lidocaine has been researched along with Methemoglobinemia in 102 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 9.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| " It teaches the recognition and management of an infant with lidocaine toxicity and resultant methemoglobinemia." | 8.02 | Pediatric Toxidrome Simulation Curriculum: Lidocaine-Induced Methemoglobinemia. ( Burns, R; Connelly, S; Davila, U; Hardy, N; Mazor, S; Pearce, J; Rosso, CD; Thomas, A, 2021) |
| "Neonatal methemoglobinemia is a rare and potentially fatal complication of local anesthetics, particularly prilocaine, administered to the mother during childbirth." | 8.02 | [Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine]. ( Alers, NO; Leijten, A; Ten Brink, F; van de Laar, R; van der Heijden, HHACM; Wieland, BV, 2021) |
| "We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery." | 7.88 | Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( Acevedo, FA; Chyatte, DA; Kim, EJ; Nielsen, VG, 2018) |
| "The results of our study were consistent with the literature; lidocaine associated methemoglobinemia is a rare complication." | 7.85 | Methemoglobinemia incidence after the application of lidocaine for small surgical procedures. ( Akkuş, Y; Çiftçi, H; Çığşar, G; Günal, E; Kahramanca, Ş; Özdemir, M, 2017) |
| "We attempted to clarify this issue by comparing the clinical course of methemoglobinemia caused by dapsone and that caused by other toxic agents." | 7.83 | Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( Ahn, S; Kim, WY; Kim, YJ; Lee, JH; Lee, YS; Lim, KS; Oh, BJ; Ryoo, SM; Seo, DW; Sohn, CH, 2016) |
| "Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia." | 7.79 | Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation. ( Fukami, T; Higuchi, R; Nakajima, M; Yokoi, T, 2013) |
| "Even though we did not measure lidocaine plasma levels, lidocaine was the most likely cause of postoperative methemoglobinemia." | 7.74 | Postoperative methemoglobinemia following infiltrative lidocaine administration for combined anesthesia in pediatric craniofacial surgery. ( Christophis, P; Heckmann, M; Howaldt, HP; Mann, V; Neuhaeuser, C; Schaaf, H; Weigand, N, 2008) |
| "Lidocaine use may lead to methemoglobinemia." | 7.71 | [Methemoglobinemia induced by repeated abuse of lidocaine viscous gel]. ( Borel, M; Goulle, J; Lacroix, C; Peureux, M, 2002) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 6.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "Methemoglobinemia is a rare condition in which the iron in hemoglobin is stabilized in the ferric (Fe(3+)) form, making it unable to bind oxygen and leading to tissue hypoxia and possibly death." | 6.52 | Lidocaine-induced methemoglobinemia: a clinical reminder. ( Barash, M; Rademaker, D; Reich, KA, 2015) |
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 5.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| " In adults, pre-TEE lidocaine anesthesia with recommended dosage results in significant increase in methemoglobin blood level, which however does not exceed normal values and does not result in clinically evident methemoglobinemia." | 5.42 | The influence of lidocaine topical anesthesia during transesophageal echocardiography on blood methemoglobin level and risk of methemoglobinemia. ( Filipiak-Strzecka, D; Kasprzak, JD; Lipiec, P; Walusiak-Skorupa, J; Wiszniewska, M, 2015) |
| "Methemoglobinemia is an uncommon cause of cyanosis; however, rapid diagnosis is critical to avoid potentially fatal consequences." | 5.31 | Methemoglobinemia after topical anesthesia with lidocaine and benzocaine for a difficult intubation. ( Dunn, BM; Kern, K; Langevin, PB, 2000) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| " A dose-response relationship between benzocaine and MHb was investigated." | 5.28 | Topical anesthetic-induced methemoglobinemia in sheep: a comparison of benzocaine and lidocaine. ( Guertler, AT; Lagutchik, MS; Martin, DG, 1992) |
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 5.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| "Neonatal methemoglobinemia is a rare and potentially fatal complication of local anesthetics, particularly prilocaine, administered to the mother during childbirth." | 4.02 | [Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine]. ( Alers, NO; Leijten, A; Ten Brink, F; van de Laar, R; van der Heijden, HHACM; Wieland, BV, 2021) |
