Page last updated: 2024-10-28

lidocaine and Lacerations

lidocaine has been researched along with Lacerations in 33 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Lacerations: Torn, ragged, mangled wounds.

Research Excerpts

ExcerptRelevanceReference
"3) to that provided by conventional lidocaine infiltration for the repair of lacerations."9.19A non-inferiority randomized controlled trial comparing the clinical effectiveness of anesthesia obtained by application of a novel topical anesthetic putty with the infiltration of lidocaine for the treatment of lacerations in the emergency department. ( Jenkins, MG; Little, C; McCarron, PA; McDonald, J; Murphy, DJ, 2014)
"Treating minor lacerations with lidocaine-epinephrine-tetracaine before wound closure with tissue adhesive reduced ratings of pain and increased the proportion of pain-free repairs among children aged 3 months to 17 years."9.17Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. ( Duncan, MJ; Harman, S; Petrcich, W; Ying, Y; Zemek, R, 2013)
"To determine the effectiveness of lidocaine-adrenaline-tetracaine (LAT) in providing adequate anesthesia for the repair of finger lacerations and to monitor the risk of digital ischemia following application of LAT gel to finger lacerations."9.11The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations. ( Bergholte, J; Brousseau, DC; Hennes, H; Kim, MK; White, NJ, 2004)
"To estimate the efficacy of lidocaine ointment in relieving pain after a vaginal delivery with an episiotomy or perineal laceration."9.10Randomized trial of lidocaine ointment versus placebo for the treatment of postpartum perineal pain. ( Jazayeri, A; Minassian, VA; Prien, SD; Stumbo, K; Timmons, RL, 2002)
"Lidocaine infiltration was performed if any sign of pain was observed."7.71[Suture of skin lacerations using LAT gel (lidocaine, adrenaline, tetracaine)]. ( Alió Y Sanz, JL; Chipont Benabent, E; García-Hermosa, P, 2001)
" The purpose of this study was to measure the effect of hydrocodone/acetaminophen elixir in reducing both pain and anxiety in children undergoing sutured laceration repair in the emergency department."5.34Evaluation of Hydrocodone/Acetaminophen for Pediatric Laceration Repair: A Randomized Trial. ( Camp, EA; Caviness, AC; Chumpitazi, CE; Grawe, GH; Shah, MI, 2020)
"Treating minor lacerations with lidocaine-epinephrine-tetracaine before wound closure with tissue adhesive reduced ratings of pain and increased the proportion of pain-free repairs among children aged 3 months to 17 years."5.17Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. ( Duncan, MJ; Harman, S; Petrcich, W; Ying, Y; Zemek, R, 2013)
"Topical lidocaine and epinephrine "sequential layered application" is an effective, safe, and less painful method of anesthesia for a wide variety of lacerations."5.12Expanding the use of topical anesthesia in wound management: sequential layered application of topical lidocaine with epinephrine. ( Gaufberg, SV; Walta, MJ; Workman, TP, 2007)
