lidocaine has been researched along with Liver Dysfunction in 52 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Excerpt | Relevance | Reference |
---|---|---|
"The lidocaine (MEGX [monoethylglycinexylidide]) test, which was performed in 200 patients with different liver diseases and in 23 organ donors, was compared with common laboratory tests." | 3.70 | The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery. ( Callivà, R; Cavallari, A; Cescon, M; Ercolani, G; Grazi, GL; Mazziotti, A; Pierangeli, F, 2000) |
"Patients with acute hepatitis and patients with compensated or decompensated cirrhosis of the liver have a decreased plasma clearance of hexobarbital." | 3.66 | [Drug metabolism in patients with liver disease (author's transl)]. ( Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W, 1980) |
"The plasma half lives of antipyrine, paracetamol, and lignocaine given by mouth were measured in 23 patients with stable chronic liver diseases of varying severity." | 3.65 | Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease. ( Adjepon-Yamoah, KK; Finlayson, ND; Forrest, JA; Prescott, LF, 1977) |
" Plasma concentrations of free (unbound) and total valdecoxib and its active hydroxylated metabolite (SC-66905) were measured following single and multiple dosing (day 1 and day 8)." | 2.71 | The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor. ( Britto, MR; Mainka, MB; Parivar, K; Sarapa, N, 2005) |
"Lidocaine concentration was significantly lower in PGE1 group than in control group at the end of the infusion." | 2.68 | [The effect of low-dose prostaglandin E1 on intra- and post-operative liver function]. ( Amaha, K; Hanaoka, K; Hayashida, M; Namiki, A; Shimada, Y, 1997) |
", differences in the type and degree of liver dysfunction of the animals and patients examined, and in the type and dosage of the inducing agent used." | 2.44 | Enzyme inhibition and induction in liver disease. ( De Martin, S; Orlando, R; Palatini, P; Pegoraro, P, 2008) |
"Lidocaine has been shown to attenuate ischemia-reperfusion (I/R) injury in the heart, lung, and brain, potentially due to modulation of inflammatory responses and apoptotic signaling pathways." | 1.38 | Systemic lidocaine does not attenuate hepatic dysfunction after liver surgery in rats. ( de Graaf, W; Diepenhorst, GM; Erdogan, D; Herroeder, S; Hollmann, MW; van Gulik, TM, 2012) |
"Lidocaine half-life was significantly lower in HIV-patients without ART." | 1.35 | Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy. ( Beste, M; Gerken, G; Kahraman, A; Miller, M; Ross, B, 2009) |
"Patients with liver cirrhosis of different aetiology showed significantly higher Lidocain plasma concentrations and lower MEGX values than patients with chronic non-cirrhotic liver disease." | 1.29 | [Lidocaine elimination and MEGX formation after oral lidocaine administration--a practicable test for assessment of quantitative liver function]. ( Bomhard, M; Dorer, J; Joeres, R; Keller, F; Klinker, H; Richter, E; Zilly, W, 1993) |
"Lidocaine (1 mg/kg) was injected i." | 1.29 | Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests. ( Luo, H; Meyer-Wyss, B; Renner, E; Scholer, A, 1993) |
"PABA is well absorbed by the gastrointestinal tract and acetylated and conjugated in the liver to glycine before being excreted." | 1.29 | Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function. ( Barr, SB; Duffy, LF; Kerzner, B; Seeff, L; Soldin, SJ, 1995) |