| "We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery." | 3.88 | Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( Acevedo, FA; Chyatte, DA; Kim, EJ; Nielsen, VG, 2018) |
| "The results of our study were consistent with the literature; lidocaine associated methemoglobinemia is a rare complication." | 3.85 | Methemoglobinemia incidence after the application of lidocaine for small surgical procedures. ( Akkuş, Y; Çiftçi, H; Çığşar, G; Günal, E; Kahramanca, Ş; Özdemir, M, 2017) |
| " Topical anesthesia with benzocaine or lidocaine occasionally causes methemoglobinemia, an uncommon but potentially fatal disorder where the blood has a reduced ability to transport oxygen." | 3.85 | Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. ( Boyne, M; Colatsky, T; Hartman, N; Mans, D; Mao, J; Patel, V; Zhou, H, 2017) |
| "We attempted to clarify this issue by comparing the clinical course of methemoglobinemia caused by dapsone and that caused by other toxic agents." | 3.83 | Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. ( Ahn, S; Kim, WY; Kim, YJ; Lee, JH; Lee, YS; Lim, KS; Oh, BJ; Ryoo, SM; Seo, DW; Sohn, CH, 2016) |
| " Methylene blue was administered and the patient promptly responded with resolution of cyanosis." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| " We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity." | 3.79 | Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013) |
| " Due to the application of EMLA(R) on the injured skin and exceeding the recommended doses of prilocaine and lidocaine the child developed symptomatic methemoglobinemia." | 3.75 | [Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries]. ( Book, A; Fehlandt, C; Krija, M; Pappert, D; Radke, M, 2009) |
| "Even though we did not measure lidocaine plasma levels, lidocaine was the most likely cause of postoperative methemoglobinemia." | 3.74 | Postoperative methemoglobinemia following infiltrative lidocaine administration for combined anesthesia in pediatric craniofacial surgery. ( Christophis, P; Heckmann, M; Howaldt, HP; Mann, V; Neuhaeuser, C; Schaaf, H; Weigand, N, 2008) |
| "We describe a 3-year-old child with mollusca contagiosa whose caregiver applied a eutectic mixture of 5% lidocaine and prilocaine (EMLA) in excessive amounts with the subsequent development of adverse reactions, including methemoglobinemia and hypoxemia." | 3.71 | Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa. ( Jackson, JB; Touma, S, 2001) |
| "Lidocaine use may lead to methemoglobinemia." | 3.71 | [Methemoglobinemia induced by repeated abuse of lidocaine viscous gel]. ( Borel, M; Goulle, J; Lacroix, C; Peureux, M, 2002) |
| "These results demonstrate that if oxidant drugs (acetaminophen, phytomenadione, or EMLA cream) did not increase blood methemoglobinemia in neonatal piglets, their association with iNO caused an increase in methemoglobin." | 3.70 | Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets. ( Klosowski, S; Kongolo, G; Lequien, P; Martin-Ponthieu, A; Rakza, T; Riou, Y; Storme, L; Zerimech, F, 2000) |
| " Methemoglobinemia was diagnosed, due to prilocaine-lignocaine cream used for local anesthesia, associated to partial G6PD deficiency." | 3.69 | [Pulse oximetry and methemoglobinemia]. ( Cloup, M; Doz, F; Hubert, P; Jouvet, P; Moretti, S; Schleiermacher, G; Zucker, JM, 1996) |
| "EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine." | 3.69 | Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision. ( Gazarian, M; Kent, G; Klein, J; Koren, G; Taddio, A, 1995) |
| "Phenazopyridine has been associated with methemoglobinemia in patients who have received an overdose, have decreased renal function, or are discovered to be unusually susceptible to the drug (ie, they may have an undetected NADH methemoglobin reductase deficiency)." | 3.68 | Acquired methemoglobinemia from multiple oxidants. ( Bailey, MK; Baker, JD; Conroy, JM; Dorman, BH; Martin, WJ, 1993) |
