lidocaine has been researched along with Intestinal Pseudo-Obstruction in 4 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Intestinal Pseudo-Obstruction: A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine was associated with an increased incidence of diagnosis of POR (OR 6." | 2.66 | Meta-analysis of the effects of lidocaine on postoperative reflux in the horse. ( Durket, E; Gillen, A; Kottwitz, J; Munsterman, A, 2020) |
| "Paralytic ileus is a major concern in the acute phase of spinal cord injury." | 1.35 | Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. ( Audibert, G; Baumann, A; Klein, O; Mertes, PM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Durket, E | 1 |
| Gillen, A | 1 |
| Kottwitz, J | 1 |
| Munsterman, A | 1 |
| Baumann, A | 1 |
| Audibert, G | 1 |
| Klein, O | 1 |
| Mertes, PM | 1 |
| Maruszyński, M | 1 |
| Lechnio, L | 1 |
| Rimbäck, G | 1 |
| Cassuto, J | 1 |
| Tollesson, PO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies[NCT02623803] | Phase 4 | 48 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time of first instance of a bowel movement will be measured as the number of days post operatively for bowel function to return. (NCT02623803)
Timeframe: up to 3 weeks postoperatively
| Intervention | days (Mean) |
|---|---|
| Treatment Group | 5.8 |
| Control Group | 5.2 |
Time of first instance of flatus will be measured as the number of days post operatively for bowel function to return. (NCT02623803)
Timeframe: up to 3 weeks postoperatively
| Intervention | days (Mean) |
|---|---|
| Treatment Group | 3.9 |
| Control Group | 2.7 |
Total opioid consumption in PACU converted to morphine equivalents in mg. (NCT02623803)
Timeframe: up to 4 hours post-operatively
| Intervention | mg (Mean) |
|---|---|
| Treatment Group | 3.9 |
| Control Group | 6.7 |
Overall pain will be measured 30 minutes after arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: 30 minutes after arrival to PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 3.3 |
| Control Group | 5.3 |
Overall pain will be measured approximately 12 hours post-operatively using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: approximately 12 hours post-operatively
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.4 |
| Control Group | 5.4 |
Overall pain will be measured on post-operative day 1 at 1 pm using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1 pm
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.8 |
| Control Group | 4.8 |
Overall pain will be measured on post-operative day 1 at 1am using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1am
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 5.1 |
| Control Group | 5.5 |
Overall pain will be measured upon arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: baseline - arrival at the PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 1.6 |
| Control Group | 2.7 |
Pain at rest will be measured 30 minutes after arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: 30 minutes after arrival to PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 3.3 |
| Control Group | 5.1 |
Pain at rest will be measured approximately 12 hours post-operatively using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: approximately 12 hours post-operatively
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.0 |
| Control Group | 5.0 |
Pain at rest will be measured at post-operative day 1 at 1 pm using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1 pm
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.0 |
| Control Group | 4.8 |
Pain at rest will be measured on post-operative day 1 at 1 am using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1 am
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.0 |
| Control Group | 4.6 |
Pain will be measured at rest upon arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: baseline - arrival at the PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 2.1 |
| Control Group | 2.6 |
Pain with coughing will be measured 30 minutes after arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: 30 minutes after arrival to PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.3 |
| Control Group | 5.8 |
Pain with coughing will be measured approximately 12 hours post-operatively using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: approximately 12 hours post-operatively
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 4.7 |
| Control Group | 7.6 |
Pain with coughing will be measured on post-operative day 1 at 1 am using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1 am
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 5.4 |
| Control Group | 7.1 |
Pain with coughing will be measured on post-operative day 1 at 1 pm using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: post-operative day 1 at 1 pm
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 5.4 |
| Control Group | 5.8 |
Pain with coughing will be measured upon arrival at the post-operative care unit (PACU) using numerical rating scale (NSR). Subjects will rate their pain after surgery on a scale from 0 to 10, where 0 is no pain and 10 is the worst pain imaginable. (NCT02623803)
Timeframe: baseline - arrival at the PACU
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Group | 2.3 |
| Control Group | 2.5 |
Total amount of opioids converted to morphine equivalents in mg administered in the first 24 hours after surgery. (NCT02623803)
Timeframe: up to 24 hours post-operatively
| Intervention | mg (Mean) |
|---|---|
| Treatment Group | 7.4 |
| Control Group | 7.9 |
This questionnaire is a short 15 question form that measures the quality of a subject's postoperative recovery. The scale is ranked from 0 to 10, where 0 is a poor response and 10 is an excellent response. (NCT02623803)
Timeframe: Day 15 post-operatively
| Intervention | score on a scale (Mean) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Able to breathe easily | Been able to enjoy food | Feeling rested | Have had a good sleep | Able to look after personal toliet and hygiene | Able to communicate with family or friends | Getting support from hospital doctors and nurse | Able to return to work or usual home activities | Feeling comfortable and in control | Having a feeling of general well-being | Moderate pain | Severe pain | Nausea or vomiting | Feeling worried or anxious | Feeling sad or depressed | |
| Control Group | 8.7 | 5.4 | 6.0 | 6.6 | 8.8 | 9.3 | 9.5 | 4.9 | 6.7 | 6.7 | 6.6 | 8.8 | 8.2 | 7.6 | 7.8 |
| Treatment Group | 9.1 | 6.2 | 7.2 | 7.1 | 9.2 | 9.6 | 8.8 | 5.4 | 7.1 | 7.5 | 7.9 | 9.4 | 8.6 | 7.7 | 8.4 |
1 review available for lidocaine and Intestinal Pseudo-Obstruction
| Article | Year |
|---|---|
Meta-analysis of the effects of lidocaine on postoperative reflux in the horse.
Topics: Administration, Intravenous; Anesthetics, Local; Animals; Digestive System Surgical Procedures; Gast | 2020 |
1 trial available for lidocaine and Intestinal Pseudo-Obstruction
| Article | Year |
|---|---|
Treatment of postoperative paralytic ileus by intravenous lidocaine infusion.
Topics: Cholecystectomy; Double-Blind Method; Drug Evaluation; Female; Humans; Infusions, Intravenous; Intes | 1990 |
Treatment of postoperative paralytic ileus by intravenous lidocaine infusion.
Topics: Cholecystectomy; Double-Blind Method; Drug Evaluation; Female; Humans; Infusions, Intravenous; Intes | 1990 |
Treatment of postoperative paralytic ileus by intravenous lidocaine infusion.
Topics: Cholecystectomy; Double-Blind Method; Drug Evaluation; Female; Humans; Infusions, Intravenous; Intes | 1990 |
Treatment of postoperative paralytic ileus by intravenous lidocaine infusion.
Topics: Cholecystectomy; Double-Blind Method; Drug Evaluation; Female; Humans; Infusions, Intravenous; Intes | 1990 |
2 other studies available for lidocaine and Intestinal Pseudo-Obstruction
| Article | Year |
|---|---|
Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury.
Topics: Adult; Aged; Female; Humans; Infusions, Intravenous; Intestinal Pseudo-Obstruction; Lidocaine; Male; | 2009 |
[Clinical usefulness of celiac plexus block].
Topics: Acute Disease; Autonomic Nerve Block; Celiac Plexus; Humans; Intestinal Obstruction; Intestinal Pseu | 1984 |