"Allopurinol and caffeine have been used to measure metabolite formation followed by renal elimination of both parent substance and metabolite." | 1.28 | Liver function assessment by drug metabolism. ( Barstow, L; Small, RE, 1990) |
"Lidocaine toxicity was life-threatening or significantly complicated the management of 15 patients." | 1.26 | Excessive serum lidocaine levels during maintenance infusions: mechanisms and prevention. ( Atkinson, AJ; Davison, R; Parker, M, 1982) |
"The pharmacokinetic parameters of lidocaine are pertinent to the determination of both appropriate loading doses and constant infusion rates that achieve a therapeutic plasma concentration while avoiding toxicity." | 1.26 | Pharmacokinetic principles of lidocaine dosing in relation to disease state. ( Waller, ES, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (46.15) | 18.7374 |
1990's | 18 (34.62) | 18.2507 |
2000's | 9 (17.31) | 29.6817 |
2010's | 1 (1.92) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Palatini, P | 1 |
De Martin, S | 1 |
Pegoraro, P | 1 |
Orlando, R | 1 |
Miller, M | 1 |
Kahraman, A | 1 |
Ross, B | 1 |
Beste, M | 2 |
Gerken, G | 2 |
de Graaf, W | 1 |
Diepenhorst, GM | 1 |
Herroeder, S | 1 |
Erdogan, D | 1 |
Hollmann, MW | 1 |
van Gulik, TM | 1 |
Chen, MY | 1 |
Li, CH | 1 |
Huang, ZQ | 1 |
Liu, JC | 1 |
Zhou, NX | 1 |
Huang, XQ | 1 |
Wang, YS | 1 |
Piwowarska, J | 1 |
Kuczyñska, J | 1 |
Pachecka, J | 1 |
Sarapa, N | 1 |
Britto, MR | 1 |
Mainka, MB | 1 |
Parivar, K | 1 |
Ascione, R | 1 |
Talpahewa, S | 1 |
Rajakaruna, C | 1 |
Reeves, BC | 1 |
Lovell, AT | 1 |
Cohen, A | 1 |
Angelini, GD | 1 |
Jochum, C | 1 |
Penndorf, V | 1 |
Farahani, MS | 1 |
Testa, G | 1 |
Nadalin, S | 1 |
Malago, M | 1 |
Broelsch, CE | 1 |
Endell, W | 1 |
Oltmanns, D | 1 |
Pottage, T | 1 |
Davison, R | 1 |
Parker, M | 1 |
Atkinson, AJ | 1 |
Waller, ES | 1 |
Chow, MS | 1 |
Ronfeld, RA | 1 |
Ruffett, D | 1 |
Fieldman, A | 1 |
Richter, E | 2 |
Epping, J | 1 |
Fuchshofen-Röckel, M | 1 |
Heusler, H | 1 |
Zilly, W | 2 |
Klinker, H | 1 |
Joeres, R | 1 |
Bomhard, M | 1 |
Keller, F | 1 |
Dorer, J | 1 |
Walsh, RM | 1 |
Tanaka, J | 1 |
Malchesky, PS | 1 |
Sato, N | 1 |
Nakayama, S | 1 |
Vogt, DP | 1 |
Broughan, TA | 1 |
Hermann, RE | 1 |
Castellani, WJ | 1 |
Van Thiel, DH | 1 |
Hassanein, T | 1 |
Meyer-Wyss, B | 1 |
Renner, E | 1 |
Luo, H | 1 |
Scholer, A | 1 |
Potter, JM | 1 |
Wright, M | 1 |
Lynch, SV | 1 |
Strong, RW | 1 |
Henderson, A | 1 |
Balderson, G | 1 |
Walker, NI | 1 |
Hickman, PE | 1 |
Shimanuki, K | 1 |
Suzuki, W | 1 |
Sakurabayashi, I | 1 |
Kiyozaki, H | 1 |
Shinohara, K | 1 |
Soda, K | 1 |
Kai, T | 1 |
Satake, M | 1 |
Miyata, M | 1 |
Luketic, VA | 1 |
Shiffman, ML | 1 |
Fisher, RA | 1 |
Sanyal, AJ | 1 |
Purdum, PP | 1 |
Posner, MP | 1 |
Duffy, LF | 1 |
Kerzner, B | 1 |
Seeff, L | 1 |
Barr, SB | 1 |
Soldin, SJ | 1 |
Zoedler, T | 1 |
Ebener, C | 1 |
Becker, H | 1 |
Roeher, HD | 1 |
Hayashida, M | 1 |
Hanaoka, K | 1 |
Shimada, Y | 1 |
Namiki, A | 1 |
Amaha, K | 1 |
Tanaka, E | 1 |
Yasuhara, H | 1 |
Kupcová, V | 2 |
Turecký, L | 1 |
Szántová, M | 1 |
Schmidtová, K | 1 |
Ercolani, G | 1 |
Grazi, GL | 1 |
Callivà, R | 1 |
Pierangeli, F | 1 |
Cescon, M | 1 |
Cavallari, A | 1 |
Mazziotti, A | 1 |
