Page last updated: 2024-10-28

lidocaine and Nasal Bleeding

lidocaine has been researched along with Nasal Bleeding in 30 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"Patients with non-traumatic epistaxis were evaluated in three treatment groups as topical lidocaine, epinephrine, and TXA."9.51Comparison of the therapeutic efficacy of topical tranexamic acid, epinephrine, and lidocaine in stopping bleeding in non-traumatic epistaxis: a prospective, randomized, double-blind study. ( Ekmekyapar, M; Gur, A; Sahin, L, 2022)
"To determine the effectiveness of intranasal topical application of tranexamic acid in reducing the need for anterior nasal packing and determine the number of episodes of rebleeding in adult patients presenting with spontaneous atraumatic anterior epistaxis."9.51Intranasal Topical Application of Tranexamic Acid in Atraumatic Anterior Epistaxis: A Double-Blind Randomized Clinical Trial. ( Asmarian, N; Babaei, A; Faramarzi, A; Hosseinialhashemi, M; Jahangiri, R; Kherad, M; Sajedianfard, S; Soltaniesmaeili, A, 2022)
"1% drops and lidocaine 2% jelly reduced the incidence and severity of epistaxis after NTI in preschool children."9.14Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery. ( Ajjoub, LF; El-Seify, ZA; Hassan, HE; Khattab, AM; Metwalli, OS; Shaaban, AA, 2010)
"To determine the effects of tranexamic acid (oral, intravenous or topical) compared with placebo, no additional intervention or any other haemostatic agent in the management of patients with epistaxis."8.98Tranexamic acid for patients with nasal haemorrhage (epistaxis). ( Bellorini, J; Burton, MJ; Joseph, J; Martinez-Devesa, P, 2018)
"Patients with non-traumatic epistaxis were evaluated in three treatment groups as topical lidocaine, epinephrine, and TXA."5.51Comparison of the therapeutic efficacy of topical tranexamic acid, epinephrine, and lidocaine in stopping bleeding in non-traumatic epistaxis: a prospective, randomized, double-blind study. ( Ekmekyapar, M; Gur, A; Sahin, L, 2022)
"To determine the effectiveness of intranasal topical application of tranexamic acid in reducing the need for anterior nasal packing and determine the number of episodes of rebleeding in adult patients presenting with spontaneous atraumatic anterior epistaxis."5.51Intranasal Topical Application of Tranexamic Acid in Atraumatic Anterior Epistaxis: A Double-Blind Randomized Clinical Trial. ( Asmarian, N; Babaei, A; Faramarzi, A; Hosseinialhashemi, M; Jahangiri, R; Kherad, M; Sajedianfard, S; Soltaniesmaeili, A, 2022)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."5.43Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)
"1% drops and lidocaine 2% jelly reduced the incidence and severity of epistaxis after NTI in preschool children."5.14Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery. ( Ajjoub, LF; El-Seify, ZA; Hassan, HE; Khattab, AM; Metwalli, OS; Shaaban, AA, 2010)
"To determine the effects of tranexamic acid (oral, intravenous or topical) compared with placebo, no additional intervention or any other haemostatic agent in the management of patients with epistaxis."4.98Tranexamic acid for patients with nasal haemorrhage (epistaxis). ( Bellorini, J; Burton, MJ; Joseph, J; Martinez-Devesa, P, 2018)
"To assess the effectiveness and complications of bilateral nasal septal cautery using silver nitrate in anterior nasal epistaxis."3.91Bilateral nasal septal chemical cautery: a safe and effective outpatient procedure for control of recurrent epistaxis, our experience in 134 patients. ( Limbrick, J; Takwoingi, YM, 2019)
"Epistaxis is one of the most common reasons for referral of children to a hospital ENT outpatient department."2.55Emergency Department care of childhood epistaxis. ( Béquignon, E; Brugel, L; Coste, A; De Kermadec, H; Gauthier, A; Prulière-Escabasse, V; Teissier, N, 2017)
"Epistaxis is a common problem that occurs in up to 60% of the general population, and is a common emergency department (ED) complaint."1.43Lidocaine Toxicity During Attempted Epistaxis Cautery. ( Nicholas, E; Thornton, MD, 2016)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199010 (33.33)18.7374
1990's2 (6.67)18.2507
2000's3 (10.00)29.6817
2010's9 (30.00)24.3611
2020's6 (20.00)2.80

