Carticaine; Dose-Response Relationship, Drug; Lidocaine | 2010 |
Local anesthetic toxicity in interscalene block: clinical series.
Topics: Aged; Amides; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Female; Humans; Lidocaine; Mal | 2010 |
Low dose lidocaine for refractory seizures in preterm neonates.
Topics: Anesthetics, Local; Drug Administration Schedule; Humans; Infant, Newborn; Infant, Premature; Infant | 2011 |
Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures.
Topics: Anticonvulsants; Arrhythmias, Cardiac; Clinical Protocols; Drug Monitoring; Female; Gestational Age; | 2011 |
Convulsion and cardiorespiratory collapse with first epidural test dose.
Topics: Adult; Analgesia, Epidural; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Seizures | 2011 |
Convulsion caused by a lidocaine test in cervical transforaminal epidural steroid injection.
Topics: Anesthetics, Local; Contrast Media; Female; Humans; Injections, Epidural; Injections, Spinal; Iopami | 2011 |
Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures.
Topics: Animals; Cattle; Chromatography, Liquid; Drug Monitoring; Humans; Infant, Newborn; Lidocaine; Linear | 2012 |
Epidural test dose and tachycardia.
Topics: Analgesia, Epidural; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Seizures | 2012 |
Convulsions after normal dose of lidocaine: a probable drug interaction.
Topics: Adrenergic alpha-Agonists; Aged; Anesthetics, Local; Anti-Arrhythmia Agents; Atrial Fibrillation; Br | 2012 |
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy; | 2012 |
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Ada | 2012 |
Lidocaine-induced seizure during carotid endarterectomy.
Topics: Aged; Anesthetics, Local; Constriction, Pathologic; Electroencephalography; Endarterectomy, Carotid; | 2013 |
Lidocaine-induced seizures in patients with history of epilepsy: effect of antiepileptic drugs.
Topics: Adult; Anesthetics, Local; Anticonvulsants; Diabetes Complications; Electroencephalography; Epilepsi | 2002 |
Effect of transient hippocampal inhibition on amygdaloid kindled seizures and amygdaloid kindling rate.
Topics: Amygdala; Animals; Hippocampus; Kindling, Neurologic; Lidocaine; Male; Rats; Rats, Sprague-Dawley; S | 2002 |
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Brain; Brain Chemistry; Citalopram; Cocai | 2003 |
Up-regulation of GABA(B) receptor mRNA and protein in the hippocampus of cocaine- and lidocaine-kindled rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Cocaine; Dose-Response Relationship, Drug; Hippocampus | 2003 |
Lidocaine administration, seizures, and causality.
Topics: Adult; Anesthetics, Local; Anticonvulsants; Epilepsy; Female; Humans; Lidocaine; Seizures | 2003 |
Lignocaine neurotoxicity following fibre-optic bronchoscopy.
Topics: Aged; Anesthetics, Local; Bronchoscopy; Fiber Optic Technology; Humans; Lidocaine; Male; Seizures | 2003 |
Lignocaine neurotoxicity.
Topics: Anesthetics, Local; Bronchoscopy; Lidocaine; Seizures | 2003 |
Convulsions following pudendal block by lignocaine.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Conduction; Anesthetics; Anesthetics, L | 1955 |
The difference in action on normal and convulsive cortical activity between a local anaesthetic (lidocaine) and barbiturates.
Topics: Anesthesia, Local; Anesthetics, Local; Barbiturates; Lidocaine; Pentobarbital; Phenobarbital; Seizur | 1956 |
Effect of lidocaine (xylocaine) on seizure and interseizure electroencephalograms in epileptics.
Topics: Electroencephalography; Epilepsy; Humans; Lidocaine; Seizures | 1959 |
[Toxic effects of xylocaine].
Topics: Humans; Lidocaine; Seizures | 1960 |
Experimental studies of the therapeutic action of electroconvulsive therapy in endogenous depression. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
Topics: Convulsive Therapy; Depression; Depressive Disorder; Electric Stimulation; Electroconvulsive Therapy | 1960 |
Seizure characteristics and therapeutic efficiency in electroconvulsive therapy: an analysis of the antidepressive efficiency of grand mal and lidocaine-modified seizures.
Topics: Antidepressive Agents; Electroconvulsive Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Lidocain | 1962 |
[The comparative anticonvulsive properties of trimecaine and xylocaine].
Topics: Anesthetics; Anesthetics, Local; Lidocaine; Seizures; Trimecaine | 1962 |
THE EFFECT OF XYLOCAINE UPON THE BURSTS OF PAROXYSMAL ACTIVITY IN THE E.E.G. OF EPILEPTICS.
Topics: Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Lidocaine; Phar | 1964 |
FATAL REACTIONS TO LIGNOCAINE.
Topics: Humans; Lidocaine; Positive-Pressure Respiration; Seizures; Succinylcholine; Thiopental; Toxicology | 1964 |
MEDICAL EMERGENCIES IN THE X-RAY DEPARTMENT PREVENTION AND TREATMENT.
Topics: Anesthesia; Anesthetics; Anesthetics, Local; Angioedema; Barium Sulfate; Contrast Media; Drug Hypers | 1964 |
FATAL CEREBRAL ANOXIA FOLLOWING THE USE OF LIGNOCAINE SPRAY FOR BRONCHOSCOPY. A CASE REPORT.
Topics: Anesthesia; Anesthesiology; Bronchoscopy; Child; Humans; Hypoxia, Brain; Iatrogenic Disease; Lidocai | 1965 |
THE RELATION BETWEEN ACUTE TOXICITY AND CRITICAL RATE OF DISPOSAL OF SEVERAL LOCAL ANESTHETICS.