| " While safe and well-tolerated when used appropriately, an overdose of these anesthetics increases the risk for local anesthetic systemic toxicity (LAST), which in severe cases can present with seizures, cardiac dysrhythmias, and ultimately cardiovascular collapse." | 2.82 | Local anesthetic systemic toxicity in the pediatric patient. ( Baker, KA; McMahon, K; Paster, J, 2022) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 2.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 1.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| "Methemoglobinemia is an uncommon cause of tissue hypoxemia that can be life-threatening if not promptly identified and treated." | 1.33 | Methemoglobinemia after transesophageal echocardiography: a life-threatening complication. ( Glick, N; Jacka, MJ; Kruger, M, 2006) |
| "Methemoglobinemia is an uncommon cause of cyanosis; however, rapid diagnosis is critical to avoid potentially fatal consequences." | 1.31 | Methemoglobinemia after topical anesthesia with lidocaine and benzocaine for a difficult intubation. ( Dunn, BM; Kern, K; Langevin, PB, 2000) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "Mild methemoglobinemia is a known side-effect of one of the constituents of EMLA cream, this topical local anesthetic is used with great caution in neonates." | 1.29 | [Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance]. ( Dhabhi, S; el Hanache, A; Gourrier, E; Karoubi, P; Leraillez, J; Merbouche, S; Mouchnino, G, 1995) |
| "Because toxic methemoglobinemia is easily treated, our report emphasizes the need to recognize this problem when topically applied anesthetic sprays are used." | 1.29 | Methemoglobinemia from topically applied anesthetic spray. ( Dinneen, SF; Fairbanks, VF; Mohr, DN, 1994) |
| " A dose-response relationship between benzocaine and MHb was investigated." | 1.28 | Topical anesthetic-induced methemoglobinemia in sheep: a comparison of benzocaine and lidocaine. ( Guertler, AT; Lagutchik, MS; Martin, DG, 1992) |
| "A patient with the acquired immunodeficiency syndrome (AIDS) developed severe cyanosis after bronchoscopy (oxygen saturation 34%) from methaemoglobinaemia." | 1.28 | Severe methaemoglobinaemia after flexible fibreoptic bronchoscopy. ( Casey, MP; Hansen-Flaschen, J; Kotler, RL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (24.51) | 18.7374 |
| 1990's | 25 (24.51) | 18.2507 |
| 2000's | 25 (24.51) | 29.6817 |
| 2010's | 21 (20.59) | 24.3611 |
| 2020's | 6 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| McMahon, K | 1 |
| Paster, J | 1 |
| Baker, KA | 1 |
| Khajavirad, N | 1 |
| Daftari, G | 1 |
| Jelodar, MR | 1 |
| Woo, NL | 1 |
| Cherian, S | 1 |
| Heaney, M | 1 |
| Wahl, G | 1 |
| Rosso, CD | 1 |
| Thomas, A | 1 |
| Hardy, N | 1 |
| Connelly, S | 1 |
| Davila, U | 1 |
| Pearce, J | 1 |
| Mazor, S | 1 |
| Burns, R | 1 |
| Thraenert, BG | 1 |
| Wiste, J | 1 |
| Cousins, NL | 1 |
| Hoehn, SM | 1 |
| Carroll, A | 1 |
| Bremer, ML | 1 |
| Thaden, JT | 1 |
| Mankad, SV | 1 |
| Kane, GC | 1 |
| Wieland, BV | 1 |
| Leijten, A | 1 |
| van der Heijden, HHACM | 1 |
| van de Laar, R | 1 |
| Ten Brink, F | 1 |
| Alers, NO | 1 |
| Acevedo, FA | 1 |
| Kim, EJ | 1 |
| Chyatte, DA | 1 |
| Nielsen, VG | 1 |
| Günal, E | 1 |
| Akkuş, Y | 1 |
| Çığşar, G | 1 |
| Çiftçi, H | 1 |
| Kahramanca, Ş | 1 |
| Özdemir, M | 1 |
| Larson, A | 1 |
| Stidham, T | 1 |
| Banerji, S | 1 |
| Kaufman, J | 1 |
| Higuchi, R | 1 |
| Fukami, T | 1 |
| Nakajima, M | 1 |
| Yokoi, T | 1 |
| Wieman, MS | 1 |
| Bertarelli, DC | 1 |
| Brockbals, C | 1 |
| Weingarten, TN | 2 |
| Sprung, J | 2 |
| Selder, J | 1 |
| Veenstra, J | 1 |
| Gutenberg, LL | 1 |
| Chen, JW | 1 |
| Trapp, L | 2 |
| Shamriz, O | 1 |
| Cohen-Glickman, I | 1 |
| Reif, S | 1 |
| Shteyer, E | 1 |
| Hartman, NR | 1 |
| Mao, JJ | 1 |
| Zhou, H | 2 |
| Boyne, MT | 1 |
| Wasserman, AM | 1 |
| Taylor, K | 1 |
| Racoosin, JA | 1 |
| Patel, V | 2 |
| Colatsky, T | 2 |
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Barash, M | 1 |
| Reich, KA | 1 |
| Rademaker, D | 1 |
| Filipiak-Strzecka, D | 1 |
| Kasprzak, JD | 1 |
| Wiszniewska, M | 1 |
| Walusiak-Skorupa, J | 1 |
| Lipiec, P | 1 |
| Hartman, N | 1 |
| Mao, J | 1 |
| Mans, D | 1 |
| Boyne, M | 1 |
| Cho, YS | 1 |
| Chung, BY | 1 |
| Park, CW | 1 |
| Kim, HO | 1 |
| Kim, YJ | 1 |
| Sohn, CH | 1 |
| Ryoo, SM | 1 |
| Ahn, S | 1 |
| Seo, DW | 1 |
| Lee, YS | 1 |
| Lee, JH | 1 |
| Oh, BJ | 1 |
| Lim, KS | 1 |
| Kim, WY | 1 |
| Bohnhorst, B | 1 |
