lidocaine has been researched along with Mucositis, Oral in 24 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| " Based on the clinical evidence of pain alleviation by topical morphine in patients with some inflammatory and painful conditions, a clinical study was undertaken to determine this effect on mucositis-associated pain." | 9.10 | Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. ( Bonomi, MR; Cerchietti, LC; Menéndez, PR; Navigante, AH; Pogany, CE; Roth, BM; Zaderajko, MA, 2002) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| " Based on the clinical evidence of pain alleviation by topical morphine in patients with some inflammatory and painful conditions, a clinical study was undertaken to determine this effect on mucositis-associated pain." | 5.10 | Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. ( Bonomi, MR; Cerchietti, LC; Menéndez, PR; Navigante, AH; Pogany, CE; Roth, BM; Zaderajko, MA, 2002) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| "Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy." | 2.67 | Treatment of radiation- and chemotherapy-induced stomatitis. ( Barnes, M; Blakeslee, DB; Carnel, SB; Oswald, SG, 1990) |
| " Utilizing a 90-day BUD, lidocaine can be packaged separately from other magic mouthwash ingredients in individual dosage units and applied to the oral cavity using the swish-and-spit method." | 1.46 | Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations. ( Brown, SD; Huffman, J; Kirk, LM; Lewis, PO; Luu, Y; Ogle, A, 2017) |
| " Solid dosage forms that act by slow dissolution, such as pastilles, are an effective alternative to mouthwashes, for their versatility, ease of administration and extended residence time in the oral cavity." | 1.46 | Nystatin and lidocaine pastilles for the local treatment of oral mucositis. ( Almeida, AJ; Machado, P; Marto, JM; Salgado, A; Silva, AN; Silva, FC, 2017) |
| "Radiation-induced oral mucositis was assessed according to the radiation therapy oncology group criteria." | 1.43 | [Effect of Kou Yan Qing Ke Li on the prevention and treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma]. ( Li, Z; Xudong, H; Yun, G; Zehui, F, 2016) |
| "For the treatment of oral mucositis, carrageenan microspheres containing allopurinol and local anesthetic agents, such as lidocaine hydrochloride, dibucaine hydrochloride and tetracaine hydrochloride were prepared using a spray-drying method." | 1.35 | Preparation and properties of carrageenan microspheres containing allopurinol and local anesthetic agents for the treatment of oral mucositis. ( Asahiyama, M; Inagi, T; Kanebako, M; Makino, K; Nakajima, T; Ohtsuki, E; Terada, H; Tomoda, K, 2009) |
| "Five patients with high-grade oral mucositis after allogeneic BMT were entered consecutively into the study." | 1.30 | Systemic absorption of lidocaine after topical application for the treatment of oral mucositis in bone marrow transplantation patients. ( Cohen, G; Elad, S; Findler, M; Galili, D; Garfunkel, AA; Or, R; Zylber-Katz, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirk, LM | 1 |
| Brown, SD | 1 |
| Luu, Y | 1 |
| Ogle, A | 1 |
| Huffman, J | 1 |
| Lewis, PO | 1 |
| Elad, S | 2 |
| Yarom, N | 1 |
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Yamaguchi, K | 2 |
| Ono, K | 2 |
| Hitomi, S | 2 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 1 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 2 |
| Terawaki, K | 1 |
| Imai, R | 1 |
| Kubota, K | 1 |
| Omiya, Y | 1 |
| Hattori, T | 1 |
| Kase, Y | 1 |
| Abo Enin, HA | 1 |
| El Nabarawy, NA | 1 |
| Elmonem, RA | 1 |
| Yun, G | 1 |
| Li, Z | 1 |
| Zehui, F | 1 |
| Xudong, H | 1 |
| Silva, FC | 1 |
| Marto, JM | 1 |
| Salgado, A | 1 |
| Machado, P | 1 |
| Silva, AN | 1 |
| Almeida, AJ | 1 |
| Tomoda, K | 1 |
| Asahiyama, M | 1 |
| Ohtsuki, E | 1 |
| Nakajima, T | 1 |
| Terada, H | 1 |
| Kanebako, M | 1 |
| Inagi, T | 1 |
| Makino, K | 1 |
| Khanal, B | 1 |
| Baliga, M | 1 |
| Uppal, N | 1 |
| Cerchietti, LC | 1 |
| Navigante, AH | 1 |
| Bonomi, MR | 1 |
| Zaderajko, MA | 1 |
| Menéndez, PR | 1 |
| Pogany, CE | 1 |
| Roth, BM | 1 |
| GREGG, JB | 1 |
| BARNETT, GL | 1 |
| ENSBERG, DL | 1 |
| Schalock, PC | 1 |
| Dinulos, JG | 1 |
| Coetzee, MJ | 1 |
| Boshoff, B | 1 |
| Goedhals, L | 1 |
| Pienaar, FD | 1 |
| Bondi, E | 1 |
| Baroni, C | 1 |
| Prete, A | 1 |
| Gatti, M | 1 |
| Carrassi, A | 1 |
| Lodi, G | 1 |
| Porter, SR | 1 |
| Cohen, G | 1 |
| Zylber-Katz, E | 1 |
| Findler, M | 1 |
| Galili, D | 1 |
| Garfunkel, AA | 1 |
| Or, R | 1 |
| Turhal, NS | 1 |
| Erdal, S | 1 |
| Karacay, S | 1 |
| Dodd, MJ | 1 |
| Dibble, SL | 1 |
| Miaskowski, C | 1 |
| MacPhail, L | 1 |
| Greenspan, D | 1 |
| Paul, SM | 1 |
| Shiba, G | 1 |
| Larson, P | 1 |
| Carnel, SB | 1 |
| Blakeslee, DB | 1 |
| Oswald, SG | 1 |
| Barnes, M | 1 |
| Arrowsmith, JB | 1 |
| Creamer, JI | 1 |
| Bosco, L | 1 |
| Hathaway, G | 1 |
| Stern, C | 1 |
| Kletzel, M | 1 |
| Dolby, AE | 1 |
| Prandi, EC | 1 |
| Lehrmann, AE | 1 |
| Goudaert, M | 1 |
| Carlier, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia During Subcutaneous Implantable Venous Access Devices Insertion: Double Blind Randomized Study.[NCT03628430] | 120 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-08-04 | Recruiting | ||
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Evaluating the Effectiveness of Topical Morphine Compared With a Routine Mouthwash in Managing Cancer Treatment-induced Mucositis in Patients With Head and Neck Cancer in Isfahan[NCT01837446] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
1 review available for lidocaine and Mucositis, Oral
| Article | Year |
|---|---|
Mycoplasma pneumoniae-induced Stevens-Johnson syndrome without skin lesions: fact or fiction?
