lidocaine has been researched along with Innate Inflammatory Response in 117 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| " administration of lidocaine as an effective anti-inflammatory therapy for systemic inflammation." | 9.14 | Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis. ( Belknap, JK; Faleiros, RR; Hubbell, JA; Lin, YJ; Loftus, JP; Peroni, JF; Ravis, WR; Williams, JM, 2010) |
| "To investigate the influence of lidocaine on systemic inflammation in the perioperative ventricular septal defect (VSD)." | 9.11 | [Influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass]. ( Chen, LB; Cheng, Y; Feang, G; Sun, CB; Zhang, WX, 2005) |
| " The purpose of this study was to compare the effects of intra-articular (IA) administration of tranexamic acid (TXA), an anti-fibrinolytic commonly used in TKA, and ALM chondroprotective solution on postoperative inflammation and joint tissue healing in a rat model of knee implant surgery." | 8.02 | Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. ( Biros, E; Dlaska, C; Dobson, GP; Hazratwala, K; Letson, HL; McEwen, P; Morris, JL; Wilkinson, M, 2021) |
| "Lidocaine (Lido) is reported to suppress inflammatory responses and exhibit a therapeutic effect in models of cecal ligation and puncture (CLP)-induced acute lung injury (ALI)." | 7.85 | RAGE deficiency attenuates the protective effect of Lidocaine against sepsis-induced acute lung injury. ( Jiang, X; Li, X; Liao, C; Liu, M; Song, D; Zhang, Z; Zhou, J, 2017) |
| "Morphine tolerance is a clinical challenge, and its pathogenesis is closely related to the neuroinflammation mediated by Toll-like receptor 4 (TLR4)." | 7.85 | Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord. ( Han, Y; Hu, L; Jiang, CY; Liu, WT; Qian, Y; Qu, J; Tao, GJ; Zhang, G; Zhang, Y, 2017) |
| "To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury." | 7.83 | Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats. ( Cerri, S; Farca, AM; Gandini, M; Giusto, G; Iussich, S; Pregel, P; Tursi, M; Vercelli, C, 2016) |
| "Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy." | 7.83 | JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 7.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| "It is unclear whether inhaled lidocaine is effective against airway hyperreactivity and inflammation in asthma." | 7.74 | Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs. ( Haraguchi, R; Iwanaga, T; Kubo, H; Muraki, M; Tohda, Y, 2008) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 7.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "The purpose of this study was to determine the relationship between inflammation, increased alpha-1-acid glycoprotein (AAG), and lidocaine tolerance during fiber-optic bronchoscopy." | 7.67 | Relationship between inflammation, alpha-1-acid glycoprotein and lidocaine tolerance during fiber-optic bronchoscopy. ( Arnaud, A; Arnaud, C; Bruguerolle, B; Philip-Joet, F, 1987) |
| "Mild ischemia was induced in segments of jejunum and large colon." | 6.84 | Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017) |
| " In this clinical trial, we conducted a comparative analysis of the pain-related behavioral, physiological, and hematological performance of calves that were administered with either lidocaine plus normal saline (n = 15) or lidocaine plus meloxicam (n = 15) before undergoing disbudding operations." | 5.69 | A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding. ( Cui, H; Deng, J; Fang, J; Geng, Y; Guo, H; Hu, Y; Huang, F; Kumbhar, MA; Li, Z; Qi, J; Ren, Z; Shah, AM; Shen, L; Yu, S; Zuo, Z, 2023) |
| "Lidocaine attenuates neuropathic pain and neuroinflammation by inhibiting HMGB1 to regulate the MIP-1α/CCR1/CCR5 pathway." | 5.62 | Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway. ( Gu, J; Gu, K; Jiang, H; Li, C; Li, M; Sun, X; Wang, G, 2021) |
| "Lidocaine has anti-inflammatory properties." | 5.62 | Effect of Intravenous Lidocaine on Inflammatory and Apoptotic Response of Ischemia-Reperfusion Injury in Pigs Undergoing Lung Resection Surgery. ( Carricondo, F; Cebollero, M; García-Aldao, U; Garutti, I; Martín-Albo, L; Ortega, J; Romera, A; Romero-Gómez, B; Simón, C; Vara, E; Zapatero, S, 2021) |
| "Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)." | 5.46 | Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage. ( Dobson, G; Letson, H, 2017) |
| "Systemic LA were shown to attenuate postoperative pain, accelerate the return of bowel function and shorten length of hospital stay in patients undergoing abdominal surgery." | 5.42 | [Adjuvants in modern anesthesia - lidocaine]. ( Boeckh, R; Hollmann, MW; Lirk, P; Picardi, S, 2015) |
| "The main objective of this study is to evaluate the effect of intravenous lidocaine on gas exchange and inflammation in acute respiratory distress syndrome due or not to Covid-19 pneumonia." | 5.41 | Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trial. ( Aberkane, O; Becker, G; Chamaraux-Tran, TN; Glady, L; Harlay, ML; Hecketsweiler, S; Julians, M; Lefebvre, F; Muller, C; Muller, M; Pottecher, J; Romoli, A; Schneider, F; Tawk, M, 2021) |
| "Lidocaine infusion reduced mechano-hyperalgesia but had no effect on mechano-allodynia or heat-hyperalgesia." | 5.35 | C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. ( Bennett, GJ; Xiao, WH, 2008) |
| "To evaluate Neosaxitoxin (NeoSTX) as a local anesthetic drug, for pain control during and after piglet castration." | 5.30 | Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine. ( Bustamante, T; Del Campo, M; Lagos, N; Muñoz, V; Piron, R; Sánchez, A; Sepúlveda, JM; Simbaina, JC; Torres, C; Valenzuela, C, 2019) |
| " The pathophysiology of POCD remains elusive, but previous work showed that intravenous lidocaine may be protective against POCD, possibly by modulating cerebral inflammation." | 5.22 | Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial. ( Berger, M; Cooter, M; Klinger, RY; Levy, JH; Mathew, JP; Newman, MF; Ortel, TL; Podgoreanu, MV; Rinder, HM; Stafford-Smith, M; Welsby, IJ, 2016) |
| " administration of lidocaine as an effective anti-inflammatory therapy for systemic inflammation." | 5.14 | Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis. ( Belknap, JK; Faleiros, RR; Hubbell, JA; Lin, YJ; Loftus, JP; Peroni, JF; Ravis, WR; Williams, JM, 2010) |
