Page last updated: 2024-10-28

lidocaine and Retinal Diseases

lidocaine has been researched along with Retinal Diseases in 18 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Retinal Diseases: Diseases involving the RETINA.

Research Excerpts

ExcerptRelevanceReference
"Posterior vitrectomy using topical anesthesia (4% lidocaine drops) was performed prospectively in 134 eyes (134 patients) with various vitreoretinal diseases, including severe proliferative diabetic retinopathy (n = 69), vitreous hemorrhage (n = 12), rhegmatogenous retinal detachments (n = 11), epiretinal membranes (n = 10), macular holes (n = 7), dislocated crystalline lens or intraocular lens (n = 6), giant retinal tears (n = 5), intraocular foreign bodies (n = 3), trauma (n = 3), endophthalmitis (n = 3), subfoveal choroidal neovascular membrane (n = 3), and neovascular glaucoma (n = 2)."5.09Topical anesthesia in posterior vitrectomy. ( Arevalo, JF; Cedeño de Yepez, J; Yepez, J, 2000)
"A Purtscher-like retinopathy occurred in a 41-year-old woman who underwent the excision of a pterygium after a retrobulbar injection of 3 ml of lidocaine HCl."3.68Purtscher-like retinopathy after retrobulbar anesthesia. ( Lemagne, JM; Michiels, X; Snyers, B; Van Causenbroeck, S, 1990)
"The efficacy of anaesthesia, degree of postoperative pain and intraoperative and postoperative complications were recorded."2.84A prospective, randomised, double-masked comparison of local anaesthetic agents for vitrectomy. ( Tong, Y; Wang, YX; Wang, ZY; Zhao, PQ; Zhou, YL, 2017)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's4 (22.22)18.2507
2000's7 (38.89)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Narendran, S1
Saravanan, VR1
Pereira, M1
Zhou, YL1
Tong, Y1
Wang, YX1
Zhao, PQ1
Wang, ZY1
Cho, HK1
Jee, D1
Lee, WK1
Shin, CH1
Ryu, JW1
Tasi, WC1
Petersen-Jones, SM1
Huang, PY1
Lin, CT1
Sanabria, MR1
Montero, JA1
Losada, MV1
Fernández-Muñoz, M1
Galindo, A1
Fernández, I1
Coco, RM1
Sampedro, A1
Calenda, E1
Quintyn, JC1
Brasseur, G1
Doat, M1
Pierre-Kahn, V1
Bejjani, RA1
Bourges, JL1
Renard, G1
Chauvaud, D1
Theocharis, IP1
Alexandridou, A1
Tomic, Z1
Klein, ML1
Jampol, LM1
Condon, PI1
Rice, TA1
Serjeant, GR1
Benedetti, S1
Agostini, A1
Blodi, BA1
Williams, CA1
Kwok, AK2
Van Newkirk, MR1
Lam, DS2
Fan, DS1
Li, HK1
Abouleish, A1
Grady, J1
Groeschel, W1
Gill, KS1
Yepez, J1
Cedeño de Yepez, J1
Arevalo, JF1
Young, AL1
Sharma, T1
Gopal, L1
Shanmugam, MP1
Bhende, P1
George, J1
Samanta, TK1
Mukesh, BN1
Lemagne, JM1
Michiels, X1
Van Causenbroeck, S1
Snyers, B1
Babel, J1
Korol, S1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomised, Single-masked Comparison of Topical Anesthesia and Topical Combined Subconjunctival (Two-step) Anesthesia in Intravitreal Injection[NCT03871062]60 participants (Anticipated)Interventional2019-03-08Recruiting
Influence of SPI-guided Analgesia With Preventive Different Peribulbar Blocks (PBB) on the Presence of OCR, Postoperative Pain, PONV in Patients Undergoing VRS Under General Anaesthesia: a Randomised, Controlled Trial[NCT03413371]175 participants (Anticipated)Interventional2018-04-26Recruiting
Influence of Surgical Pleth Index-guided Analgesia Using Different Techniques on the Perioperative Outcomes in Patients Undergoing Vitreoretinal Surgery Under General Anaesthesia: Randomised, Controlled Trial[NCT02973581]176 participants (Actual)Interventional2016-02-29Completed
Pain During Pars Plana Vitrectomy Comparing Peribulbar Anesthesia Versus Sub-tenon Injection Plus Topical Jelly Anesthesia[NCT03902925]Phase 1/Phase 256 participants (Actual)Interventional2019-01-01Completed
A Randomized Trial of Buffered vs Nonbuffered Lidocaine With Epinephrine for Cervical Loop Excision[NCT01405768]Phase 256 participants (Actual)Interventional2011-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Injection Pain Score (Mean)

