Page last updated: 2024-10-28

lidocaine and Osteoarthritis

lidocaine has been researched along with Osteoarthritis in 39 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Research Excerpts

ExcerptRelevanceReference
"The lidocaine patch 5% was generally well tolerated and no patients discontinued due to treatment-related adverse events."6.71Topical lidocaine patch 5% may target a novel underlying pain mechanism in osteoarthritis. ( Burch, F; Codding, C; Galer, BS; Gammaitoni, AR; Patel, N; Sheldon, E, 2004)
"Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test."5.38Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012)
" We examined the utility of the Neuropathic Pain Scale (NPS) for assessing changes in pain qualities after open label lidocaine patch 5% in 3 samples of patients: patients with peripheral neuropathic pain, low back pain, and osteoarthritis."5.11Assessment of pain quality in chronic neuropathic and nociceptive pain clinical trials with the Neuropathic Pain Scale. ( Dworkin, RH; Galer, BS; Gammaitoni, AR; Jensen, MP; Olaleye, DO; Oleka, N, 2005)
": To examine whether lidocaine cytotoxicity to chondrocytes has been implicated in the development of osteoarthritis of the zygapophysial joints."3.75Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro. ( Baba, H; Kobayashi, S; Kubota, M; Meir, A; Miyazaki, T; Shimada, S; Takeno, K; Urban, J, 2009)
"The lidocaine patch 5% was generally well tolerated and no patients discontinued due to treatment-related adverse events."2.71Topical lidocaine patch 5% may target a novel underlying pain mechanism in osteoarthritis. ( Burch, F; Codding, C; Galer, BS; Gammaitoni, AR; Patel, N; Sheldon, E, 2004)
" In order to ensure that intra-articular lidocaine is safe to use, treatments aimed at mitigating chondrocyte death have recently been investigated."1.48Protective effects of platelet-rich plasma against lidocaine cytotoxicity on canine articular chondrocytes. ( Bianchini, E; Buratta, S; Chiaradia, E; Di Meo, A; Floridi, C; Mancini, F; Moscati, L; Pepe, M; Pistilli, A; Stabile, A, 2018)
"Osteoarthritis is the most common form of arthritis and includes manifestations of both nociceptive and neuropathic mechanisms."1.40Osteoarthritis pain has a significant neuropathic component: an exploratory in vivo patient model. ( Ashford, RL; Dimitroulas, T; Duarte, RV; Kitas, GD; Raphael, JH; Southall, JL; Sparkes, E, 2014)
"This syndrome is usually related to anatomic variants (involving the bone structures, fibrous bands, or muscles and tendons)."1.38Supraclavicular nerve entrapment syndrome. ( Bruyère, PJ; Courtois, AC; Crielaard, JM; Douchamps, F, 2012)
"Whether ongoing pain is present in this model is unknown."1.38Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. ( Brion, T; Davis, P; Dussor, GO; King, T; Liu, P; Okun, A; Ossipov, MH; Porreca, F; Remeniuk, B; Ren, J; Xie, J, 2012)
"Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test."1.38Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012)
"Anserine bursitis is commonly found in Koreans with OA of the knee, and its presence is unrelated to age, sex, and radiographic severity."1.31Anserine bursitis in patients with osteoarthritis of the knee. ( Han, SW; Kang, I, 2000)
"The occipital pain and headache of cervical arthritis also often respond to injection of 2 to 3 ml of long-acting anesthetic into the greater and lesser occipital nerves at the sites where they pierce the trapezius."1.26Relieving pain with nerve blocks. ( Carron, H, 1978)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199018 (46.15)18.7374
1990's3 (7.69)18.2507
2000's8 (20.51)29.6817
2010's7 (17.95)24.3611
2020's3 (7.69)2.80

