Page last updated: 2024-10-28

lidocaine and Injuries

lidocaine has been researched along with Injuries in 75 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.

Research Excerpts

ExcerptRelevanceReference
"Topical 2% lidocaine does not attenuate the pain of infiltration of buffered lidocaine more than does topical normal saline."9.08Does topical lidocaine attenuate the pain of infiltration of buffered lidocaine? ( Bartfield, JM; Raccio-Robak, N; Salluzzo, RF, 1995)
"The results of the treatment of 36 patients with posttraumatic reflex sympathetic dystrophy of the upper extremity with regional intravenous blocks of methylprednisolone and lidocaine are presented."9.08Results of the treatment of posttraumatic reflex sympathetic dystrophy of the upper extremity with regional intravenous blocks of methylprednisolone and lidocaine. ( Zyluk, A, 1998)
" However, with lidocaine there was a significant plasma concentration-dependent decrease in pain scores starting at 1."9.08Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. ( Dyck, BJ; Rossi, SS; Wallace, MS; Yaksh, TL, 1996)
"Lidocaine hydrochloride is frequently used for management of painful wounds."8.125% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre Observational Study. ( Arnez, ZM; Davini, G; Dini, V; Janowska, A; Oranges, T; Papa, G; Romanelli, M; Stocco, C, 2022)
" Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage."8.02Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021)
"Adenosine, lidocaine, and magnesium, as administered in this study, are inferior to current Hextend-based resuscitation for survival from prolonged hemorrhagic shock in this model."7.91Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock. ( Cardin, S; Fryer, DM; Glaser, JJ; How, RA; Morgan, CG; Ozuna, KM; Sams, VG; Schaub, LJ, 2019)
"Intracellular calcium, cytoskeleton remodelling, and cell migration were assessed in vitro in MDA-MB-231 cells, a human breast cancer epithelial cell line, after exposure to lidocaine (10 μM or 100 μM)."7.88Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration. ( Anselmi, L; Borgeat, A; Cecchinato, V; D'Agostino, G; Saporito, A; Silvestri, Y; Uguccioni, M, 2018)
"The prognostic value of a dynamic liver-function test, based on the hepatic conversion of lidocaine to monoethylglycinexylidide (MEGX), in predicting multiple organ failure (MOF) was prospectively investigated in 28 critically ill patients after multiple trauma."7.69Monoethylglycinexylidide as an early predictor of posttraumatic multiple organ failure. ( Armstrong, VW; Lehmann, U; Oellerich, M; Pape, D; Regel, G; Schütz, E, 1995)
" Controlling for pre-VAC change pain, the lidocaine intervention was associated with 2."5.17Lidocaine analgesia for removal of wound vacuum-assisted closure dressings: a randomized double-blinded placebo-controlled trial. ( Christensen, TJ; Kubiak, EN; Thorum, T, 2013)
"A topical lidocaine patch is effective in the treatment of posttraumatic peripheral neuropathy (PTPN), but it is not suited for breakthrough pain because of difficulty with an additional application."5.14The analgesic effect of a metered-dose 8% lidocaine pump spray in posttraumatic peripheral neuropathy: a pilot study. ( Kanai, A; Koto, M; Okamoto, H; Okamoto, T; Segawa, Y, 2009)
"Topical 2% lidocaine does not attenuate the pain of infiltration of buffered lidocaine more than does topical normal saline."5.08Does topical lidocaine attenuate the pain of infiltration of buffered lidocaine? ( Bartfield, JM; Raccio-Robak, N; Salluzzo, RF, 1995)
"The results of the treatment of 36 patients with posttraumatic reflex sympathetic dystrophy of the upper extremity with regional intravenous blocks of methylprednisolone and lidocaine are presented."5.08Results of the treatment of posttraumatic reflex sympathetic dystrophy of the upper extremity with regional intravenous blocks of methylprednisolone and lidocaine. ( Zyluk, A, 1998)
" However, with lidocaine there was a significant plasma concentration-dependent decrease in pain scores starting at 1."5.08Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. ( Dyck, BJ; Rossi, SS; Wallace, MS; Yaksh, TL, 1996)
"3 mg/kg) and buffered lidocaine in reducing the anxiety associated with the repair of childhood lacerations."5.08A randomized, controlled trial of oral midazolam and buffered lidocaine for suturing lacerations in children (the SLIC Trial). ( Fatovich, DM; Jacobs, IG, 1995)
"Analysis of pooled data and paired data (using patients as their own controls) revealed that infiltrating buffered lidocaine was significantly less painful than plain lidocaine (P = ."5.06Buffered versus plain lidocaine as a local anesthetic for simple laceration repair. ( Barbera, J; Bartfield, JM; Breuer, B; Gallagher, EJ; Gennis, P, 1990)
"Lidocaine hydrochloride is frequently used for management of painful wounds."4.125% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre Observational Study. ( Arnez, ZM; Davini, G; Dini, V; Janowska, A; Oranges, T; Papa, G; Romanelli, M; Stocco, C, 2022)
" Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage."4.02Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021)