Ol'rikh, M | 1 |
Kukes, VG | 1 |
Igonin, AA | 1 |
Perovic, J | 1 |
Petrovic, V | 1 |
Obradovic, O | 1 |
Todorovic, L | 1 |
Colgan, FJ | 1 |
Asahara, A | 1 |
Ueda, H | 1 |
Hishinuma, S | 1 |
Takagi, M | 1 |
Bond, WS | 1 |
Itoh, K | 1 |
Furudate, M | 1 |
Nasuhara, K | 1 |
Irie, G | 1 |
Aburano, T | 1 |
Kuwajima, A | 1 |
Koizumi, K | 1 |
Hutatsuya, R | 1 |
Tonami, N | 1 |
Hisada, K | 1 |
Ito, K | 1 |
Kawaguchi, S | 1 |
Iio, M | 1 |
Yamada, H | 1 |
Murata, H | 1 |
Chiba, K | 1 |
Matsui, K | 1 |
Toyama, H | 1 |
Prescott, LF | 3 |
Forrest, JA | 3 |
Adjepon-Yamoah, KK | 3 |
Finlayson, ND | 3 |
Meyer, B | 1 |
Luo, HS | 1 |
Bargetzi, M | 1 |
Renner, EL | 1 |
Stalder, GA | 1 |
Oellerich, M | 1 |
Burdelski, M | 1 |
Ringe, B | 1 |
Wittekind, C | 1 |
Lamesch, P | 1 |
Lautz, HU | 1 |
Gubernatis, G | 1 |
Beyrau, R | 1 |
Pichlmayr, R | 1 |
Weiss, M | 1 |
Barstow, L | 1 |
Small, RE | 1 |
Gremse, DA | 1 |
A-Kader, HH | 1 |
Schroeder, TJ | 1 |
Balistreri, WF | 1 |
Gueugniaud, PY | 1 |
Guerin, C | 1 |
Mahul, P | 1 |
Deu, C | 1 |
Robert, D | 1 |
Miyamoto, M | 1 |
Hayano, Y | 1 |
Noguchi, T | 1 |
Oda, S | 1 |
Taniguchi, K | 1 |
Honda, N | 1 |
Ebihara, A | 1 |
Dunn, GD | 1 |
Hayes, P | 1 |
Breen, KJ | 1 |
Schenker, S | 1 |
Black, M | 1 |
Kessler, KM | 1 |
Josephson, ME | 1 |
Caracta, AR | 1 |
Lau, SH | 1 |
Gallagher, JJ | 1 |
Damato, AN | 1 |
Levy, RH | 1 |
Smith, GH | 1 |
Thomson, PD | 1 |
Rowland, M | 1 |
Melmon, KL | 1 |
Hernandez, C | 1 |
Cachin, M | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
[NCT00005306] | 0 participants | Observational | 1988-03-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for lidocaine and Liver Dysfunction
Article | Year |
---|---|
Enzyme inhibition and induction in liver disease.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzy | 2008 |
Assessment of liver function: the current situation.
Topics: Caffeine; Cytochrome P-450 Enzyme System; Humans; Lidocaine; Liver; Liver Circulation; Liver Disease | 1995 |
[Evaluation of liver function in liver diseases using drugs as indicators].
Topics: Aminopyrine; Antipyrine; Erythromycin; Humans; Lidocaine; Liver; Liver Diseases; Liver Function Test | 1997 |
[Importance of determination of monoethylglycinexylidide (MEGX)--as a liver function test in hepatology and liver transplantation].
Topics: Animals; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantation | 1999 |
Problems with postoperative drug therapy.
Topics: Anesthesia; Anesthetics; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Drug Therap | 1977 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
The liver in congestive heart failure: a review.
Topics: Alkaline Phosphatase; Anticoagulants; Ascites; Bilirubin; Digitalis Glycosides; Diuretics; Heart Fai | 1973 |
Liver disease and drug therapy.
Topics: Amobarbital; Azathioprine; Half-Life; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Metabolic | 1974 |
Individualization of dosage of antiarrhythmic drugs.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Heart Diseases; Humans; Ki | 1974 |
3 trials available for lidocaine and Liver Dysfunction
Article | Year |
---|---|
The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.
Topics: Adult; Aged; Area Under Curve; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 | 2005 |
Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial.