| "To investigate the influence of lidocaine on systemic inflammation in the perioperative ventricular septal defect (VSD)." | 5.11 | [Influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass]. ( Chen, LB; Cheng, Y; Feang, G; Sun, CB; Zhang, WX, 2005) |
| "The purpose of this study was to compare the extent of inflammation response in the middle carpal joints of healthy horses following intra-articular injection of 2% lidocaine, 0." | 4.31 | Effects of a Single Intra-Articular Injection of 2% Lidocaine or 0.5% Bupivacaine on Synovial Fluid Acute Phase Protein Concentrations in Healthy Horses. ( da Fonseca, LA; Di Filippo, PA; Dos Santos, GC; Quirino, CR, 2023) |
| " The purpose of this study was to compare the effects of intra-articular (IA) administration of tranexamic acid (TXA), an anti-fibrinolytic commonly used in TKA, and ALM chondroprotective solution on postoperative inflammation and joint tissue healing in a rat model of knee implant surgery." | 4.02 | Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. ( Biros, E; Dlaska, C; Dobson, GP; Hazratwala, K; Letson, HL; McEwen, P; Morris, JL; Wilkinson, M, 2021) |
| " Lidocaine formulations significantly reduced the paw edema on day 6 after Walker 256 cells inoculation." | 3.96 | Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response. ( Abdalla, HB; Burga-Sánchez, J; da Costa, JP; de Freitas Domingues, JS; Ferreira, LEN; Groppo, FC; Volpato, MC, 2020) |
| "Lidocaine (Lido) is reported to suppress inflammatory responses and exhibit a therapeutic effect in models of cecal ligation and puncture (CLP)-induced acute lung injury (ALI)." | 3.85 | RAGE deficiency attenuates the protective effect of Lidocaine against sepsis-induced acute lung injury. ( Jiang, X; Li, X; Liao, C; Liu, M; Song, D; Zhang, Z; Zhou, J, 2017) |
| "Morphine tolerance is a clinical challenge, and its pathogenesis is closely related to the neuroinflammation mediated by Toll-like receptor 4 (TLR4)." | 3.85 | Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord. ( Han, Y; Hu, L; Jiang, CY; Liu, WT; Qian, Y; Qu, J; Tao, GJ; Zhang, G; Zhang, Y, 2017) |
| "To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury." | 3.83 | Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats. ( Cerri, S; Farca, AM; Gandini, M; Giusto, G; Iussich, S; Pregel, P; Tursi, M; Vercelli, C, 2016) |
| "Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy." | 3.83 | JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 3.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| "Inhalation of JMF2-1, an analog of lidocaine with reduced anesthetic activity, prevents airway contraction and lung inflammation in experimental asthma models." | 3.78 | Two for one: cyclic AMP mediates the anti-inflammatory and anti-spasmodic properties of the non-anesthetic lidocaine analog JMF2-1. ( Coelho, LP; Cordeiro, RS; da Costa, JC; Martins, MA; Olsen, PC; Silva, PM, 2012) |
| "Using murine peritonitis induced by zymosan and a systems approach, we report that lidocaine delayed and blocked key events in resolution of inflammation." | 3.74 | Anesthetics impact the resolution of inflammation. ( Chiang, N; Fredman, G; Gelman, S; Kasuga, K; Schwab, JM; Serhan, CN, 2008) |
| "It is unclear whether inhaled lidocaine is effective against airway hyperreactivity and inflammation in asthma." | 3.74 | Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs. ( Haraguchi, R; Iwanaga, T; Kubo, H; Muraki, M; Tohda, Y, 2008) |
| "The involvement of bradykinin and some other inflammatory mediators in formalin-induced oedema and plasma extravasation was examined." | 3.70 | The inflammatory reaction induced by formalin in the rat paw. ( Damas, J; Liégeois, JF, 1999) |
| "We have assessed the effects of intraplantar local anaesthetics (bupivacaine and lignocaine) on carrageenan-induced oedema, mechanical allodynia and spinal c-fos protein expression." | 3.69 | Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat. ( Besson, JM; Buritova, J; Fletcher, D; Honoré, P, 1996) |
| "The actions and interactions of putative mediators of inflammation, such as substance P (SP), histamine, bradykinin and prostaglandins (PGE2) were studied in human skin." | 3.68 | Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. ( Håkanson, R; Wallengren, J, 1992) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 3.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "The purpose of this study was to determine the relationship between inflammation, increased alpha-1-acid glycoprotein (AAG), and lidocaine tolerance during fiber-optic bronchoscopy." | 3.67 | Relationship between inflammation, alpha-1-acid glycoprotein and lidocaine tolerance during fiber-optic bronchoscopy. ( Arnaud, A; Arnaud, C; Bruguerolle, B; Philip-Joet, F, 1987) |
| "There was a lower incidence of postoperative nausea and vomiting (PONV) in group LD than in group C (P < 0." | 3.01 | Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial. ( Hu, S; Ju, X; Li, Q; Li, Y; Wang, S; Xu, S, 2021) |
| "Mild ischemia was induced in segments of jejunum and large colon." | 2.84 | Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017) |
| "Ligenten gel is a combined dosage form containing gentamicin (a broad spectrum antibiotic), lidocaine (an anesthetic) and ethonium (an antiseptic)." | 2.67 | [Ligenten--a combination drug with anesthetic and antibacterial action for local use in urology and gynecology]. ( Darenkov, AF; Kotliarova, GA; Lebed', SV; Makarov, OV; Perepanova, TS; Savchenko, TN; Strachunskiĭ, LS; Tsibina, LV; Vasil'ev, MM; Zharov, EV, 1994) |
| "Lidocaine attenuates neuropathic pain and neuroinflammation by inhibiting HMGB1 to regulate the MIP-1α/CCR1/CCR5 pathway." | 1.62 | Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway. ( Gu, J; Gu, K; Jiang, H; Li, C; Li, M; Sun, X; Wang, G, 2021) |
| "Lidocaine has anti-inflammatory properties." | 1.62 | Effect of Intravenous Lidocaine on Inflammatory and Apoptotic Response of Ischemia-Reperfusion Injury in Pigs Undergoing Lung Resection Surgery. ( Carricondo, F; Cebollero, M; García-Aldao, U; Garutti, I; Martín-Albo, L; Ortega, J; Romera, A; Romero-Gómez, B; Simón, C; Vara, E; Zapatero, S, 2021) |
| "Although migraine is one of the most common primary headaches, its therapy is still limited in many cases." | 1.56 | Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats. ( Bohár, Z; Fejes-Szabó, A; Laborc, KF; Nagy-Grócz, G; Párdutz, Á; Spekker, E; Szűcs, M; Vécsei, L, 2020) |