Topics: Adolescent; Azithromycin; Child; Conjunctivitis; Fluid Therapy; Humans; Lidocaine; Male; Mycoplasma | 2005 |
7 trials available for lidocaine and Mucositis, Oral
| Article | Year |
|---|---|
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Chi-Square Distribution; Cranial Irr | 2010 |
Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Ant | 2002 |
Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.
Topics: Adolescent; Aluminum Hydroxide; Amphotericin B; Antineoplastic Agents; Bone Marrow Transplantation; | 1997 |
Efficacy of treatment to relieve mucositis-induced discomfort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Antineoplastic Agents; Diphenhydrami | 2000 |
Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis.
Topics: Aluminum Hydroxide; Analysis of Variance; Anesthetics, Local; Antacids; Anti-Infective Agents, Local | 2000 |
Treatment of radiation- and chemotherapy-induced stomatitis.
Topics: Administration, Topical; Cocaine; Diphenhydramine; Drug Combinations; Humans; Kaolin; Lidocaine; Mou | 1990 |
16 other studies available for lidocaine and Mucositis, Oral
| Article | Year |
|---|---|
Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics; Antineoplastic Agents; Diphenhydramine; Drug C | 2017 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis | 2019 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
Treatment of Radiation-Induced Oral Mucositis Using a Novel Accepted Taste of Prolonged Release Mucoadhesive Bi-medicated Double-Layer Buccal Films.
Topics: Adhesiveness; Adhesives; Administration, Buccal; Adult; Analgesics; Animals; Anti-Inflammatory Agent | 2017 |
[Effect of Kou Yan Qing Ke Li on the prevention and treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma].
Topics: Carcinoma; Humans; Lidocaine; Mouth Mucosa; Mouthwashes; Nasopharyngeal Carcinoma; Nasopharyngeal Ne | 2016 |
Nystatin and lidocaine pastilles for the local treatment of oral mucositis.
Topics: Antifungal Agents; Candida albicans; Candidiasis, Oral; Drug Liberation; Hardness; Humans; Lidocaine | 2017 |
Preparation and properties of carrageenan microspheres containing allopurinol and local anesthetic agents for the treatment of oral mucositis.
Topics: Allopurinol; Anesthetics; Carrageenan; Drug Carriers; Lidocaine; Microscopy, Electron, Scanning; Mic | 2009 |
Mucosal slough reaction to topical anesthetic, lidocaine.
Topics: Anesthesia, Local; Anesthetics, Local; Humans; Lidocaine; Stomatitis | 1963 |
Formula C--popular, cheap and readily available relief for radiation and cancer chemotherapy mucositis.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Betamethasone; D | 1997 |
Systemic absorption of lidocaine after topical application for the treatment of oral mucositis in bone marrow transplantation patients.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Bone Marrow Transplantation; Case-Co | 1999 |
Severe dermatologic reactions reported after treatment with tocainide.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Dermatitis, Exfoliative; Drug Eruptions; Ery | 1987 |
Clinical problem: mucositis.
Topics: Antineoplastic Agents; Child; Drug Combinations; Humans; Lidocaine; Neomycin; Nystatin; Stomatitis | 1986 |
Management of recurrent oral ulceration.
Topics: Administration, Topical; Anti-Inflammatory Agents; Chlordiazepoxide; Humans; Hydrocortisone; Isocarb | 1973 |
[Herpetic gingivostomatitis: diagnosis and therapeutic approach].
Topics: Adult; Anti-Bacterial Agents; Herpes Simplex; Humans; Lidocaine; Male; Stomatitis | 1968 |
[3 cases of necrosis of the palatine mucosa after local anesthesia].
Topics: Adult; Anesthesia, Dental; Humans; Lidocaine; Male; Mouth Mucosa; Necrosis; Palate; Stomatitis | 1968 |