"Adenosine, lidocaine, and magnesium, as administered in this study, are inferior to current Hextend-based resuscitation for survival from prolonged hemorrhagic shock in this model."3.91Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock. ( Cardin, S; Fryer, DM; Glaser, JJ; How, RA; Morgan, CG; Ozuna, KM; Sams, VG; Schaub, LJ, 2019)
"Intracellular calcium, cytoskeleton remodelling, and cell migration were assessed in vitro in MDA-MB-231 cells, a human breast cancer epithelial cell line, after exposure to lidocaine (10 μM or 100 μM)."3.88Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration. ( Anselmi, L; Borgeat, A; Cecchinato, V; D'Agostino, G; Saporito, A; Silvestri, Y; Uguccioni, M, 2018)
"The study concludes that lidocaine reduced pain during castration and that meloxicam reduced pain after castration."3.77Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration. ( Hansson, M; Johansson, G; Lundeheim, N; Nyman, G, 2011)
" We proposed that the introduction of a topical anaesthetic gel (lidocaine, adrenaline, tetracaine - LAT) might help to reduce the number of referrals, by allowing the ED staff to perform the procedures, in combination with nonpharmacological approaches."3.76Topical anaesthesia in children: reducing the need for specialty referral. ( Mullarkey, C; O'Connor, G, 2010)
"One hundred twelve patients with posttraumatic reflex sympathetic dystrophy were treated using 4 methods: regional intravenous blocks with lignocaine and methylprednisolone, mannitol i."3.70The reasons for poor response to treatment of posttraumatic reflex sympathetic dystrophy. ( Zyluk, A, 1998)
"The prognostic value of a dynamic liver-function test, based on the hepatic conversion of lidocaine to monoethylglycinexylidide (MEGX), in predicting multiple organ failure (MOF) was prospectively investigated in 28 critically ill patients after multiple trauma."3.69Monoethylglycinexylidide as an early predictor of posttraumatic multiple organ failure. ( Armstrong, VW; Lehmann, U; Oellerich, M; Pape, D; Regel, G; Schütz, E, 1995)
"This post-operative/post-traumatic neuropathic chronic cutaneous pain (PNCCP) may be a side-effect of any incision of the skin in the context of a surgical procedure or a traumatic event."2.74Management of neuropathic pain after surgical and non-surgical trauma with lidocaine 5% patches: study of 40 consecutive cases. ( Hans, G; Joukes, E; Vercauteren, M; Verhulst, J, 2009)
"Primary hyperalgesia was quantified by determining mechanical (von Frey hairs) and thermal (Peltier thermode) pain thresholds."2.69Effect of pre- or post-traumatically applied i.v. lidocaine on primary and secondary hyperalgesia after experimental heat trauma in humans. ( Holthusen, H; Irsfeld, S; Lipfert, P, 2000)
" Physicians must adhere to recommendations to avoid mucous membrane contact and ensure appropriate dosing with these agents."2.40Topical anesthesia. ( Keyes, PD; Rizos, J; Tallon, JM, 1998)
" In addition to changing serum drug concentration/response relationships, the pharmacokinetic behavior of drugs bound to alpha 1-acid glycoprotein should also change."2.37Hepatic drug clearance following traumatic injury. ( Hassett, JM; Slaughter, RL, 1985)
"Topical application of lidocaine in wounds has been studied in combination with vasoconstrictive additives, but the effect without these additives is unknown."1.43Anesthesia with topical lidocaine hydrochloride gauzes in acute traumatic wounds in triage, a pilot study. ( Goddijn, H; Goslings, JC; Hollmann, MW; Leenders, N; Lirk, P; Ridderikhof, ML; Schep, NW, 2016)
"Lidocaine and phenol were injected into the sciatic nerves of the rats in Groups 1 and 2, respectively."1.32Free radical-induced damage in experimental peripheral nerve injection injury. ( Apan, A; Kisa, U; Saray, A, 2003)
"the day of trauma in most elderly, whereas minor changes were observed in the young."1.31MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following trauma. ( Baldassarre, M; Furlanut, M; Licari, M; Pea, F, 2002)
"The infection rates of wounds anesthetized with plain lidocaine versus buffered lidocaine were compared in an observational cohort study."1.30Comparison of wound infection rates using plain versus buffered lidocaine for anesthesia of traumatic wounds. ( Brogan, GX; Giarrusso, E; Hollander, JE; Singer, AJ; Thode, HC; Valentine, SM, 1997)
"Clonidine was more potent in CCI then in CFA rats in reducing the response to cold."1.30The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. ( Franssen, M; Goff, JR; Janni, G; Jasmin, L; Kohan, L, 1998)
"To study the pharmacokinetic parameters of morphine and lidocaine after a single intravenous (i."1.30The pharmacokinetics of morphine and lidocaine in nine severe trauma patients. ( Almog, S; Berkenstadt, H; Ezra, D; Mayan, H; Perel, A; Rotenberg, M; Segal, E, 1999)
"Lidocaine was added to all serum samples from four of the patients and to selected samples from all of the healthy subjects and protein binding was determined."1.26Alpha1-acid glycoprotein concentration and protein binding in trauma. ( Cerra, F; Edwards, DJ; Lalka, D; Slaughter, RL, 1982)