| "Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)." | 1.46 | Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage. ( Dobson, G; Letson, H, 2017) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | 1.43 | CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| " Compared with intravenous injection, another method for rAAV delivery to the broad central nervous system (CNS), the intrathecal injection reduced the dosage of rAAV required to achieve similar or higher levels of transgene expression in the CNS by ~100-fold." | 1.43 | A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord. ( Gao, G; Guo, Y; Qiao, T; Su, Q; Wang, D; Xu, Z; Yang, C, 2016) |
| "Systemic LA were shown to attenuate postoperative pain, accelerate the return of bowel function and shorten length of hospital stay in patients undergoing abdominal surgery." | 1.42 | [Adjuvants in modern anesthesia - lidocaine]. ( Boeckh, R; Hollmann, MW; Lirk, P; Picardi, S, 2015) |
| "Inflammation is clinically well known to decrease the efficiency of local anesthesia, an effect which has been explained mechanistically by tissue acidosis in the literature." | 1.35 | Membrane effect of lidocaine is inhibited by interaction with peroxynitrite. ( Mizogami, M; Takakura, K; Tsuchiya, H; Ueno, T, 2008) |
| "Lidocaine infusion reduced mechano-hyperalgesia but had no effect on mechano-allodynia or heat-hyperalgesia." | 1.35 | C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. ( Bennett, GJ; Xiao, WH, 2008) |
| "Measuring primary hyperalgesia from deep somatic tissue (ie, muscle and joint) is difficult in laboratory animals but clinically important." | 1.33 | Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. ( Radhakrishnan, R; Skyba, DA; Sluka, KA, 2005) |
| "Prevention of late hyperalgesia can be provided not only by the preinjury block but also by the postinjury block administered when hyperalgesia is already well established." | 1.30 | Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. ( Bradley, EL; Kissin, I; Lee, SS, 1998) |
| "Clonidine was more potent in CCI then in CFA rats in reducing the response to cold." | 1.30 | The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. ( Franssen, M; Goff, JR; Janni, G; Jasmin, L; Kohan, L, 1998) |
| "In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin)." | 1.26 | [Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol]. ( Kalbhen, DA; Smalla, HD, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (17.95) | 18.7374 |
| 1990's | 22 (18.80) | 18.2507 |
| 2000's | 25 (21.37) | 29.6817 |
| 2010's | 33 (28.21) | 24.3611 |
| 2020's | 16 (13.68) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Hasan, D | 1 |
| Shono, A | 1 |
| van Kalken, CK | 1 |
| van der Spek, PJ | 1 |
| Krenning, EP | 1 |
| Kotani, T | 1 |
| Morris, JL | 1 |
| Letson, HL | 2 |
| McEwen, P | 1 |
| Biros, E | 1 |
| Dlaska, C | 1 |
| Hazratwala, K | 1 |
| Wilkinson, M | 1 |
| Dobson, GP | 3 |
| Sayegh, MJ | 1 |
| Pinpin, C | 1 |
| Larsen, CG | 1 |
| Neufeld, EV | 1 |
| Intravia, JM | 1 |
| Nellans, KW | 1 |
| Lane, LB | 1 |
| Grande, D | 1 |
| Ma, X | 1 |
| Yan, W | 1 |
| He, N | 1 |
| Weinschenk, S | 1 |
| Weiss, C | 1 |
| Benrath, J | 1 |
| von Baehr, V | 1 |
| Strowitzki, T | 1 |
| Feißt, M | 1 |
| Buchanan, MW | 1 |
| Furman, BD | 1 |
| McNulty, AL | 1 |
| Olson, SA | 1 |
| Tian, C | 1 |
| Wang, Z | 1 |
| Huang, L | 1 |
| Liu, Y | 1 |
| Wu, K | 1 |
| Li, Z | 2 |
| Han, B | 1 |
| Jiao, D | 1 |
| Han, X | 1 |
| Zhao, Y | 1 |
| Dos Santos, GC | 1 |
| Di Filippo, PA | 1 |
| da Fonseca, LA | 1 |
| Quirino, CR | 1 |
| Qi, J | 1 |
| Fang, J | 1 |
| Huang, F | 1 |
| Kumbhar, MA | 1 |
| Cui, H | 1 |
| Guo, H | 1 |
| Shen, L | 1 |
| Ren, Z | 1 |
| Geng, Y | 1 |
| Hu, Y | 1 |
| Deng, J | 1 |
| Yu, S | 1 |
| Shah, AM | 1 |
| Zuo, Z | 1 |
| Leon-Constantin, MM | 1 |
| Alexa-Stratulat, T | 1 |
| Luca, A | 1 |
| Tamba, BI | 1 |
| Trandafir, LM | 1 |
| Harabagiu, V | 1 |
| Cojocaru, E | 1 |
| Li, M | 2 |
| Jiang, H | 1 |
| Gu, K | 1 |
| Sun, X | 1 |
| Gu, J | 1 |
| Li, C | 1 |
| Wang, G | 1 |
| Ferreira, LEN | 1 |
| Abdalla, HB | 1 |
| da Costa, JP | 1 |
| de Freitas Domingues, JS | 1 |
| Burga-Sánchez, J | 1 |
| Groppo, FC | 1 |
| Volpato, MC | 1 |
| Laborc, KF | 1 |
| Spekker, E | 1 |
| Bohár, Z | 1 |
| Szűcs, M | 1 |
| Nagy-Grócz, G | 1 |
| Fejes-Szabó, A | 1 |
| Vécsei, L | 1 |
| Párdutz, Á | 1 |
| Xu, S | 1 |
| Hu, S | 1 |
| Ju, X | 1 |
| Li, Y | 1 |
| Li, Q | 1 |
| Wang, S | 1 |
| Frydendal, C | 1 |
| Nielsen, KB | 1 |
| Berg, LC | 1 |
| van Galen, G | 1 |
| Adler, DMT | 1 |
| Andreassen, SM | 1 |
| Jacobsen, S | 1 |
| Muller, M | 1 |
| Lefebvre, F | 1 |
| Harlay, ML | 1 |
| Glady, L | 1 |
| Becker, G | 1 |
| Muller, C | 1 |
| Aberkane, O | 1 |
| Tawk, M | 1 |
| Julians, M | 1 |
| Romoli, A | 1 |
| Hecketsweiler, S | 1 |
| Schneider, F | 1 |
| Pottecher, J | 1 |
| Chamaraux-Tran, TN | 1 |
| Romera, A | 1 |
| Cebollero, M | 1 |
| Romero-Gómez, B | 1 |
| Carricondo, F | 1 |
| Zapatero, S | 1 |
| García-Aldao, U | 1 |
| Martín-Albo, L | 1 |
| Ortega, J | 1 |
| Vara, E | 1 |
| Garutti, I | 1 |
| Simón, C | 1 |
| Davenport, L | 1 |
| Bauck, AG | 1 |
| Grosche, A | 1 |
| Morton, AJ | 1 |
| Graham, AS | 1 |
| Vickroy, TW | 1 |
| Freeman, DE | 1 |
| Zhang, Y | 1 |
| Tao, GJ | 1 |
| Hu, L | 1 |
| Qu, J | 1 |
| Han, Y | 1 |
| Zhang, G | 1 |
| Qian, Y | 1 |
| Jiang, CY | 1 |
| Liu, WT | 1 |
| Letson, H | 1 |
| Dobson, G | 1 |
| Chatigny, F | 1 |
| Groman, DB | 1 |
| Martinson, SA | 1 |
| Stevens, ED | 1 |
| Kan, H | 1 |
| Wang, Y | 1 |
| Wang, D | 2 |
| Sun, H | 1 |
| Zhou, S | 1 |
| Wang, H | 1 |
| Guan, J | 1 |
| Wang, L | 1 |
| Wang, M | 1 |
| Li, S | 1 |
| Wu, H | 1 |
| Shen, Q | 1 |
| Zhang, S | 1 |
| Fang, L | 1 |
| Liu, R | 1 |
| Othman, AH | 1 |
| Ahmed, DG | 1 |
| Abd El-Rahman, AM | 1 |
| El Sherif, FA | 1 |
| Mansour, S | 1 |
| Aboeleuon, E | 1 |
| Valenzuela, C | 1 |
| Torres, C | 1 |
| Muñoz, V | 1 |
| Simbaina, JC | 1 |
| Sánchez, A | 1 |
| Bustamante, T | 1 |
| Sepúlveda, JM | 1 |
| Piron, R | 1 |
| Del Campo, M | 1 |
| Lagos, N | 1 |
| Zheng, Y | 1 |
| Hou, X | 1 |
| Yang, S | 1 |
| Youngquist, ST | 1 |
| Niemann, JT | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Intravenous Dexmedetomidine, Lidocaine and Their Combination on Postoperative Inflammation Cytokines After Laparoscopic Hysterectomy With General Anesthesia[NCT03276533] | 160 participants (Actual) | Interventional | 2017-11-01 | Completed | |||
| Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia[NCT04609865] | Phase 3 | 100 participants (Anticipated) | Interventional | 2020-11-04 | Recruiting | ||
| Effect of Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia on Inflammatory Response and Pain Following Radical Cytsectomy[NCT03002909] | 40 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
| Efficacy of Combined Periportal and Preperitoneal Local Anesthetic Infiltration (CPPLAI) in Laparoscopic Sleeve Gastrectomy Patients[NCT04680923] | 120 participants (Actual) | Interventional | 2020-12-08 | Completed | |||
| Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964] | 550 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
| Evaluating the Efficacy of an Ablative Fractional Carbon Dioxide Laser on Pathologic Symptoms in Pediatric Hypertrophic Scars: a Prospective Split-scar Controlled Trial[NCT04236167] | 6 participants (Actual) | Interventional | 2020-11-01 | Terminated (stopped due to Lack of participants to enroll. Early findings not supportive of fractionated c02 laser improving scars in population studied when used alone.) | |||
| Continuous Cerebral Autoregulation Monitoring to Reduce Brain Injury From Cardiac Surgery[NCT00981474] | 460 participants (Actual) | Interventional | 2009-09-01 | Completed | |||
| Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients[NCT01836614] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn (stopped due to Study was closed due to recommendations of performing a PK study first.) | ||
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic[NCT04043624] | Phase 4 | 80 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | ||
| Pharmacokinetics of Intravenous Lidocaine Infusion in Children[NCT02241096] | Phase 1 | 2 participants (Actual) | Interventional | 2015-01-31 | Terminated (stopped due to Lack of available study participants.) | ||
| Therapeutic Efficacy of Intravenous Lidocaine Infusion Compared With Epidural Analgesia for Postoperative Pain Control in Adult Patients Undergoing Major Abdominal Surgery: Non-Inferiority Clinical Trial[NCT04017013] | Phase 4 | 210 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| Effect of Intravenous Single-bolus Lidocaine Infusion Versus Intravenous Single-bolus Magnesium Sulfate Infusion on Postoperative Pain, Emotional Status and Quality of Life in Patients Undergoing Spine Fusion Surgery[NCT04776369] | Phase 4 | 60 participants (Actual) | Interventional | 2022-05-01 | Active, not recruiting | ||
| A Prospective, Randomized, Double-blind Study of the Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Inferior Alveolar Nerve Blocks.[NCT01574807] | Phase 4 | 100 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.27 |
| Placebo | -0.89 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.57 |
| Placebo | 0.16 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.09 |
| Placebo | 0.07 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.07 |
| Placebo | 0.07 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 6.3 |
| Placebo | 6.96 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -10.98 |
| Placebo | -11.67 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.07 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.04 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.02 |
| Placebo | -0.02 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.04 |
| Placebo | -0.01 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.71 |
| Placebo | -1.16 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 1.23 |
| Placebo | -0.49 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.20 |
| Placebo | 0.03 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.95 |
| Placebo | 1.59 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -6.70 |
| Placebo | -6.39 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -7.12 |
| Placebo | -6.31 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.39 |
| Placebo | -1.48 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.67 |
| Placebo | -0.8 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.46 |
| Placebo | -1.02 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -3 |
| Placebo | -3.21 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.15 |
| Placebo | -0.31 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 2.46 |
| Placebo | 2.1 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Lidocaine | 87 |
| Placebo | 83 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 1 year Change Work Activities | 1 year Change General health perception | |
| Lidocaine | -1.37 | -0.28 |
| Placebo | -1.42 | -0.43 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 6-Week Change Work activities | 6-Week Change General health perception | |
| Lidocaine | 2.71 | -0.004 |
| Placebo | 3 | -0.03 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.15 | 0.02 | -0.73 | -0.10 |
| Placebo | -0.43 | -0.73 | -0.40 | 0.19 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -4.22 | -2.46 | -0.34 | 1.21 |
| Placebo | -0.04 | 1.83 | 2.64 | 0.54 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -2.02 | 0.56 | 0.58 | 1.04 |
| Placebo | -0.08 | 0.17 | 1.19 | -0.68 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.03 | 0.03 | 0.33 | 0.37 |
| Placebo | 0.35 | 0.43 | 0.05 | 0.27 |
Subject developed acute kidney injury within 7 days after surgical procedure. Based on Kidney disease: Improving Global Outcomes (KDIGO) classification system. (NCT00981474)
Timeframe: 7 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 56 |
| Intervention | 62 |
The composite neurological outcome was composed of clinical stroke, or new ischemic lesions detected on postoperative brain diffusion weighted magnetic resonance imaging(DWI), or cognitive decline from baseline to 4-6 weeks after surgery. (NCT00981474)
Timeframe: Up to 6 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Usual Care Group (Control) | 79 |
| Autoregulation Group | 70 |
Procedural insertion of intra-aortic balloon pump within 7 days after surgical procedure (NCT00981474)
Timeframe: 7 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 19 |
| Intervention | 14 |
Subjects need for mechanical lung ventilation more than 24 hours after planned surgical procedure. (NCT00981474)
Timeframe: Up to 28 days after surgery.
