lidocaine has been researched along with Neural Tube Defects in 4 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the presence of 250 microM of lidocaine, embryos showed a increased incidence of situs inversus compared with control group but were otherwise normal." | 3.70 | Assessment of teratogenic effects of lidocaine in rat embryos cultured in vitro. ( Fujinaga, M, 1998) |
| "05 micrograms/ml), colchicine (1 microgram/ml), or ionophore A23187 (25 micrograms/ml), although all treatments produced neural tube defects." | 3.67 | Neural tube defects caused by local anesthetics in early chick embryos. ( Lee, H; Nagele, RG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Shea, KS | 1 |
| Kaufman, MH | 1 |
| Fujinaga, M | 1 |
| Lee, H | 2 |
| Bush, KT | 1 |
| Nagele, RG | 2 |
4 other studies available for lidocaine and Neural Tube Defects
| Article | Year |
|---|---|
Neural tube closure defects following in vitro exposure of mouse embryos to xylocaine.
Topics: Animals; Embryo, Mammalian; Female; Lidocaine; Mice; Neural Crest; Neural Tube Defects; Pregnancy | 1980 |
Assessment of teratogenic effects of lidocaine in rat embryos cultured in vitro.
Topics: Anesthetics, Local; Animals; Culture Media; Culture Techniques; Dose-Response Relationship, Drug; Em | 1998 |
Time-lapse photographic study of neural tube closure defects caused by xylocaine in the chick.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Lidocaine; Morphogenesis; Neural Tube Defects; P | 1988 |
Neural tube defects caused by local anesthetics in early chick embryos.
Topics: Anesthetics, Local; Animals; Calcimycin; Chick Embryo; Colchicine; Cytochalasin B; Ketamine; Lidocai | 1985 |