| Hartmann, H | 1 |
| Lange, M | 1 |
| Moreno Higueras, M | 1 |
| López Robles, MC | 1 |
| Giner Escobar, MP | 1 |
| Cantero Hinojosa, J | 1 |
| Book, A | 1 |
| Fehlandt, C | 1 |
| Krija, M | 1 |
| Radke, M | 1 |
| Pappert, D | 1 |
| Guay, J | 1 |
| Will, J | 1 |
| Sambrook, PJ | 1 |
| Smith, W | 1 |
| Elijah, J | 1 |
| Goss, AN | 1 |
| Gleich, SJ | 1 |
| Craig, JR | 1 |
| Schmitt, C | 1 |
| Matulic, M | 1 |
| Kervégant, M | 1 |
| Tichadou, L | 1 |
| Boutin, A | 1 |
| Glaizal, M | 1 |
| de Haro, L | 1 |
| Sinisterra, S | 1 |
| Miravet, E | 1 |
| Alfonso, I | 1 |
| Soliz, A | 1 |
| Papazian, O | 1 |
| Picton, P | 1 |
| Wilkins, AN | 1 |
| DEAS, TC | 1 |
| SCOTT, DB | 2 |
| OWEN, JA | 1 |
| RICHMOND, J | 1 |
| BURNE, D | 1 |
| DOUGHTY, A | 1 |
| HJELM, M | 2 |
| HOLMDAHL, MH | 2 |
| ASTROEM, A | 1 |
| Hahn, IH | 1 |
| Hoffman, RS | 1 |
| Nelson, LS | 1 |
| Maran, J | 1 |
| Guan, Y | 1 |
| Ou, CN | 1 |
| Prchal, JT | 1 |
| Pérez-Caballero Macarrón, C | 1 |
| Pérez Palomino, A | 1 |
| Moreno Fernández, L | 1 |
| Paparella, S | 1 |
| Jacka, MJ | 1 |
| Kruger, M | 1 |
| Glick, N | 1 |
| Gutta, R | 1 |
| Louis, PJ | 1 |
| Elsaie, ML | 1 |
| Neuhaeuser, C | 1 |
| Weigand, N | 1 |
| Schaaf, H | 1 |
| Mann, V | 1 |
| Christophis, P | 1 |
| Howaldt, HP | 1 |
| Heckmann, M | 1 |
| Shachor-Meyouhas, Y | 1 |
| Galbraith, R | 1 |
| Shavit, I | 1 |
| O'Donohue, WJ | 1 |
| Moss, LM | 1 |
| Angelillo, VA | 1 |
| Gourrier, E | 3 |
| Leraillez, J | 3 |
| Boudreau, GA | 1 |
| Nioloux, C | 1 |
| Floch-Tudal, C | 1 |
| Jaby-Sergent, MP | 1 |
| Lejeune, C | 1 |
| Dinneen, SF | 1 |
| Mohr, DN | 1 |
| Fairbanks, VF | 1 |
| Conroy, JM | 1 |
| Baker, JD | 1 |
| Martin, WJ | 1 |
| Bailey, MK | 1 |
| Dorman, BH | 1 |
| Karoubi, P | 2 |
| el Hanache, A | 2 |
| Merbouche, S | 2 |
| Mouchnino, G | 2 |
| Dhabhi, S | 1 |
| Litman, SJ | 1 |
| Vitkun, SA | 1 |
| Poppers, PJ | 2 |
| Moretti, S | 1 |
| Jouvet, P | 1 |
| Schleiermacher, G | 1 |
| Hubert, P | 1 |
| Doz, F | 1 |
| Zucker, JM | 1 |
| Cloup, M | 1 |
| Gazarian, M | 1 |
| Taddio, A | 3 |
| Klein, J | 1 |
| Kent, G | 1 |
| Koren, G | 3 |
| Puthoff, TD | 1 |
| Visconti, JA | 1 |
| Tschampel, MM | 1 |
| Law, RM | 1 |
| Halpern, S | 1 |
| Martins, RF | 1 |
| Reich, H | 1 |
| Innanen, V | 1 |
| Ohlsson, A | 1 |
| Stevens, B | 2 |
| Craig, K | 1 |
| Rastogi, P | 1 |
| Ben-David, S | 1 |
| Shennan, A | 1 |
| Mulligan, P | 1 |
| Kumar, AR | 1 |
| Dunn, N | 1 |
| Naqvi, M | 1 |
| Elsner, P | 1 |
| Dummer, R | 1 |
| Capron, F | 1 |
| Perry, D | 1 |
| Capolaghi, B | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Johnston, C | 1 |
| Jack, A | 1 |
| Narciso, J | 1 |
| Stremler, R | 1 |
| Aranda, J | 1 |
| Frey, B | 1 |
| Kehrer, B | 1 |
| Riou, Y | 1 |
| Storme, L | 1 |
| Klosowski, S | 1 |
| Rakza, T | 1 |
| Kongolo, G | 1 |
| Zerimech, F | 1 |
| Martin-Ponthieu, A | 1 |
| Lequien, P | 1 |
| Kern, K | 1 |
| Langevin, PB | 1 |
| Dunn, BM | 1 |
| Couper, RT | 1 |
| Touma, S | 1 |
| Jackson, JB | 1 |
| Lorelli, DR | 1 |
| Morris, DE | 1 |
| Lewis, JW | 1 |
| Karim, A | 1 |
| Ahmed, S | 1 |
| Siddiqui, R | 1 |
| Mattana, J | 1 |
| Baraka, AS | 1 |
| Ayoub, CM | 1 |
| Kaddoum, RN | 1 |
| Maalouli, JM | 1 |
| Chehab, IR | 1 |
| Hadi, UM | 1 |
| Friedman, PM | 1 |
| Mafong, EA | 1 |
| Friedman, ES | 1 |
| Geronemus, RG | 1 |
| Voelker, CA | 1 |
| Brown, L | 1 |
| Hinson, RM | 1 |
| Lacroix, C | 1 |
| Peureux, M | 1 |
| Borel, M | 1 |
| Goulle, J | 1 |
| Guertler, AT | 1 |
| Lagutchik, MS | 1 |
| Martin, DG | 1 |
| Radford, M | 1 |
| Pinder, AM | 1 |
| Nilsson, A | 3 |
| Engberg, G | 2 |
| Henneberg, S | 2 |
| Danielson, K | 2 |
| De Verdier, CH | 1 |
| Hansen-Flaschen, J | 2 |
| Frayling, IM | 1 |
| Addison, GM | 1 |
| Chattergee, K | 1 |
| Meakin, G | 1 |
| Kotler, RL | 1 |
| Casey, MP | 1 |
| Bader, AM | 1 |
| Concepcion, M | 1 |
| Hurley, RJ | 1 |
| Arthur, GR | 1 |
| Foxworth, JW | 1 |
| Roberts, JA | 1 |
| Mahmoud, SF | 1 |
| Weiss, LD | 1 |
| Generalovich, T | 1 |
| Heller, MB | 1 |
| Paris, PM | 1 |
| Stewart, RD | 1 |
| Kaplan, RM | 1 |
| Thompson, DR | 1 |
| Konietzke, D | 1 |
| Leyser, KH | 1 |
| Lanz, E | 1 |
| Jakobson, B | 1 |
| Eriksson, E | 1 |
| Harris, WH | 2 |
| Geddes, IC | 1 |
| Dudley, AG | 1 |
| Conrad, LL | 1 |
| Markham, SM | 1 |
| Epstein, BS | 1 |
| Coakley, CS | 1 |