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 22 |
| Intervention | 13 |
Subject death within 28 days after surgical procedure (NCT00981474)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 12 |
| Intervention | 5 |
Use of multiple inotropic drugs greater than 24 hours after the planned surgical procedure until discharge from the hospital. (NCT00981474)
Timeframe: 7 days after surgery
| Intervention | participants (Number) |
|---|---|
| Usual Care Group (Control) | 13 |
| Autoregulation Group | 6 |
Subject diagnosis of multisystem organ failure after surgery. (NCT00981474)
Timeframe: Up to 28 days after surgery.
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 7 |
| Intervention | 2 |
Subjects requiring new renal replacement therapy prior to discharge from hospital (NCT00981474)
Timeframe: Up to 28 days after surgery.
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 6 |
| Intervention | 4 |
Clinical diagnosis of postoperative atrial fibrillation from date of surgical procedure to discharge from the hospital. (NCT00981474)
Timeframe: Up to 28 days after surgery.
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 89 |
| Intervention | 79 |
Assessed with Confusion Assessment Method or Confusion Assessment Method-ICU along with adjudication by team of experts (NCT00981474)
Timeframe: Postoperative days 1-4
| Intervention | Participants (Count of Participants) |
|---|---|
| Usual Care Group (Control) | 34 |
| Autoregulation Group | 19 |
Clinical diagnosis of sepsis from time of surgical procedure to discharge from the hospital. (NCT00981474)
Timeframe: Up to 28 days after surgery.
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 7 |
| Intervention | 2 |
An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes. Measurements of less than 80 on the EPT is considered not numb (anesthesia failure). Readings of 80 equate to anesthetic success. (NCT01574807)
Timeframe: 60 minutes per injection sequence.
| Intervention | Participants (Count of Participants) |
|---|---|
| Mepivacaine + Lidocaine | 44 |
| Lidocaine + Lidocaine | 40 |
7 reviews available for lidocaine and Innate Inflammatory Response
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling.
Topics: Adenosine Triphosphate; Anti-Inflammatory Agents; COVID-19; Critical Care; Cytokine Release Syndrome | 2022 |
A brief review of innovative uses for local anesthetics.
Topics: Anesthetics, Local; Animals; Brain Ischemia; Decompression Sickness; Dose-Response Relationship, Dru | 2008 |
Effects of anaesthesia on the inflammatory response to injury.
Topics: Anesthesia; Animals; Cardiac Surgical Procedures; Humans; Inflammation; Interleukin-1beta; Lidocaine | 2011 |
The role of sodium channels in chronic inflammatory and neuropathic pain.
Topics: Anesthetics, Local; Calcium Signaling; Chronic Disease; Humans; Inflammation; Lidocaine; Nervous Sys | 2006 |
Lidocaine for acute lung injury: questions still to answer.
Topics: Animals; Critical Illness; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Inflammatio | 2000 |
Effects of local anesthetics, antihistamines, and glucocorticoids on peripheral blood flow and vascular smooth muscle.
Topics: Anesthetics, Local; Animals; Blood Vessels; Cats; Diphenhydramine; Dogs; Glucocorticoids; Histamine; | 1974 |
18 trials available for lidocaine and Innate Inflammatory Response
| Article | Year |
|---|---|
A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding.
Topics: Animal Welfare; Animals; Cattle; Caustics; Dinoprostone; Horns; Hydroxyl Radical; Inflammation; Lido | 2023 |
Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Dexmedetomidine; Drug Therapy, Combination; Female; Hu | 2021 |
Impact of intravenous lidocaine on clinical outcomes of patients with ARDS during COVID-19 pandemia (LidoCovid): A structured summary of a study protocol for a randomised controlled trial.
Topics: Administration, Intravenous; Clinical Trials, Phase III as Topic; COVID-19; COVID-19 Drug Treatment; | 2021 |
Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.
Topics: Animals; Cyclooxygenase 2; Horse Diseases; Horses; Inflammation; Intestinal Mucosa; Ischemia; Jejuna | 2017 |
Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Local; Anes | 2019 |
Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Local; Anes | 2019 |
Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Local; Anes | 2019 |
Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Local; Anes | 2019 |
Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine.
Topics: Anesthetics, Local; Animals; Inflammation; Lidocaine; Male; Orchiectomy; Pain; Prospective Studies; | 2019 |
Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.
Topics: Adult; Aged; Anesthetics, Local; Brain Diseases; Cardiac Surgical Procedures; Cardiopulmonary Bypass | 2016 |
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.
Topics: Aged; Anesthesia; Anesthetics, Local; Cardiac Surgical Procedures; Cognition Disorders; Double-Blind | 2009 |
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.