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-199023 (30.67)18.7374
1990's27 (36.00)18.2507
2000's15 (20.00)29.6817
2010's8 (10.67)24.3611
2020's2 (2.67)2.80

Authors

AuthorsStudies
Letson, HL1
Dobson, GP1
Janowska, A1
Papa, G1
Romanelli, M1
Davini, G1
Oranges, T1
Stocco, C1
Arnez, ZM1
Dini, V1
D'Agostino, G1
Saporito, A1
Cecchinato, V1
Silvestri, Y1
Borgeat, A1
Anselmi, L1
Uguccioni, M1
Li, X1
Wang, C1
Yang, S1
Liu, P1
Zhang, B1
How, RA1
Glaser, JJ1
Schaub, LJ1
Fryer, DM1
Ozuna, KM1
Morgan, CG1
Sams, VG1
Cardin, S1
Azizkhani, R1
Forghani, M1
Maghami-Mehr, A1
Masomi, B1
Ridderikhof, ML1
Leenders, N1
Goddijn, H1
Schep, NW1
Lirk, P1
Goslings, JC1
Hollmann, MW1
Kanai, A1
Segawa, Y1
Okamoto, T1
Koto, M1
Okamoto, H1
O'Connor, G1
Mullarkey, C1
Hans, G1
Joukes, E1
Verhulst, J1
Vercauteren, M1
Hansson, M1
Lundeheim, N1
Nyman, G1
Johansson, G1
Christensen, TJ1
Thorum, T1
Kubiak, EN1
Pea, F1
Licari, M1
Baldassarre, M1
Furlanut, M1
Green, SM2
EDDY, DD2
ASCHHEIM, E2
FARBER, EM2
PATMAN, RD2
POULOS, E1
SHIRES, GT1
CORNAGLIA, C1
DANIELI, GG1
VERNONI, S1
ZIPERMAN, HH1
MCGINTY, JB1
ROTH, RJ1
EPINETTE, WW1
MONTY, CP1
DELLER, CR1
Saray, A1
Apan, A1
Kisa, U1
Fowler, E2
Mert, T1
Daglioglu, YK1
Gunay, I1
Gocmen, C1
Kawasaki, T1
Choudhry, MA1
Schwacha, MG1
Bland, KI1
Chaudry, IH1
Forde, G1
Lundborg, G1
Björkman, A1
Rosén, B1
Holovics, HJ1
Anderson, CR1
Levine, BS1
Hui, HW1
Lunte, CE1
Hewitt, CE1
Mitchell, N1
Torgerson, DJ1
Elvin, AT1
Axelson, JE1
Lalka, D2
Edwards, DJ1
Cerra, F1
Slaughter, RL2
Bartfield, JM3
Raccio-Robak, N2
Salluzzo, RF1
Lehmann, U1
Armstrong, VW1
Schütz, E1
Regel, G1
Pape, D1
Oellerich, M1
Blackburn, PA1
Butler, KH1
Hughes, MJ1
Clark, MR1
Riker, RL1
Schilling, CG1
Bank, DE1
Borchert, BA1
Klatzko, MD1
Uden, DL1
Fatovich, DM1
Jacobs, IG1
Kendall, JM1
Charters, A1
McCabe, SE1
Ernst, AA1
Marvez-Valls, E1
Nick, TG1
Wahle, M1
Wallace, MS1
Dyck, BJ1
Rossi, SS1
Yaksh, TL1
Morisaki, H1
Masuda, J1
Fukushima, K1
Iwao, Y1
Suzuki, K1
Matsushima, M1
Eriksson, AS1
Sinclair, R1
Brogan, GX1
Singer, AJ1
Valentine, SM1
Thode, HC1
Giarrusso, E1
Hollander, JE1
Nathan, B1
McKeever, J1
Smith, GA1
Strausbaugh, SD1
Harbeck-Weber, C1
Cohen, DM1
Shields, BJ1
Powers, JD1
Denkler, K1
Sokaris, SJ1
Adler, AJ1
Dubinisky, I1
Eisen, J1
Jasmin, L1
Kohan, L1
Franssen, M1
Janni, G1
Goff, JR1
Keyes, PD1
Tallon, JM1
Rizos, J1
Zyluk, A2
Resch, K1
Schilling, C1
Borchert, BD1
Klatzko, M1
Uden, D1
Quinlan, K1
Berkenstadt, H1
Mayan, H1
Segal, E1
Rotenberg, M1
Almog, S1
Perel, A1
Ezra, D1
Holthusen, H1
Irsfeld, S1
Lipfert, P1
Hawkins, JA1
Mathewson, HS1
Nakayama, DK1
Waggoner, T1
Venkataraman, ST1
Gardner, M1