Topics: Anesthetics; Anesthetics, Local; Blood; Lidocaine; Metabolism; Procaine; Propoxycaine; Rabbits; Rese | 1965 |
THE ACTION OF PRONETHALOL ON SPINAL REFLEXES.
Topics: Anesthetics; Anesthetics, Local; Blood Pressure; Electrophysiology; Electroshock; Ethanolamines; Gui | 1965 |
Experimental studies of electroencephalographic changes following electroconvulsive therapy: the role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
Topics: Convulsive Therapy; Electric Stimulation; Electricity; Electroconvulsive Therapy; Electroencephalogr | 1960 |
Effect of lidocaine and procaine on the electroshock seizure threshold, with a comparison of the effects of phenytoin and phenobarbital.
Topics: Convulsive Therapy; Electroconvulsive Therapy; Electroshock; Humans; Hydantoins; Lidocaine; Phenobar | 1960 |
Effect of lidocaine on the seizure discharge in electroconvulsive therapy.
Topics: Convulsive Therapy; Electroconvulsive Therapy; Humans; Lidocaine; Patient Discharge; Seizures | 1960 |
Experimental studies of memory impairment after electroconvulsive therapy. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge.
Topics: Convulsive Therapy; Electric Stimulation; Electroconvulsive Therapy; Humans; Lidocaine; Memory; Memo | 1960 |
The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.
Topics: Anesthetics, Local; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Gas Anal | 2003 |
Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium Channels; Cats; Cerebral Cortex; Cesium; Che | 2004 |
Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis.
Topics: Anesthetics, Local; Anticonvulsants; Bromazepam; Child, Preschool; Diazepam; Female; Gastroenteritis | 2004 |
Neonatal seizures following lidocaine administration for elective circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Male; | 2004 |
Perinatal hypothyroidism increases the susceptibility to lidocaine-kindling in adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Disease Susceptibility; Female; Hypothyroidism; Kindling, Ne | 2004 |
[Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion].
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous | 2004 |
Convulsions with intraurethral instillation of lignocaine.
Topics: Adult; Anesthetics, Local; Anticonvulsants; Diazepam; Humans; Lidocaine; Male; Rectal Neoplasms; Sei | 2005 |
Effect of fentanyl on lidocaine-induced convulsions in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Injections, Intraperitoneal; Li | 2005 |
Ketamine reduces lidocaine-induced seizures in mice.
Topics: Anesthetics, Local; Animals; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamin | 2005 |
Seizures after a Bier block with clonidine and lidocaine: is clonidine really the culprit?
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Clonidine; Drug Interactions; Humans; Lidoca | 2005 |
Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid | 2005 |
[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female | 2005 |
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Behavior, Animal; Brain Chemistry; Cocain | 2006 |
[Effect of lidocaine and lidocaine with adrenaline on development of cerebral seizures].
Topics: Animals; Brain; Drug Combinations; Electrodes, Implanted; Epinephrine; Lidocaine; Male; Rats; Rats, | 2006 |
Lidocaine-induced altered mental status and seizure after hematoma block.
Topics: Aged, 80 and over; Anesthetics, Local; Female; Fracture Fixation; Hematoma; Humans; Injections, Intr | 2006 |
Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity.
Topics: Animals; Brain; Central Nervous System; Drug Synergism; Epinephrine; Extracellular Fluid; Infusions, | 2006 |
ED treatment of brainstem anesthesia after retrobulbar block.
Topics: Aged; Anesthetics, Local; Brain Stem; Humans; Lidocaine; Male; Nerve Block; Seizures | 2007 |
JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats.
Topics: Anesthetics; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Cell Line; Histamine; Leukocy | 2007 |
The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Antiparasitic Agents; Convulsants; Dose-Response Relat | 2007 |
Generalized seizures following topical lidocaine administration during circumcision: establishing causation.
Topics: Administration, Topical; Anesthetics, Local; Circumcision, Male; Dose-Response Relationship, Drug; D | 2007 |
Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats.
Topics: Amygdala; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Calcium; Cell Count; Cell Size; Diazepam | 2007 |
[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases].
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Apnea; Female; Humans; Infant, Newborn; Lidocaine; Male | 2008 |
[Case of serious lidocaine intoxication].
Topics: Anesthetics, Local; Atropine; Brachial Plexus; Cardiac Pacing, Artificial; Diazepam; Heart Arrest; H | 2008 |
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca | 2008 |
Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anticonvulsants; Brain; Dose-Response Rela | 2008 |
Intravenous toxicity--subjective symptoms and acid-base influences on the toxicity of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Bicarbonates; Carbon Dioxide; Cell Membrane; Dog | 1966 |
Studies on the absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species.
Topics: Anesthetics, Local; Animals; Brain; Carbon Isotopes; Cats; Female; Kidney; Lidocaine; Liver; Lung; M | 1966 |
Effect of carbon dioxide on the cortical seizure threshold to lidocaine.
Topics: Amygdala; Animals; Apnea; Blood Pressure Determination; Brain; Carbon Dioxide; Cats; Cerebral Cortex | 1967 |
Studies on the post-ictal rise in seizure threshold.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane | 1981 |
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Dr | 1983 |
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizure | 1983 |
Cyclic nucleotides in rat brain during lidocaine infusion.
Topics: Animals; Bicuculline; Cerebellar Cortex; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Electroencephalogr | 1984 |
Antiarrhythmic effects of tocainide and lidocaine in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catecholamines; Coronary Disease; Dogs; Heart | 1983 |
[Mechanisms of local anesthetic-induced convulsions. The relation to brain catecholamines].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Dihydroxypheny | 1984 |
Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Dopamine; Droxidopa; Fenclonin | 1981 |
The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine.