"A Likert visual analog scale will be used to document each study participant's level of pain experienced during injection of the cervical block.~Within 30 minutes of completion of the procedure and after instruction by the investigators, women reported the intensity of their pain by marking single lines across 100-mm Likert visual analog scales. Scales did not include hashmarks or internal descriptors, as these have been shown to bias responses and diminish reliability.~Patient marks on 100-mm Likert scale lines were measured, and a score was determined by the length marked off in millimeters. Patients who wrote no pain were considered to have marked 0 mm." (NCT01405768)
Timeframe: Within 30 minutes of completion of procedure

Interventionunits on a scale (Mean)
Lidocaine Arm25
Buffered Lidocaine19

Injection Pain Score (Median)

"A Likert visual analog scale will be used to document each study participant's level of pain experienced during injection of the cervical block.~Within 30 minutes of completion of the procedure and after instruction by the investigators, women reported the intensity of their pain by marking single lines across 100-mm Likert visual analog scales. Scales did not include hashmarks or internal descriptors, as these have been shown to bias responses and diminish reliability.~Patient marks on 100-mm Likert scale lines were measured, and a score was determined by the length marked off in millimeters. Patients who wrote no pain were considered to have marked 0 mm." (NCT01405768)
Timeframe: Within 30 minutes of completion of the procedure

Interventionunits on a scale (Median)
Lidocaine Arm26
Buffered Lidocaine18

Overall LEEP Procedure Pain Including Procedural Pain and Cramping (Mean)

"A Likert visual analog scale will be used to determine the overall pain experienced by each study participant including injection pain, procedural pain, and cramping.~Within 30 minutes of completion of the procedure and after instruction by the investigators, women reported the intensity of their pain by marking single lines across 100-mm Likert visual analog scales. Scales did not include hashmarks or internal descriptors, as these have been shown to bias responses and diminish reliability.~Patient marks on 100-mm Likert scale lines were measured, and a score was determined by the length marked off in millimeters. Patients who wrote no pain were considered to have marked 0 mm." (NCT01405768)
Timeframe: Within 30 minutes of completion of procedure

,
Interventionunits on a scale (Mean)
Injection painProcedure painCramping pain
Buffered Lidocaine191918
Lidocaine Arm252719

Overall LEEP Procedure Pain Including Procedural Pain and Cramping (Median)

"A Likert visual analog scale will be used to determine the overall pain experienced by each study participant including injection pain, procedural pain, and cramping.~Within 30 minutes of completion of the procedure and after instruction by the investigators, women reported the intensity of their pain by marking single lines across 100-mm Likert visual analog scales. Scales did not include hashmarks or internal descriptors, as these have been shown to bias responses and diminish reliability.~Patient marks on 100-mm Likert scale lines were measured, and a score was determined by the length marked off in millimeters. Patients who wrote no pain were considered to have marked 0 mm." (NCT01405768)
Timeframe: Within 30 minutes of completion of procedure

,
Interventionunits on a scale (Median)
Injection painProcedure painCramping pain
Buffered Lidocaine181314
Lidocaine Arm262519

Reviews

1 review available for lidocaine and Retinal Diseases

ArticleYear
[What retinal structures are investigated using ERG and EOG? Morphological and functional correlation].
    Bulletin de la Societe belge d'ophtalmologie, 1974, Volume: 166, Issue:2

    Topics: Acetates; Animals; Chloroquine; Electrooculography; Electroretinography; Glutamates; Glycine; Iodate

1974

Trials

4 trials available for lidocaine and Retinal Diseases

ArticleYear
A prospective, randomised, double-masked comparison of local anaesthetic agents for vitrectomy.
    The British journal of ophthalmology, 2017, Volume: 101, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amides; Anesthetics, Combined; Anesthetics, Local; Bupiv

2017
Ocular pain after intravitreal injection.
    Current eye research, 2013, Volume: 38, Issue:2

    Topics: Aged; Aged, 80 and over; Anesthetics, Local; Angiogenesis Inhibitors; Anti-Bacterial Agents; Anti-In