Lynch, JM1
Orr, RA1
Zhu, ZX1
Zhang, YJ1
Wang, TJ1
Want, Y1
Liu, XY1
Anderson, AB1
Colecchi, C1
Baronoski, R1
DeWitt, TG1
Gennis, P1
Barbera, J1
Breuer, B1
Gallagher, EJ1
Spivey, WH1
McNamara, RM1
MacKenzie, RS1
Bhat, S1
Burdick, WP1
Driuk, NF1
Keĭsevich, LV1
Kaban, AP1
Proleev, AV1
Kostrub, AA1
Baumgardner, DJ1
Hassett, JM1
Thompson, JE1
Persson, AV1
Brooks, JB1
Kellogg, DS1
Alley, CC1
Short, HB1
Handsfield, HH1
Huff, B1
Schlag, G1
Miller, RD1
Way, WL1
Sportelli, S1
Garelli, R1
Solini, A1
Gostishchev, VK1
Tolstykh, PI1
Kukufaté, EA1
Doutre, LP1
Périssat, J1
Giddon, DB1
Lindhe, J1
Karczewski, J1
Ginal, M1
Croce, V1
Marino, F1
Scaraglio, C1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial of Lidocaine Patch for Lower Limb Amputation Pain[NCT02696720]Phase 20 participants (Actual)Interventional2016-05-13Withdrawn (stopped due to Lack of recruitment)
Lidocaine Analgesia For Removal Of Wound Vacuum Assisted Closure Dressings: A Randomized Double Blinded Controlled Trial[NCT01126359]11 participants (Actual)Interventional2008-08-31Completed
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain : A Pilot Study[NCT02217267]Phase 329 participants (Actual)Interventional2014-08-01Completed
Saline Injection - Assisted Anesthesia in Eyelid Surgery[NCT01239498]Phase 460 participants (Anticipated)Interventional2010-11-30Recruiting
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia[NCT02647892]Phase 470 participants (Actual)Interventional2016-01-08Terminated (stopped due to IRB protocol administratively closed, Continuing Review or Study Completion Report not submitted)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Break-through Narcotic Requirement

Patient break-through narcotic requirements in morphine equivalents are 0.2 mg of dilaudid = 1 mg of morphine, iv., used during and after VAC dressing change. (NCT01126359)
Timeframe: 20 minutes

,,
InterventionNarcotic Requirements (mg) (Mean)
During VAC change5 min post-VAC change10 min post VAC change20 min post VAC change
Lidocaine1.30.80.20.0
Lidocaine Minus Placebo-Saline Difference-1.7-0.4-0.2-0.3
Placebo-Saline3.01.10.40.3

Visual Analog Scale Pain Score

Visial Analog Pain Scores (VAS) range from 0 (no pain) - 10 (worst pain ever). Visial Analog Pain Scores are determined at each pain measurement time point (during/after VAC dressing removal). (NCT01126359)
Timeframe: 20 minutes

,,
InterventionVisial Analog Pain Score (VAS) (Mean)
During VAC change5 min post-VAC change10 min post VAC change20 min post VAC change
Lidocaine6.54.43.22.4
Lidocaine Minus Placebo-Saline Difference-2.4-2.0-1.5-1.8
Placebo-Saline8.96.44.74.2