| Barter, RH | 1 |
| Chamberlain, G | 1 |
| Usubiaga, JE | 1 |
| La Iuppa, M | 1 |
| Moya, F | 1 |
| Wikinski, JA | 1 |
| Velazco, R | 1 |
| Truant, AP | 1 |
| Slater, EM | 1 |
| Bell, HM | 1 |
| Vosburgh, GJ | 1 |
| Finster, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Fractional Carbon Dioxide Laser Assisted Delivery of Topical Anesthetics: a Randomized Controlled Pilot Study[NCT02246179] | Phase 4 | 10 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time[NCT03279757] | Phase 4 | 15 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Laser Type and Laser Settings[NCT02938286] | Phase 4 | 15 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Does Use of Lidocaine Spray on an Endoscope Immediately Before Insertion Improve Patient Tolerance to Endoscopy? A Single Center, Case-Control Study.[NCT02307773] | 497 participants (Actual) | Observational | 2013-11-30 | Completed | |||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
6 reviews available for lidocaine and Methemoglobinemia
| Article | Year |
|---|---|
Local anesthetic systemic toxicity in the pediatric patient.
Topics: Anesthetics, Local; Child; Female; Humans; Infant; Lidocaine; Lidocaine, Prilocaine Drug Combination | 2022 |
Methemoglobinemia induced by lidocaine-prilocaine cream.
Topics: Anesthetics, Combined; Anesthetics, Local; Child; Cyanosis; Enzyme Inhibitors; Female; Humans; Lidoc | 2014 |
Lidocaine-induced methemoglobinemia: a clinical reminder.
Topics: Anesthetics, Local; Hemoglobins; Humans; Lidocaine; Methemoglobinemia; Oxidants | 2015 |
Methemoglobinemia related to local anesthetics: a summary of 242 episodes.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Anesthetics, Local; Benzocaine; Chi | 2009 |
Acquired methemoglobinemia revisited.
Topics: Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Enzyme Inhibitors; Hemogl | 2010 |
Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia.
Topics: Administration, Topical; Aerosols; Anesthetics, Local; Benzocaine; Dose-Response Relationship, Drug; | 2005 |
7 trials available for lidocaine and Methemoglobinemia
| Article | Year |
|---|---|
Methemoglobin levels in generally anesthetized pediatric dental patients receiving prilocaine versus lidocaine.
Topics: Analysis of Variance; Anesthesia, Dental; Anesthesia, General; Anesthetics, Local; Chi-Square Distri | 2013 |
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Crying; Double-Blind Method; Drug Combina | 1997 |
Use of EMLA cream in a department of neonatology.
Topics: Anesthetics, Local; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; Hospital Departments; | 1996 |
Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
Topics: Anesthetics, Combined; Anesthetics, Local; Heel; Humans; Infant, Newborn; Infant, Premature; Lidocai | 1999 |
[Comparison of prilocaine 2% versus lidocaine 2% with adrenaline in peridural anesthesia. A clinical double-blind study].
Topics: Adult; Analgesia; Anesthesia, Epidural; Clinical Trials as Topic; Double-Blind Method; Epinephrine; | 1985 |
Review of the properties of two new local anaesthetics, prilocaine and lidocaine.
Topics: Adjuvants, Anesthesia; Anesthesia, Local; Anesthesia, Spinal; Animals; Brain; Clinical Trials as Top | 1966 |
Choice of anesthetic agents for intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Benzoates; Central Nervous System; Clinical Trials | 1969 |
89 other studies available for lidocaine and Methemoglobinemia
| Article | Year |
|---|---|
Hemolysis and acquired methemoglobinemia associated with lidocaine and benzocaine topical application: a case report.
Topics: Adult; Anesthetics, Local; Benzocaine; Hemolysis; Humans; Lidocaine; Male; Methemoglobinemia; Methyl | 2023 |
Methaemoglobinaemia secondary to topical prilocaine toxicity: A cautionary circumcision tale.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Lidocaine; Male; Methemoglobinemia; Prilocaine | 2021 |
Pediatric Toxidrome Simulation Curriculum: Lidocaine-Induced Methemoglobinemia.
Topics: Computer Simulation; Curriculum; Humans; Infant; Lidocaine; Male; Methemoglobinemia; Pediatric Emerg | 2021 |
Nursing Staff Administered Topical Lidocaine Anesthesia in Transesophageal Echocardiography: Impact on Quality, Delivery of Care, and the Rates of Methemoglobinemia.