Topics: Aged; Alanine Transaminase; Amylases; Aspartate Aminotransferases; Blood Glucose; Carbohydrates; Car | 2006 |
[The effect of low-dose prostaglandin E1 on intra- and post-operative liver function].
Topics: Abdomen; Adult; Alprostadil; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthetics, Local; Dose- | 1997 |
40 other studies available for lidocaine and Liver Dysfunction
Article | Year |
---|---|
Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy.
Topics: Adult; Antiviral Agents; Female; Galactose; Half-Life; Hepatitis B; Hepatitis C; HIV Infections; Hum | 2009 |
Systemic lidocaine does not attenuate hepatic dysfunction after liver surgery in rats.
Topics: Animals; Lidocaine; Liver Diseases; Male; Postoperative Complications; Random Allocation; Rats; Rats | 2012 |
Protective effects of lidocaine injected into the hepatoduodenal ligament on warm ischemia-reperfusion injury to the rat liver.
Topics: Animals; Duodenum; Injections; Lidocaine; Ligaments; Liver; Liver Diseases; Male; Rats; Rats, Spragu | 2004 |
Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function.
Topics: Bilirubin; Calibration; Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Diseases; Liv | 2004 |
Quantitative liver function tests in donors and recipients of living donor liver transplantation.
Topics: Adult; Female; Galactose; Half-Life; Humans; Indocyanine Green; Lidocaine; Liver Diseases; Liver Fun | 2006 |
Alteration of the kinetics of tocainide in combined hepatic and renal insufficiency.
Topics: Anti-Arrhythmia Agents; Humans; Kidney Diseases; Lidocaine; Liver Diseases; Metabolic Clearance Rate | 1983 |
Excessive serum lidocaine levels during maintenance infusions: mechanisms and prevention.
Topics: Aged; Arrhythmias, Cardiac; Body Weight; Chromatography, Gas; Disease Susceptibility; Heart Arrest; | 1982 |
Pharmacokinetic principles of lidocaine dosing in relation to disease state.
Topics: Adult; Age Factors; Aged; Animals; Dogs; Drug Therapy, Combination; Half-Life; Heart Failure; Humans | 1981 |
Lidocaine pharmacokinetics during cardiac arrest and external cardiopulmonary resuscitation.
Topics: Adult; Aged; Cardiac Output; Coronary Circulation; Female; Femoral Artery; Femoral Vein; Heart Arres | 1981 |
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; H | 1980 |
[Lidocaine elimination and MEGX formation after oral lidocaine administration--a practicable test for assessment of quantitative liver function].
Topics: Administration, Oral; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Meta | 1993 |
Monoethylglycinexylidide formation as an independent measure of warm hepatic ischemia and reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Hot Temperature; Lidocaine; Liver; Liver Diseases; Male; Mitochondr | 1995 |
Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests.
Topics: Adolescent; Adult; Aminopyrine; Breath Tests; Child; Galactose; Humans; Lidocaine; Liver Diseases; L | 1993 |
Lignocaine metabolism and liver function testing in primary graft failure following orthotopic liver transplantation.
Topics: Female; Graft Rejection; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantat | 1993 |
[Evaluation of lidocaine metabolite (monoethylglycinexylidide) as a liver function test].
Topics: Evaluation Studies as Topic; Female; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Liver | 1993 |
Hepatic lidocaine metabolism is useful in the selection of patients in need of liver transplantation.
Topics: Hepatitis; Humans; Lidocaine; Liver; Liver Cirrhosis; Liver Diseases; Liver Transplantation | 1993 |
Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function.
Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bil | 1995 |
Evaluation of liver function tests to predict operative risk in liver surgery.
Topics: Galactose; Humans; Indocyanine Green; Lidocaine; Liver Diseases; Liver Failure; Liver Function Tests | 1995 |
[Monoethylglycinexylidide--a metabolite of lidocaine--as an index of liver function in chronic hepatic parenchymal diseases].
Topics: Adult; Aged; Chronic Disease; Female; Fluorescence Polarization Immunoassay; Humans; Lidocaine; Live | 1999 |
The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Carcinoma, Hepatocellular | 2000 |
[Role of lidocaine metabolism studies in the diagnosis of liver diseases].
