lidocaine has been researched along with Obesity in 25 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to determine whether the application of lidocaine patches around the cesarean incision in women with obesity reduces the total dose of opioids administered in the first 24 hours after cesarean delivery." | 5.41 | Lidocaine patches for postcesarean pain control in obese women: a pilot randomized controlled trial. ( Adams, JH; Antony, KM; Chappell, RJ; Gnadt, SE; Hetzel, S; Jacques, L; Tevaarwerk, AJ, 2021) |
| " access, and blood sampling pain and stress affect hormone values, treatment with N(2)O or midazolam influence the glucose and stress hormone levels differently." | 5.16 | Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children. ( Ekbom, K; Jakobsson, J; Kalman, S; Marcus, C, 2012) |
| "Intranasal lidocaine reduced hunger and the desire to eat, but this did not translate into a significant reduction in food intake suggesting that intranasal lidocaine will not have value in treating obesity." | 5.12 | Using intranasal lidocaine to reduce food intake. ( Caruso, MK; Cowley, MA; Cruickshank, S; DeYoung, L; Dumas, K; England, M; Greenway, FL; Gupta, AK; Kamdar, K; Laidlaw, BJ; Martin, CK; Roberts, AT; Rogers, B; Whitehouse, J, 2007) |
| "The foreskin-deglove plus shaft-fix procedure under local anesthesia with lidocaine and ropivacaine mesylate may achieve desirable penile erection and appearance in the treatment of phimosis or redundant prepuce in obese adult patients." | 3.83 | [Circumcision versus the foreskin-deglove plus shaft-fix procedure for phimosis or redundant prepuce in obese adult patients]. ( Chen, XY; Li, RB; Sun, X; Wang, YM; Wen, XF; Zhou, L, 2016) |
| "Sufentanil has been widely used to inhibit the hemodynamic responses caused by tracheal intubation." | 3.30 | Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients. ( He, C; Jia, D; Tu, F; Yuan, X, 2023) |
| "Lidocaine has been shown to be clinically beneficial during bariatric surgery." | 2.94 | Serum Concentrations of Lidocaine During Bariatric Surgery. ( Bouffard, Y; Carabalona, JF; Citterio-Quentin, A; Delwarde, B; Duclos, A; Le Goff, MC; Moulsma, M; Rimmelé, T, 2020) |
| "Local anesthetic inguinal hernia repair in the obese is safe and well tolerated." | 1.35 | Local anesthetic hernia repair in overweight and obese patients. ( Reid, TD; Sanjay, P; Woodward, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (28.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 8 (32.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, D | 1 |
| Yuan, X | 1 |
| He, C | 1 |
| Tu, F | 1 |
| Al Nebaihi, HM | 1 |
| Al Batran, R | 1 |
| Ussher, JR | 1 |
| Maayah, ZH | 1 |
| El-Kadi, AOS | 1 |
| Brocks, DR | 1 |
| Tovikkai, P | 1 |
| Rogers, SJ | 1 |
| Cello, JP | 1 |
| Mckay, RE | 1 |
| Plass, F | 1 |
| Nicolle, C | 1 |
| Zamparini, M | 1 |
| Al Issa, G | 1 |
| Fiant, AL | 1 |
| Le Roux, Y | 1 |
| Gérard, JL | 1 |
| Fischer, MO | 1 |
| Alvès, A | 1 |
| Hanouz, JL | 1 |
| Li, X | 1 |
| Lv, X | 1 |
| Jiang, Z | 1 |
| Nie, X | 1 |
| Wang, X | 1 |
| Li, T | 1 |
| Zhang, L | 1 |
| Liu, S | 1 |
| Baek, SY | 1 |
| Kim, JW | 1 |
| Kim, TW | 1 |
| Han, W | 1 |
| Lee, DE | 1 |
| Ryu, KH | 1 |
| Park, SG | 1 |
| Jeong, CY | 1 |
| Park, DH | 1 |
| Antony, KM | 1 |
| Adams, JH | 1 |
| Jacques, L | 1 |
| Hetzel, S | 1 |
| Chappell, RJ | 1 |
| Gnadt, SE | 1 |
| Tevaarwerk, AJ | 1 |
| Carabalona, JF | 1 |
| Delwarde, B | 1 |
| Duclos, A | 1 |
| Le Goff, MC | 1 |
| Moulsma, M | 1 |
| Citterio-Quentin, A | 1 |
| Bouffard, Y | 1 |