"To determine the effectiveness of lidocaine-adrenaline-tetracaine (LAT) in providing adequate anesthesia for the repair of finger lacerations and to monitor the risk of digital ischemia following application of LAT gel to finger lacerations."5.11The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations. ( Bergholte, J; Brousseau, DC; Hennes, H; Kim, MK; White, NJ, 2004)
"To estimate the efficacy of lidocaine ointment in relieving pain after a vaginal delivery with an episiotomy or perineal laceration."5.10Randomized trial of lidocaine ointment versus placebo for the treatment of postpartum perineal pain. ( Jazayeri, A; Minassian, VA; Prien, SD; Stumbo, K; Timmons, RL, 2002)
" Supplemental lidocaine was then infiltrated through the wound edges and the pain of infiltration was recorded by the patient (or guardian) on a 100-mm visual analog scale marked "most pain" at the high end."5.09LET versus EMLA for pretreating lacerations: a randomized trial. ( Singer, AJ; Stark, MJ, 2001)
"A randomized, prospective, double-blind study comparing benzyl alcohol with epinephrine, 1:100,000 (BA), and lidocaine with epinephrine, 1:100,000 (LID), as local anesthetics was carried out on adult patients with simple lacerations."5.09Benzyl alcohol with epinephrine as an alternative to lidocaine with epinephrine. ( Bartfield, JM; Lai, SY; May-Wheeling, HE; Raccio-Robak, N, 2001)
"The literature has shown that the induction of anaesthesia in lacerations has remained largely unchanged over the past few years, with lidocaine infiltration still the preferred method."4.85The use of topical anaesthesia during repair of minor lacerations in Departments of Emergency Medicine: a literature review. ( Jenkins, MG; Kelly, OJ; Little, C; McCarron, P; Murphy, D, 2009)
"LAT (lidocaine, adrenaline, and tetracaine) gel is a topical anesthetic that can be applied on lacerations before suturing."3.85LAT gel for laceration repair in the emergency department: not only for children? ( de Cock, P; Lemoyne, S; van de Voorde, P; van der Gucht, A; Vandamme, E, 2017)
"Lidocaine infiltration was performed if any sign of pain was observed."3.71[Suture of skin lacerations using LAT gel (lidocaine, adrenaline, tetracaine)]. ( Alió Y Sanz, JL; Chipont Benabent, E; García-Hermosa, P, 2001)
" Skin lacerations are common in children and their repair is a very unpleasant experience for a child."1.56Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study. ( Boettcher, J; Boettcher, M; Königs, I; Reinshagen, K; Wenskus, J, 2020)
" Plasma sample analysis was carried out by employing liquid chromatography coupled with tandem mass spectrometric (LC-MS/MS) method, and the pharmacokinetic analysis of the mouse plasma samples was estimated by standard non-compartmental methods."1.38A pharmacokinetic study of a topical anesthetic (EMLA® ) in mouse soft tissue laceration. ( Al-Musawi, A; Andersson, L; Kombian, SB; Matar, K, 2012)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (42.42)29.6817
2010's14 (42.42)24.3611
2020's5 (15.15)2.80

