lidocaine has been researched along with Injury, Myocardial Reperfusion in 58 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy of a bolus of lidocaine administered by way of the pump before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation." | 9.09 | Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping. ( Baraka, A; Dabbous, A; Kawkabani, N; Nawfal, M, 2000) |
| "The authors compared bretylium and lidocaine for reducing the incidence and persistence of ventricular fibrillation following aortic cross-clamp release performed during coronary artery bypass surgery." | 9.06 | Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery. ( Briggs, R; Goglin, W; Grishkin, B; Helsel, R; Kirlangitis, J; Knight, R; Middaugh, R, 1990) |
| "A pilot study was designed to assess the safety of combined intravenous adenosine and lidocaine in patients with acute myocardial infarction and to estimate the likelihood of a beneficial effect on final infarct size." | 7.70 | Intravenous adenosine and lidocaine in patients with acute myocardial infarction. ( Bailey, KR; Garratt, KN; Gibbons, RJ; Hodge, DO; Holmes, DR; Laudon, DA; Lobl, JK; Molina-Viamonte, V; Reeder, GS, 1998) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 7.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 7.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "Lidocaine addition to crystalloid cardioplegic solution for prevention of reperfusion ventricular fibrillation after the release of the aortic cross-clamp was studied in 50 patients undergoing coronary artery bypass grafting and in 30 patients undergoing mitral or aortic valve replacement." | 7.68 | Lidocaine cardioplegia for prevention of reperfusion ventricular fibrillation. ( Baraka, A; Dabbous, A; el-Khoury, N; Ghabash, M; Hirt, N; Jamhoury, M; Rouhana, C; Sibaii, A; Taha, S, 1993) |
| "Isolated guinea pig hearts subjected to global ischemia, were used to investigate whether lidocaine exerts an antiarrhythmic action against reperfusion-induced arrhythmias, and the effects of this drug upon myocardial ion contents during ischemia and reperfusion were studied." | 7.67 | Protective effect of lidocaine against ischemia and reperfusion-induced arrhythmias and shifts of myocardial sodium, potassium, and calcium content. ( Balint, S; Szekeres, L; Tosaki, A, 1988) |
| "The decreased incidence of arrhythmias was statistically significant for 5 to 50 microM lidocaine (P less than ." | 5.28 | Effects of lidocaine on reperfusion arrhythmias and electrophysiological properties in an isolated ventricular muscle model of ischemia and reperfusion. ( Ferrier, GR; Li, GR, 1991) |
| "To determine the efficacy of a bolus of lidocaine administered by way of the pump before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation." | 5.09 | Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping. ( Baraka, A; Dabbous, A; Kawkabani, N; Nawfal, M, 2000) |
| "Lidocaine has been used as the primary antiarrhythmic agent for ventricular arrhythmias during acute myocardial infarction (MI) and open heart surgery." | 5.08 | Does lidocaine protect the heart during coronary revascularisation? ( Kaukinen, S; Rinne, T, 1998) |