| Rimmelé, T | 1 |
| Jung, GS | 1 |
| Chen, XY | 1 |
| Wen, XF | 1 |
| Li, RB | 1 |
| Zhou, L | 1 |
| Sun, X | 1 |
| Wang, YM | 1 |
| Reid, TD | 1 |
| Sanjay, P | 1 |
| Woodward, A | 1 |
| Wells, JH | 1 |
| Hurvitz, KA | 1 |
| Ekbom, K | 1 |
| Kalman, S | 1 |
| Jakobsson, J | 1 |
| Marcus, C | 1 |
| Xiong, XQ | 1 |
| Chen, WW | 1 |
| Han, Y | 1 |
| Zhou, YB | 1 |
| Zhang, F | 1 |
| Gao, XY | 1 |
| Zhu, GQ | 1 |
| DEJONG, RH | 1 |
| Greenway, FL | 1 |
| Martin, CK | 1 |
| Gupta, AK | 1 |
| Cruickshank, S | 1 |
| Whitehouse, J | 1 |
| DeYoung, L | 1 |
| Kamdar, K | 1 |
| Caruso, MK | 1 |
| Roberts, AT | 1 |
| England, M | 1 |
| Dumas, K | 1 |
| Laidlaw, BJ | 1 |
| Rogers, B | 1 |
| Cowley, MA | 1 |
| Varela, C | 1 |
| Palacio, F | 1 |
| Reina, MA | 1 |
| López, A | 1 |
| Benito-León, J | 1 |
| Tsui, BC | 1 |
| Dillane, D | 1 |
| Yee, MS | 1 |
| Abernethy, DR | 1 |
| Greenblatt, DJ | 1 |
| Large, V | 1 |
| Reynisdottir, S | 1 |
| Eleborg, L | 1 |
| van Harmelen, V | 1 |
| Strömmer, L | 1 |
| Arner, P | 1 |
| Fox, GS | 1 |
| Doherty, JE | 1 |
| Mantse, L | 1 |
| Fisher, J | 1 |
| James, ML | 1 |
| Holland, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial[NCT04524130] | Phase 4 | 87 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| Transdermal Lidocaine Patch for Post-Cesarean Pain Control for Women With Obesity: a Single-blind Randomized Controlled Trial[NCT03810235] | Phase 4 | 66 participants (Actual) | Interventional | 2019-02-15 | Completed | ||
| Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery[NCT02525016] | Phase 3 | 50 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Dose opioids (measured in total morphine milligram equivalents (mg) of all pills) prescribed at discharge (NCT03810235)
Timeframe: up to 72 hours
| Intervention | MME (mg) (Mean) |
|---|---|
| Transdermal Lidocaine Patch | 168.35 |
| Transdermal Hydrocolloid Placebo Patch | 154.10 |
Measured in hours from admission to time of discharge This will be measured in hours from the documented time of admission until discharge (NCT03810235)
Timeframe: up to 120 hours
| Intervention | hours (Median) |
|---|---|
| Transdermal Lidocaine Patch | 75.5 |
| Transdermal Hydrocolloid Placebo Patch | 76 |
Gestational age at delivery will be recorded as weeks and days of gestation (NCT03810235)
Timeframe: up to 24 hours
| Intervention | weeks (Mean) |
|---|---|
| Transdermal Lidocaine Patch | 38.7 |
| Transdermal Hydrocolloid Placebo Patch | 38.85 |
The number of opioid pills prescribed at discharge (NCT03810235)
Timeframe: up to 72 hours
| Intervention | Number of pills (Mean) |
|---|---|
| Transdermal Lidocaine Patch | 17.3 |
| Transdermal Hydrocolloid Placebo Patch | 16.0 |
"Complications of lidocaine use include local burning, nausea, dizziness, drowsiness, serious skin reactions such as blistering, confusion, blurred vision, ringing in the ears, and allergies and hypersensitivities.~Definition: Patient reported side effects which will be reported as frequencies of occurrence. (These will be reported as dichotomous Yes/No outcomes for each side effect)" (NCT03810235)
Timeframe: up to 6 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Transdermal Lidocaine Patch | 2 |
| Transdermal Hydrocolloid Placebo Patch | 4 |
"Patient-reported opioid-related side effects include pruritis, constipation, nausea, and mental clouding.~Definition: Patient reported side effects which will be reported as frequencies of occurrence. (These will be reported as dichotomous Yes/No outcomes for each side effect)" (NCT03810235)