2013
Topical anesthesia in posterior vitrectomy.
    Retina (Philadelphia, Pa.), 2000, Volume: 20, Issue:1

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Female; Humans; Injections; Lens Subluxation; Li

2000
Comparison of pH-adjusted bupivacaine with a mixture of non-pH-adjusted bupivacaine and lignocaine in primary vitreoretinal surgery.
    Retina (Philadelphia, Pa.), 2002, Volume: 22, Issue:2

    Topics: Alkalies; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Double-Blind Me

2002

Other Studies

13 other studies available for lidocaine and Retinal Diseases

ArticleYear
Purtscher-like retinopathy: A rare complication of peribulbar anesthesia.
    Indian journal of ophthalmology, 2016, Volume: 64, Issue:6

    Topics: Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Fluorescein Angiography; Fundus Oculi; H

2016
Purtscher-like retinopathy after retrobulbar anaesthesia in a patient with an intracanal mass.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2010, Volume: 45, Issue:5

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Blindness; Cataract Extraction; Evoked Potentials, Vis

2010
The neuroprotective effects of lidocaine and methylprednisolone in a rat model of retinal ischemia-reperfusion injury.
    The Journal of veterinary medical science, 2012, Volume: 74, Issue:3

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Blindness; Electroretinography; Intraocular P

2012
Peribulbar anaesthesia using a combination of lidocaine, bupivocaine and clonidine in vitreoretinal surgery.
    Indian journal of ophthalmology, 2002, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local; Anesthetics, Combined; Anesthetics, L

2002
Peribulbar anaesthesia using a combination of lidocaine, bupivocaine and clonidine in vitreoretinal surgery.
    Indian journal of ophthalmology, 2002, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local; Anesthetics, Combined; Anesthetics, L

2002
Peribulbar anaesthesia using a combination of lidocaine, bupivocaine and clonidine in vitreoretinal surgery.
    Indian journal of ophthalmology, 2002, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local; Anesthetics, Combined; Anesthetics, L

2002
Peribulbar anaesthesia using a combination of lidocaine, bupivocaine and clonidine in vitreoretinal surgery.
    Indian journal of ophthalmology, 2002, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anesthesia, Local; Anesthetics, Combined; Anesthetics, L

2002
[Inadvertent intravitreal lidocaine injection following subcutaneous palpebral anesthesia: retinal toxicity of lidocaine?].
    Journal francais d'ophtalmologie, 2006, Volume: 29, Issue:2

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Eyelids; Humans; Lidocaine; Male; Medication Errors; R

2006
A two-year prospective study comparing lidocaine 2% jelly versus peribulbar anaesthesia for 25G and 23G sutureless vitrectomy.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:9

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Cons

2007
Central retinal artery occlusion without retrobulbar hemorrhage after retrobulbar anesthesia.
    American journal of ophthalmology, 1982, Volume: 93, Issue:5

    Topics: Adult; Anesthesia, Local; Arterial Occlusive Diseases; Eye; Female; Humans; Injections; Lidocaine; L

1982
Peribulbar anesthesia in vitreoretinal surgery.
    Retina (Philadelphia, Pa.), 1994, Volume: 14, Issue:3

    Topics: Aged; Aged, 80 and over; Anesthesia, Local; Bupivacaine; Drug Combinations; Humans; Hyaluronoglucosa

1994
Purtscher-like retinopathy after uncomplicated administration of retrobulbar anesthesia.
    American journal of ophthalmology, 1997, Volume: 124, Issue:5

    Topics: Aged; Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Fluorescein Angiography; Fundus Oc

1997
Sub-Tenon's anesthesia in vitreoretinal surgery: a needleless technique.
    Retina (Philadelphia, Pa.), 1999, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Conn

1999
Sub-Tenon's injection for local anesthesia in posterior segment surgery.
    Ophthalmology, 2000, Volume: 107, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bupiva

2000
Efficacy of lignocaine gel for outpatient laser treatment in inflamed eyes.
    Eye (London, England), 2001, Volume: 15, Issue:Pt 5

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Child; Eye

2001
Purtscher-like retinopathy after retrobulbar anesthesia.
    Ophthalmology, 1990, Volume: 97, Issue:7

    Topics: Anesthesia, Local; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Lidocai

1990