Topics: Animals; Bupivacaine; Cardiac Output; Dogs; Electrocardiography; Electroencephalography; Female; Hea | 1984 |
Oral flunitrazepam in the prevention of local anaesthetic-induced convulsions in mice.
Topics: Administration, Oral; Anesthetics, Local; Animals; Bupivacaine; Flunitrazepam; Lidocaine; Male; Mice | 1984 |
Metabolic and behavioral consequences of lidocaine-kindled seizures.
Topics: Aggression; Amygdala; Animals; Electroshock; Glucose; Humans; Lidocaine; Limbic System; Male; Pentyl | 1984 |
Bupivacaine-induced cardiac arrhythmias in sheep.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Electrocardiography; Fem | 1984 |
Sinus standstill following accidental lidocaine overdose.
Topics: Aged; Electrocardiography; Female; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Seizures | 1984 |
Lidocaine toxicity following subcutaneous administration.
Topics: Child, Preschool; Diagnosis, Differential; Emergencies; Female; Humans; Injections, Subcutaneous; Li | 1984 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures.
Topics: Amygdala; Animals; Apomorphine; Cocaine; Electric Stimulation; Humans; Lidocaine; Male; Motor Activi | 1981 |
Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine.
Topics: Anesthesia, Local; Gingiva; Humans; Infant; Lidocaine; Male; Seizures; Tooth Eruption | 1983 |
Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration.
Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Cats; Central Nervo | 1983 |
Lidocaine metabolism and toxicity: a laboratory experiment for dental students.
Topics: Anesthesia, Dental; Anesthesiology; Animals; Carbon Tetrachloride; Lidocaine; Liver; Male; Phenobarb | 1980 |
Role of nasal air flow in convulsions induced by lidocaine in the rat.
Topics: Animals; Electrodes, Implanted; Lidocaine; Male; Olfactory Bulb; Pentylenetetrazole; Pulmonary Venti | 1982 |
Prolonged seizures associated with the use of viscous lidocaine.
Topics: Absorption; Administration, Oral; Child, Preschool; Female; Humans; Infant; Lidocaine; Male; Seizure | 1982 |
Localized clonic convulsions after spinal anesthesia with lidocaine and epinephrine.
Topics: Anesthesia, Spinal; Epinephrine; Female; Humans; Hydatidiform Mole; Hysterectomy; Lidocaine; Middle | 1982 |
The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats.
Topics: Animals; Behavior, Animal; Brain; Cats; Dose-Response Relationship, Drug; Electroencephalography; Fe | 1982 |
[Adult respiratory distress syndrome (ARDS) after poisoning by local anesthetics].
Topics: Arrhythmias, Cardiac; Child, Preschool; Dibucaine; Female; Humans; Intracranial Pressure; Lidocaine; | 1982 |
Deaths from local anesthetic-induced convulsions in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Female; Injections, Intr | 1980 |
Benzodiazepines protect mice from local anesthetic convulsions and deaths.
Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female; | 1981 |
Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Cats; Dose-Response Relationship, Drug; El | 1982 |
Cerebral energy state and glycolytic metabolism during lidocaine infusion in the rat.
Topics: Animals; Blood Pressure; Brain; Electroencephalography; Energy Metabolism; Glycolysis; Infusions, Pa | 1981 |
Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia.
Topics: Anesthesia; Animals; Brain Diseases; Cats; Enflurane; Female; Lidocaine; Male; Pentylenetetrazole; S | 1981 |
Effect of cocaine and lidocaine on the expression of kindled seizures in the rat.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cocaine; Electric Stimulation; Lidocaine; Male; Olfactor | 1981 |
Toxicity of lidocaine in adult, newborn, and fetal sheep.
Topics: Animals; Animals, Newborn; Cardiovascular System; Central Nervous System; Female; Fetus; Hypotension | 1981 |
Inadvertent massive lidocaine overdose causing temporary complete heart block in myocardial infarction.
Topics: Adult; Electrocardiography; Electrophysiology; Heart Block; Hemodynamics; Humans; Lidocaine; Male; M | 1981 |
Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol.
Topics: Animals; Behavior, Animal; Cocaine; Electric Stimulation; Kindling, Neurologic; Lidocaine; Male; Olf | 1981 |
Neuropsychiatric sequelae of pharmacotherapy of cardiac arrhythmias and hypertension.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Brain; Drug Interactions; Gua | 1981 |
Lidocaine ingestion.
Topics: Diazepam; Female; Humans; Infant; Lidocaine; Respiratory Insufficiency; Seizures | 1980 |
Toxicity of local anesthetic mixtures.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice | 1980 |
Selective metabolic activation of the hippocampus during lidocaine-induced pre-seizure activity.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Female; | 1981 |
Mixtures of local anesthetics are no more toxic than the parent drugs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice | 1981 |
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.
Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br | 1995 |
Amiodarone interaction with lidocaine.
Topics: Aged; Amiodarone; Drug Interactions; Humans; Infusions, Intravenous; Lidocaine; Male; Seizures | 1993 |
Effect of vasoconstrictive agents added to lidocaine on intravenous lidocaine-induced convulsions in rats.
Topics: Acute Disease; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Dose-Response Relationshi | 1995 |
Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock).
Topics: Animals; Convulsants; Electroshock; Lidocaine; Male; Rats; Rats, Wistar; Regression Analysis; Seizur | 1993 |
Lignocaine-induced convulsion does not induce c-fos protein (c-Fos) in rat hippocampus.
Topics: Animals; Electroencephalography; Hippocampus; Immunohistochemistry; Lidocaine; Male; Proto-Oncogene | 1994 |
Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cocaine; Dopamine | 1993 |
Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat.