Topics: Aged; Anesthesia; Anesthetics, Local; Cardiac Surgical Procedures; Cognition Disorders; Double-Blind | 2009 |
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.
Topics: Aged; Anesthesia; Anesthetics, Local; Cardiac Surgical Procedures; Cognition Disorders; Double-Blind | 2009 |
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.
Topics: Aged; Anesthesia; Anesthetics, Local; Cardiac Surgical Procedures; Cognition Disorders; Double-Blind | 2009 |
Differential effects of skin nerves on allergic skin inflammation.
Topics: Anesthetics, Local; Double-Blind Method; Humans; Hypersensitivity; Inflammation; Lidocaine; Lidocain | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
The effect of perioperative intravenous lidocaine on postoperative pain and immune function.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Cell Proliferation; Ce | 2009 |
Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis.
Topics: Anesthetics, Local; Animals; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Inflammation; Jug | 2010 |
Evaluation of inflammatory and hemostatic surgical stress responses in male cats after castration under general anesthesia with or without local anesthesia.
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Animals; Cats; I | 2012 |
Cortisol responses to dehorning of calves given a 5-h local anaesthetic regimen plus phenylbutazone, ketoprofen, or adrenocorticotropic hormone prior to dehorning.
Topics: Adrenocorticotropic Hormone; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; B | 2002 |
[Influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass].
Topics: Adolescent; Cardiopulmonary Bypass; Child; Female; Heart Septal Defects, Ventricular; Humans; Inflam | 2005 |
Prilocaine -- an investigation into its use in the presence of inflammation and in combination with lignocaine.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Animals; Clinical Trials as Topic; Double-Blind Method | 1981 |
[Ligenten--a combination drug with anesthetic and antibacterial action for local use in urology and gynecology].
Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Anti-Infective Agents, Local; Child; Drug Combinat | 1994 |
[The combined preparation ligentin in the treatment of inflammatory disease of the urogenital organs].
Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Drug Combinations; Female; Female Urogenital Disea | 1995 |
General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state.
Topics: Aged; Analysis of Variance; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2000 |
92 other studies available for lidocaine and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty.
Topics: Adenosine; Administration, Intravenous; Animals; Antifibrinolytic Agents; Arthroplasty, Replacement, | 2021 |
Effects of Premixing Betamethasone and Lidocaine on Chondrocyte Inflammation in an
Topics: Anesthetics, Local; Betamethasone; Chondrocytes; Humans; Inflammation; Lidocaine | 2023 |
Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway.
Topics: A549 Cells; Apoptosis; Ferroptosis; Humans; Hypoxia; Inflammation; Lidocaine; Lung; Oxidative Stress | 2022 |
Anti-Inflammatory Characteristics of Local Anesthetics: Inhibition of TNF-α Secretion of Lipopolysaccharide-Stimulated Leucocytes in Human Blood Samples.
Topics: Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Humans; Inflammation; Lidocaine; Lipopoly | 2022 |
Combination of Lidocaine and IL-1Ra Is Effective at Reducing Degradation of Porcine Cartilage Explants.
Topics: Animals; Cartilage Diseases; Cartilage, Articular; Humans; Inflammation; Interleukin 1 Receptor Anta | 2022 |
One-step fabrication of lidocaine/CalliSpheres
Topics: Carrageenan; Embolization, Therapeutic; Hemolysis; Humans; Inflammation; Interleukin-10; Interleukin | 2022 |
Effects of a Single Intra-Articular Injection of 2% Lidocaine or 0.5% Bupivacaine on Synovial Fluid Acute Phase Protein Concentrations in Healthy Horses.
Topics: Acute-Phase Proteins; Animals; Bupivacaine; Horse Diseases; Horses; Inflammation; Injections, Intra- | 2023 |
The morphofunctional impact of topical Lidocaine formulation in inflammatory pain - experimental study.
Topics: Administration, Topical; Anesthetics, Local; Animal Experimentation; Animals; Disease Models, Animal | 2019 |
Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway.
Topics: Anesthetics, Local; Animals; Chemokine CCL3; Female; HMGB1 Protein; Inflammation; Lidocaine; Neuralg | 2021 |
Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Che | 2020 |
Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats.
Topics: Animals; Dura Mater; Freund's Adjuvant; Headache; Inflammation; Lidocaine; Male; Migraine Disorders; | 2020 |
Influence of clinical and experimental intra-articular inflammation on neutrophil gelatinase-associated lipocalin concentrations in horses.
Topics: Animals; Biomarkers; Female; Horse Diseases; Horses; Inflammation; Joint Diseases; Lidocaine; Lipoca | 2021 |
Effect of Intravenous Lidocaine on Inflammatory and Apoptotic Response of Ischemia-Reperfusion Injury in Pigs Undergoing Lung Resection Surgery.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosi | 2021 |
Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg
Topics: Adenosine; Alkalosis, Respiratory; Animals; Blood Coagulation; Blood Platelets; Complex Mixtures; Di | 2017 |
Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord.
Topics: AMP-Activated Protein Kinase Kinases; Analgesics, Opioid; Anesthetics, Local; Animals; Cell Line; Dr | 2017 |
Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Blood Platelet Disorders; Cytokines; Fluid Therapy; | 2017 |
Evaluation of tissue changes following intramuscular infiltration of lidocaine in rainbow trout Oncorhynchus mykiss.
Topics: Animals; Connective Tissue; Hemorrhage; Inflammation; Lidocaine; Muscle, Skeletal; Necrosis; Oncorhy | 2018 |
Cordycepin rescues lidocaine-induced neurotoxicity in dorsal root ganglion by interacting with inflammatory signaling pathway MMP3.
Topics: Animals; Apoptosis; Deoxyadenosines; Down-Regulation; Ganglia, Spinal; Gene Expression Regulation, E | 2018 |
Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Down-Regulation; Female; Inflammation; | 2018 |
Lidocaine Potentiates SOCS3 to Attenuate Inflammation in Microglia and Suppress Neuropathic Pain.
Topics: Animals; Calcium-Binding Proteins; Cell Line; Chronic Disease; Constriction, Pathologic; Cyclic AMP | 2019 |
Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Coronary Vessels; Diseas | 2013 |
[Adjuvants in modern anesthesia - lidocaine].
Topics: Abdomen; Anesthesia; Anesthetics, Local; Chemotherapy, Adjuvant; Humans; Inflammation; Infusions, In | 2015 |
A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord.