| "The authors compared bretylium and lidocaine for reducing the incidence and persistence of ventricular fibrillation following aortic cross-clamp release performed during coronary artery bypass surgery." | 5.06 | Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery. ( Briggs, R; Goglin, W; Grishkin, B; Helsel, R; Kirlangitis, J; Knight, R; Middaugh, R, 1990) |
| "A pilot study was designed to assess the safety of combined intravenous adenosine and lidocaine in patients with acute myocardial infarction and to estimate the likelihood of a beneficial effect on final infarct size." | 3.70 | Intravenous adenosine and lidocaine in patients with acute myocardial infarction. ( Bailey, KR; Garratt, KN; Gibbons, RJ; Hodge, DO; Holmes, DR; Laudon, DA; Lobl, JK; Molina-Viamonte, V; Reeder, GS, 1998) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 3.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 3.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "Lidocaine addition to crystalloid cardioplegic solution for prevention of reperfusion ventricular fibrillation after the release of the aortic cross-clamp was studied in 50 patients undergoing coronary artery bypass grafting and in 30 patients undergoing mitral or aortic valve replacement." | 3.68 | Lidocaine cardioplegia for prevention of reperfusion ventricular fibrillation. ( Baraka, A; Dabbous, A; el-Khoury, N; Ghabash, M; Hirt, N; Jamhoury, M; Rouhana, C; Sibaii, A; Taha, S, 1993) |
| " The action of IHC-72 against aconitine induced arrhythmia was similar to that of Lid but stronger than that of Ver in anesthetized rats." | 3.68 | [Comparison of antiarrhythmic effects of IHC-72 (an iodonium-72), lidocaine and verapamil]. ( Ji, GJ; Liu, DQ; Sheng, BH; Zhao, DH, 1992) |
| "The effects of the antiarrhythmic drugs lidocaine and bretylium tosylate on myocardial necrosis were studied in anesthetized pigs subjected to 60-min coronary occlusion followed by 3-h reperfusion." | 3.68 | Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs. ( Corday, E; Drury, JK; Fishbein, MC; Hatori, N; Roberts, RL; Ryden, L; Satomura, K; Stiehm, ER; Tadokoro, H, 1991) |
| "Isolated guinea pig hearts subjected to global ischemia, were used to investigate whether lidocaine exerts an antiarrhythmic action against reperfusion-induced arrhythmias, and the effects of this drug upon myocardial ion contents during ischemia and reperfusion were studied." | 3.67 | Protective effect of lidocaine against ischemia and reperfusion-induced arrhythmias and shifts of myocardial sodium, potassium, and calcium content. ( Balint, S; Szekeres, L; Tosaki, A, 1988) |
| "Lidocaine has been demonstrated to exert cardioprotective effects against myocardial ischaemia and reperfusion injury." | 2.76 | Impact of intravenous lidocaine on myocardial injury after off-pump coronary artery surgery. ( Chin, JH; Choi, DK; Choi, IC; Chung, CH; Chung, HJ; Lee, EH; Lee, HM; Sim, JY, 2011) |