Topics: Animals; Electroencephalography; Excitatory Amino Acid Antagonists; Halothane; Lidocaine; Male; Pipe | 1994 |
Propofol prevents or elevates the threshold for lidocaine-induced seizures in rats.
Topics: Animals; Anticonvulsants; Blood Pressure; Dose-Response Relationship, Drug; Electroencephalography; | 1994 |
Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?
Topics: Animals; Circadian Rhythm; Drug Interactions; Flumazenil; Lidocaine; Male; Mice; Seizures | 1993 |
Alterations in t-butylbicyclophosphorothionate binding in the brains of lidocaine-kindled rats.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compou | 1993 |
Convulsion during lignocaine infiltration.
Topics: Anesthesia, Epidural; Female; Humans; Lidocaine; Seizures | 1993 |
Clonidine does not affect lidocaine seizure threshold in rats.
Topics: Animals; Blood Pressure; Carbon Dioxide; Clonidine; Dose-Response Relationship, Drug; Heart Rate; He | 1993 |
Fit with finger block.
Topics: Fingers; Hand; Humans; Lidocaine; Nerve Block; Seizures | 1993 |
Involvement of brain serotonergic function in lidocaine-induced convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electric Stimulation; Lidocaine; Male; Mice; N | 1993 |
Fit with finger block.
Topics: Anxiety; Fingers; Humans; Lidocaine; Nerve Block; Seizures; Syncope | 1993 |
Modification of intravenous lidocaine-induced convulsions by epinephrine in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain Chemistry; Dose-Response Relationship, Drug; Drug Inte | 1993 |
The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat.
Topics: Animals; Anticonvulsants; Blood Pressure; Body Temperature; Brain; Carbon Dioxide; Convulsants; Elec | 1996 |
One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cocaine; Drug Tolerance; Lidocaine; Male; Mice | 1996 |
[Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Lidocain | 1997 |
Cocaine and lidocaine in combination are synergistic convulsants.
Topics: Animals; Cocaine; Drug Synergism; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
The amygdala is critical for seizure propagation from brainstem to forebrain.
Topics: Acoustic Stimulation; Amygdala; Anesthetics, Local; Animals; Brain Stem; Carbon Radioisotopes; Deoxy | 1997 |
Seizures after ureteral stone manipulation with lidocaine.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Seizures; Ureteral Calculi | 1997 |
Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat.
Topics: Anesthetics, Local; Animals; Cocaine; Dextromethorphan; Excitatory Amino Acid Antagonists; Incidence | 1997 |
Lidocaine pharmacokinetics and toxicity in newborn pigs.
Topics: Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Anticonvulsants; Awareness; Brain; Dose- | 1997 |
Prior brain injury protects death from local anaesthetic-induced convulsion.
Topics: Anesthetics, Local; Animals; Brain Injuries; Lidocaine; Male; Mice; Reaction Time; Seizures; Surviva | 1997 |
Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine.
Topics: Animals; Brain Chemistry; Cocaine; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Dr | 1997 |
Re: Seizures after ureteral stone manipulation with lidocaine.
Topics: Anesthetics, Local; Humans; Lidocaine; Seizures; Ureteral Calculi; Urinary Catheterization | 1998 |
Propofol sedation produces dose-dependent suppression of lidocaine-induced seizures in rats.
Topics: Anesthetics, Local; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Heart Rate; Hydrogen- | 1998 |
Routine procedure--bad outcome.
Topics: Aged; Anesthetics, Local; Bradycardia; Brain Diseases; Bronchoscopy; Drug Overdose; Heart Arrest; Hu | 1998 |
Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation.
Topics: Animals; Electric Stimulation Therapy; Electroshock; Female; Hydroxydopamines; Lidocaine; Locus Coer | 1998 |
[Convulsive crisis and methemoglobinemia after the application of anesthetic cream].
Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Eczema; Female; Humans; Lidocaine; Lido | 1998 |
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe | 1999 |
Propofol for lidocaine-induced seizures.
Topics: Anesthetics, Local; Anticonvulsants; Humans; Lidocaine; Propofol; Seizures | 1999 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pent | 1999 |
[Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition].
Topics: Action Potentials; Anesthetics, Local; Animals; Dentate Gyrus; gamma-Aminobutyric Acid; Lidocaine; M | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists | 1999 |
Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain.
Topics: Animals; Brain; Gene Expression Regulation; In Situ Hybridization; Injections, Intraperitoneal; Lido | 1999 |
Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Brain; Drug Synergism; Lidocaine; Mal | 2000 |
Lidocaine toxicity secondary to postoperative bladder instillation in a pediatric patient.
Topics: Administration, Intravesical; Anesthetics; Child, Preschool; Female; Humans; Lidocaine; Postoperativ | 1999 |
A decrease in seizure susceptibility to lidocaine in kindled epileptic rats.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electroencephalography; Kindling, Neurologic; L | 2000 |
CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Central Nervous System; Female; | 2000 |
The role of nitrergic system in lidocaine-induced convulsion in the mouse.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Arginine; Diazepam; Enzyme Inhibitors; Lidocaine; Male | 2001 |
Thyroid hormones modify susceptibility to lidocaine-kindling in rats.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Kindling, Neurologic; Lidocaine; Models, Animal; | 2001 |
Temporary bilateral blindness after acute lidocaine toxicity.
Topics: Acute Disease; Adult; Anesthetics, Local; Blindness; Female; Fractures, Bone; GABA Modulators; Hand | 2002 |
Cardiorespiratory and behavioral reactions to the lidocaine-induced convulsions in the dog.