Topics: Animals; Dependovirus; Inflammation; Injections; Lidocaine; Lumbar Vertebrae; Mice; Organ Specificit | 2016 |
Hitting a nerve to ease asthma.
Topics: Anesthetics, Local; Animals; Asthma; Bronchial Spasm; Inflammation; Lidocaine; Lung; Mice; Nocicepto | 2015 |
JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bronchial Spasm; Disease Models, Animal; Infl | 2016 |
Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Drug Combinations; Drug Synergism; Inflammation; Infusions, Paren | 2016 |
Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain.
Topics: Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; Female; Ganglia, Spinal; Homeostasis | 2016 |
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein | 2016 |
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BALB 3T3 Cells; Cells, Cultured; Disease Models, A | 2017 |
RAGE deficiency attenuates the protective effect of Lidocaine against sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Gene Knockout Techniques; HMGB1 Protein; Inflammation; Lidocaine; MAP Ki | 2017 |
Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Dermatitis, Phototoxic; Female; Humans; Hyperpigmentat | 2008 |
Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats.
Topics: Aerosols; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Animals; Bronchoalv | 2010 |
Membrane polarity: a target for myocardial protection and reduced inflammation in adult and pediatric cardiothoracic surgery.
Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Cardi | 2010 |
Lidocaine-derivative JMF2-1 prevents ovalbumin-induced airway inflammation by regulating the function and survival of T cells.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Bronchial Hyperreactivity; Cytokines; Dexamethasone; I | 2011 |
Why change?
Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Cardi | 2010 |
Two for one: cyclic AMP mediates the anti-inflammatory and anti-spasmodic properties of the non-anesthetic lidocaine analog JMF2-1.
Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents; Apoptosis; Asthma; Carbachol; Caspase 8; Cell | 2012 |
Effect of lidocaine- and prilocaine-based topical anesthetics on the inflammatory exudates in subcutaneous tissue of rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Biocompatible Materials; Capillary Permeability; | 2012 |
The effect of local anesthetics and amitriptyline on peroxidation in vivo in an inflammatory rat model: preliminary reports.
Topics: Amides; Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Bupivacaine; C | 2002 |
Nerve root "irritation" or inflammation diagnosed by magnetic resonance imaging.
Topics: Humans; Inflammation; Lidocaine; Magnetic Resonance Imaging; Spinal Nerve Roots | 2003 |
Influence of local anaesthetics on inflammatory activity postburn.
Topics: Administration, Topical; Anesthetics, Local; Animals; Burns; Free Radicals; Inflammation; Leukotrien | 2003 |
Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation.
Topics: Anesthetics, Local; Animals; Brain Stem; Freund's Adjuvant; Immunohistochemistry; Inflammation; Lido | 2003 |
Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation.
Topics: Anesthetics, Local; Calcium; Cell Line; Cell Movement; Chemokine CCL2; Chemotaxis, Leukocyte; DNA Pr | 2003 |
Characterization of a method for measuring primary hyperalgesia of deep somatic tissue.
Topics: Animals; Arthralgia; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Infla | 2005 |
Orbital inflammation after sub-Tenon's anesthesia.
Topics: Aged; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Fascia; Female; Glu | 2005 |
Orbital inflammation after posterior sub-Tenon's anesthesia.
Topics: Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Fascia; Glucocorticoids; | 2006 |
The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.
Topics: Anesthetics, Local; Animals; Atropine; Autonomic Pathways; Carbachol; Cholinergic Fibers; Cocaine; I | 2006 |
Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Benzoates; Dose-Response Relationship, Drug; Drug Int | 2006 |
Membrane effect of lidocaine is inhibited by interaction with peroxynitrite.
Topics: Anesthetics, Local; Fluorescence Polarization; Inflammation; Lidocaine; Liposomes; Membrane Fluidity | 2008 |
Anesthetics impact the resolution of inflammation.
Topics: Anesthetics; Animals; Apoptosis; Flow Cytometry; Humans; Inflammation; Isoflurane; Leukocytes; Lidoc | 2008 |
Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Anesthetics, Local; Animals; Bronchial Hyperreactivity; Bronchoalveolar | 2008 |
C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels.
Topics: Animals; Chronic Disease; Hyperalgesia; Inflammation; Infusion Pumps; Lidocaine; Male; Nanostructure | 2008 |
Influence of plasma factors and drugs on in vitro leukocyte adhesiveness.
Topics: Blood Proteins; Cell Adhesion; Cells, Cultured; Edetic Acid; Ethanol; Female; Humans; Inflammation; | 1980 |
The failure of local anaesthesia in acute inflammation. Some recent concepts.
Topics: Action Potentials; Anesthesia, Dental; Animals; Exudates and Transudates; Inflammation; Lidocaine; M | 1981 |
Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites.
Topics: Animals; Cell Adhesion; Dose-Response Relationship, Drug; Granulocytes; Humans; Inflammation; Inject | 1980 |
Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity.
Topics: Animals; Electromyography; Female; Inflammation; Injections; Irritants; Jaw; Lidocaine; Male; Muscle | 1995 |
Local anaesthesia prevents acute inflammatory changes in neuropeptide messenger RNA expression in rat dorsal root ganglia neurons.
Topics: Anesthesia, Local; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Ganglia, Spina | 1994 |
Further substantiation of a significant role for the sympathetic nervous system in inflammation.
Topics: Animals; Arthritis; Bradykinin; Exudates and Transudates; Inflammation; Knee Joint; Lidocaine; Male; | 1993 |
Further evidence for the involvement of SmI cortical neurons in nociception: their responsiveness at 24 hr after carrageenin-induced hyperalgesic inflammation in the rat.
Topics: Animals; Aspirin; Brain Mapping; Carrageenan; Dominance, Cerebral; Evoked Potentials, Somatosensory; | 1993 |
Effects of preemptive or postinjury intrathecal local anesthesia on persistent nociceptive responses in rats. Confounding influences of peripheral inflammation and the general anesthetic regimen.
Topics: Analgesia; Anesthesia, Spinal; Anesthetics, Local; Animals; Barbiturates; Formaldehyde; Inflammation | 1996 |
Cortical facilitatory action on centralis lateralis thalamic activity during the development of carrageenin-produced inflammation.
