lidocaine has been researched along with Pancreatitis in 14 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine sprayed on the major papilla does not decrease the frequency of post-ERCP pancreatitis." | 9.11 | The effect of lidocaine sprayed on the major duodenal papilla on the frequency of post-ERCP pancreatitis. ( Ahmad, NA; Brensinger, CM; Ginsberg, GG; Kochman, ML; Lew, RJ; Long, WB; Schwartz, JJ; Shah, JN, 2004) |
| "To evaluate the efficacy of intra-arterial infusion of lidocaine into the celiac trunk in treatment of cerulein-induced acute pancreatitis." | 7.96 | Efficacy of intra-arterial lidocaine infusion in the treatment of cerulein-induced acute pancreatitis. ( Antkowiak, R; Antkowiak, Ł; Arent, Z; Domosławski, P; Grzegorczyn, S; Kabała, N; Nalik-Iwaniak, K; Stęplewska, K; Warmusz-Reichman, E, 2020) |
| " When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed." | 7.69 | Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995) |
| "Lidocaine sprayed on the major papilla does not decrease the frequency of post-ERCP pancreatitis." | 5.11 | The effect of lidocaine sprayed on the major duodenal papilla on the frequency of post-ERCP pancreatitis. ( Ahmad, NA; Brensinger, CM; Ginsberg, GG; Kochman, ML; Lew, RJ; Long, WB; Schwartz, JJ; Shah, JN, 2004) |
| "To evaluate the efficacy of intra-arterial infusion of lidocaine into the celiac trunk in treatment of cerulein-induced acute pancreatitis." | 3.96 | Efficacy of intra-arterial lidocaine infusion in the treatment of cerulein-induced acute pancreatitis. ( Antkowiak, R; Antkowiak, Ł; Arent, Z; Domosławski, P; Grzegorczyn, S; Kabała, N; Nalik-Iwaniak, K; Stęplewska, K; Warmusz-Reichman, E, 2020) |
| "Microinjection of lidocaine into either the NG or the RVM produced a time-related reversal of pancreatitis-induced pain." | 3.73 | Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. ( King, T; Kowal, J; Ossipov, MH; Porreca, F; Vera-Portocarrero, LP; Xie, JY; Yie, JX, 2006) |
| " When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed." | 3.69 | Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995) |
| "Biliary acute pancreatitis or postendoscopic iatrogenia acute pancreatitis (AP) are likely triggered by autonomous arc reflexes (AAR) initiated in the peri-Vaterian duodenum (PV-D)." | 1.32 | Acute pancreatitis possible initial triggering mechanism and prophylaxis. ( Binker, MG; Cosen-Binker, LI; Negri, G; Tiscornia, O, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Antkowiak, R | 1 |
| Antkowiak, Ł | 1 |
| Grzegorczyn, S | 1 |
| Nalik-Iwaniak, K | 1 |
| Kabała, N | 1 |
| Arent, Z | 1 |
| Warmusz-Reichman, E | 1 |
| Stęplewska, K | 1 |
| Domosławski, P | 1 |
| Sun, JJ | 1 |
| Chu, ZJ | 1 |
| Liu, WF | 1 |
| Qi, SF | 1 |
| Yang, YH | 1 |
| Ge, PL | 1 |
| Zhang, XH | 1 |
| Li, WS | 1 |
| Yang, C | 1 |
| Zhang, YM | 1 |
| Cosen-Binker, LI | 1 |
| Binker, MG | 1 |
| Negri, G | 1 |
| Tiscornia, O | 1 |
| Schwartz, JJ | 1 |
| Lew, RJ | 1 |
| Ahmad, NA | 1 |
| Shah, JN | 1 |
| Ginsberg, GG | 1 |
| Kochman, ML | 1 |
| Brensinger, CM | 1 |
| Long, WB | 1 |
| Vera-Portocarrero, LP | 1 |
| Xie, JY | 1 |
| Yie, JX | 1 |
| Kowal, J | 1 |
| Ossipov, MH | 1 |
| King, T | 1 |
| Porreca, F | 1 |
| Parer, C | 1 |
| Rodier, M | 1 |
| Batier, C | 1 |
| Marchal, J | 1 |
| Mirouze, J | 1 |
| Maruszyński, M | 1 |
| Lechnio, L | 1 |
| Portiansky, EL | 1 |
| González, PH | 1 |
| Opacić, M | 1 |
| Rustemović, N | 1 |
| Pulaníc, R | 1 |
| Vucelić, B | 1 |
| Frković, M | 1 |
| Mandić, A | 1 |
| Mäkelä, A | 1 |
| Kuusi, T | 1 |