Topics: Animals; Blood Pressure; Body Temperature; Body Weight; Carbon Dioxide; Dogs; Female; Heart Rate; He | 1977 |
[Fenfluramin (ponderax) intoxications in children (author's transl)].
Topics: Adolescent; Adrenergic beta-Antagonists; Anticonvulsants; Child, Preschool; Chlorpromazine; Coma; El | 1978 |
Death after paracervical block.
Topics: Abortion, Induced; Cervix Uteri; Female; Humans; Lidocaine; Nerve Block; Pregnancy; Respiratory Insu | 1977 |
Interaction between local anesthetics and analeptic drugs.
Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai | 1975 |
Central nervous system effects of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides; | 1975 |
Effects of acute and chronic administration of methylphenidate on lidocaine convulsions in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Lidocaine; Male; Methylphenidate; Mice | 1978 |
Central-nervous-system toxicity of local anesthetic mixtures in monkeys.
Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Brain; Drug Co | 1977 |
Potentiation of lidocaine toxicity by pentobarbital in the dog.
Topics: Animals; Blood Pressure; Dogs; Drug Synergism; Electrocardiography; Female; Lidocaine; Male; Pentoba | 1979 |
The effects of lidocaine on hyperoxic seizure activity in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperbaric Oxygenation; L | 1978 |
Intravenous lidocaine in the treatment of convulsions.
Topics: Adolescent; Adult; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Seizures | 1978 |
Sympathetic nervous system response to lidocaine induced seizures in cats.
Topics: Animals; Blood Pressure; Cats; Electroencephalography; Ganglia, Autonomic; Injections, Intravenous; | 1978 |
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Dise | 1975 |
Diazepam in the prophylaxis of lignocaine seizures.
Topics: Acid-Base Equilibrium; Animals; Behavior, Animal; Carbon Dioxide; Diazepam; Haplorhini; Lidocaine; M | 1976 |
[Personal experience with retrograde intravenous loco-regional anesthesia].
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Body Image; Extremities; Humans; Lidocaine; Percept | 1977 |
Local anesthetic convulsions in cats with limbic brain seizure foci.
Topics: Amygdala; Animals; Cats; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; El | 1977 |
Tricyclic antidepressive poisoning with special reference to cardiac complications.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; Child, Presc | 1975 |
Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.
Topics: Acetanilides; Acid-Base Equilibrium; Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Anima | 1975 |
Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
Topics: Administration, Oral; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; I | 1975 |
Diazepam prophylaxis for lignocaine induced convulsions.
Topics: Animals; Diazepam; Gait; Injections, Intraperitoneal; Lidocaine; Phenobarbital; Rats; Seizures; Wake | 1975 |
Progressive behavioral changes during chronic lidocaine administration: relationship to kindling.
Topics: Animals; Coprophagia; Feeding Behavior; Humans; Lidocaine; Limbic System; Male; Rats; Seizures; Time | 1975 |
Gestational differences in lidocaine toxicity in the fetal lamb.
Topics: Animals; Blood Pressure; Cerebellar Cortex; Female; Femoral Artery; Fetal Diseases; Fetus; Gestation | 1976 |
Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats.
Topics: Animals; Anticonvulsants; Bicarbonates; Blood Pressure; Carbon Dioxide; Convulsants; Diazepam; Dose- | 1992 |
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic | 1992 |
Rapid onset of seizures following aspiration of viscous lidocaine.
Topics: Drainage, Postural; Extracorporeal Membrane Oxygenation; Female; Humans; Inappropriate ADH Syndrome; | 1992 |
Fit with finger block.
Topics: Adult; Fingers; Humans; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Seizures | 1992 |
Lidocaine for treatment of severe seizures in newborn infants. II. Blood concentrations of lidocaine and metabolites during intravenous infusion.
Topics: Electroencephalography; Humans; Infant, Newborn; Infusions, Intravenous; Lidocaine; Seizures | 1992 |
Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat.
Topics: Animals; Brain; Female; Hemodynamics; Infusions, Intravenous; Lidocaine; Male; Pregnancy; Rats; Rats | 1992 |
The dosage of dilute lignocaine for the infiltration technique of local analgesia.
Topics: Adult; Anesthesia, Local; Drug Administration Schedule; Epinephrine; Humans; Injections, Intra-Arter | 1991 |
Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions.
Topics: Animals; Brain Chemistry; Catecholamines; Lidocaine; Male; Mice; Mice, Inbred Strains; Neurons; Pent | 1991 |
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Topics: Aminooxyacetic Acid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyr | 1991 |
Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; | 1991 |
Lidocaine potentiation of cocaine toxicity.
Topics: Animals; Cocaine; Drug Synergism; Lidocaine; Male; Rats; Rats, Inbred Strains; Seizures | 1991 |
Pregnancy does not alter lidocaine toxicity.
Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn | 1990 |
Does inhibition of K+ transport in glial cells by local anaesthetics contribute to seizures?
Topics: Anesthetics, Local; Animals; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Globus P | 1990 |
Accidental lidocaine overdosage in an infant.
Topics: Drug Overdose; Hemodynamics; Humans; Infant, Newborn; Injections, Intravenous; Lidocaine; Male; Medi | 1990 |
Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels.
Topics: Diazepam; Humans; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Lidocaine; Seizures | 1990 |
Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog.
Topics: Amides; Animals; Arrhythmias, Cardiac; Bupivacaine; Carbon Dioxide; Dogs; Dose-Response Relationship | 1989 |
Differential sensitivity of long-sleep and short-sleep mice to high doses of cocaine.
Topics: Animals; Body Temperature; Cocaine; Dopamine; Dose-Response Relationship, Drug; Female; Heart Rate; | 1989 |
Effect of cocaine and lidocaine on the development of kindled seizures.