Timeframe: up to 6 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Transdermal Lidocaine Patch | 2 |
| Transdermal Hydrocolloid Placebo Patch | 4 |
"Includes urinary tract infections, thromboembolic events, pneumonia, postpartum blood transfusions, falls, myocardial infarctions.~These events will be reported as frequencies of occurrence. (These will be reported as dichotomous Yes/No outcomes for each side effect)" (NCT03810235)
Timeframe: up to 120 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Transdermal Lidocaine Patch | 0 |
| Transdermal Hydrocolloid Placebo Patch | 0 |
Measured in minutes from arrival in the post-anesthesia care unit (PACU) until the first as needed opioid dose is administered. This will be recorded in minutes from the time of the surgery completion (surgery end time) until the first opioid analgesic medication is administered. Data in table is noted in hours. (NCT03810235)
Timeframe: up to 24 hours
| Intervention | hours (Median) |
|---|---|
| Transdermal Lidocaine Patch | 1.4 |
| Transdermal Hydrocolloid Placebo Patch | 1.7 |
All opioid doses will be converted into oral morphine equivalents. This will be recorded as the total dose of opioids received during the hospitalization (following surgery) calculated as oral morphine equivalents. (NCT03810235)
Timeframe: up to 120 hours
| Intervention | MME, morphine milligram equivalents (Median) |
|---|---|
| Transdermal Lidocaine Patch | 200 |
| Transdermal Hydrocolloid Placebo Patch | 192 |
The total dose of opioids received in the first 24 hours following Cesarean delivery measured as oral morphine equivalents. This total dose will be calculated for every subject in the study, and the average and standard deviation (or appropriate non-parametric values if the data is not normally distributed) will be compared between the subjects randomized to the intervention arm and the placebo arm of the study. (NCT03810235)
Timeframe: up to 24 hours
| Intervention | MME, morphine milligram equivalents (Mean) |
|---|---|
| Transdermal Lidocaine Patch | 87 |
| Transdermal Hydrocolloid Placebo Patch | 83.9 |
All opioid doses will be converted into oral morphine equivalents. This will be recorded as the total dose of opioids received in 48 hours following surgery calculated as oral morphine equivalents (NCT03810235)
Timeframe: up to 48 hours
| Intervention | MME, morphine milligram equivalents (Mean) |
|---|---|
| Transdermal Lidocaine Patch | 149.3 |
| Transdermal Hydrocolloid Placebo Patch | 139.0 |
The post-operative pain score at 24 hours post-operatively will be measured using the numeric rating scale (NRS), wherein subjects rate pain on a 0-10 scale (10 meaning the most pain and 0 meaning no pain). The median NRS score at 24 hours will be compared between the two groups. (NCT03810235)
Timeframe: up to 24 hours
| Intervention | score on a scale (Median) | ||||
|---|---|---|---|---|---|
| Median Pain Score (0-10) | Pre pregnancy BMI 30-39.9 | Prepregancy BMI >40 | Delivery BMI 30 -39.9 | Delivery BMI >40 | |
| Transdermal Hydrocolloid Placebo Patch | 3.5 | 3.0 | 4.0 | 3.0 | 4.0 |
| Transdermal Lidocaine Patch | 3.0 | 3.0 | 4.0 | 3.0 | 3.0 |
1 review available for lidocaine and Obesity
| Article | Year |
|---|---|
Clinical use of digitalis glycosides. An update.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Age Factors; Anti-Arrhythmia Agents; Antihyperten | 1985 |
8 trials available for lidocaine and Obesity
| Article | Year |
|---|---|
Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients.