Authors

AuthorsStudies
Siembieda, J1
Heyming, T1
Padlipsky, P1
Young, KD1
Scribner-O'Pray, M1
Taylor, ED1
Krause, E1
Nickel, A1
Bergmann, KR1
Königs, I1
Wenskus, J1
Boettcher, J1
Reinshagen, K1
Boettcher, M1
Chumpitazi, CE1
Caviness, AC1
Grawe, GH1
Camp, EA1
Shah, MI1
Jones, A1
Kelly, E1
Borumandi, F1
Martin, HA1
Farahmand, S1
Hamrah, H1
Arbab, M1
Sedaghat, M1
Basir Ghafouri, H1
Bagheri-Hariri, S1
Lambert, C1
Goldman, RD1
Harman, S1
Zemek, R1
Duncan, MJ1
Ying, Y1
Petrcich, W1
Jenkins, MG2
Murphy, DJ1
Little, C2
McDonald, J1
McCarron, PA1
Wang, B1
Hill, VK1
Wilson, MH1
Felstead, AM1
Sherman, JM1
Sheppard, P1
Hoppa, E1
Krief, W1
Avarello, J1
Vandamme, E1
Lemoyne, S1
van der Gucht, A1
de Cock, P1
van de Voorde, P1
Şener, A2
Demircan, A1
Keleş, A1
Bildik, F1
Karakurt, K1
Al-Musawi, A2
Matar, K2
Kombian, S1
Andersson, L4
Okur, OM1
Kavakli, HŞ1
Çelik, GK1
Doğan, NÖ1
Içme, F1
Günaydin, GP1
Kelly, OJ1
Murphy, D1
McCarron, P1
Musawi, AA1
McNulty, RJ1
Handley, TP1
Devlin, MF1
Kombian, SB1
Minassian, VA1
Jazayeri, A1
Prien, SD1
Timmons, RL1
Stumbo, K1
Priestley, S1
Kelly, AM1
Chow, L1
Powell, C1
Williams, A1
Karcioglu, O1
Topacoglu, H1
Ayrik, C1
Ozucelik, DN1
Soysal, S1
Adriansson, C1
Suserud, BO1
Bergbom, I1
White, NJ1
Kim, MK1
Brousseau, DC1
Bergholte, J1
Hennes, H1
Gaufberg, SV1
Walta, MJ1
Workman, TP1
Al-Asfour, A1
Al-Melh, M1
Joseph, B1
Singer, AJ2
Stark, MJ2
Van-Liaw, P1
Chipont Benabent, E1
García-Hermosa, P1
Alió Y Sanz, JL1
Kalghatgi, S1
Bartfield, JM1
May-Wheeling, HE1
Raccio-Robak, N1
Lai, SY1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of 2 Application Techniques for LET (Lidocaine 4%; Epinephrine 0.1%; Tetracaine 0.5%) Gel Used Prior to Simple Laceration Repair in Children[NCT04203225]Phase 448 participants (Actual)Interventional2017-05-22Completed
Comparison of 2 Application Techniques for LET (Lidocaine 4%; Epinephrine 0.1%; Tetracaine 0.5%) Gel Used Prior to Simple Laceration Repair[NCT04536493]Phase 448 participants (Actual)Interventional2019-06-19Completed
Traditional Dorsal Digital Block vs Volar Subcutaneous Digital Block[NCT05280704]150 participants (Anticipated)Interventional2023-12-31Not yet recruiting
The Effect of Sonophoresis on Topical Anesthesia: a Clinical Trial[NCT01283490]Phase 150 participants (Actual)Interventional2011-02-28Completed
Prospective Evaluation of Topical Analgesia Using a Lidocaine/Prilocaine Cream for Laceration Repair in the Emergency Department[NCT03071601]Phase 4132 participants (Actual)Interventional2017-12-01Completed
Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547]Phase 20 participants (Actual)Interventional2016-07-14Withdrawn (stopped due to Lack of human ressources)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Need for Additional Local Anesthetic

Need for additional infiltrated local anesthetic (lidocaine) (NCT04203225)
Timeframe: At any time during suturing procedure, time frame is duration of procedure, generally 10-20 minutes, less than one hour. Determined by chart review immediately after procedure completion.

InterventionParticipants (Count of Participants)
Single LET4
Triple LET5

Visual Analog Scale Pain Score

Pain score self-rated by patient on 100m Visual Analog Pain scale, minimum value 0, maximum value 100, higher scores equal more pain (worse outcome) (NCT04203225)
Timeframe: Immediately on placement or attempt at placement of first suture

Interventionmm (Mean)
Single LET16
Triple LET16

Reviews

2 reviews available for lidocaine and Lacerations

ArticleYear
Factors Associated With Low Procedural Pain Scores Among 1- to 5-Year-Old Patients Undergoing Facial Laceration Repair.
    Pediatric emergency care, 2023, Mar-01, Volume: 39, Issue:3

    Topics: Anti-Anxiety Agents; Child, Preschool; Epinephrine; Humans; Infant; Lacerations; Lidocaine; Pain; Pa

2023
The use of topical anaesthesia during repair of minor lacerations in Departments of Emergency Medicine: a literature review.
    International emergency nursing, 2009, Volume: 17, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Cocaine; Drug Combinations; Epinephrine; Humans; Lacera

2009

Trials

16 trials available for lidocaine and Lacerations

ArticleYear
Triple Versus Single Application of Lidocaine, Epinephrine, and Tetracaine for Laceration Repair in Children.
    Pediatric emergency care, 2022, Feb-01, Volume: 38, Issue:2