Topics: Anesthesia; Echocardiography, Transesophageal; Humans; Lidocaine; Methemoglobinemia; Nursing Staff | 2021 |
[Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine].
Topics: Anesthetics, Local; Cyanosis; Humans; Infant, Newborn; Lidocaine; Methemoglobinemia; Prilocaine | 2021 |
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia.
Topics: Aged, 80 and over; Anesthetics, Local; Coronary Artery Bypass; Delirium; Humans; Hypoxia; Lidocaine; | 2018 |
Methemoglobinemia incidence after the application of lidocaine for small surgical procedures.
Topics: Adult; Anesthetics, Local; Cross-Sectional Studies; Emergencies; Female; Hospitals, University; Huma | 2017 |
Seizures and methemoglobinemia in an infant after excessive EMLA application.
Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Infant; Lidoca | 2013 |
Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation.
Topics: Adult; Animals; Carboxylesterase; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Down-Regulation; | 2013 |
Response to Weingarten, "Methemoglobinemia in the setting of chronic transdermal lidocaine patch use," Pain Medicine 2012.
Topics: Female; Humans; Lidocaine; Methemoglobinemia; Transdermal Patch | 2013 |
Response to letter by dr. Wieman.
Topics: Female; Humans; Lidocaine; Methemoglobinemia; Transdermal Patch | 2013 |
[Methaemoglobinaemia after using EMLA cream].
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Female; Humans; Lidocaine | 2013 |
More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems.
Topics: Anesthetics, Local; Aniline Compounds; Benzocaine; Cytochrome P-450 Enzyme System; Humans; In Vitro | 2014 |
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
The influence of lidocaine topical anesthesia during transesophageal echocardiography on blood methemoglobin level and risk of methemoglobinemia.
Topics: Administration, Cutaneous; Aged; Anesthesia, Local; Anesthetics, Local; Biomarkers; Echocardiography | 2015 |
Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine.
Topics: Acetaminophen; Anesthetics, Local; Benzocaine; Humans; Lidocaine; Methemoglobin; Methemoglobinemia | 2017 |
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Dermatitis, Atopic; Female; Humans; L | 2016 |
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Dapsone; Dose-Response Relationship, Drug; Dru | 2016 |
Severe methemoglobinemia caused by continuous lidocaine infusion in a term neonate.
Topics: Anesthetics, Local; Female; Humans; Infant, Newborn; Infusions, Intravenous; Lidocaine; Methemoglobi | 2017 |
[Methemoglobinemia induced by local anesthetic administration previous to laser depilation].
Topics: Adult; Anesthetics, Local; Female; Hair Removal; Humans; Lasers; Lidocaine; Methemoglobinemia; Prilo | 2008 |
[Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries].
Topics: Administration, Topical; Anesthetics, Local; Bandages; Burns; Cyanosis; Diagnosis, Differential; Hum | 2009 |
Severe adverse reactions to dental local anaesthetics: systemic reactions.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den | 2011 |
Methemoglobinemia in the setting of chronic transdermal lidocaine patch use.
Topics: Administration, Topical; Anesthetics, Local; Female; Humans; Lidocaine; Methemoglobinemia; Middle Ag | 2012 |
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Topics: Anesthetics, Combined; Child, Preschool; Dosage Forms; Drug Overdose; Female; Humans; Lidocaine; Lid | 2012 |
Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.
Topics: Administration, Inhalation; Anesthetics, Combined; Anesthetics, Local; Female; Humans; Infant; Lidoc | 2002 |
The use of lubricants to achieve tracheal intubation in neonates and infants.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Female; Humans; Infant, Newborn; Intubation, Intratracheal | 2002 |
Severe methemoglobinemia following dental extractions under lidocaine anesthesia.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthetics; Anesthetics, Local; Humans; Lidocaine; | 1956 |
METHAEMOGLOBINAEMIA DUE TO PRILOCAINE.
Topics: Anesthetics; Anesthetics, Local; Cyanosis; Humans; Lidocaine; Methemoglobinemia; Prilocaine; Toxicol | 1964 |
METHAEMOGLOBINAEMIA FOLLOWING LIGNOCAINE.
Topics: Anesthesia; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthesiology; Humans; Lidocaine; Methemog | 1964 |
METHAEMOGLOBINAEMIA FOLLOWING LIGNOCAINE.
Topics: Anesthetics; Anesthetics, Local; Humans; Lidocaine; Methemoglobinemia; Methylene Blue; Procaine; Tox | 1965 |
RECENT ADVANCES IN LOCAL ANALGESIA. SOME PHARMACOLOGICAL PROPERTIES DETERMINING ACTION AND TOXICITY OF LOCAL ANAESTHETICS.
Topics: Analgesia; Anesthesia, Local; Anesthetics; Anesthetics, Local; Animals; Anura; Central Nervous Syste | 1965 |
RECENT ADVANCES IN LOCAL ANALGESIA. TOXICITY AND CLINICAL USE OF PILOCAINE.