Topics: Acute Disease; Afferent Pathways; Anesthetics, Local; Animals; Carrageenan; Chronic Disease; Edema; | 1996 |
Leukocyte hydrogen peroxide production in a surgical wound in mice. The effects of an amide local anaesthetic.
Topics: Anesthetics, Local; Animals; Diffusion Chambers, Culture; Hydrogen Peroxide; Inflammation; Leukocyte | 1996 |
Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Edema; Inflammation; Lidocaine; Male; Nocicep | 1996 |
[The author's own method of local anesthesia for skin incision around implants during limb lengthening].
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Bone Lengthening; Child; Child, Preschool; Cost C | 1997 |
Sub-anesthetic doses of bupivacaine or lidocaine increase peripheral ICS-205 930-induced analgesia against inflammatory pain in rats.
Topics: Analgesia; Anesthetics, Local; Animals; Bupivacaine; Drug Synergism; Indoles; Inflammation; Lidocain | 1997 |
Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia.
Topics: Animals; Hyperalgesia; Inflammation; Lidocaine; Male; Nerve Block; Rats; Rats, Sprague-Dawley; Time | 1998 |
Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons.
Topics: Anesthetics, Local; Animals; Bradykinin; Brain Stem; Dinoprostone; Dura Mater; Electric Stimulation; | 1998 |
The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Clonidine; Cold | 1998 |
Sensitization of the nervous system, induced by two successive hindpaw inflammations, is suppressed by a local anesthetic.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Carrageenan; Edema; Hindlimb; Inflammation; Injec | 1998 |
The inflammatory reaction induced by formalin in the rat paw.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bradykinin; Capillary Permeability; Capsaicin; Dose-Res | 1999 |
Efficacy of lignocaine gel for outpatient laser treatment in inflamed eyes.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Child; Eye | 2001 |
[Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol].
Topics: Aminopyrine; Animals; Arthritis, Rheumatoid; Dipyrone; Drug Combinations; Drug Evaluation, Preclinic | 1977 |
Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint.
Topics: Analgesia; Animals; Aspirin; Blood Pressure; Bradykinin; Carrageenan; Depression, Chemical; Dogs; Fe | 1975 |
Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin.
Topics: Adult; Axons; Bradykinin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomet | 1992 |
Treatment of inflammatory, neuropathic and sympathetically maintained pain in a patient with Sjögren's syndrome.
Topics: Action Potentials; Adult; Female; Humans; Inflammation; Lidocaine; Nerve Block; Pain; Pain Managemen | 1992 |
Further evidence for the involvement of SmI cortical neurons in nociception: modifications of their responsiveness over the early stage of a carrageenin-induced inflammation in the rat.
Topics: Afferent Pathways; Animals; Brain Mapping; Carrageenan; Evoked Potentials, Somatosensory; Hindlimb; | 1992 |
Iontophoresis: an effective modality for the treatment of inflammatory disorders of the temporomandibular joint and myofascial pain.
Topics: Adult; Discitis; Epinephrine; Facial Pain; Female; Humans; Inflammation; Iontophoresis; Joint Disloc | 1990 |
Methylprednisolone acetate does not cause inflammatory changes in the epidural space.
Topics: Animals; Anti-Inflammatory Agents; Epidural Space; Inflammation; Injections, Epidural; Lidocaine; Me | 1990 |
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.
Topics: Animals; Antipyrine; In Vitro Techniques; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranol | 1987 |
Modifications in the responsiveness of rat ventrobasal thalamic neurons at different stages of carrageenin-produced inflammation.
Topics: Action Potentials; Acute-Phase Reaction; Animals; Aspirin; Carrageenan; Inflammation; Lidocaine; Mal | 1986 |
Effect of lidocaine on the function of immunocompetent cells. II. Chronic in vivo exposure and its effects on mouse lymphocyte activation and expression of immunity.
Topics: Animals; Cell Movement; Electrophoresis; Female; Inflammation; Lidocaine; Lymphocyte Activation; Lym | 1985 |
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.
Topics: Animals; Antipyrine; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranolol; Rats; Rats, Inbre | 1988 |
Relationship between inflammation, alpha-1-acid glycoprotein and lidocaine tolerance during fiber-optic bronchoscopy.
Topics: Bronchoscopy; Fiber Optic Technology; Humans; Inflammation; Lidocaine; Male; Middle Aged; Optical Fi | 1987 |
Alpha 1-acid glycoprotein and serum binding of drugs in healthy and diseased dogs.
Topics: Animals; Blood Sedimentation; Diazepam; Digitoxin; Dog Diseases; Dogs; Female; Inflammation; Lidocai | 1987 |
[The histo-pathological changes in the epidural space and changes in the effect of anesthesia after long-term continuous epidural block].
Topics: Anesthesia; Animals; Autonomic Nerve Block; Dogs; Epidural Space; Inflammation; Lidocaine; Spinal Ca | 1986 |
Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat.
Topics: Animals; Carrageenan; Hyperalgesia; Inflammation; Lidocaine; Male; Nociceptors; Rats; Rats, Inbred S | 1987 |
Consequences of inflammatory processes on lignocaine protein binding during anaesthesia in fibreoptic bronchoscopy.
Topics: Anesthesia, Local; Bronchoscopy; Humans; Inflammation; Lidocaine; Middle Aged; Protein Binding | 1985 |
Cutaneous responses to human C 3 anaphylatoxin in man.
Topics: Biopsy; Cell Movement; Complement System Proteins; Erythema; Histamine; Histamine H1 Antagonists; Hi | 1972 |
Treatment of chondritis in the burned ear by the local instillation of antibiotics.
Topics: Anti-Bacterial Agents; Burns; Cartilage; Drug Therapy, Combination; Ear, External; Gentamicins; Huma | 1974 |
Deposition of osmium in rheumatoid synovial tissue after intra-articular injection of osmic acid. A histological and electron microscopical study.
Topics: Adipose Tissue; Arthritis, Rheumatoid; Histiocytes; Humans; Inflammation; Injections, Intra-Articula | 1972 |
Antagonism by protriptyline and desipramine of the response of the vas deferens of the rat to norepinephrine, acetylcholine and potassium.
Topics: Acetylcholine; Animals; Cocaine; Desipramine; Dibenzocycloheptenes; Dose-Response Relationship, Drug | 1973 |
[Various local anesthetics].
Topics: Amino Alcohols; Anesthetics, Local; Animals; Benzoates; Capillary Permeability; Cyclohexylamines; Ep | 1971 |