Topics: Animals; Cocaine; Electric Stimulation; Kindling, Neurologic; Lidocaine; Male; Rats; Seizures | 1989 |
Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats.
Topics: Animals; Drug Interactions; Epinephrine; Injections, Intraperitoneal; Injections, Intravenous; Lidoc | 1989 |
[Total spinal anesthesia complicating peridural anesthesia].
Topics: Anesthesia, Epidural; Anesthesia, Spinal; Coma; Humans; Lidocaine; Male; Middle Aged; Seizures; Spee | 1989 |
Combined application of propranolol and local anesthetics: enhanced anticonvulsant action.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Lidocaine; | 1989 |
Emergency management of seizures: an overview.
Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epileptic | 1989 |
Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep.
Topics: Amides; Anesthetics, Local; Animals; Brain; Bupivacaine; Cause of Death; Hemodynamics; Infusions, In | 1989 |
Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep.
Topics: Acid-Base Equilibrium; Amides; Anesthetics, Local; Animals; Bupivacaine; Hemodynamics; Injections, I | 1989 |
Lidocaine treatment of neonatal convulsions, a therapeutic dilemma.
Topics: Female; Half-Life; Humans; Infant, Newborn; Infusions, Parenteral; Lidocaine; Male; Seizures; Status | 1989 |
Seizure-like reaction associated with subcutaneous lidocaine injection.
Topics: Aged; Female; Humans; Injections, Subcutaneous; Lidocaine; Seizures | 1989 |
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol | 1988 |
Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats.
Topics: Anesthesia, Inhalation; Animals; Atracurium; Cats; Electroencephalography; Halothane; Lidocaine; Pan | 1988 |
Safety of "topical" lignocaine.
Topics: Administration, Rectal; Humans; Infant; Lidocaine; Seizures | 1988 |
Anticonvulsive and convulsive effects of lidocaine: comparison with those of phenytoin, and implications for mechanism of action concepts.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Lidocaine; Male; Mice; Mice | 1988 |
A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity?
Topics: Aged; Drug Synergism; Drug Therapy, Combination; Humans; Lidocaine; Male; Seizures; Substance Withdr | 1986 |
Effect on the seizure threshold in dogs of tocainide/lidocaine administration.
Topics: Animals; Dogs; Drug Interactions; Female; Lidocaine; Seizures; Tocainide | 1987 |
Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation.
Topics: Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Mice; Pentylenetetrazole; Seizures; Sleep | 1988 |
Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Etidocaine; Lidocaine; Male; Mepivacaine; Seizures | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Ne | 1988 |
Complete maternal and fetal recovery after prolonged cardiac arrest.
Topics: Adult; Female; Heart Arrest; Humans; Infant, Newborn; Lidocaine; Medication Errors; Pregnancy; Pregn | 1988 |
Seizures secondary to oral viscous lidocaine.
Topics: Administration, Oral; Female; Humans; Infant; Lidocaine; Male; Seizures; Stomatitis, Herpetic; Tooth | 1988 |
Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study.
Topics: Animals; Calcium; Electron Probe Microanalysis; Female; Hippocampus; Histocytochemistry; Lidocaine; | 1987 |
Seizures after intraurethral instillation of lidocaine.
Topics: Administration, Topical; Aged; Aged, 80 and over; Cystoscopy; Humans; Lidocaine; Male; Petrolatum; S | 1987 |
The influence of a right-to-left cardiac shunt on lidocaine pharmacokinetics.
Topics: Animals; Heart Septal Defects; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Seizures; | 1987 |
Systemic absorption of intraurethral lidocaine.
Topics: Absorption; Aged; Humans; Lidocaine; Male; Seizures | 1987 |
Intravenous lidocaine overdosage in a child.
Topics: Child; Dopamine; Glucagon; Half-Life; Humans; Hypotension; Isoproterenol; Kinetics; Lidocaine; Liver | 1986 |
Local cerebral blood flow during lidocaine-induced seizures in rats.
Topics: Animals; Basal Metabolism; Cerebrovascular Circulation; Electroencephalography; Female; Lidocaine; R | 1986 |
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.
Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Inte | 1986 |
Lidocaine depresses synaptic activity in the rat hippocampal slice.
Topics: Animals; Depression, Chemical; Hippocampus; In Vitro Techniques; Lidocaine; Male; Rats; Rats, Inbred | 1986 |
Seizures following oral lidocaine for esophageal anesthesia.
Topics: Aged; Anesthesia, Local; Esophagus; Humans; Lidocaine; Male; Middle Aged; Seizures | 1985 |
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol; | 1985 |
Bupivacaine toxicity in pregnant and nonpregnant ewes.
Topics: Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Female; Fetus; H | 1985 |
Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Bupivacaine; Cats; Electrocardiography; Electroence | 1985 |
Comment: Lidocaine seizures.
Topics: Humans; Lidocaine; Risk; Seizures | 1985 |
Effect of cocaine and pentylenetetrazol on cortical kindling.
Topics: Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Infusions, Parenteral; Kindling, Neurologic | 1985 |
Lidocaine (Xylocaine) as an anti-arrhythmic agent.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Hea | 1971 |
Drug-induced convulsions. Report from Boston Collaborative Drug Surveillance Program.
Topics: Chlorpromazine; Ephedrine; Female; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Is | 1972 |
Lidocaine as an antiarrhythmic Experience in 68 patients.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Card | 1969 |
Diazepam prevents and aborts lidocaine convulsions in monkeys.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Injections, | 1974 |
Electrographic and behavioral study of convulsants in the cat.
Topics: 4-Aminobenzoic Acid; Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Brain; Cats; Electroen | 1969 |
Lack of depression of the cortical neurons activity by topical anesthetics in the rabbit.
Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Animals; Cerebral Cortex; Cortical Spreading Depression; Di | 1969 |
Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fen | 1974 |
Cooperative study on cardiac catheterization. Complications involving the nervous system.
Topics: Adolescent; Adult; Angiocardiography; Cardiac Catheterization; Central Nervous System Diseases; Chil | 1968 |
Central actions of lidocaine--synaptic transmission.
Topics: Action Potentials; Anesthesia, Endotracheal; Animals; Blood Pressure; Cats; Halothane; Injections, I | 1969 |
Local anesthetic seizures.
Topics: Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Brain; Cats; Lidocaine; Reflex, Monosynapti | 1969 |
Effects of diphenylaminoethanol and lidocaine on central inhibition.
Topics: Action Potentials; Amino Alcohols; Animals; Cats; Central Nervous System; Cerebellum; Decerebrate St | 1969 |
Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.
Topics: Amino Alcohols; Animals; Atropine; Bradycardia; Central Nervous System; Drug Synergism; Ethers; Hear | 1966 |
Experimental epilepsy and blood-brain barrier.
Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Cerebral Cortex | 1967 |
[A severe complication of stellatum blockade].
Topics: Autonomic Nerve Block; Ganglionic Blockers; Humans; Lidocaine; Male; Middle Aged; Procaine; Seizures | 1969 |
Diazepam blocks cerebral metabolic and circulatory responses to local anesthetic-induced seizures.
Topics: Anesthesia, Local; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Elec | 1974 |
Plasma levels of lidocaine during combined treatment with phenytoin and procainamide.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Pressu | 1974 |
Local anesthesia and experimental epilepsy.
Topics: Animals; Benzocaine; Cats; Disease Models, Animal; Female; Lidocaine; Male; Procaine; Seizures; Time | 1974 |
5-Hydroxytryptophan intensifies local anesthetic-induced convulsions.
Topics: 5-Hydroxytryptophan; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Drug Synergism | 1974 |
Dental care of epileptics.
Topics: Anesthesia, Dental; Dental Caries; Dentistry; Dentures; Epilepsy; Gingival Hyperplasia; Humans; Hyda | 1972 |
Diazepam treatment of local anesthetic-induced seizures.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Bupivacaine; Diazepam; Dose-Response Relationship, | 1972 |
Bupivacaine and lignocaine induced seizures in rhesus monkeys.
Topics: Animals; Behavior, Animal; Blood; Bupivacaine; Carbon Dioxide; Consciousness; Electroencephalography | 1972 |
Elevation of lidocaine seizure threshold by gallamine in rhesus monkeys.
Topics: Animals; Blood Gas Analysis; Brain; Dose-Response Relationship, Drug; Electroencephalography; Gallam | 1973 |
[Complications of local anesthesia using lignocaine].
Topics: Adult; Anesthesia, Local; Central Nervous System Diseases; Child; Coma; Developing Countries; Female | 1972 |
Site of action of diazepam in the prevention of lidocaine induced seizure activity in cats.
Topics: Amygdala; Animals; Brain; Cats; Caudate Nucleus; Diazepam; Hippocampus; Lidocaine; Limbic System; Me | 1973 |
Comparison of methyllidocaine and lidocaine on arrhythmias produced by coronary occlusion in the dog.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brain; Coronary Disease; | 1973 |
The convulsant potency of lidocaine and its N-dealkylated metabolites.
Topics: Acetanilides; Amines; Animals; Behavior, Animal; Dealkylation; Dose-Response Relationship, Drug; Dru | 1973 |
The prevention of ethanol withdrawal seizures in mice by lidocaine.
Topics: Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hum | 1973 |
[Anticonvulsive effect of clonazepam and Ro 8-4192 on penicillin and lidocaine induced convulsions].
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Benzazepines; Cerebral Cortex; Electroencepha | 1973 |
Diazepam and lidocaine-induced cardiovascular changes.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Diazepam; Drug Interactions; Electrocardiograph | 1973 |
Side effects of water-soluble contrast media in lumbar myelography.
Topics: Anesthesia, Spinal; Diazepam; Female; Headache; Humans; Hyperesthesia; Hypotension; Iothalamic Acid; | 1973 |
Convulsions induced by local anaesthetic: time course of diazepam prophylaxis.
Topics: Anesthesia, Intravenous; Anesthesia, Local; Animals; Cats; Diazepam; Dose-Response Relationship, Dru | 1974 |
The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Specimen Collection; Brain; Carbon Dioxide; Cere | 1974 |
A "neutral" local anesthetic for reasearch in experimental epilepsy.
Topics: Anesthetics, Local; Animals; Benzocaine; Cats; Cerebral Cortex; Electric Stimulation; Evoked Potenti | 1974 |
The effect of local anaesthetics on the central circulation and respiration in man and dog.
Topics: Anesthetics, Local; Animals; Blood Circulation; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs | 1968 |
Diazepam prevents local anesthetic seizures.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Circulation; Brain; Cats; Diazepam; Electroence | 1971 |
The effects of intravenous lidocaine on optic evoked potentials in light and darkness.
Topics: Anesthesia; Animals; Barbiturates; Blood Pressure; Cats; Darkness; Electric Stimulation; Electrocard | 1971 |
Electrical seizure activity produced by Xylocaine and Citanest.
Topics: Anesthetics, Local; Animals; Dogs; Electric Stimulation; Electroencephalography; Hippocampus; Lidoca | 1965 |
Acid-base changes during lidocaine induced seizures in Macaca mulatta.
Topics: Acid-Base Equilibrium; Amygdala; Animals; Behavior, Animal; Body Weight; Caudate Nucleus; Electroenc | 1969 |
Local anesthetic seizure prevention: diazepam versus pentobarbital.