| "Myocardial infarction is the leading cause of death worldwide." | 1.46 | Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. ( Chang, YT; Chen, CC; Chen, WH; Chen, YH; Cheng, YF; Shih, HC; Shyu, BC, 2017) |
| "Duration of ventricular tachycardia (VT) episodes was reduced from 15." | 1.37 | First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model. ( Bhandari, A; Dow, JS; Kloner, RA, 2011) |
| "Lidocaine has been demonstrated to exert antiinflammatory pleiotropic effects." | 1.35 | Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. ( Echtermeyer, F; Gillmann, HJ; Hahnenkamp, K; Harendza, T; Herzog, C; Hildebrand, R; Kaczmarek, DJ; Larmann, J; Osthaus, AW; Schmitz, M; Theilmeier, G; Werdehausen, R; Westermann, A; Wollert, KC, 2009) |
| "Lidocaine was infused continuously 5 minutes before and throughout 30 minutes of ischemia and ceased at reperfusion." | 1.33 | Pretreatment with an adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial ischemic preconditioning. ( Canyon, SJ; Dobson, GP, 2005) |
| "Flecainide was equi-effective at low and high concentrations, with VF incidence reduced from 92% to 17% (p < 0." | 1.31 | Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts. ( Curtis, MJ; Farkas, A, 2002) |
| "Pretreatment with lidocaine (5 mg/kg), verapamil (0." | 1.30 | Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx. ( Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P, 1999) |
| " R56865 was given before ischemia and with the onset of reperfusion, applying different dosing schedules, including an initial loading dose." | 1.29 | R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion. ( Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B, 1995) |
| "Reperfusion arrhythmias (RA) occurred in 19(79." | 1.28 | [Reperfusion arrhythmias in acute myocardial infarction]. ( Gao, R, 1992) |
| "The decreased incidence of arrhythmias was statistically significant for 5 to 50 microM lidocaine (P less than ." | 1.28 | Effects of lidocaine on reperfusion arrhythmias and electrophysiological properties in an isolated ventricular muscle model of ischemia and reperfusion. ( Ferrier, GR; Li, GR, 1991) |
| "Adenosine treatment alone or lidocaine treatment alone did not affect RMBF." | 1.28 | Combined adenosine and lidocaine administration limits myocardial reperfusion injury. ( Fletcher, DD; Hoff, PT; Homeister, JW; Lucchesi, BR, 1990) |
| "In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64." | 1.28 | Effects of polyoxyethylene-modified superoxide dismutase on reperfusion induced arrhythmias in isolated rat and guinea-pig hearts. ( Garcia-Alves, M; Iwashita, Y; Kadowaki, Y; Nishi, K; Yamakawa, T; Yokoyama, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.45) | 18.7374 |
| 1990's | 28 (48.28) | 18.2507 |
| 2000's | 17 (29.31) | 29.6817 |
| 2010's | 10 (17.24) | 24.3611 |
| 2020's | 1 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Koini, EN | 1 |
| Papazafiri, P | 1 |
| Vassilopoulos, A | 1 |
| Koufaki, M | 1 |
| Horváth, Z | 1 |
| Koncz, I | 1 |
| Virág, L | 1 |
| Papp, GJ | 1 |
| Varró, A | 1 |
| Calogeropoulou, T | 1 |
| Kirschner, A | 1 |
