lidocaine and Peripheral Nerve Injury studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the effects of IV lidocaine on spontaneous and evoked pain (allodynia and hyperalgesia) due to peripheral nerve injury (postherpetic neuralgia or nerve trauma) using quantitative sensory testing."	9.11	Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. ( Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J, 2004)
" Eleven patients suffering from neuropathic pain after peripheral nerve injury received both a lidocaine and saline infusion in separate study sessions."	9.08	Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. ( Dyck, BJ; Rossi, SS; Wallace, MS; Yaksh, TL, 1996)
"Systemic lidocaine (3-4 mg/kg) was tested for its effect on identified spinal cord wide-dynamic-range (WDR) neurons in rats with a unilateral chronic neuropathy induced by two different peripheral nerve injuries (section or compression by ligatures)."	7.68	Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats. ( Lacerenza, M; Marchettini, P; Sotgiu, ML, 1992)
"This qualitative review found insufficient, heterogenous evidence and therefore no recommendation can be made for lidocaine infusion treatment in patients with chronic neuropathic pain due to spinal cord injury, peripheral nerve injury, diabetic neuropathy, postherpetic neuralgia, or complex regional pain syndrome type II."	5.22	Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. ( Argoff, CE; Bhullar, RK; Koutalianos, EP; Lee, JH; Leimer, EM, 2022)
" In this study, we evaluated the AMPA/GluR5 receptor antagonist NS1209 for efficacy, safety, and tolerability in comparison with placebo and lidocaine for the treatment of chronic neuropathic pain and allodynia in patients with peripheral nerve injury."	5.14	The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. ( Almqvist, PM; Finnerup, NB; Gormsen, L; Jensen, TS, 2009)
"To investigate the effects of IV lidocaine on spontaneous and evoked pain (allodynia and hyperalgesia) due to peripheral nerve injury (postherpetic neuralgia or nerve trauma) using quantitative sensory testing."	5.11	Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. ( Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J, 2004)
" Eleven patients suffering from neuropathic pain after peripheral nerve injury received both a lidocaine and saline infusion in separate study sessions."	5.08	Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. ( Dyck, BJ; Rossi, SS; Wallace, MS; Yaksh, TL, 1996)
"Systemic lidocaine (3-4 mg/kg) was tested for its effect on identified spinal cord wide-dynamic-range (WDR) neurons in rats with a unilateral chronic neuropathy induced by two different peripheral nerve injuries (section or compression by ligatures)."	3.68	Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats. ( Lacerenza, M; Marchettini, P; Sotgiu, ML, 1992)
"Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain."	1.42	Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. ( Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y, 2015)
"Fourteen patients with neuropathic pain (7 with unilateral foot pain due to peripheral nerve injury and 7 with bilateral pain in the feet due to distal polyneuropathy) underwent comprehensive characterization of somatosensory function by quantitative sensory testing."	1.40	Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. ( Bendtsen, TF; Finnerup, NB; Haroutounian, S; Hasselstrøm, JB; Jensen, TS; Kristensen, AD; Nikolajsen, L, 2014)
"Lidocaine and phenol were injected into the sciatic nerves of the rats in Groups 1 and 2, respectively."	1.32	Free radical-induced damage in experimental peripheral nerve injection injury. ( Apan, A; Kisa, U; Saray, A, 2003)

Research

Studies (21)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

The Cumulative Dose of Oxaliplatin

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (9.52)	18.7374
1990's	3 (14.29)	18.2507
2000's	4 (19.05)	29.6817
2010's	11 (52.38)	24.3611
2020's	1 (4.76)	2.80