Topics: Humans; Intubation, Intratracheal; Lidocaine; Obesity; Propofol; Saline Solution; Sufentanil | 2023 |
Effect of intra-operative intravenous lidocaine on opioid consumption after bariatric surgery: a prospective, randomised, blinded, placebo-controlled study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Dou | 2021 |
Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Colonoscopy; Double-Blind Method; Female; Humans; | 2020 |
Lidocaine patches for postcesarean pain control in obese women: a pilot randomized controlled trial.
Topics: Female; Humans; Lidocaine; Obesity; Pain Measurement; Pain, Postoperative; Pilot Projects; Pregnancy | 2021 |
Serum Concentrations of Lidocaine During Bariatric Surgery.
Topics: Adult; Anesthetics, Local; Body Mass Index; Drug Administration Schedule; Drug Dosage Calculations; | 2020 |
Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children.
Topics: Adolescent; Anesthetics, Local; Blood Glucose; Blood Specimen Collection; Catheterization, Periphera | 2012 |
Using intranasal lidocaine to reduce food intake.
Topics: Administration, Intranasal; Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blin | 2007 |
Blood gas changes during spinal and epidural analgesia.
Topics: Adult; Aged; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Spinal; Carbon Dioxide; Cardia | 1969 |
16 other studies available for lidocaine and Obesity
| Article | Year |
|---|---|
Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet.
Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diet, High-Fat; Female; Lidocaine; | 2020 |
Intraoperative lidocaine infusion and 24-hour postoperative opioid consumption in obese patients undergoing laparoscopic bariatric surgery.
Topics: Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Humans; Laparoscopy; Lidocaine; Obesity; | 2020 |
Opioid-free anesthesia with a mixture of dexmedetomidine, ketamine, and lidocaine in one syringe for surgery in obese patients.
Topics: Analgesics, Opioid; Anesthesia; Cesarean Section; Dexmedetomidine; Double-Blind Method; Female; Huma | 2020 |
Effectiveness of Local Fat-Dissolving Solution Injection.
Topics: Adipose Tissue; Adult; Aminophylline; Ascorbic Acid; Body Mass Index; Carnitine; Cheek; Drug Combina | 2019 |
[Circumcision versus the foreskin-deglove plus shaft-fix procedure for phimosis or redundant prepuce in obese adult patients].
Topics: Adult; Amides; Anesthetics, Local; Body Mass Index; Circumcision, Male; Foreskin; Humans; Lidocaine; | 2016 |
Local anesthetic hernia repair in overweight and obese patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Body Mass Index; | 2009 |
An evidence-based approach to liposuction.
Topics: Adult; Anesthetics, Local; Comorbidity; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Female; | 2011 |
Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension.
Topics: Adipose Tissue, White; Angiotensin II; Animals; Blood Pressure; Capsaicin; Diet, High-Fat; Diterpene | 2012 |
ARTERIAL CARBON DIOXIDE AND OXYGEN TENSIONS DURING SPINAL BLOCK.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Gas Analysis; Carbon Diox | 1965 |
[Horner's syndrome secondary to epidural anesthesia].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Arm; Bupivacaine; Cesarean | 2007 |
Patient-controlled oral airway insertion to facilitate awake fibreoptic intubation.
Topics: Anesthetics, Local; Fiber Optic Technology; Humans; Intubation, Intratracheal; Laryngeal Masks; Lido | 2008 |
Lidocaine disposition in obesity.
Topics: Adult; Female; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Obesity | 1984 |
Lipolysis in human fat cells obtained under local and general anesthesia.
Topics: Abdomen; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Agonists; Adult; Anesthesia, General; Anesth | 1997 |
Anaesthesia for intestinal short circuiting in the morbidly obese with reference to the pathophysiology of gross obesity.
Topics: Anesthesia, Epidural; Anesthesia, General; Epinephrine; Humans; Intestines; Intubation, Intratrachea | 1975 |
Liposuction under local anesthesia: a retrospective analysis of 100 patients.
Topics: Adipose Tissue; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Female; Humans; Lido | 1987 |
The effect of bovine anterior pituitary extract on lipid mobilization in the rat and man.
Topics: Adipose Tissue; Animals; Epididymis; Fasting; Fatty Acids, Nonesterified; Female; Humans; Lidocaine; | 1969 |