| Schröder, T | 2 |
| Kinnunen, PK | 1 |
| Lempinen, M | 1 |
| Havlůjová, L | 1 |
| Karger, P | 1 |
| Rubín, A | 1 |
| Tosovský, V | 1 |
| Sedlácková, M | 1 |
| Kamenická, E | 1 |
| Browne, RA | 1 |
| Ashworth, EJ | 1 |
| Kriessmann, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199] | 506 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138] | Phase 4 | 0 participants (Actual) | Interventional | 2023-11-30 | Withdrawn (stopped due to Lack of Funding) | ||
| Effects of High Intra-procedural Oxygen Fraction on Post-ERCP Pancreatitis: A Randomized Clinical Trial[NCT04876768] | 25 participants (Actual) | Interventional | 2021-05-18 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure
| Intervention | participants (Number) |
|---|---|
| Lidocaine | 26 |
| Normal Saline | 20 |
serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP
| Intervention | units/liter (Mean) |
|---|---|
| Lidocaine | 130 |
| Normal Saline | 128 |
2 trials available for lidocaine and Pancreatitis
| Article | Year |
|---|---|
Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis.
Topics: Abdominal Pain; Acute Disease; Adult; Anesthetics, Local; Celiac Plexus; China; Female; Gastrointest | 2013 |
The effect of lidocaine sprayed on the major duodenal papilla on the frequency of post-ERCP pancreatitis.
Topics: Administration, Topical; Ampulla of Vater; Cholangiopancreatography, Endoscopic Retrograde; Cholecys | 2004 |
12 other studies available for lidocaine and Pancreatitis
| Article | Year |
|---|---|
Efficacy of intra-arterial lidocaine infusion in the treatment of cerulein-induced acute pancreatitis.
Topics: Acute Disease; Animals; Ceruletide; Infusions, Intra-Arterial; Lidocaine; Pancreas; Pancreatitis; Ra | 2020 |
Acute pancreatitis possible initial triggering mechanism and prophylaxis.
Topics: Acute Disease; Anesthetics, Local; Animals; Disease Models, Animal; Duodenum; Lidocaine; Male; Pancr | 2003 |
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Drug Interactions; Immunohistochemistry; Injections | 2006 |
[Diagnostic celiac block. Alternative to surgery in chronic pancreatitis].
Topics: Autonomic Nerve Block; Celiac Plexus; Chronic Disease; Humans; Lidocaine; Male; Pancreatitis | 1984 |
[Clinical usefulness of celiac plexus block].
Topics: Acute Disease; Autonomic Nerve Block; Celiac Plexus; Humans; Intestinal Obstruction; Intestinal Pseu | 1984 |
Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis.
Topics: Animals; Aphthovirus; Edema; Foot-and-Mouth Disease; Lidocaine; Male; Mice; Necrosis; Neutrophils; P | 1995 |
Percutaneous pancreatography under ultrasonographic guidance.
Topics: Anesthesia, Local; Chronic Disease; Diagnosis, Differential; Fluoroscopy; Humans; Lidocaine; Pancrea | 1996 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste | 1997 |
Xylocaine treatment in experimental pancreatitis in pigs.
Topics: Acute Disease; Animals; Drug Evaluation, Preclinical; Hemorrhage; Infusions, Parenteral; Lidocaine; | 1978 |
[Course and treatment of severe form of acute relapsing pancreatitis in an adolescent girl].
Topics: Adolescent; Aprotinin; Cholecystectomy; Female; Humans; Lidocaine; Pancreatitis; Parenteral Nutritio | 1974 |
The use of epidural block in acute pancreatitis: a report of eight cases.
Topics: Acute Disease; Adult; Aged; Anesthesia, Spinal; Electrocardiography; Electrolytes; Female; Humans; L | 1969 |
[The hypotonic duodenography].
Topics: Adult; Barium; Diagnosis, Differential; Duodenal Diseases; Duodenal Neoplasms; Duodenum; Equipment a | 1968 |