Authors	Studies
Lee, JH	1
Koutalianos, EP	1
Leimer, EM	1
Bhullar, RK	1
Argoff, CE	1
Sagalajev, B	1
Wei, H	1
Chen, Z	1
Albayrak, I	1
Koivisto, A	1
Pertovaara, A	1
Cooper, AH	1
Brightwell, JJ	1
Hedden, NS	1
Taylor, BK	2
Conger, A	1
McCormick, ZL	1
Henrie, AM	1
Marvizon, JC	1
Chen, W	1
Fu, W	1
Madsen, CS	1
Johnsen, B	1
Fuglsang-Frederiksen, A	1
Jensen, TS	3
Finnerup, NB	3
Farber, SJ	1
Saheb-Al-Zamani, M	1
Zieske, L	1
Laurido-Soto, O	1
Bery, A	1
Hunter, D	2
Johnson, P	1
Mackinnon, SE	1
Haroutounian, S	1
Nikolajsen, L	1
Bendtsen, TF	1
Kristensen, AD	1
Hasselstrøm, JB	1
Xu, ZZ	1
Kim, YH	1
Bang, S	1
Zhang, Y	1
Berta, T	1
Wang, F	1
Oh, SB	1
Ji, RR	1
Byram, SC	1
Byram, SW	1
Miller, NM	1
Fargo, KN	1
Gormsen, L	1
Almqvist, PM	1
Romanzi, L	1
Eker, HE	1
Cok, OY	1
Aribogan, A	1
Arslan, G	1
Saray, A	1
Apan, A	1
Kisa, U	1
Attal, N	1
Rouaud, J	1
Brasseur, L	1
Chauvin, M	1
Bouhassira, D	1
Lirk, P	1
Haller, I	1
Colvin, HP	1
Frauscher, S	1
Kirchmair, L	1
Gerner, P	1
Klimaschewski, L	1
Gentili, F	1
Hudson, AR	1
Kline, DG	1
Wallace, MS	1
Dyck, BJ	1
Rossi, SS	1
Yaksh, TL	1
Sotgiu, ML	1
Lacerenza, M	1
Marchettini, P	1
Tanelian, DL	1
Brose, WG	1
Omer, GE	1
Thomas, SR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and Hip Osteoarthritis[NCT05490355]		80 participants (Anticipated)	Interventional	2022-12-20	Recruiting
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]		301 participants (Anticipated)	Interventional	2022-11-01	Recruiting
The Significance of Peripheral Input in Patients With Post Surgery Neuropathic Pain: Evaluation of Trigger Point Anesthesia. A Double-blind, Randomized, Controlled Exploratory Study[NCT04764045]		12 participants (Anticipated)	Interventional	2019-11-20	Recruiting
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain : A Pilot Study[NCT02217267]	Phase 3	29 participants (Actual)	Interventional	2014-08-01	Completed
Intravenous Lidocaine for Preventing Painful Oxaliplatin-induced Peripheral Neuropathy (OIPN)[NCT03254394]	Phase 1/Phase 2	26 participants (Actual)	Interventional	2017-09-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The cumulative dose of oxaliplatin received over the course (up to 12 cycles) of mFOLFOX6 treatment regimen. It corresponds to the absolute summed up quantity of Oxaliplatin administered to the patient over time. There is no range for this measure. Since this is a dose-limiting neuropathy prevention study, the higher value can be interpreted as better outcome. (NCT03254394)
Timeframe: 24 weeks

Area Under the Curve (AUC) of Intensity of Oxaliplatin-induced Cold Pain/Unpleasantness vs Time

Intervention	mg (Mean)
Placebo + FOLFOX	1161.8
Lidocaine + FOLFOX	1294.8

"The intensity of cold pain and cold unpleasantness is evaluated separately, assessed daily on a 0-10 scale, upon holding a pre-cooled (~8°C) metal cylinder for 10 seconds. the area under the curve of cold pain and cold unpleasantness vs time is calculated per chemotherapy cycle (every two weeks) and serves as a primary outcome measure.~For intervention (lidocaine+FOLFOX) and control (placebo+FOLFOX) groups, the average of cold pain AUC and cold unpleasantness AUC over 7 cycles was calculated. The average AUCs over 7 cycles were compared between study arms.~The AUC is measured as a score on a 0-10 scale multiplied by 14 days and may range between 0 and 140. Higher AUC values represent more intense cold pain/unpleasantness." (NCT03254394)
Timeframe: 14 weeks

Changes in NPSI Score.

Intervention	score on a scale*days (Mean)
	pain AUC	unpleasantness AUC
Lidocaine + FOLFOX	9.5	25.4
Placebo + FOLFOX	16.4	33.1

Changes in Neuropathic Pain Symptom Inventory (NPSI) descriptors of neuropathic pain over time from baseline to cycle 3(6 weeks), cycle 6 (12 weeks), and the last follow-up (34-36 weeks). The total NPSI score ranges from 0 to 100; a higher NPSI total score represents a worse neuropathy outcome. The changes in scores from baseline are compared between study arms. (NCT03254394)
Timeframe: 6 weeks, 12 weeks, 34-36 weeks

CIPN Score on EORTC QLQ-CIPN20

Intervention	score on a scale (Median)
	6 weeks visit	12 weeks visit	last follow-up visit
Lidocaine + FOLFOX	0	0	13.5
Placebo + FOLFOX	0	0	3.0