Authors

AuthorsStudies
Moser, LB1
Bauer, C1
Jeyakumar, V1
Niculescu-Morzsa, EP1
Nehrer, S1
Backhouse, MR1
Halstead, J1
Roddy, E1
Dhukaram, V1
Chapman, A1
Arnold, S1
Bruce, J1
Mc Colgan, R1
Dalton, DM1
O'Sullivan, HP1
Sproule, JA1
Malahias, MA1
Roumeliotis, L1
Nikolaou, VS1
Chronopoulos, E1
Sourlas, I1
Babis, GC1
Bianchini, E1
Mancini, F1
Di Meo, A1
Stabile, A1
Buratta, S1
Moscati, L1
Pistilli, A1
Floridi, C1
Pepe, M1
Chiaradia, E1
Duarte, RV1
Raphael, JH1
Dimitroulas, T1
Sparkes, E1
Southall, JL1
Ashford, RL1
Kitas, GD1
Jahangiri, A1
Moghaddam, FR1
Najafi, S1
Takeno, K1
Kobayashi, S1
Miyazaki, T1
Shimada, S1
Kubota, M1
Meir, A1
Urban, J1
Baba, H1
Douchamps, F1
Courtois, AC1
Bruyère, PJ1
Crielaard, JM1
Okun, A1
Liu, P1
Davis, P1
Ren, J1
Remeniuk, B1
Brion, T1
Ossipov, MH1
Xie, J1
Dussor, GO1
King, T1
Porreca, F1
Ferreira-Gomes, J1
Adães, S1
Mendonça, M1
Castro-Lopes, JM1
LAURENT, G1
COMPERE, EL1
Galer, BS3
Sheldon, E1
Patel, N1
Codding, C1
Burch, F1
Gammaitoni, AR3
Jensen, MP2
Dworkin, RH2
Olaleye, DO2
Oleka, N1
Rabago, D1
Best, TM1
Beamsley, M1
Patterson, J1
Stitik, TP1
Altschuler, E1
Foye, PM1
Tantó, Z1
Molnár, L1
Kálózdi, T1
Maros, M1
Várhelyi, M1
Mund-Hoym, WD1
Gu, ZY1
Wu, HL1
Wu, QL1
Cao, ZQ1
Zhang, YX1
Kang, I1
Han, SW1
Waxman, J1
Goel, TC1
Carron, H1
Clarke, AM1
Matthews, JG1
Lark, MR1
Gangarosa, LP1
Konsens, RM1
Seitz, WH1
Voleník, O1
Nilsson, G1
Abrahamsen, D1
Sadowska-Wrõblewska, M1
Steinberg, MD1
Beck, O1
Chitil, W1
Ortner, H1
Schopen, RD1
Iser, H1
Marmor, L1
Peter, JB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Which is More Effective: Prolotherapy or Paraffin Waxes for Hand Ostearthritis[NCT03839108]42 participants (Actual)Interventional2018-12-14Completed
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]301 participants (Anticipated)Interventional2022-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for lidocaine and Osteoarthritis

ArticleYear
A systematic review of prolotherapy for chronic musculoskeletal pain.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2005, Volume: 15, Issue:5

    Topics: Anesthetics, Local; Chronic Disease; Glucose; Humans; Injections; Lidocaine; Low Back Pain; Musculos

2005
Pharmacotherapy of osteoarthritis.
    American journal of physical medicine & rehabilitation, 2006, Volume: 85, Issue:11 Suppl

    Topics: Acetaminophen; Administration, Topical; Analgesics; Anesthetics, Local; Capsaicin; Delayed-Action Pr

2006
[Drug therapy in degenerative joint diseases].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1971, Jul-01, Volume: 24, Issue:13

    Topics: Animals; Cartilage, Articular; Humans; Hydrocortisone; Indomethacin; Lidocaine; Osteoarthritis; Pyra

1971

Trials

8 trials available for lidocaine and Osteoarthritis

ArticleYear
Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical Trial.
    Cartilage, 2021, Volume: 12, Issue:1

    Topics: Adrenal Cortex Hormones; Carpometacarpal Joints; Female; Humans; Injections, Intra-Articular; Lidoca

2021
Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: a double-blind randomized clinical trial.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2014, Volume: 19, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Inflammatory Agents; Carpometacarpal Joints

2014
Topical lidocaine patch 5% may target a novel underlying pain mechanism in osteoarthritis.
    Current medical research and opinion, 2004, Volume: 20, Issue:9

    Topics: Administration, Cutaneous; Administration, Topical; Anesthetics, Local; Female; Humans; Lidocaine; M

2004
Assessment of pain quality in chronic neuropathic and nociceptive pain clinical trials with the Neuropathic Pain Scale.
    The journal of pain, 2005, Volume: 6, Issue:2

    Topics: Administration, Cutaneous; Adult; Aged; Analysis of Variance; Anesthetics, Local; Clinical Trials as

2005
Symptom profiles differ in patients with neuropathic versus non-neuropathic pain.
    The journal of pain, 2007, Volume: 8, Issue:2

    Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Diabetic Neuropathies; Female; Humans; Lid

2007
Intra-arterial use of No-Spa+lidocaine in coxarthrosis.
    Therapia Hungarica (English edition), 1982, Volume: 30, Issue:3