Authors

AuthorsStudies
Mutlu, V1
Kaya, A1
Ekmekyapar, M1
Sahin, L1
Gur, A1
Hosseinialhashemi, M1
Jahangiri, R1
Faramarzi, A1
Asmarian, N1
Sajedianfard, S1
Kherad, M1
Soltaniesmaeili, A1
Babaei, A1
Garzaro, M1
Dell'Era, V1
Rosa, MS1
Cerasuolo, M1
Garzaro, G1
Aluffi Valletti, P1
Dutta, M1
Ray, A1
Biswas, S1
Manjunath, MB1
Meena, VP1
Sethi, P1
Sinha, S1
Komatsu, M1
Komasawa, N1
Yonehara, S1
Minami, T1
Bellew, SD1
Johnson, KL1
Nichols, MD1
Kummer, T1
Joseph, J1
Martinez-Devesa, P1
Bellorini, J1
Burton, MJ1
Limbrick, J1
Takwoingi, YM1
Valdes, CJ1
Al Badaai, Y1
Bogado, M1
Samaha, M1
Harris, R1
Nicholas, E1
Thornton, MD1
Béquignon, E1
Teissier, N1
Gauthier, A1
Brugel, L1
De Kermadec, H1
Coste, A1
Prulière-Escabasse, V1
El-Seify, ZA1
Khattab, AM1
Shaaban, AA1
Metwalli, OS1
Hassan, HE1
Ajjoub, LF1
SZABO, E2
FORTAY, SO1
Wolfe, TR1
Bernstone, T1
Tseng, CC1
Ho, CY1
Woodall, NM1
Harwood, RJ1
Barker, GL1
Gross, JB1
Hartigan, ML1
Schaffer, DW1
Greim, CA1
Brederlau, J1
Kraus, I1
Apfel, C1
Thiel, H1
Roewer, N1
Seidman, MD1
Bharadwaj, VK1
Novotny, GM1
Barga, JL1
Smith, R1
Goldstein, A1
Verma, PL1
Kohli, GS1
Padrnos, RE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.[NCT02285634]68 participants (Actual)Interventional2014-11-30Completed
Feasibility Study of a Nasal Compression Device in Comparison to Digital Nasal Compression for Stopping Epistaxis[NCT05789264]40 participants (Anticipated)Interventional2023-09-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

Change from baseline in diastolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%5.7
Phenylephrine 0.25%7.9
Lidocaine 1% Plus Epinephrine 1:100,0006.2
Bacteriostatic 0.9% NaCL9.3

Change in Heart Rate

Change from baseline in heart rate. (NCT02285634)
Timeframe: baseline, 30 minutes

Interventionbeats/min (Mean)
Oxymetazoline 0.05%2.8
Phenylephrine 0.25%5.2
Lidocaine 1% Plus Epinephrine 1:100,0007.5
Bacteriostatic 0.9% NaCL6.8

Change in Mean Arterial Blood Pressure

Change in mean arterial blood pressure from the baseline measurement (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%5.1
Phenylephrine 0.25%6.4
Lidocaine 1% Plus Epinephrine 1:100,0004.6
Bacteriostatic 0.9% NaCL6.5

Change in Systolic Blood Pressure

Change from baseline in systolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%7.5
Phenylephrine 0.25%8.2
Lidocaine 1% Plus Epinephrine 1:100,0003.5
Bacteriostatic 0.9% NaCL8.9

Reviews

3 reviews available for lidocaine and Nasal Bleeding

ArticleYear
Tranexamic acid for patients with nasal haemorrhage (epistaxis).
    The Cochrane database of systematic reviews, 2018, Dec-31, Volume: 12

    Topics: Administration, Oral; Administration, Topical; Antifibrinolytic Agents; Blood Transfusion; Epinephri