"Change in CIPN (Chemotherapy-induced peripheral Neuropathy) score (on EORTC QLQ-CIPN20 tool ) from baseline to the Cycle 6 (12 weeks), and from baseline to last follow-up (34-36 weeks). EORTC QLQ-CIPN20 ranges from 0 (no symptoms) to 100 (worst symptoms). A higher score represents worse neuropathy. The changes in scores are compared between study arms.~EORTC QLQ-CIPN20 tool is a quality of life questionnaire (QLQ) from the European Organization for Research and Treatment of Cancer (EORTC) for evaluation of CIPN." (NCT03254394)
Timeframe: 12 weeks and 34-36 weeks

Article	Year
The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Adult; Aged; Analgesia; Anesthetics, Local; Chronic Disease; Cross-Over Studies; Double-Blind Method	2009
Management of neuropathic pain with methylprednisolone at the site of nerve injury. Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:3 Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Male; Methylprednisolone; Middle	2012
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Pain, 1996, Volume: 66, Issue:1 Topics: Adult; Aged; Computers; Humans; Infusion Pumps; Lidocaine; Middle Aged; Pain; Pain Measurement; Pain	1996

Article	Year
Oxidative Stress in the Amygdala Contributes to Neuropathic Pain. Neuroscience, 2018, 09-01, Volume: 387 Topics: Amygdala; Animals; Carbenoxolone; Conditioning, Psychological; Cyclic N-Oxides; Internal Capsule; Li	2018
The left central nucleus of the amygdala contributes to mechanical allodynia and hyperalgesia following right-sided peripheral nerve injury. Neuroscience letters, 2018, 09-25, Volume: 684 Topics: Anesthetics, Local; Animals; Central Amygdaloid Nucleus; Functional Laterality; Hyperalgesia; Lidoca	2018
Pes Anserine Tendon Injury Resulting from Cooled Radiofrequency Ablation of the Inferior Medial Genicular Nerve. PM & R : the journal of injury, function, and rehabilitation, 2019, Volume: 11, Issue:11 Topics: Aged; Anesthetics, Local; Catheter Ablation; Chronic Pain; Combined Modality Therapy; Female; Follow	2019
Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury. Neuropharmacology, 2019, 11-01, Volume: 158 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium Channel Blockers; Capsaicin; Cyclic	2019
Differential effects of a 5% lidocaine medicated patch in peripheral nerve injury. Muscle & nerve, 2013, Volume: 48, Issue:2 Topics: Adult; Anesthetics, Local; Evoked Potentials; Female; Humans; Hyperalgesia; Lidocaine; Male; Middle	2013
Peripheral nerve injury after local anesthetic injection. Anesthesia and analgesia, 2013, Volume: 117, Issue:3 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Injections; Lidocaine; Male; Microscopy, Electron;	2013
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nature medicine, 2015, Volume: 21, Issue:11 Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; F	2015
Bupivacaine increases the rate of motoneuron death following peripheral nerve injury. Restorative neurology and neuroscience, 2017, Volume: 35, Issue:1 Topics: Animals; Axotomy; Bupivacaine; Cell Death; Disease Models, Animal; Lidocaine; Male; Mice; Mice, Inbr	2017
Techniques of pudendal nerve block. The journal of sexual medicine, 2010, Volume: 7, Issue:5 Topics: Adrenal Cortex Hormones; Anal Canal; Anesthetics, Local; Clitoris; Female; Genitalia, Female; Humans	2010
Free radical-induced damage in experimental peripheral nerve injection injury. Journal of reconstructive microsurgery, 2003, Volume: 19, Issue:6 Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Injury	2003
In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity. Anesthesia and analgesia, 2007, Volume: 105, Issue:6 Topics: Animals; Axons; Caspases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Female; Lidocaine; Neur	2007
Nerve injection injury with local anesthetic agents: a light and electron microscopic, fluorescent microscopic, and horseradish peroxidase study. Neurosurgery, 1980, Volume: 6, Issue:3 Topics: Anesthetics, Local; Animals; Bupivacaine; Evans Blue; Injections; Lidocaine; Mepivacaine; Microscopy	1980
Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats. Somatosensory & motor research, 1992, Volume: 9, Issue:3 Topics: Animals; Evoked Potentials; Functional Laterality; Ganglia, Spinal; Lidocaine; Neural Inhibition; Ne	1992
Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: lidocaine, carbamazepine, and mexiletine. Anesthesiology, 1991, Volume: 74, Issue:5 Topics: Adult; Aged; Carbamazepine; Female; Humans; Lidocaine; Male; Mexiletine; Neuralgia; Peripheral Nerve	1991
The management of chronic pain syndromes in the upper extremity. Clinical orthopaedics and related research, 1974, Issue:104 Topics: Analgesia; Arm; Causalgia; Electric Stimulation Therapy; Female; Humans; Lidocaine; Male; Nerve Bloc	1974

lidocaine and Peripheral Nerve Injury