    Topics: Clinical Trials as Topic; Hip Joint; Humans; Injections, Intra-Arterial; Lidocaine; Osteoarthritis;

1982
The effect of intra-articular irrigation injection therapy on osteoarthrosis of the temporomandibular joint.
    The Chinese journal of dental research, 1998, Volume: 1, Issue:3

    Topics: Adult; Chi-Square Distribution; Female; Humans; Injections, Intra-Articular; Lidocaine; Male; Middle

1998
[A contribution to the combined physical and drug therapy of arthroses].
    Wiener medizinische Wochenschrift (1946), 1965, Dec-04, Volume: 115, Issue:49

    Topics: Aminopyrine; Clinical Trials as Topic; Diathermy; Humans; Lidocaine; Osteoarthritis; Prednisolone; S

1965

Other Studies

28 other studies available for lidocaine and Osteoarthritis

ArticleYear
Hyaluronic Acid as a Carrier Supports the Effects of Glucocorticoids and Diminishes the Cytotoxic Effects of Local Anesthetics in Human Articular Chondrocytes In Vitro.
    International journal of molecular sciences, 2021, Oct-25, Volume: 22, Issue:21

    Topics: Anesthetics, Local; Bupivacaine; Cell Survival; Cells, Cultured; Chondrocytes; Drug Therapy, Combina

2021
A multi-professional survey of UK practice in the use of intra-articular corticosteroid injection for symptomatic first metatarsophalangeal joint osteoarthritis.
    Journal of foot and ankle research, 2023, Oct-17, Volume: 16, Issue:1

    Topics: Adrenal Cortex Hormones; Anesthetics, Local; Cross-Sectional Studies; Humans; Injections, Intra-Arti

2023
The prescription of lidocaine patches in osteoarthritis-a complete audit cycle.
    Irish journal of medical science, 2019, Volume: 188, Issue:2

    Topics: Aged; Anesthetics, Local; Commission on Professional and Hospital Activities; Female; Humans; Lidoca

2019
Protective effects of platelet-rich plasma against lidocaine cytotoxicity on canine articular chondrocytes.
    Acta veterinaria Scandinavica, 2018, Oct-26, Volume: 60, Issue:1

    Topics: Anesthetics, Local; Animals; Cell Survival; Chondrocytes; Cytoprotection; Dog Diseases; Dogs; Inject

2018
Osteoarthritis pain has a significant neuropathic component: an exploratory in vivo patient model.
    Rheumatology international, 2014, Volume: 34, Issue:3

    Topics: Adult; Aged; Anesthetics, Local; Arthralgia; Female; Humans; Infusions, Intravenous; Lidocaine; Male

2014
Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro.
    Spine, 2009, Dec-15, Volume: 34, Issue:26

    Topics: Analysis of Variance; Animals; Cartilage, Articular; Cell Count; Cell Survival; Cells, Cultured; Cho

2009
Supraclavicular nerve entrapment syndrome.
    Joint bone spine, 2012, Volume: 79, Issue:1

    Topics: Analgesics; Antirheumatic Agents; Brachial Plexus; Clavicle; Humans; Lidocaine; Male; Middle Aged; N

2012
Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.
    Pain, 2012, Volume: 153, Issue:4

    Topics: Afferent Pathways; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, In

2012
Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:4

    Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Diclofenac; Disease Models, Animal; Injection

2012
[RESULTS OF A MEDICAL TREATMENT OF MUSCULAR DYSTONY ACCOMPANYING COXARTHROSIS].
    Maroc medical, 1964, Volume: 43

    Topics: Anesthetics; Anesthetics, Local; Hip; Humans; Lidocaine; Muscular Diseases; Osteoarthritis; Osteoart

1964
THE PAINFUL SHOULDER.
    JAMA, 1964, Sep-14, Volume: 189

    Topics: Arthritis; Bursitis; Drug Therapy; Humans; Hydrocortisone; Joints; Lidocaine; Osteoarthritis; Pain;

1964
A patch for osteoarthritis relief.
    The Johns Hopkins medical letter health after 50, 2005, Volume: 17, Issue:10

    Topics: Administration, Cutaneous; Anesthetics, Local; Humans; Lidocaine; Middle Aged; Osteoarthritis

2005
[The treatment of hip and knee joint arthroses].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Nov-10, Volume: 56, Issue:31

    Topics: Adult; Aged; Arthritis; Drug Therapy, Combination; Female; Glucosamine; Hip Joint; Humans; Knee Join