Topics: Analgesia; Anesthesia; Anesthesia, Conduction; Anesthesia, Spinal; Anesthetics; Anesthetics, Local; | 1965 |
BIOCHEMICAL EFFECTS OF AROMATIC AMINES. II. CYANOSIS, METHAEMOGLOBINAEMIA AND HEINZ-BODY FORMATION INDUCED BY A LOCAL ANAESTHETIC AGENT (PRILOCAINE).
Topics: Alanine Transaminase; Amines; Anesthesia, Local; Anesthetics, Local; Bilirubin; Blood; Creatine; Cre | 1965 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
Heterogeneity of the molecular biology of methemoglobinemia: a study of eight consecutive patients.
Topics: Amino Acid Substitution; Cytochrome-B(5) Reductase; DNA Mutational Analysis; Female; Humans; Introns | 2005 |
[Probable methemoglobinemia following EMLA administration].
Topics: Anesthetics, Local; Child; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2005 |
Methemoglobinemia after transesophageal echocardiography: a life-threatening complication.
Topics: Adult; Anesthetics, Local; Benzocaine; Echocardiography, Transesophageal; Female; Humans; Lidocaine; | 2006 |
Methemoglobinemia--an unusual cause of intraoperative hypoxia.
Topics: Administration, Topical; Adult; Aerosols; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Lo | 2007 |
Cardiovascular collapse developing after topical anesthesia.
Topics: Administration, Topical; Adult; Anesthetics, Local; Arrhythmias, Cardiac; Cardiovascular System; Fem | 2007 |
Postoperative methemoglobinemia following infiltrative lidocaine administration for combined anesthesia in pediatric craniofacial surgery.
Topics: Anesthesia, General; Anesthetics, Combined; Anesthetics, Local; Craniofacial Abnormalities; Female; | 2008 |
Application of topical analgesia in triage: a potential for harm.
Topics: Administration, Topical; Anesthetics, Local; Emergency Nursing; Enzyme Inhibitors; Female; Humans; I | 2008 |
Acute methemoglobinemia induced by topical benzocaine and lidocaine.
Topics: Adult; Benzocaine; Humans; Lidocaine; Male; Methemoglobinemia | 1980 |
[Risk of methemoglobinemia after Emla application in premature infants].
Topics: Anesthetics, Local; Drug Combinations; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidoca | 1995 |
EMLA's safety for small infants.
Topics: Anesthetics, Local; Drug Combinations; Humans; Infant; Infant, Newborn; Lidocaine; Lidocaine, Priloc | 1995 |
[Local anesthesia with Emla cream and risk of methemoglobinemia in a premature infant].
Topics: Anesthetics, Local; Dose-Response Relationship, Drug; Drug Combinations; Humans; Infant, Newborn; In | 1995 |
Methemoglobinemia from topically applied anesthetic spray.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Local; Benzocaine; Female; Humans; Li | 1994 |
Acquired methemoglobinemia from multiple oxidants.
Topics: Administration, Topical; Adult; Analgesia, Epidural; Blood Gas Analysis; Bupivacaine; Cytochrome-B(5 | 1993 |
[Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance].
Topics: Administration, Cutaneous; Anesthetics, Local; Dose-Response Relationship, Drug; Drug Combinations; | 1995 |
Use of EMLA cream in the treatment of post-herpetic neuralgia.
Topics: Administration, Topical; Aged; Anesthetics, Local; Drug Combinations; Female; Herpesviridae Infectio | 1996 |
[Pulse oximetry and methemoglobinemia].
Topics: Anesthetics, Local; Blood Gas Monitoring, Transcutaneous; Child, Preschool; Drug Combinations; Human | 1996 |
Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision.
Topics: Absorption; Anesthetics, Local; Animals; Animals, Newborn; Circumcision, Male; Cross-Over Studies; D | 1995 |
Use of Emla prior to circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc | 1996 |
Measurement of methemoglobin after EMLA analgesia for newborn circumcision.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidoc | 1996 |
Methemoglobinemia associated with a prilocaine-lidocaine cream.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc | 1997 |
Signs of methaemoglobinaemia after topical application of EMLA cream in an infant with haemangioma.
Topics: Anesthesia, Local; Anesthetics, Combined; Female; Hemangioma; Humans; Infant, Newborn; Lidocaine; Li | 1997 |
[Convulsive crisis and methemoglobinemia after the application of anesthetic cream].
Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Eczema; Female; Humans; Lidocaine; Lido | 1998 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |
Toxic methaemoglobin concentrations in premature infants after application of a prilocaine-containing cream and peridural prilocaine.
Topics: Anesthesia, Caudal; Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Infant, Prematur | 1999 |
Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets.
Topics: Acetaminophen; Administration, Inhalation; Animals; Animals, Newborn; Drug Evaluation, Preclinical; | 2000 |
Methemoglobinemia after topical anesthesia with lidocaine and benzocaine for a difficult intubation.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Benzocaine; Carbon Dioxide; Enzyme Inhibitors; Female; | 2000 |
Methaemoglobinaemia secondary to topical lignocaine/ prilocaine in a circumcised neonate.
Topics: Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; L | 2000 |
Lidocaine + prilocaine before 3 months of age: new indication. Correct use is crucial.
Topics: Administration, Cutaneous; Age Factors; Blood Specimen Collection; Circumcision, Male; Drug Therapy, | 2000 |
Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa.