Reviews

4 reviews available for lidocaine and Injuries

ArticleYear
Adjuvant analgesics for the treatment of neuropathic pain: evaluating efficacy and safety profiles.
    The Journal of family practice, 2007, Volume: 56, Issue:2 Suppl Pa

    Topics: Administration, Cutaneous; Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents; Arthritis;

2007
What is the role of diphenhydramine in local anesthesia?
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1996, Volume: 3, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Drug Hypersensitivity; Emergency Medical Ser

1996
Topical anesthesia.
    Canadian family physician Medecin de famille canadien, 1998, Volume: 44

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Child; Cocaine; Drug Combinations; Epinephrine; Hu

1998
Hepatic drug clearance following traumatic injury.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:11

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Humans; Kinetics; Lidocaine; Liver; Liver Circula

1985

Trials

21 trials available for lidocaine and Injuries

ArticleYear
The analgesic effect of a metered-dose 8% lidocaine pump spray in posttraumatic peripheral neuropathy: a pilot study.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine;

2009
Management of neuropathic pain after surgical and non-surgical trauma with lidocaine 5% patches: study of 40 consecutive cases.
    Current medical research and opinion, 2009, Volume: 25, Issue:11

    Topics: Administration, Cutaneous; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Lidocaine;

2009
Lidocaine analgesia for removal of wound vacuum-assisted closure dressings: a randomized double-blinded placebo-controlled trial.
    Journal of orthopaedic trauma, 2013, Volume: 27, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Cross-Over Studies; Device Removal;

2013
Enhanced sensory relearning after nerve repair by using repeated forearm anaesthesia: aspects on time dynamics of treatment.
    Acta neurochirurgica. Supplement, 2007, Volume: 100

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Female; Follow-Up Studies;

2007
Does topical lidocaine attenuate the pain of infiltration of buffered lidocaine?
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1995, Volume: 2, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Double-Blind Method; Emergencies; F

1995
Comparison of tetracaine-adrenaline-cocaine (TAC) with topical lidocaine-epinephrine (TLE): efficacy and cost.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Cocaine; Cost Savings; Double-Blind

1995
Tetracaine, epinephrine (adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children.
    Annals of emergency medicine, 1995, Volume: 25, Issue:2

    Topics: Adolescent; Anesthesia, Local; Child; Child, Preschool; Cocaine; Double-Blind Method; Drug Combinati

1995
A randomized, controlled trial of oral midazolam and buffered lidocaine for suturing lacerations in children (the SLIC Trial).
    Annals of emergency medicine, 1995, Volume: 25, Issue:2

    Topics: Administration, Oral; Anesthesia, Local; Anxiety; Buffers; Child; Child, Preschool; Double-Blind Met

1995
Topical anaesthesia for children's lacerations: an acceptable approach?
    Journal of accident & emergency medicine, 1996, Volume: 13, Issue:2

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Cocaine; Drug Comb

1996
Comparison trial of four injectable anesthetics for laceration repair.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1996, Volume: 3, Issue:3

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Therapy, Co

1996
Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury.
    Pain, 1996, Volume: 66, Issue:1

    Topics: Adult; Aged; Computers; Humans; Infusion Pumps; Lidocaine; Middle Aged; Pain; Pain Measurement; Pain

1996
Wound infiltration with lidocaine prolongs postoperative analgesia after haemorrhoidectomy with spinal anaesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:9

    Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle

1996
New non-cocaine-containing topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
    Pediatrics, 1997, Volume: 100, Issue:5

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; C

1997
Local anesthesia for lacerations: pain of infiltration inside vs outside the wound.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:2

    Topics: Adult; Anesthetics, Local; Buffers; Female; Humans; Injections, Intralesional; Lidocaine; Male; Pain

1998
Does the use of topical lidocaine, epinephrine, and tetracaine solution provide sufficient anesthesia for laceration repair?
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:2

    Topics: Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Epinephrin

1998
Topical anesthesia for pediatric lacerations: a randomized trial of lidocaine-epinephrine-tetracaine solution versus gel.
    Annals of emergency medicine, 1998, Volume: 32, Issue:6

    Topics: Age Factors; Anesthetics, Combined; Anesthetics, Local; Chemistry, Pharmaceutical; Child; Epinephrin

1998
Results of the treatment of posttraumatic reflex sympathetic dystrophy of the upper extremity with regional intravenous blocks of methylprednisolone and lidocaine.
    Acta orthopaedica Belgica, 1998, Volume: 64, Issue:4

    Topics: Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Female; Heparin; Humans; Infusions, Intra