Topics: Anesthesia, Local; Animals; Arousal; Cats; Central Nervous System; Diazepam; Electroencephalography; | 1972 |
Nitrous oxide elevates local anesthetic seizure threshold.
Topics: Anesthetics, Local; Animals; Cats; Electrodes, Implanted; Electroencephalography; Injections, Intrav | 1972 |
[Comparison of 2 modern antiarrhythmic drugs: lidocaine and diphenylhydantoin].
Topics: Arrhythmias, Cardiac; Brain; Chronic Disease; Hemodynamics; Humans; Hypotension; Lidocaine; Necrosis | 1972 |
Effects of nitrous oxide on the lidocaine seizure threshold and diazepam protection.
Topics: Anesthesia, Local; Animals; Cats; Diazepam; Drug Interactions; Electroencephalography; Lidocaine; Ni | 1972 |
The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.
Topics: Acetanilides; Administration, Oral; Animals; Arrhythmias, Cardiac; Blood Pressure; Chloroform; Dogs; | 1971 |
[Anticonvulsants. 5. Treatment of convulsions in the neonatal period].
Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Phe | 1971 |
Effectiveness of various doses of premedicating drugs used for dental procedures in altering toxicity of procaine and lidocaine.
Topics: Dental Care; Drug Synergism; Lidocaine; Meperidine; Preanesthetic Medication; Procaine; Promethazine | 1971 |
Safety and usefulness of intravenous regional anaesthesia.
Topics: Anemia, Sickle Cell; Anesthesia, Conduction; Anesthesia, Intravenous; Child; Child, Preschool; Diabe | 1969 |
Teething troubles.
Topics: Diarrhea, Infantile; Female; Fever; Humans; Infant; Lidocaine; Male; Seizures; Tooth Eruption | 1970 |
Cortical blindness following convulsions and fever in Nigerian children.
Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor | 1970 |
[Drugs and children. 1. Treatment of seizures in children].
Topics: Adolescent; Barbiturates; Child; Child, Preschool; Chloral Hydrate; Diazepam; Electroencephalography | 1970 |
The antagonism of local anesthetic induced convulsions by the benzodiazepine derivative diazepam.
Topics: Animals; Cats; Diazepam; Drug Antagonism; Electroencephalography; Electromyography; Female; Lidocain | 1970 |
The effects of inhalation anaesthetic agents on convulsant (LD-50) doses of local anaesthetics in the rat.
Topics: Anesthesia, Inhalation; Anesthetics, Local; Animals; Cardiovascular System; Drug Antagonism; Drug Sy | 1970 |
Rare complication during stellate ganglion block: a case report.
Topics: Adult; Anesthesia, Intravenous; Anesthesia, Local; Central Nervous System; Female; Humans; Injection | 1970 |
Influence of some antiarrhythmic agents on electrically induced convulsive seizures in rats.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Chloroquine; Electroshock; Female; Lidocaine; Male | 1970 |
The effect of central nervous system depressants on the tolerance to local anesthetic solutions.
Topics: Anesthetics, Local; Animals; Barbiturates; Chlorpromazine; Drug Synergism; Lidocaine; Male; Meperidi | 1971 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocai | 1971 |
[Use of lidocaine in an unusual case of ventricular fibrillation].
Topics: Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Female; Humans; Lidocaine; Middle Aged; | 1971 |
[203. The dangers of local anesthesia].
Topics: Adult; Anesthetics, Local; Epinephrine; Female; Heart Arrest; Humans; Infant; Lidocaine; Male; Mepiv | 1967 |
[Stellate block. A case with a rare complication].
Topics: Autonomic Nerve Block; Barbiturates; Diazepam; Humans; Lidocaine; Male; Middle Aged; Seizures; Stell | 1967 |
Convulsive properties of the anilide-derived local anesthetic drugs.
Topics: Animals; Epinephrine; Lidocaine; Mepivacaine; Prilocaine; Rats; Seizures | 1968 |
EEG evaluation of lidocaine convulsions.
Topics: Electroencephalography; Humans; Lidocaine; Seizures; Tachycardia | 1968 |
[Studies on the central action, and use as an epidural anesthetic, of a new local anesthetic, 2'-methyl-2-methyl-2-n-propylaminopropionanilide (LA-012)].
Topics: Anesthesia, Spinal; Anesthetics, Local; Anilides; Animals; Arousal; Central Nervous System; Electric | 1968 |
Lidocaine vs parabens as convulsants.
Topics: Humans; Lidocaine; Parabens; Respiratory Insufficiency; Seizures | 1968 |
Single-injection caudal anesthesia in obstetrics.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Female; Fetus; Humans; Infant, Newborn; Lidocaine; | 1969 |
The use of local anesthetic agents in obstetrics.
Topics: Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Delivery, Obstetric; Female; | 1969 |
Xylocaine induced protection against electrically induced convulsions in mice.
Topics: Animals; Electroconvulsive Therapy; Lidocaine; Mice; Seizures | 1965 |
Convulsive properties of four local anesthetic preparations.
Topics: Aminobenzoates; Anesthetics, Local; Animals; Benzoates; Epinephrine; Female; Lidocaine; Male; Pentyl | 1966 |
[Apropos of a case of convulsions after local anesthesia].
Topics: Anesthesia, Local; Humans; Lidocaine; Seizures | 1966 |
[Incidents and accidents related to the intravenous use of xylocaine for the purpose of general anesthesia, and the method of their prevention and treatment].
Topics: Anesthesia, General; Anesthesia, Intravenous; Humans; Hypotension; Lidocaine; Respiratory Insufficie | 1966 |