| Koch, SE | 1 |
| Robbins, N | 1 |
| Karthik, F | 1 |
| Mudigonda, P | 1 |
| Ramasubramanian, R | 1 |
| Nieman, ML | 1 |
| Lorenz, JN | 1 |
| Rubinstein, J | 1 |
| Cheng, YF | 1 |
| Chang, YT | 1 |
| Chen, WH | 1 |
| Shih, HC | 1 |
| Chen, YH | 1 |
| Shyu, BC | 1 |
| Chen, CC | 1 |
| Govindapillai, A | 1 |
| Hua, R | 1 |
| Rose, R | 1 |
| Friesen, CH | 1 |
| O'Blenes, SB | 1 |
| Wang, L | 2 |
| Lopaschuk, GD | 1 |
| Clanachan, AS | 2 |
| Kaczmarek, DJ | 1 |
| Herzog, C | 1 |
| Larmann, J | 1 |
| Gillmann, HJ | 1 |
| Hildebrand, R | 1 |
| Schmitz, M | 1 |
| Westermann, A | 1 |
| Harendza, T | 1 |
| Werdehausen, R | 1 |
| Osthaus, AW | 1 |
| Echtermeyer, F | 1 |
| Hahnenkamp, K | 1 |
| Wollert, KC | 1 |
| Theilmeier, G | 1 |
| Aldakkak, M | 1 |
| Stowe, DF | 2 |
| Lesnefsky, EJ | 1 |
| Heisner, JS | 1 |
| Chen, Q | 2 |
| Camara, AK | 2 |
| Lu, HR | 2 |
| Rohrbacher, J | 1 |
| Vlaminckx, E | 1 |
| Van Ammel, K | 1 |
| Yan, GX | 1 |
| Gallacher, DJ | 1 |
| Rudd, DM | 1 |
| Dobson, GP | 4 |
| Krzemiński, TF | 1 |
| Mitrega, K | 1 |
| Zorniak, M | 1 |
| Porc, M | 1 |
| Kloner, RA | 1 |
| Dow, JS | 1 |
| Bhandari, A | 1 |
| Lee, EH | 1 |
| Lee, HM | 1 |
| Chung, CH | 1 |
| Chin, JH | 1 |
| Choi, DK | 1 |
| Chung, HJ | 1 |
| Sim, JY | 1 |
| Choi, IC | 1 |
| Tsuchiya, H | 1 |
| Mizogami, M | 1 |
| Shigemi, K | 1 |
| Soliman, D | 1 |
| Hamming, KS | 1 |
| Yang, W | 1 |
| Fatehi, M | 1 |
| Carter, CC | 1 |
| Light, PE | 1 |
| Hinokiyama, K | 1 |
| Hatori, N | 2 |
| Ochi, M | 1 |
| Maehara, T | 1 |
| Tanaka, S | 1 |
| Mioni, C | 2 |
| Giuliani, D | 1 |
| Cainazzo, MM | 2 |
| Leone, S | 1 |
| Iannone, A | 1 |
| Bazzani, C | 2 |
| Grieco, P | 1 |
| Novellino, E | 1 |
| Tomasi, A | 1 |
| Bertolini, A | 2 |
| Guarini, S | 2 |
| Jones, MW | 1 |
| Rhodes, SS | 1 |
| Riess, ML | 1 |
| Canyon, SJ | 2 |
| Niwano, S | 1 |
| Inuo, K | 1 |
| Morohoshi, Y | 1 |
| Nakayama, S | 1 |
| Yuge, M | 1 |
| Imaki, R | 1 |
| Izumi, T | 1 |
| Wang, S | 1 |
| Radhakrishnan, J | 1 |
| Ayoub, IM | 1 |
| Kolarova, JD | 1 |
| Taglieri, DM | 1 |
| Gazmuri, RJ | 1 |
| Yan, M | 1 |
| Chen, C | 1 |
| Zhang, F | 1 |
| Chen, G | 1 |
| Hoque, AN | 1 |
| Hoque, N | 1 |
| Hashizume, H | 1 |
| Abiko, Y | 1 |
| Cave, AC | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Bellemin-Baurreau, J | 1 |
| Poizot, A | 1 |
| Hicks, PE | 1 |
| Armstrong, JM | 1 |
| Liu, JX | 1 |
| Tanonaka, K | 1 |
| Ohtsuka, Y | 1 |
| Sakai, Y | 1 |
| Takeo, S | 1 |
| Balashov, VP | 1 |
| Kostin, IaV | 1 |
| Sedova, DG | 1 |
| Sernov, LN | 1 |
| Gatsura, VV | 2 |
| Coetzee, A | 1 |
| Moolman, J | 1 |
| Baraka, A | 2 |
| Hirt, N | 1 |
| Dabbous, A | 2 |
| Taha, S | 1 |
| Rouhana, C | 1 |
| el-Khoury, N | 1 |
| Ghabash, M | 1 |
| Jamhoury, M | 1 |
| Sibaii, A | 1 |
| Scheufler, E | 1 |
| Mozes, A | 1 |
| Guttmann, I | 1 |
| Wilffert, B | 1 |
| Manning, AS | 1 |
| Bruyninckx, C | 1 |
| Ramboux, J | 1 |
| Chatelain, P | 1 |
| Vander Heide, RS | 1 |
| Reimer, KA | 1 |
| Murasato, Y | 1 |
| Nagamoto, Y | 1 |
| Urabe, T | 1 |
| Kuraoka, F | 1 |
| Nakashima, Y | 1 |
| Kuroiwa, A | 1 |