1998
Effect of pre- or post-traumatically applied i.v. lidocaine on primary and secondary hyperalgesia after experimental heat trauma in humans.
    Pain, 2000, Dec-01, Volume: 88, Issue:3

    Topics: Adult; Analysis of Variance; Anesthetics, Local; Burns; Cross-Over Studies; Double-Blind Method; Hot

2000
Local anesthesia in pediatric patients: topical TAC versus lidocaine.
    Annals of emergency medicine, 1990, Volume: 19, Issue:5

    Topics: Administration, Topical; Adolescent; Anesthesia, Local; Anesthetics, Local; Child; Cocaine; Double-B

1990
Buffered versus plain lidocaine as a local anesthetic for simple laceration repair.
    Annals of emergency medicine, 1990, Volume: 19, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Buffers; Double-Blind Method; Emergencies; Femal

1990
Buffered versus plain lidocaine as a local anesthetic for simple laceration repair.
    Annals of emergency medicine, 1990, Volume: 19, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Buffers; Double-Blind Method; Emergencies; Femal

1990
Buffered versus plain lidocaine as a local anesthetic for simple laceration repair.
    Annals of emergency medicine, 1990, Volume: 19, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Buffers; Double-Blind Method; Emergencies; Femal

1990
Buffered versus plain lidocaine as a local anesthetic for simple laceration repair.
    Annals of emergency medicine, 1990, Volume: 19, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Buffers; Double-Blind Method; Emergencies; Femal

1990
A clinical comparison of lidocaine and bupivacaine.
    Annals of emergency medicine, 1987, Volume: 16, Issue:7

    Topics: Adult; Bupivacaine; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Emergencies; Fem

1987

Other Studies

50 other studies available for lidocaine and Injuries

ArticleYear
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research.
    Shock (Augusta, Ga.), 2021, 03-01, Volume: 55, Issue:3

    Topics: Adenosine; Analgesia; Analgesics, Opioid; Animals; Biomedical Research; Buprenorphine; Disease Model

2021
5% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre Observational Study.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2022, Volume: 35, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Hum

2022
Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration.
    British journal of anaesthesia, 2018, Volume: 121, Issue:4

    Topics: Anesthetics, Local; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Ch

2018
Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Anti-Bacterial Agents; Bacteria; Bandages; Cell Death; Chitosan; Drug Liberation; Fibroblasts; Human

2018
Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.
    The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:1

    Topics: Adenosine; Animals; Cardioplegic Solutions; Disease Models, Animal; Emergency Medical Services; Lido

2019
The effects of injections of warmed bicarbonate-buffered Lidocaine as a painkiller for patients with trauma.
    Journal of injury & violence research, 2015, Volume: 7, Issue:2

    Topics: Analgesics; Anesthetics, Local; Bicarbonates; Buffers; Hot Temperature; Humans; Injections, Intrader

2015
Anesthesia with topical lidocaine hydrochloride gauzes in acute traumatic wounds in triage, a pilot study.
    International emergency nursing, 2016, Volume: 28

    Topics: Administration, Topical; Adult; Emergency Service, Hospital; Female; Humans; Lidocaine; Male; Middle

2016
Topical anaesthesia in children: reducing the need for specialty referral.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2010, Volume: 17, Issue:2

    Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Local; Child; Child Welfare; Child, Prescho

2010
Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration.
    Acta veterinaria Scandinavica, 2011, May-31, Volume: 53

    Topics: Analgesia; Anesthesia, Local; Anesthetics, Local; Animal Welfare; Animals; Animals, Newborn; Anti-In

2011
MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following trauma.
    Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:6

    Topics: Adult; Aged; APACHE; Area Under Curve; Biomarkers; Critical Illness; Female; Half-Life; Humans; Lido

2002
Pediatric wound triage protocols.
    Annals of emergency medicine, 2003, Volume: 42, Issue:1

    Topics: Anesthesia, Local; Child; Double-Blind Method; Emergency Service, Hospital; Epinephrine; Humans; Lid

2003
EXPERIMENTAL ANALYSIS OF ISOMORPHIC (KOEBNER) RESPONSE IN PSORIASIS.
    Archives of dermatology, 1964, Volume: 89

    Topics: Chloroquine; Colchicine; Cold Temperature; Dermabrasion; Histology; Humans; Idoxuridine; Iontophores

1964
THE MANAGEMENT OF CIVILIAN ARTERIAL INJURIES.
    Surgery, gynecology & obstetrics, 1964, Volume: 118

    Topics: Adolescent; Amputation, Surgical; Aneurysm; Angiography; Arteries; Arteriovenous Fistula; Blood Vess