Topics: Adult; Animals; Clinical Enzyme Tests; Critical Care; Diagnosis, Differential; Dogs; Female; Hepatit | 2000 |
The influence of liver functional ability on blood levels of lidocaine after intraoral submucous application.
Topics: Female; Humans; Injections; Lidocaine; Liver; Liver Diseases; Male | 1979 |
[Studies of hepatobiliary scintigraphy and functional examination with 99mTc-HIDA (author's transl)].
Topics: Adolescent; Adult; Biliary Tract; Biliary Tract Diseases; Child; Child, Preschool; Evaluation Studie | 1979 |
Clinical relevance of the effect of hepatic disease on drug disposition.
Topics: Anti-Infective Agents; Antineoplastic Agents; Central Nervous System; Digoxin; Humans; Lidocaine; Li | 1978 |
[Hepatobiliary scintigraphy with a new 99mTc-tagged radiopharmaceutical, 99mTc-HIDA. (author's transl)].
Topics: Aged; Biliary Tract Diseases; Drug Evaluation; Female; Humans; Iodine Radioisotopes; Lidocaine; Live | 1978 |
[Clinical usefulness of 99mTc-HIDA hepatobiliary scintigraphy (author's transl)].
Topics: Biliary Tract Diseases; Drug Evaluation; Humans; Lidocaine; Liver Diseases; Radionuclide Imaging; Te | 1978 |
[Evaluation of 99mTc-HIDA (n-2.6 dimethylphenylcarbamoylmethyl iminodiacetic acid) scanning in the various hepatobiliary disorders (author's transl)].
Topics: Adult; Aged; Biliary Tract Diseases; Drug Evaluation; Female; Humans; Lidocaine; Liver Diseases; Mal | 1978 |
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Half-Life; Humans; Kinetics; Lidoca | 1977 |
Proceedings: Antipyrine, lingocaine and paracetamol metabolism in chronic liver disease.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Chronic Disease; Female; Humans; Lidocaine; Liver Diseases; | 1975 |
Quantitation of intrinsic drug-metabolizing capacity in human liver biopsy specimens: support for the intact-hepatocyte theory.
Topics: Adrenergic beta-Antagonists; Ethanolamines; Hepatitis, Chronic; Humans; Lidocaine; Liver; Liver Cirr | 1991 |
Functional state of the donor liver and early outcome of transplantation.
Topics: Graft Survival; Humans; Lidocaine; Liver Diseases; Liver Function Tests; Liver Transplantation; Prog | 1991 |
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationsh | 1990 |
Liver function assessment by drug metabolism.
Topics: Acetamides; Adult; Allopurinol; Aminopyrine; Caffeine; Half-Life; Humans; Indocyanine Green; Lidocai | 1990 |
Assessment of lidocaine metabolite formation as a quantitative liver function test in children.
Topics: Adolescent; Bilirubin; Child; Child, Preschool; Chronic Disease; Fluoroimmunoassay; Humans; Infant; | 1990 |
[Torsade de pointes induced by the combination lidocaine-erythromycin and hepatic insufficiency].
Topics: Aged; Drug Therapy, Combination; Erythromycin; Humans; Lidocaine; Liver Diseases; Male; Tachycardia | 1985 |
[Plasma lidocaine concentrations during epidural anesthesia--a comparison between patients with normal liver functions and those with abnormal functions].
Topics: Adult; Aged; Anesthesia, Epidural; Female; Humans; Lidocaine; Liver; Liver Diseases; Male; Middle Ag | 1988 |
Effects of lidocaine on refractory periods in man.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Catheterization; Electrocardiography; Female; Heart Atria | 1972 |
Dosage regimens of antiarrhythmics. II. Applications.
Topics: Anti-Arrhythmia Agents; Heart Failure; Humans; Injections, Intravenous; Kidney Diseases; Lidocaine; | 1973 |
The influence of heart failure, liver disease, and renal failure on the disposition of lidocaine in man.
Topics: Arrhythmias, Cardiac; Heart Failure; Humans; Kidney; Kidney Failure, Chronic; Lidocaine; Liver; Live | 1971 |
[Morphologic methods of studying the hepatic circulation: selective arteriography, portography and cavography].
Topics: Angiography; Hemodynamics; Humans; Iodine Isotopes; Lidocaine; Liver Circulation; Liver Diseases; Me | 1967 |