Topics: Administration, Topical; Anesthetics, Combined; Child, Preschool; Female; Follow-Up Studies; Humans; | 2001 |
Drug-induced methemoglobinemia during thoracoscopic lung biopsy.
Topics: Aerosols; Benzocaine; Bronchiolitis Obliterans; Gels; Humans; Intraoperative Complications; Lidocain | 2001 |
Methemoglobinemia complicating topical lidocaine used during endoscopic procedures.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anesthetics, Local; Bronchoscopy; Drug-Related S | 2001 |
Severe oxyhemoglobin desaturation during induction of anesthesia in a patient with congenital methemoglobinemia.
Topics: Adult; Apnea; Blood Gas Analysis; Humans; Lidocaine; Male; Methemoglobinemia; Methylene Blue; Oximet | 2001 |
Topical anesthetics update: EMLA and beyond.
Topics: Anesthetics, Local; Drug Combinations; Drug Costs; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Dr | 2001 |
Perioperatively acquired methaemoglobinaemia in a preterm infant.
Topics: Anesthetics, Local; Benzocaine; Cyanosis; Diseases in Twins; Female; Humans; Infant, Newborn; Infant | 2002 |
[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].
Topics: Adult; Anesthetics, Local; Humans; Lidocaine; Male; Methemoglobinemia; Substance-Related Disorders | 2002 |
Topical anesthetic-induced methemoglobinemia in sheep: a comparison of benzocaine and lidocaine.
Topics: Administration, Topical; Anesthesia; Animals; Benzocaine; Dose-Response Relationship, Drug; Female; | 1992 |
Topical anaesthesia in upper gastrointestinal endoscopy.
Topics: Anesthesia, Local; Endoscopy, Gastrointestinal; Humans; Lidocaine; Methemoglobinemia | 1991 |
Methaemoglobinaemia in children treated with prilocaine-lignocaine cream.
Topics: Child; Humans; Lidocaine; Methemoglobinemia; Ointments; Prilocaine | 1990 |
Inverse relationship between age-dependent erythrocyte activity of methaemoglobin reductase and prilocaine-induced methaemoglobinaemia during infancy.
Topics: Age Factors; Anesthetics, Local; Cytochrome-B(5) Reductase; Drug Combinations; Erythrocytes; Female; | 1990 |
Methemoglobinemia after lidocaine administration.
Topics: Humans; Lidocaine; Methemoglobinemia | 1990 |
Methaemoglobinaemia in children treated with prilocaine-lignocaine cream.
Topics: Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Humans; Infant; Lidocaine; Lidocaine | 1990 |
Severe methaemoglobinaemia after flexible fibreoptic bronchoscopy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Benzocaine; Bronchoscopy; Fiber Optic Technology; Humans; | 1989 |
Comparison of lidocaine and prilocaine for intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Drug Evaluation; Humans; Lidocaine; Methemoglobinem | 1988 |
Acquired methemoglobinemia. A case report.
Topics: Aged; Aged, 80 and over; Benzocaine; Female; Humans; Lidocaine; Methemoglobinemia | 1987 |
Plasma concentrations of prilocaine and lidocaine and methaemoglobin formation in infants after epicutaneous application of a 5% lidocaine-prilocaine (EMLA).
Topics: Administration, Topical; Female; Hemoglobins; Humans; Infant; Lidocaine; Male; Methemoglobinemia; Oi | 1987 |
Methemoglobin levels following intravenous lidocaine administration.
Topics: Adult; Aged; Coronary Disease; Emergencies; Female; Humans; Injections, Intravenous; Lidocaine; Male | 1987 |
Methemoglobinemia associated with a prilocaine-lidocaine cream and trimetoprim-sulphamethoxazole. A case report.
Topics: Administration, Topical; Drug Combinations; Drug Synergism; Humans; Infant; Lidocaine; Male; Methemo | 1985 |
Local anaesthetics.
Topics: Amides; Anesthetics, Local; Brain Edema; Cardiovascular Diseases; Central Nervous System Diseases; C | 1971 |
Continuous intrapartum lumbar epidural block: a comparative study employing propitocaine 2 percent, lidocaine 1.5 percent with epinephrine, and 1.5 percent lidocaine.
Topics: Anemia; Anesthesia, Conduction; Anesthesia, Epidural; Anesthesia, Obstetrical; Epinephrine; Female; | 1971 |
New developments in epidural anesthesia for obstetrics.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Epinephrine; Female; Fetus; Humans; Lidocaine; Mepivaca | 1970 |
Passage of procaine hydrochloride and para-aminobenzoic acid across the human placenta.
Topics: Adjuvants, Anesthesia; Aminobenzoates; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, | 1968 |
Local anesthetic and toxicologic properties of Citanest.
Topics: Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Cats; Lidocaine; Methemoglob | 1965 |
Regional anesthesia by the intravenous route.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Arm Injuries; Female; Fractures | 1965 |
Methemoglobinemia following epidural analgesia during labor. A case report and literature review.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Female; Glucose; Humans; Lidocaine; | 1966 |
Citanest--a local anesthetic.
Topics: Anesthetics, Local; Female; Fetus; Humans; Lidocaine; Male; Methemoglobinemia; Pregnancy | 1966 |