1964
[OUR EXPERIENCE WITH REGIONAL ANESTHESIA, USING INTRAVENOUS ADMINISTRATION].
    Rivista di patologia e clinica, 1963, Volume: 18

    Topics: Administration, Intravenous; Anesthesia; Anesthesia, Conduction; Anesthesia, Intravenous; Cellulitis

1963
TRAUMATIC INTRATHORACIC TIBIA.
    The Journal of trauma, 1964, Volume: 4

    Topics: Accidents; Accidents, Traffic; Black People; Blood Circulation; Blood Transfusion; Bone Transplantat

1964
ROLE OF TRAUMA IN ISOMORPHIC RESPONSE IN PSORIASIS.
    Archives of dermatology, 1965, Volume: 91

    Topics: Biomedical Research; Chymotrypsin; Humans; Hyaluronoglucosaminidase; Hypothermia; Hypothermia, Induc

1965
EXPERIENCES WITH INTRAVENOUS REGIONAL ANAESTHESIA.
    Proceedings of the Royal Society of Medicine, 1965, Volume: 58

    Topics: Anesthesia; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthesiology; Humans; Lidocaine; Orth

1965
Free radical-induced damage in experimental peripheral nerve injection injury.
    Journal of reconstructive microsurgery, 2003, Volume: 19, Issue:6

    Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Injury

2003
Plain talk about wound pain.
    Ostomy/wound management, 2003, Volume: 49, Issue:9

    Topics: Administration, Cutaneous; Algorithms; Anesthetics, Local; Chronic Disease; Decision Trees; Humans;

2003
Changes in electrophysiological properties of regenerating rat peripheral nerves after crush injury.
    Neuroscience letters, 2004, Jun-17, Volume: 363, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Electric Stimulation; Electrophysiology; Female; Lidoca

2004
Plain talk about wound pain.
    Ostomy/wound management, 2005, Volume: 51, Issue:11A Suppl

    Topics: Acute Disease; Anesthetics, Local; Attitude to Health; Chronic Disease; Humans; Lidocaine; Nursing A

2005
Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:5

    Topics: Animals; Bone Marrow Cells; Cell Proliferation; Cell Survival; Concanavalin A; Cytokines; Enzyme Act

2006
Investigation of drug delivery by iontophoresis in a surgical wound utilizing microdialysis.
    Pharmaceutical research, 2008, Volume: 25, Issue:8

    Topics: Animals; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Iontophoresis; L

2008
Listen to the data when results are not significant.
    BMJ (Clinical research ed.), 2008, Jan-05, Volume: 336, Issue:7634

    Topics: Abortifacient Agents, Nonsteroidal; Administration, Inhalation; Administration, Oral; Adolescent; An

2008
Tocainide protein binding in normal volunteers and trauma patients.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:6

    Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Orosomucoid; Protein Binding; Tocainide; Wounds and Injur

1982
Alpha1-acid glycoprotein concentration and protein binding in trauma.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Female; Humans; Lidocaine; Male; Middle Aged; Orosomucoid; Protein Binding; Wound

1982
Monoethylglycinexylidide as an early predictor of posttraumatic multiple organ failure.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:2

    Topics: Adult; Aged; Bilirubin; Diagnosis, Differential; Female; Humans; Lidocaine; Liver Function Tests; Ma

1995
Leukocyte hydrogen peroxide production in a surgical wound in mice. The effects of an amide local anaesthetic.
    Inflammation, 1996, Volume: 20, Issue:5

    Topics: Anesthetics, Local; Animals; Diffusion Chambers, Culture; Hydrogen Peroxide; Inflammation; Leukocyte

1996
Comparison of wound infection rates using plain versus buffered lidocaine for anesthesia of traumatic wounds.
    The American journal of emergency medicine, 1997, Volume: 15, Issue:1

    Topics: Adult; Anesthetics, Local; Buffers; Emergencies; Female; Humans; Lidocaine; Logistic Models; Male; P

1997
Topical analgesia for children.
    Journal of accident & emergency medicine, 1997, Volume: 14, Issue:1

    Topics: Administration, Topical; Anesthetics, Local; Child; Cocaine; Drug Combinations; Epinephrine; Gels; H

1997
Repairing lacerations in children.
    American family physician, 1997, Oct-15, Volume: 56, Issue:6

    Topics: Anesthetics, Local; Child; Child, Preschool; Cocaine; Dermatologic Surgical Procedures; Drug Therapy