    Topics: Adolescent; Child; Epinephrine; Humans; Lacerations; Lidocaine; Single-Blind Method; Tetracaine

2022
Evaluation of Hydrocodone/Acetaminophen for Pediatric Laceration Repair: A Randomized Trial.
    Plastic and reconstructive surgery, 2020, Volume: 145, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adolescent; Age Factors; Anxiety; Child; Child, Preschool; D

2020
Pain management of acute limb trauma patients with intravenous lidocaine in emergency department.
    The American journal of emergency medicine, 2018, Volume: 36, Issue:7

    Topics: Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Local; Arm Injuries

2018
Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013, Sep-17, Volume: 185, Issue:13

    Topics: Administration, Cutaneous; Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Combination

2013
A non-inferiority randomized controlled trial comparing the clinical effectiveness of anesthesia obtained by application of a novel topical anesthetic putty with the infiltration of lidocaine for the treatment of lacerations in the emergency department.
    Annals of emergency medicine, 2014, Volume: 63, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Lacerations; Lidocai

2014
Comparison of local infiltration anesthesia and peripheral nerve block: a randomized prospective study in hand lacerations.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Female; Hand; Humans; Lacerations; L

2015
Two injection digital block versus single subcutaneous palmar injection block for finger lacerations.
    European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2017, Volume: 43, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Drug Administration Schedule; Emergency Service,

2017
Randomized trial of lidocaine ointment versus placebo for the treatment of postpartum perineal pain.
    Obstetrics and gynecology, 2002, Volume: 100, Issue:6

    Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Episi

2002
Application of topical local anesthetic at triage reduces treatment time for children with lacerations: a randomized controlled trial.
    Annals of emergency medicine, 2003, Volume: 42, Issue:1

    Topics: Anesthesia, Local; Child; Child, Preschool; Double-Blind Method; Emergency Service, Hospital; Epinep

2003
Prilocaine versus plain or buffered lidocaine for local anesthesia in laceration repair: randomized double-blind comparison.
    Croatian medical journal, 2003, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Double-Blind Method; Female; Humans; Lacerations; Lidoc

2003
The use of topical anaesthesia at children's minor lacerations: an experimental study.
    Accident and emergency nursing, 2004, Volume: 12, Issue:2

    Topics: Administration, Topical; Adolescent; Anesthesia, Local; Anesthetics, Local; Anxiety; Child; Female;

2004
The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations.
    Pediatric emergency care, 2004, Volume: 20, Issue:12

    Topics: Anesthesia, Local; Anesthetics, Local; Child; Drug Therapy, Combination; Epinephrine; Female; Finger

2004
Expanding the use of topical anesthesia in wound management: sequential layered application of topical lidocaine with epinephrine.
    The American journal of emergency medicine, 2007, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Dose-Response Relationship, Drug; Dr

2007
Pretreatment of lacerations with lidocaine, epinephrine, and tetracaine at triage: a randomized double-blind trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2000, Volume: 7, Issue:7

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Child; Chil

2000
LET versus EMLA for pretreating lacerations: a randomized trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2001, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Double-Blind Method; Female; Humans;

2001
Benzyl alcohol with epinephrine as an alternative to lidocaine with epinephrine.
    The Journal of emergency medicine, 2001, Volume: 21, Issue:4

    Topics: Adult; Anesthetics, Local; Benzyl Alcohol; Double-Blind Method; Epinephrine; Female; Humans; Lacerat

2001

Other Studies

15 other studies available for lidocaine and Lacerations

ArticleYear
Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2020, Volume: 30, Issue:6

    Topics: Administration, Topical; Anesthetics, Combined; Child; Epinephrine; Female; Gels; Humans; Laceration

2020
The Role of Topical Anesthetics in the Treatment of Pediatric Facial Lacerations.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2021, Volume: 79, Issue:10