| Galenko-Iaroshevskiĭ, Pa | 3 |
| Uvarov, AV | 2 |
| Galygo, DS | 1 |
| Reznikov, AIu | 1 |
| Khankoeva, AI | 2 |
| Bartashevich, VV | 1 |
| Popov, PB | 2 |
| Leonidov, NB | 1 |
| Fitilev, SB | 1 |
| Kniazhev, VA | 1 |
| Kryzhanovskiĭ, SA | 1 |
| Turovaia, AIu | 1 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Hicks, MN | 1 |
| Kane, KA | 1 |
| Lee, R | 1 |
| Nitta, T | 1 |
| Schmid, RA | 1 |
| Schuessler, RB | 1 |
| Harris, KM | 1 |
| Gay, WA | 1 |
| Garratt, KN | 1 |
| Holmes, DR | 1 |
| Molina-Viamonte, V | 1 |
| Reeder, GS | 1 |
| Hodge, DO | 1 |
| Bailey, KR | 1 |
| Lobl, JK | 1 |
| Laudon, DA | 1 |
| Gibbons, RJ | 1 |
| Rinne, T | 1 |
| Kaukinen, S | 1 |
| Yang, P | 1 |
| Remeysen, P | 1 |
| Saels, A | 1 |
| Dai, DZ | 1 |
| De Clerck, F | 1 |
| Kawkabani, N | 1 |
| Nawfal, M | 1 |
| Ebel, D | 1 |
| Lipfert, P | 1 |
| Frässdorf, J | 1 |
| Preckel, B | 1 |
| Müllenheim, J | 1 |
| Thämer, V | 1 |
| Schlack, W | 1 |
| Ferrazza, G | 1 |
| Farkas, A | 1 |
| Curtis, MJ | 1 |
| Ji, GJ | 1 |
| Zhao, DH | 1 |
| Liu, DQ | 1 |
| Sheng, BH | 1 |
| Gao, R | 1 |
| Aidonidis, I | 1 |
| Brachmann, J | 1 |
| Seller, H | 1 |
| Demowsky, K | 1 |
| Czachurski, J | 1 |
| Kübler, W | 1 |
| Roberts, RL | 1 |
| Tadokoro, H | 1 |
| Ryden, L | 1 |
| Satomura, K | 1 |
| Fishbein, MC | 1 |
| Stiehm, ER | 1 |
| Corday, E | 1 |
| Drury, JK | 1 |
| Bengtsson, L | 1 |
| Gunnes, S | 1 |
| Norman, B | 1 |
| Karlsson, J | 1 |
| Rozanski, GJ | 1 |
| Witt, RC | 1 |
| Li, GR | 1 |
| Ferrier, GR | 1 |
| Kirlangitis, J | 1 |
| Middaugh, R | 1 |
| Knight, R | 1 |
| Goglin, W | 1 |
| Helsel, R | 1 |
| Grishkin, B | 1 |
| Briggs, R | 1 |
| Homeister, JW | 1 |
| Hoff, PT | 1 |
| Fletcher, DD | 1 |
| Lucchesi, BR | 1 |
| Tosaki, A | 1 |
| Balint, S | 1 |
| Szekeres, L | 1 |
| Yamakawa, T | 1 |
| Kadowaki, Y | 1 |
| Garcia-Alves, M | 1 |
| Yokoyama, M | 1 |
| Iwashita, Y | 1 |
| Nishi, K | 1 |
4 trials available for lidocaine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Impact of intravenous lidocaine on myocardial injury after off-pump coronary artery surgery.
Topics: Aged; Anesthetics, Local; Biomarkers; Cardiotonic Agents; Coronary Artery Bypass, Off-Pump; Creatine | 2011 |
Does lidocaine protect the heart during coronary revascularisation?
Topics: Anti-Arrhythmia Agents; Biomarkers; Cardioplegic Solutions; Creatine Kinase; Electrocardiography; Fe | 1998 |
Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Female; Hemodynamics; Humans; Lidocaine | 2000 |
Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery.
Topics: Aged; Bretylium Compounds; Constriction; Double-Blind Method; Female; Humans; Lidocaine; Male; Middl | 1990 |
54 other studies available for lidocaine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
Topics: Action Potentials; Amides; Animals; Anti-Arrhythmia Agents; Antioxidants; Benzopyrans; Benzoxazines; | 2009 |
Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response.
Topics: Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; Echocardiography; Forelimb; Ischemic | 2021 |
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus.
