lidocaine has been researched along with Respiration Disorders in 17 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Respiration Disorders: Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perioperative respiratory adverse events (PRAEs) are a major cause of morbidity and mortality associated with pediatric anesthesia." | 2.82 | Site-directed topical lidocaine spray attenuates perioperative respiratory adverse events in children undergoing elective surgery. ( Ai, Y; Chu, Q; He, L; Li, LW; Zhang, W, 2016) |
| "Patients with chronic obstructive pulmonary disease (COPD) often report greater relief of breathlessness with nebulised bronchodilators than with the same medicine administered from a metered dose inhaler (MDI)." | 2.71 | Comparison of the effects of nebulised and inhaled salbutamol on breathlessness in severe COPD. ( Black, PN; Brodie, SM; Poole, PJ; Saini, R, 2005) |
| "Upper gastrointestinal endoscopies (UGEs) performed under ketamine sedation may increase the risk of respiratory adverse events (RAEs) due to pharyngeal stimulation." | 1.51 | Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children. ( Estalella-Mendoza, A; Flores-González, JC; Lechuga-Sancho, AM; Rodríguez-Campoy, P; Saldaña-Valderas, M, 2019) |
| "Episodic airway obstruction and reversible bronchial hyperresponsiveness to non-specific irritants are the major symptoms of asthma." | 1.33 | Bronchial epilepsy or broncho-pulmonary hyper-excitability as a model of asthma pathogenesis. ( Graeme Shaw, D; Hoang, BX; Hoang, C; Levine, SA; Pham, P, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, R | 1 |
| Bao, X | 1 |
| Gao, X | 1 |
| Li, T | 1 |
| Wang, Q | 1 |
| Li, Y | 1 |
| Flores-González, JC | 1 |
| Estalella-Mendoza, A | 1 |
| Rodríguez-Campoy, P | 1 |
| Saldaña-Valderas, M | 1 |
| Lechuga-Sancho, AM | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Li, LW | 1 |
| He, L | 1 |
| Ai, Y | 1 |
| Chu, Q | 1 |
| Zhang, W | 1 |
| Arance, GM | 1 |
| Fernández, JP | 1 |
| Pérez, TM | 1 |
| Varela, LR | 1 |
| Poole, PJ | 1 |
| Saini, R | 1 |
| Brodie, SM | 1 |
| Black, PN | 1 |
| Hoang, BX | 1 |
| Levine, SA | 1 |
| Graeme Shaw, D | 1 |
| Pham, P | 1 |
| Hoang, C | 1 |
| van Donselaar-van der Pant, KA | 1 |
| Buwalda, M | 1 |
| van Leeuwen, HJ | 1 |
| Buffington, CW | 1 |
| Buehler, PK | 1 |
| Glauber, DT | 1 |
| Hornbein, TF | 1 |
| Hamacher, EN | 1 |
| St John, WM | 1 |
| Bledsoe, TA | 1 |
| Sokol, HW | 1 |
| Wilcock, A | 1 |
| Corcoran, R | 1 |
| Tattersfield, AE | 1 |
| Bunting, HE | 1 |
| Kelly, MC | 1 |
| Milligan, KR | 1 |
| Spivey, K | 1 |
| Campbell, D | 1 |
| Forrest, F | 1 |
| Nay, PG | 1 |
| el Harrar, N | 1 |
| Idali, B | 1 |
| el Belhaji, M | 1 |
| el Amraoui, A | 1 |
| Benaguida, M | 1 |
| Caranza, R | 1 |
| Raphael, JH | 1 |
| Nandwani, N | 1 |
| Langton, JA | 1 |
| Rodney, GE | 1 |
| Callander, CC | 1 |
| Harmer, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
5 trials available for lidocaine and Respiration Disorders
| Article | Year |
|---|---|
The impact of topical lidocaine and timing of LMA removal on the incidence of airway events during the recovery period in children: a randomized controlled trial.
Topics: Administration, Topical; Anesthesia Recovery Period; Child, Preschool; China; Female; Humans; Incide | 2021 |
Site-directed topical lidocaine spray attenuates perioperative respiratory adverse events in children undergoing elective surgery.
Topics: Administration, Topical; Airway Extubation; Anesthesia, General; Anesthetics, Local; Child; Child, P | 2016 |
Comparison of the effects of nebulised and inhaled salbutamol on breathlessness in severe COPD.
Topics: Aged; Aged, 80 and over; Albuterol; Anesthetics, Local; Bronchodilator Agents; Cross-Over Studies; F | 2005 |
Effect of nebulized lignocaine on airway irritation and haemodynamic changes during induction of anaesthesia with desflurane.
Topics: Adult; Anesthesia, Local; Anesthetics, Inhalation; Anesthetics, Local; Cardiovascular Diseases; Desf | 1995 |
Effect of nebulised lignocaine on the quality of induction of anaesthesia in cigarette smokers.
Topics: Administration, Inhalation; Adult; Aged; Anesthesia, General; Anesthetics, Local; Double-Blind Metho | 1997 |
12 other studies available for lidocaine and Respiration Disorders
| Article | Year |
|---|---|
Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children.
Topics: Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Local; Child; Child, Preschool; Conscious | 2019 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
[Loss of consciousness and respiratory depression after a retrobulbar intraorbital block for eye surgery: a case report].
Topics: Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Corneal Transplantation; Humans; Injec | 2009 |
Bronchial epilepsy or broncho-pulmonary hyper-excitability as a model of asthma pathogenesis.
Topics: Airway Obstruction; Asthma; Bronchi; Bronchial Hyperreactivity; Cell Membrane; gamma-Aminobutyric Ac | 2006 |
[Lidocaine: local anaesthetic with systemic toxicity].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Dose-Response Relationship, | 2008 |
A new system of infiltration anesthesia and sedation for plastic surgery.
Topics: Adult; Aged; Anesthesia, Intravenous; Arrhythmias, Cardiac; Blood Pressure; Epinephrine; Female; Hum | 1984 |
Identification of medullary loci critical for neurogenesis of gasping.
Topics: Animals; Brain Stem; Cats; Cold Temperature; Electric Stimulation; Female; Kainic Acid; Lidocaine; M | 1984 |
Safety and efficacy of nebulized lignocaine in patients with cancer and breathlessness.
Topics: Administration, Intranasal; Aged; Female; Humans; Lidocaine; Male; Nebulizers and Vaporizers; Neopla | 1994 |
Nebulised lignocaine: an aid to weaning.
Topics: Administration, Inhalation; Aged; Cough; Female; Humans; Lidocaine; Respiration Disorders; Ventilato | 1994 |
Nebulized lignocaine before gaseous induction with desflurane.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Desflurane; Humans; Isoflurane; Lidocaine; Respiration | 1996 |
[Respiratory arrest after retrobulbar anesthesia. Apropos of 2 cases].
Topics: Aged; Cataract Extraction; Female; Humans; Lidocaine; Middle Aged; Nerve Block; Ophthalmic Nerve; Re | 1996 |
Spondyloepiphyseal dysplasia congenita. Caesarean section under epidural anaesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Blood Pressure; Cesarean Section; Female; Huma | 1991 |