2018
Emergency Department care of childhood epistaxis.
    Emergency medicine journal : EMJ, 2017, Volume: 34, Issue:8

    Topics: Adolescent; Anesthetics; Cautery; Child; Child, Preschool; Electrocoagulation; Emergency Service, Ho

2017
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.
    Journal of emergency nursing, 2004, Volume: 30, Issue:2

    Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio

2004

Trials

8 trials available for lidocaine and Nasal Bleeding

ArticleYear
Comparison of the effects of articaine, tetracaine, and lidocaine application on pain and hemorrhage during and after nasal pack removal.
    Revista da Associacao Medica Brasileira (1992), 2021, Volume: 67, Issue:11

    Topics: Carticaine; Double-Blind Method; Epistaxis; Humans; Lidocaine; Pain, Postoperative; Prospective Stud

2021
Comparison of the therapeutic efficacy of topical tranexamic acid, epinephrine, and lidocaine in stopping bleeding in non-traumatic epistaxis: a prospective, randomized, double-blind study.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:9

    Topics: Administration, Topical; Adult; Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Me

2022
Intranasal Topical Application of Tranexamic Acid in Atraumatic Anterior Epistaxis: A Double-Blind Randomized Clinical Trial.
    Annals of emergency medicine, 2022, Volume: 80, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Double-Blind Method; Epistaxis; Humans; Iran; Lidocaine; Phenylephri

2022
Effects of glove finger- versus lidocaine-soaked nasal packing after endoscopic nasal surgery: a prospective randomized controlled trial.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bandages; Endoscopy; Epistaxis; Fema

2020
Utility of nasal application of lignocaine gel using cotton tip swab versus squirting with slip-tip syringe for transnasal fibreoptic bronchoscopy: a pilot randomised controlled trial.
    Postgraduate medical journal, 2022, Volume: 98, Issue:1163

    Topics: Bronchoscopy; Epistaxis; Humans; Lidocaine; Pain; Pilot Projects; Syringes

2022
Effect of Intranasal Vasoconstrictors on Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of emergency medicine, 2018, Volume: 55, Issue:4

    Topics: Administration, Intranasal; Anesthetics, Local; Blood Pressure; Double-Blind Method; Emergency Servi

2018
Does pterygopalatine canal injection with local anaesthetic and adrenaline decrease bleeding during functional endoscopic sinus surgery?
    The Journal of laryngology and otology, 2014, Volume: 128, Issue:9

    Topics: Adult; Aged; Anesthetics, Local; Blood Loss, Surgical; Chronic Disease; Epinephrine; Epistaxis; Fema

2014
Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:4

    Topics: Administration, Intranasal; Anesthesia, Dental; Anesthetics, Local; Child; Child, Preschool; Double-

2010

Other Studies

19 other studies available for lidocaine and Nasal Bleeding

ArticleYear
Unaltered, Endoscopic View of the Sphenoethmoid Recess Through the Second Pass.
    Ear, nose, & throat journal, 2021, Volume: 100, Issue:8

    Topics: Anesthetics, Local; Endoscopy; Epinephrine; Epistaxis; Ethmoid Sinus; Humans; Lidocaine; Male; Middl

2021
Efficacy of videolaryngoscope-guided glossopharyngeal nerve block in a patient with severe nasal bleeding.
    Journal of clinical anesthesia, 2018, Volume: 44

    Topics: Administration, Topical; Anesthetics, Local; Cautery; Emergency Treatment; Epistaxis; Glossopharynge

2018
Bilateral nasal septal chemical cautery: a safe and effective outpatient procedure for control of recurrent epistaxis, our experience in 134 patients.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anesthetics, Local; Anti-Infective Agen

2019
Greater palatine block in the treatment of acute epistaxis.
    Annals of the Royal College of Surgeons of England, 2015, Volume: 97, Issue:2

    Topics: Acute Disease; Anesthetics, Local; Cautery; Epinephrine; Epistaxis; Humans; Injections; Lidocaine; P