Topics: Animals; Butadienes; Chronic Pain; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; H | 2017 |
Discussion.
Topics: Age Factors; Aging; Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Heart Arrest, Indu | 2013 |
Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts.
Topics: Age Factors; Aging; Animals; Biomarkers; Cardiac Output; Cardiac Surgical Procedures; Cardioplegic S | 2013 |
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.
Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agen | 2008 |
Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects.
Topics: Animals; Apoptosis; Cardiotonic Agents; Lidocaine; Mice; Myocardial Ischemia; Myocardial Reperfusion | 2009 |
Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.
Topics: Animals; Calcium; Cardioplegic Solutions; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart | 2009 |
Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; CHO Cells; Cricetinae; Cricetulus; Drug Evalu | 2010 |
Early reperfusion with warm, polarizing adenosine-lidocaine cardioplegia improves functional recovery after 6 hours of cold static storage.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Blood Pressure; Cardiac Output; Cardioplegic Solu | 2011 |
Differential effects of four xylidine derivatives in the model of ischemia- and re-perfusion-induced arrhythmias in rats in vivo.
Topics: Amides; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; C | 2010 |
First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model.
Topics: Acetanilides; Animals; Anti-Arrhythmia Agents; Enzyme Inhibitors; Female; Infusions, Intravenous; In | 2011 |
Increasing membrane interactions of local anaesthetics as hypothetic mechanism for their cardiotoxicity enhanced by myocardial ischaemia.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Animals; Bupivacaine; Cardiolipins; Chemical | 2012 |
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
Topics: Acetanilides; Animals; Animals, Newborn; Calcium; Calcium Signaling; Cardiac Glycosides; Electrophys | 2012 |
Myocardial protective effect of lidocaine during experimental off-pump coronary artery bypass grafting.
Topics: Animals; Coronary Artery Bypass; Disease Models, Animal; Female; Lidocaine; Male; Myocardial Reperfu | 2003 |
Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors.
Topics: alpha-MSH; Animals; Coronary Disease; Cosyntropin; Female; FMRFamide; gamma-MSH; Hypotension; Inject | 2003 |
Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation.
Topics: Adenosine; Animals; Bicarbonates; Blood Flow Velocity; Body Water; Calcium Chloride; Cardioplegic So | 2004 |
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihy | 2004 |
Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Drug Combinations; Hemodynamics; Lidocaine; Male; Myocar | 2004 |
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, A | 2004 |
Pretreatment with an adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial ischemic preconditioning.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiovascular Agents; Ischemic Preconditioning, | 2005 |
Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium; Coronary Circulation; Disease Models, Anim | 2007 |
Lidocaine abolishes the myocardial protective effect of sevoflurane post-conditioning.
Topics: Animals; Biomarkers; Cardiotonic Agents; Heart; Heart Ventricles; In Vitro Techniques; KATP Channels | 2008 |
A study on dilazep: II. Dilazep attenuates lysophosphatidylcholine-induced mechanical and metabolic derangements in the isolated, working rat heart.
Topics: Animals; Blood Pressure; Dilazep; Fatty Acids, Nonesterified; Heart; Heart Rate; In Vitro Techniques | 1995 |
Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Energy Metabolism; Heart; Hypoxia; Lidocaine; M | 1994 |
An in vitro method for the evaluation of antiarrhythmic and antiischemic agents by using programmed electrical stimulation of rabbit heart.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimulation; Glycine; Heart; | 1994 |
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Flecainide; Heart; Lidocai | 1993 |
[The effect of fructose-1,6-diphosphate and phosphoenolpyruvate on the course of early occlusion and reperfusion arrhythmias in rats].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Drug Evaluation, Preclinica | 1993 |
Halothane and the reperfusion injury in the intact animal model.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Halothane; | 1993 |
Lidocaine cardioplegia for prevention of reperfusion ventricular fibrillation.
