lidocaine has been researched along with Neuroblastoma in 12 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, the lidocaine released from lidocaine HCl electrospun patches retained biological activity, inhibiting veratridine-mediated opening of voltage-gated sodium channels in SH-SY5Y neuroblastoma cells." | 3.91 | Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging. ( Clitherow, KH; Colley, HE; Handler, AM; Hatton, PV; Jacobsen, J; Janfelt, C; Murdoch, C; Mørck Nielsen, H; Spain, SG; Stie, MB, 2019) |
| "The role of endogenous GM1 ganglioside in neurite outgrowth has been studied in N18 and NG108-15 neuroblastoma cells with the GM1-specific ligand cholera toxin B subunit (Ctx B), which stimulates Ca(2+) influx together with neuritogenesis." | 3.71 | Characterization of cholera toxin B subunit-induced Ca(2+) influx in neuroblastoma cells: evidence for a voltage-independent GM1 ganglioside-associated Ca(2+) channel. ( Fang, Y; Ledeen, RW; Wu, G; Xie, X, 2002) |
| " The ability of lifarizine (RS-87476) to block human voltage-sensitive Na+ channel currents was studied by use of whole cell patch clamp recording from differentiated neuroblastoma cells (SH-SY5Y)." | 3.69 | Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. ( Brown, NA; Kemp, JA; Seabrook, GR, 1994) |
| "The influence of diazepam, an agonist, and flumazenil (Ro 15-1788), an antagonist of the benzodiazepine receptor, on repetitive firing of action potentials in cultured spinal neurons and on voltage-dependent Na+ currents in cultured N2A neuroblastoma cells was examined." | 3.68 | Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil. ( Backus, KH; Pflimlin, P; Trube, G, 1991) |
| "Differentiated mouse neuroblastoma cells (C 1300) were exposed to various mitosis-inhibitors (vinblastine, colchicine and griseofulvin) and substances with anesthetic action (lidocaine, tetracaine, chlorpromazine and sodium dodecyl sulphate)." | 3.65 | Reversal of morphological differentiation of mouse neuroblastoma cells by mitosis-inhibitors and anesthetics. ( Edström, A; Erkell, LJ; Hansson, HA, 1975) |
| "Lidocaine treatment resulted in suppression of the mitochondrial electron transport chain and subsequent attenuation of mitochondrial membrane potential, as well as enhanced ROS production, activation of caspase-3/7 and caspase-9, and induction of apoptosis and necrosis in SH-SY5Y cells in a dose- and time-dependent manner." | 1.43 | The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. ( Hirota, K; Kusunoki, M; Matsuo, Y; Nishi, K; Okamoto, A; Oku, K; Shingu, K; Sumi, C; Takenaga, K; Tanaka, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Featherly, J | 1 |
| Baxter Wojnowicz, S | 1 |
| Steidl, K | 1 |
| Burgess, J | 1 |
| Wang, YC | 1 |
| Chen, YS | 1 |
| Hsieh, ST | 1 |
| Clitherow, KH | 1 |
| Murdoch, C | 1 |
| Spain, SG | 1 |
| Handler, AM | 1 |
| Colley, HE | 1 |
| Stie, MB | 1 |
| Mørck Nielsen, H | 1 |
| Janfelt, C | 1 |
| Hatton, PV | 1 |
| Jacobsen, J | 1 |
| Okamoto, A | 1 |
| Tanaka, M | 1 |
| Sumi, C | 1 |
| Oku, K | 1 |
| Kusunoki, M | 1 |
| Nishi, K | 1 |
| Matsuo, Y | 1 |
| Takenaga, K | 1 |
| Shingu, K | 1 |
| Hirota, K | 1 |
| Fang, Y | 1 |
| Xie, X | 1 |
| Ledeen, RW | 1 |
| Wu, G | 1 |
| Parent, AT | 1 |
| Barnes, NY | 1 |
| Taniguchi, Y | 1 |
| Thinakaran, G | 1 |
| Sisodia, SS | 1 |
| Brown, NA | 1 |
| Kemp, JA | 1 |
| Seabrook, GR | 1 |
| Wallace, MS | 1 |
| Lee, J | 1 |
| Sorkin, L | 1 |
| Dunn, JS | 1 |
| Yaksh, T | 1 |
| Yu, A | 1 |
| Hilton, AB | 1 |
| Lockhart, EM | 1 |
| Penning, DH | 1 |
| Edström, A | 1 |
| Erkell, LJ | 1 |
| Hansson, HA | 1 |
| Backus, KH | 1 |
| Pflimlin, P | 1 |
| Trube, G | 1 |
| Oortgiesen, M | 1 |
| van Kleef, RG | 1 |
| Vijverberg, HP | 1 |
12 other studies available for lidocaine and Neuroblastoma
| Article | Year |
|---|---|
Lidocaine for dinutuximab-associated pain? A multicenter retrospective observational cohort study.
Topics: Antibodies, Monoclonal; Child; Humans; Lidocaine; Morphine Derivatives; Neuralgia; Neuroblastoma; Re | 2022 |
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model.
Topics: Adenosine; Animals; Cardioplegic Solutions; Cobalt; Disease Models, Animal; Glucose; Humans; Ischemi | 2022 |
Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging.
Topics: Administration, Buccal; Anesthetics; Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberati | 2019 |
The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells.
Topics: Acetylcysteine; Anesthetics, Local; Antioxidants; Apoptosis; Bupivacaine; Cell Death; Cell Line, Tum | 2016 |
Characterization of cholera toxin B subunit-induced Ca(2+) influx in neuroblastoma cells: evidence for a voltage-independent GM1 ganglioside-associated Ca(2+) channel.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Different | 2002 |
Presenilin attenuates receptor-mediated signaling and synaptic function.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Carbazoles; | 2005 |
Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine.
Topics: Cell Differentiation; Electrophysiology; Humans; Imidazoles; Kinetics; Lidocaine; Membrane Potential | 1994 |
Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma--a report of a series.
Topics: Antibodies, Monoclonal; Child; Child, Preschool; Female; Gangliosides; Humans; Infusions, Intravenou | 1997 |
Epidural analgesia in parturients with previous spinal irradiation.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Loc | 1998 |
Reversal of morphological differentiation of mouse neuroblastoma cells by mitosis-inhibitors and anesthetics.
Topics: Animals; Cell Aggregation; Cell Differentiation; Chlorpromazine; Colchicine; Griseofulvin; Lidocaine | 1975 |
Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil.
Topics: Action Potentials; Animals; Carbamazepine; Cell Line; Cells, Cultured; Diazepam; Embryo, Mammalian; | 1991 |
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Me | 1990 |