lidocaine has been researched along with Malignant Melanoma in 10 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, little information is available concerning whether lidocaine sensitizes the cytotoxicity of 5-fluorouracil (5-FU) in melanoma cells." | 7.85 | Lidocaine sensitizes the cytotoxicity of 5-fluorouacil in melanoma cells ( Huang, S; Liu, W; Wang, Y; Xie, J; Xing, Y; Zhang, R, 2017) |
| "Lidocaine treatment resulted in the arrest of cell-cycle progression in the G1 phase and inhibited Ki-67 expression in a dose-dependent manner." | 5.51 | Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation. ( Chen, J; Jiao, Z; Wang, A; Zhong, W, 2019) |
| "Ropivacaine and lidocaine but not bupivacaine inhibited migration and proliferation, and induced apoptosis in melanoma cells." | 3.96 | Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade. ( Peng, X; Zhang, Y; Zheng, Q, 2020) |
| " However, little information is available concerning whether lidocaine sensitizes the cytotoxicity of 5-fluorouracil (5-FU) in melanoma cells." | 3.85 | Lidocaine sensitizes the cytotoxicity of 5-fluorouacil in melanoma cells ( Huang, S; Liu, W; Wang, Y; Xie, J; Xing, Y; Zhang, R, 2017) |
| "5% lidocaine and 1:200,000 epinephrine) injected into digits, comorbid patient conditions, and postoperative complications including ischemia or necrosis." | 3.75 | Local anesthesia using buffered 0.5% lidocaine with 1:200,000 epinephrine for tumors of the digits treated with Mohs micrographic surgery. ( Davis, N; Firoz, B; Goldberg, LH, 2009) |
| " An established human melanoma cell line (SHG) derived from malignant ascites was used to evaluate the growth-inhibitory effects of local anesthetics (procaine and lidocaine) as well as of doxorubicin at incubation temperatures of 37." | 3.66 | Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line. ( Block, JB; Chlebowski, RT; Cundiff, D; Dietrich, MF, 1982) |
| "Lidocaine treatment resulted in the arrest of cell-cycle progression in the G1 phase and inhibited Ki-67 expression in a dose-dependent manner." | 1.51 | Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation. ( Chen, J; Jiao, Z; Wang, A; Zhong, W, 2019) |
| "Bupivacaine was more potent than lidocaine both on the glycolytic enzymes and on cell viability." | 1.31 | Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics. ( Beitner, R; Schwartz, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tibensky, M | 1 |
| Blasko, F | 1 |
| Vargovic, P | 1 |
| Jakubikova, J | 1 |
| Cholujova, D | 1 |
| Jakubechova, J | 1 |
| Mravec, B | 1 |
| Zheng, Q | 1 |
| Peng, X | 1 |
| Zhang, Y | 1 |
| Lemaître, S | 1 |
| Arora, AK | 1 |
| Wang, Y | 1 |
| Xie, J | 1 |
| Liu, W | 1 |
| Zhang, R | 1 |
| Huang, S | 1 |
| Xing, Y | 1 |
| Chen, J | 1 |
| Jiao, Z | 1 |
| Wang, A | 1 |
| Zhong, W | 1 |
| Firoz, B | 1 |
| Davis, N | 1 |
| Goldberg, LH | 1 |
| Topar, G | 1 |
| Zelger, B | 1 |
| Chlebowski, RT | 1 |
| Block, JB | 1 |
| Cundiff, D | 1 |
| Dietrich, MF | 1 |
| Schwartz, D | 1 |
| Beitner, R | 1 |
| Venkei, T | 1 |
| Bozóky, L | 1 |
10 other studies available for lidocaine and Malignant Melanoma
| Article | Year |
|---|---|
Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy.
Topics: Anesthetics, Local; Animals; Lidocaine; Melanoma; Mice; Tetracaine | 2023 |
Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade.
Topics: Anesthetics, Local; Bupivacaine; Cell Death; Cell Line, Tumor; Humans; In Vitro Techniques; Lidocain | 2020 |
Use of adjuvant sub-Tenon's anaesthesia in reducing the incidence of oculocardiac reflex and postoperative pain in primary enucleations for uveal melanoma.
Topics: Anesthesia; Anesthesia, Local; Anesthetics, Local; Humans; Incidence; Lidocaine; Melanoma; Pain, Pos | 2021 |
Lidocaine sensitizes the cytotoxicity of 5-fluorouacil in melanoma cells
Topics: Anesthetics, Local; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Line, Tumor; | 2017 |
Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation.
Topics: Animals; Anti-Arrhythmia Agents; Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Extra | 2019 |
Local anesthesia using buffered 0.5% lidocaine with 1:200,000 epinephrine for tumors of the digits treated with Mohs micrographic surgery.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Carcinoma, Basal Cell; Carcinoma, Sq | 2009 |
Assessment of value of the sentinel lymph node biopsy in melanoma in children and adolescents and applicability of subcutaneous infusion anesthesia.
Topics: Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Child; Colloids; Coloring Agents; Female; | 2007 |
Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line.
Topics: Cell Line; Cell Survival; Doxorubicin; Drug Synergism; Humans; Lidocaine; Melanoma; Procaine; Temper | 1982 |
Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics.
Topics: Anesthetics, Local; Animals; Antineoplastic Agents; Bupivacaine; Cell Death; Cell Survival; Cytoskel | 2000 |
[Absorption rate of intracutaneous injected radioactive sodium in the region of precancerous and malignant tumors].
Topics: Adult; Aged; Female; Humans; Infrared Rays; Injections, Intradermal; Lidocaine; Male; Melanoma; Midd | 1973 |