Topics: Cardioplegic Solutions; Coronary Artery Bypass; Female; Heart Arrest, Induced; Heart Block; Heart Va | 1993 |
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Block | 1995 |
SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs.
Topics: Adenosine; Animals; Dogs; Female; Lidocaine; Male; Myocardial Infarction; Myocardial Ischemia; Myoca | 1996 |
Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts.
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Coronary Vessels; Diltiazem; Disease Models, A | 1997 |
[Effect of sufan, lidocaine and their combination on the course of early occlusive and reperfusion arrhythmias in cats].
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Cardiotonic Agents; | 1997 |
[Effect of KLN-93 on ventricular fibrillation induced by reperfusion or electrical stimulation in cats].
Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relati | 1997 |
[Cardioprotective effects of the cyclic derivative of gamma-aminobutyric acid T3-146 during reperfusion].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cats; Electr | 1997 |
Effects of lignocaine on dispersion of repolarisation and refractoriness in a working rabbit heart model of regional myocardial ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Heart C | 1998 |
Retrograde infusion of lidocaine or L-arginine before reperfusion reduces myocardial infarct size.
Topics: Anesthetics, Local; Animals; Arginine; Cardiovascular Agents; Coloring Agents; Coronary Vessels; Ech | 1998 |
Intravenous adenosine and lidocaine in patients with acute myocardial infarction.
Topics: Adenosine; Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Combined Modality Th | 1998 |
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.
Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calci | 1999 |
Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Creatine Kinase; Lidocaine; Male; Metabolic Clear | 2001 |
Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury.
Topics: Adrenocorticotropic Hormone; Animals; Central Nervous System; Disease Models, Animal; Dose-Response | 2002 |
Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Fl | 2002 |
[Comparison of antiarrhythmic effects of IHC-72 (an iodonium-72), lidocaine and verapamil].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Edetic Acid; Female; Guinea Pigs; | 1992 |
[Reperfusion arrhythmias in acute myocardial infarction].
Topics: Aged; Angioplasty, Balloon, Coronary; Arrhythmias, Cardiac; Female; Humans; Lidocaine; Male; Middle | 1992 |
Cardiac sympathetic nervous activity during myocardial ischemia, reperfusion and ventricular fibrillation in the dog--effects of intravenous lidocaine.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Electrocardiography; Female; Heart; Heart Conductio | 1992 |
Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arterial Occlusive Diseases; Bretylium Tosylate; Coronary Circulation; Coronary Disease; Gr | 1991 |
The effect of lidocaine on myocardial ischemia with asanguinous reperfusion. An in vitro study.
Topics: Adenine Nucleotides; Animals; Coronary Circulation; Heart Arrest, Induced; In Vitro Techniques; Lact | 1991 |
Early afterdepolarizations and triggered activity in rabbit cardiac Purkinje fibers recovering from ischemic-like conditions. Role of acidosis.
Topics: Acidosis, Lactic; Animals; Cell Hypoxia; Lidocaine; Membrane Potentials; Myocardial Reperfusion Inju | 1991 |
Effects of lidocaine on reperfusion arrhythmias and electrophysiological properties in an isolated ventricular muscle model of ischemia and reperfusion.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Diastole; Electrophysiology; Guinea Pigs; Heart Bl | 1991 |
Combined adenosine and lidocaine administration limits myocardial reperfusion injury.
Topics: Adenosine; Animals; Coronary Circulation; Dogs; Drug Combinations; Hemodynamics; Lidocaine; Male; My | 1990 |
Protective effect of lidocaine against ischemia and reperfusion-induced arrhythmias and shifts of myocardial sodium, potassium, and calcium content.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Guinea P | 1988 |
Effects of polyoxyethylene-modified superoxide dismutase on reperfusion induced arrhythmias in isolated rat and guinea-pig hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Guinea Pigs; Heart Rate; Lidoc | 1989 |