2015
Lidocaine Toxicity During Attempted Epistaxis Cautery.
    The Journal of emergency medicine, 2016, Volume: 51, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Bradycardia; Cautery; Epistaxis; Humans; Lidocaine; Male; Sei

2016
[ON THE CLINICAL ASPECTS AND THERAPY OF NOSEBLEED].
    Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie, 1963, Volume: 97

    Topics: Arteriosclerosis; Climacteric; Epistaxis; Geriatrics; Humans; Hypertension; Lidocaine; Menopause; Pr

1963
A NEW APPROACH TO THE PROBLEM OF SEVERE EPISTAXIS.
    The Annals of otology, rhinology, and laryngology, 1964, Volume: 73

    Topics: Anesthesia; Anesthesia, Local; Epistaxis; Hemostasis; Humans; Lidocaine; Menstrual Hygiene Products;

1964
THE NATURAL HISTORY AND THERAPY OF NASAL BLEEDING PRODUCING GERIATRIC PROBLEMS.
    The Journal of laryngology and otology, 1965, Volume: 79

    Topics: Arteriosclerosis; Blood Transfusion; Drug Therapy; Epistaxis; Geriatrics; Humans; Hypertension; Lido

1965
Removal of a nasal leech: a safe and effective method.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2005, Volume: 132, Issue:5

    Topics: Aged; Anesthetics, Local; Animals; Child; Epistaxis; Female; Humans; Leeches; Lidocaine; Male; Nasal

2005
Complications of awake fibreoptic intubation without sedation in 200 healthy anaesthetists attending a training course.
    British journal of anaesthesia, 2008, Volume: 100, Issue:6

    Topics: Anesthesia, Local; Anesthesiology; Anesthetics, Local; Awareness; Conscious Sedation; Education, Med

2008
A suitable substitute for 4% cocaine before blind nasotracheal intubation: 3% lidocaine-0.25% phenylephrine nasal spray.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:10

    Topics: Anesthesia, Local; Blood Pressure; Cocaine; Double-Blind Method; Drug Combinations; Epistaxis; Heart

1984
Transnasal transesophageal echocardiography: a modified application mode for cardiac examination in ventilated patients.
    Anesthesia and analgesia, 1999, Volume: 88, Issue:2

    Topics: Anatomy, Cross-Sectional; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Local; Bias; Bloo

1999
Hot-water irrigation in the treatment of posterior epistaxis.
    Archives of otolaryngology--head & neck surgery, 1999, Volume: 125, Issue:11

    Topics: Anesthetics, Local; Epistaxis; Hemostatics; Hot Temperature; Humans; Lidocaine; Phenylephrine; Tampo

1999
Greater palatine canal injection: an alternative to the posterior nasal packing and arterial ligation in epistaxis.
    The Journal of otolaryngology, 1986, Volume: 15, Issue:2

    Topics: Adult; Aged; Arteries; Epistaxis; Female; Hemostatic Techniques; Humans; Injections; Length of Stay;

1986
How to treat nosebleed.
    American family physician, 1973, Volume: 8, Issue:2

    Topics: Age Factors; Anticoagulants; Blood Coagulation Disorders; Cocaine; Craniocerebral Trauma; Drug Combi

1973
Managing epistaxis.
    Postgraduate medicine, 1974, Volume: 55, Issue:4

    Topics: Anesthesia, Local; Carotid Artery, External; Cocaine; Epistaxis; Ethmoid Sinus; Hemostasis; Humans;

1974
Postvaricella bleeding presenting as epistaxis.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:2

    Topics: Blood Coagulation; Chickenpox; Child, Preschool; Electrocoagulation; Epistaxis; Humans; Lidocaine; M

1970
Leech: a rare cause of epistaxis.
    The Journal of laryngology and otology, 1970, Volume: 84, Issue:1

    Topics: Adult; Epistaxis; Female; Humans; Leeches; Lidocaine

1970
A method for control of posterior nasal hemorrhage.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1968, Volume: 87, Issue:2

    Topics: Epinephrine; Epistaxis; Hemostasis; Humans; Injections; Lidocaine; Palate; Posture; Sphenoid Sinus

1968