    Topics: Anesthesia, Local; Anesthetics, Local; Child; Epinephrine; Humans; Lacerations; Lidocaine; Tetracain

2021
The Power of Lidocaine, Epinephrine, and Tetracaine (LET) and a Child Life Specialist When Suturing Lacerations in Children.
    Journal of emergency nursing, 2017, Volume: 43, Issue:2

    Topics: Anesthetics, Local; Child; Drug Combinations; Epinephrine; Gels; Humans; Lacerations; Lidocaine; Ped

2017
Pain management for children needing laceration repair.
    Canadian family physician Medecin de famille canadien, 2018, Volume: 64, Issue:12

    Topics: Administration, Cutaneous; Anesthetics, Local; Child; Drug Combinations; Epinephrine; Humans; Lacera

2018
LAT gel, a powerful tool underused in the repair of paediatric lacerations.
    International journal of oral and maxillofacial surgery, 2014, Volume: 43, Issue:8

    Topics: Anesthetics, Local; Child; Debridement; Drug Combinations; Emergency Service, Hospital; Epinephrine;

2014
Let Us Use LET: A Quality Improvement Initiative.
    Pediatric emergency care, 2016, Volume: 32, Issue:7

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Drug Combinations; Emerge

2016
LAT gel for laceration repair in the emergency department: not only for children?
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2017, Volume: 24, Issue:1

    Topics: Administration, Topical; Adult; Anesthetics, Local; Emergency Service, Hospital; Epinephrine; Female

2017
Blood concentration of prilocaine and lidocaine after the use of topical anesthesia (Oraqix
    Dental traumatology : official publication of International Association for Dental Traumatology, 2016, Volume: 32, Issue:6

    Topics: Anesthesia; Anesthetics, Local; Animals; Lacerations; Lidocaine; Lidocaine, Prilocaine Drug Combinat

2016
Use of topical as only anesthetic for suturing a traumatic facial laceration.
    Dental traumatology : official publication of International Association for Dental Traumatology, 2010, Volume: 26, Issue:3

    Topics: Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Cheek; Eyelids; Facial Injuries

2010
Reducing the need for general anaesthesia in children: use of LAT gel in treating facial lacerations.
    The British journal of oral & maxillofacial surgery, 2013, Volume: 51, Issue:6

    Topics: Administration, Topical; Anesthesia, General; Anesthesia, Local; Anesthetics, Combined; Anesthetics,

2013
A pharmacokinetic study of a topical anesthetic (EMLA® ) in mouse soft tissue laceration.
    Dental traumatology : official publication of International Association for Dental Traumatology, 2012, Volume: 28, Issue:6

    Topics: Anesthetics, Local; Animals; Area Under Curve; Chromatography, Liquid; Lacerations; Lidocaine; Lidoc

2012
Healing pattern of experimental soft tissue lacerations after application of novel topical anesthetic agents - an experimental study in rabbits.
    Dental traumatology : official publication of International Association for Dental Traumatology, 2008, Volume: 24, Issue:1

    Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Gels; Lacerations; Lidocaine; Lidocaine, Priloca

2008
Resident's column: Use of topical anesthetics in children.
    Pediatric annals, 2001, Volume: 30, Issue:4

    Topics: Administration, Cutaneous; Anesthetics, Local; Chin; Female; Humans; Infant; Injections, Subcutaneou

2001
[Suture of skin lacerations using LAT gel (lidocaine, adrenaline, tetracaine)].
    Archivos de la Sociedad Espanola de Oftalmologia, 2001, Volume: 76, Issue:8

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Child; Child, Preschool; Dermatologic Surgical Procedur

2001
Just the berries. Allergy to local anesthetics.
    Canadian family physician Medecin de famille canadien, 2001, Volume: 47

    Topics: Aged; Anesthetics, Local; Drug Hypersensitivity; Humans; Lacerations; Lidocaine; Male; Skin Test End

2001