1980
Anserine bursitis in patients with osteoarthritis of the knee.
    Southern medical journal, 2000, Volume: 93, Issue:2

    Topics: Anesthetics, Local; Anti-Inflammatory Agents; Bursitis; Female; Humans; Injections; Knee; Korea; Lid

2000
Acromioclavicular disease in rheumatologic practice--the forgotten joint.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1977, Volume: 129, Issue:1

    Topics: Acromioclavicular Joint; Female; Humans; Injections, Intra-Articular; Lidocaine; Male; Middle Aged;

1977
Injection treatment for pain in osteo-arthrosis of knee joint.
    Journal of the Indian Medical Association, 1977, Jul-16, Volume: 69, Issue:2

    Topics: Aged; Female; Humans; Knee Joint; Lidocaine; Male; Middle Aged; Osteoarthritis; Palliative Care

1977
Relieving pain with nerve blocks.
    Geriatrics, 1978, Volume: 33, Issue:4

    Topics: Acute Disease; Aged; Back Pain; Bursitis; Humans; Intervertebral Disc; Joint Diseases; Lidocaine; Mi

1978
Osteoarthritis of the fabella: a fourth knee compartment?
    Journal of the Royal College of Surgeons of Edinburgh, 1991, Volume: 36, Issue:1

    Topics: Aged; Humans; Injections, Intra-Articular; Knee Joint; Lidocaine; Male; Osteoarthritis; Radiography;

1991
Iontophoresis: an effective modality for the treatment of inflammatory disorders of the temporomandibular joint and myofascial pain.
    Cranio : the journal of craniomandibular practice, 1990, Volume: 8, Issue:2

    Topics: Adult; Discitis; Epinephrine; Facial Pain; Female; Humans; Inflammation; Iontophoresis; Joint Disloc

1990
Post-traumatic arthrosis of the index carpometacarpal joint. A rationale for treatment and report of two cases.
    Orthopedics, 1987, Volume: 10, Issue:10

    Topics: Adult; Arthrodesis; Chronic Disease; Female; Humans; Lidocaine; Male; Metacarpus; Methylprednisolone

1987
[Differential diagnosis and rational therapy of humero-scapular periarthritis and omarthritis].
    Fysiatricky a reumatologicky vestnik, 1974, Volume: 52, Issue:6

    Topics: Diagnosis, Differential; Humans; Hydrocortisone; Joint Diseases; Lidocaine; Osteoarthritis; Shoulder

1974
Lameness and pathologic changes in the distal joints and the phalanges of the standardbred horse. A correlative study.
    Acta veterinaria Scandinavica. Supplementum, 1973, Volume: 44, Issue:0

    Topics: Animals; Equipment and Supplies; Female; Forelimb; Fractures, Bone; Gait; Hindlimb; Hoof and Claw; H

1973
Letter: Therapy of osteoarthritis of the great toe.
    JAMA, 1973, Oct-22, Volume: 226, Issue:4

    Topics: Female; Humans; Hyaluronoglucosaminidase; Lidocaine; Osteoarthritis

1973
Therapy of osteoarthritis of the great toe and hallux rigidus.
    JAMA, 1971, Jul-12, Volume: 217, Issue:2

    Topics: Drug Synergism; Female; Hallux; Humans; Hyaluronoglucosaminidase; Injections; Lidocaine; Male; Osteo

1971
[The effectiveness of the protease inhibitor Contrykal in the drug therapy of arthrosis deformans].
    Beitrage zur Orthopadie und Traumatologie, 1971, Volume: 18, Issue:2

    Topics: Aprotinin; Hip Joint; Humans; Injections, Intra-Articular; Injections, Intramuscular; Knee Joint; Li

1971
[Dexamonosone as a rheuma therapeutic agent].
    Munchener medizinische Wochenschrift (1950), 1970, Jul-17, Volume: 29

    Topics: Anti-Inflammatory Agents; Arm; Arthritis; Brachial Plexus Neuritis; Dosage Forms; Erythema Nodosum;

1970
[Treatment of rheumatic diseases with Supertendin].
    Die Medizinische Welt, 1968, Oct-26, Volume: 43

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dexamethasone; Humans; Joint Diseases; Lidocaine; O

1968
Osteoarthritis of the carpometacarpal joint of the thumb.
    American journal of surgery, 1969, Volume: 117, Issue:5

    Topics: Anti-Inflammatory Agents; Arthrodesis; Arthroplasty; Female; Humans; Injections, Intra-Articular; Li

1969