lidocaine has been researched along with Invasiveness, Neoplasm in 9 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine is well known as a local anesthetic that has been reported to play an antitumor role in numerous cancers, including glioma." | 8.02 | Lidocaine inhibits glioma cell proliferation, migration and invasion by modulating the circEZH2/miR-181b-5p pathway. ( Ding, Y; Li, X; Wen, J; Xiao, Y; Zheng, S, 2021) |
| "NCI-H838 lung adenocarcinoma cells were incubated with ropivacaine or lidocaine (1 nM-100 µM) in absence/presence of TNFα (20 ng ml(-1)) for 20 min or 4 h, respectively." | 7.81 | Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. ( Beck-Schimmer, B; Borgeat, A; Dull, RO; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE, 2015) |
| "Lidocaine is well known as a local anesthetic that has been reported to play an antitumor role in numerous cancers, including glioma." | 4.02 | Lidocaine inhibits glioma cell proliferation, migration and invasion by modulating the circEZH2/miR-181b-5p pathway. ( Ding, Y; Li, X; Wen, J; Xiao, Y; Zheng, S, 2021) |
| "NCI-H838 lung adenocarcinoma cells were incubated with ropivacaine or lidocaine (1 nM-100 µM) in absence/presence of TNFα (20 ng ml(-1)) for 20 min or 4 h, respectively." | 3.81 | Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. ( Beck-Schimmer, B; Borgeat, A; Dull, RO; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE, 2015) |
| "Metastatic breast and colon cancer cells express neonatal and adult splice variants of NaV1." | 1.40 | Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. ( Baptista-Hon, DT; Hales, TG; Lee, NH; Lydon, EL; Owen, SJ; Robertson, FM; Robertson, GB; Rogers, GW, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Gu, G | 1 |
| Li, X | 2 |
| Zhang, C | 1 |
| Wen, J | 1 |
| Ding, Y | 1 |
| Zheng, S | 1 |
| Xiao, Y | 1 |
| Baptista-Hon, DT | 1 |
| Robertson, FM | 1 |
| Robertson, GB | 1 |
| Owen, SJ | 1 |
| Rogers, GW | 1 |
| Lydon, EL | 1 |
| Lee, NH | 1 |
| Hales, TG | 1 |
| Piegeler, T | 1 |
| Schläpfer, M | 1 |
| Dull, RO | 1 |
| Schwartz, DE | 1 |
| Borgeat, A | 1 |
| Minshall, RD | 1 |
| Beck-Schimmer, B | 1 |
| Abbott, AM | 1 |
| Miller, BT | 1 |
| Tuttle, TM | 1 |
| Akural, E | 1 |
| Ojala, RO | 1 |
| Järvimäki, V | 1 |
| Kariniemi, J | 1 |
| Tervonen, OA | 1 |
| Blanco Sequeiros, R | 1 |
| Mammoto, T | 1 |
| Higashiyama, S | 1 |
| Mukai, M | 1 |
| Mammoto, A | 1 |
| Ayaki, M | 1 |
| Mashimo, T | 1 |
| Hayashi, Y | 1 |
| Kishi, Y | 1 |
| Nakamura, H | 1 |
| Akedo, H | 1 |
| Cserni, G | 1 |
| McLachlin, CM | 1 |
| Devine, P | 1 |
| Muto, M | 1 |
| Genest, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial.[NCT03570541] | Phase 4 | 69 participants (Actual) | Interventional | 2018-06-28 | Completed | ||
| Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery[NCT03974984] | 0 participants (Actual) | Observational | 2020-06-04 | Withdrawn (stopped due to Not feasable due to logistics) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for lidocaine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Lidocaine alleviates cisplatin resistance and inhibits migration of MGC-803/DDP cells through decreasing miR-10b.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Movement; Cisplatin; Down-Reg | 2020 |
Lidocaine inhibits glioma cell proliferation, migration and invasion by modulating the circEZH2/miR-181b-5p pathway.
Topics: Anesthetics, Local; Animals; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; | 2021 |
Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function.
Topics: Adult; Age Factors; Amides; Anesthetics, Local; Cell Movement; Collagen; Colonic Neoplasms; Dose-Res | 2014 |
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Amides; Anesthetics, Local; Caveolin 1; Cell Movement; Drug | 2015 |
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Amides; Anesthetics, Local; Caveolin 1; Cell Movement; Drug | 2015 |
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Amides; Anesthetics, Local; Caveolin 1; Cell Movement; Drug | 2015 |
Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Amides; Anesthetics, Local; Caveolin 1; Cell Movement; Drug | 2015 |
Outcomes after tumescence technique versus electrocautery mastectomy.
Topics: Anesthetics, Local; Breast Neoplasms; Bronchodilator Agents; Electrocoagulation; Epinephrine; Female | 2012 |
MR-guided neurolytic celiac plexus ablation: an evaluation of effect and injection spread pattern in cancer patients with celiac tumor infiltration.
Topics: Abdominal Pain; Aged; Aged, 80 and over; Anesthetics, Local; Catheter Ablation; Celiac Plexus; Ethan | 2013 |
Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF).
Topics: Anesthetics, Local; Animals; Calcium; Cell Membrane; Cell Movement; Epidermal Growth Factor; ErbB Re | 2002 |
Interpretation of artifactual vascular invasion in cervical squamous precursors due to lidocaine injection.
Topics: Artifacts; Humans; Injections, Intravenous; Lidocaine; Neoplasm Invasiveness; Uterine Cervical Dyspl | 1995 |
Pseudoinvasion of vascular spaces: report of an artifact caused by cervical lidocaine injection prior to loop diathermy.
Topics: Adult; Anesthesia, Local; Artifacts; Blood Vessels; Cervix Uteri; Diathermy; Female; Humans; Injecti | 1994 |