1997
The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models.
    Pain, 1998, Volume: 75, Issue:2-3

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Clonidine; Cold

1998
The reasons for poor response to treatment of posttraumatic reflex sympathetic dystrophy.
    Acta orthopaedica Belgica, 1998, Volume: 64, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Inflammatory Agents; Calcitonin; Diuretics,

1998
Tips on avoiding lidocaine infiltration for simple wound repairs and using LET effectively in the emergency department: one pediatric ED nurse's experience.
    Journal of emergency nursing, 2000, Volume: 26, Issue:1

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Emergency Nursing; Epinep

2000
The pharmacokinetics of morphine and lidocaine in nine severe trauma patients.
    Journal of clinical anesthesia, 1999, Volume: 11, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Female; Humans; Lidocaine; M

1999
Emergency control of convulsions.
    AANA journal, 1979, Volume: 47, Issue:2

    Topics: Anesthesia, General; Barbiturates; Benzodiazepines; Chlormethiazole; Emergencies; Humans; Lidocaine;

1979
The use of drugs in emergency airway management in pediatric trauma.
    Annals of surgery, 1992, Volume: 216, Issue:2

    Topics: Adjuvants, Anesthesia; Adolescent; Anesthesia; Child; Child, Preschool; Clinical Protocols; Diazepam

1992
Increasing flap survival: a new method.
    Annals of plastic surgery, 1990, Volume: 24, Issue:5

    Topics: Animals; Burns; Chloramphenicol; Infection Control; Infections; Lidocaine; Rats; Surgical Flaps; Swi

1990
[The use of immobilized preparations for the control of suppurative-inflammatory complications and the pain syndrome in trauma and after the operation].
    Klinicheskaia khirurgiia, 1988, Issue:4

    Topics: Adolescent; Adult; Anti-Infective Agents; Child; Dimethylpolysiloxanes; Female; Humans; Lidocaine; M

1988
How to remove tightly adherent gauze from open wounds.
    Postgraduate medicine, 1987, Volume: 82, Issue:5

    Topics: Adult; Bandages; Female; Humans; Lidocaine; Solutions; Wounds and Injuries

1987
Management of post-traumatic pain syndromes: report of 113 cases.
    Annals of surgery, 1973, Volume: 177, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arm Injuries; Autonomic Nerve Block; Causalgia; C

1973
Gas chromatography as a potential means of diagnosing arthritis. I. Differentiation between staphylococcal, streptococcal, gonococcal, and traumatic arthritis.
    The Journal of infectious diseases, 1974, Volume: 129, Issue:6

    Topics: Anhydrides; Anti-Bacterial Agents; Arthritis; Arthritis, Infectious; Butyrates; Chromatography, Gas;

1974
[The intravenous local anesthesia in surgery of accidents].
    Monatsschrift fur Unfallheilkunde, Versicherungs-, Versorgungs- und Verkehrsmedizin, 1966, Volume: 69, Issue:5

    Topics: Accidents; Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthesia, Local; Extremities; Female;

1966
Inhibition of succinylcholine-induced increased intragastric pressure by nondepolarizing muscle relaxants and lidocaine.
    Anesthesiology, 1971, Volume: 34, Issue:2

    Topics: Abdominal Muscles; Adolescent; Adult; Gallamine Triethiodide; Gastroesophageal Reflux; Humans; Intub

1971
[Peripheral anesthesia in orthopedics and traumatology].
    Minerva anestesiologica, 1974, Volume: 40, Issue:11

    Topics: Anesthesia, Conduction; Bupivacaine; Humans; Lidocaine; Orthopedics; Wounds and Injuries

1974
[Inhibitors of proteolysis in the treatment of thermal and mechanical injuries].
    Sovetskaia meditsina, 1974, Issue:10

    Topics: Aminocaproates; Animals; Aprotinin; Bradykinin; Burns; Humans; Kallidin; Lidocaine; Methionine; Mice

1974
[Propofan as an antalgic in general surgery. Apropos of 50 cases].
    Bordeaux medical, 1972, Volume: 5, Issue:18

    Topics: Acetaminophen; Analgesics; Aspirin; Bone Diseases; Caffeine; Chlorpheniramine; Dextropropoxyphene; D

1972
In vivo quantitation of local anesthetic suppression of leukocyte adherence.
    The American journal of pathology, 1972, Volume: 68, Issue:2

    Topics: Anesthetics, Local; Animals; Cell Adhesion; Cheek; Cricetinae; Leukocytes; Lidocaine; Microscopy; So

1972
[Case of ventilatory disorders following blunt injury of the carotid artery].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1972, Jul-24, Volume: 27, Issue:30

    Topics: Adult; Carotid Artery Injuries; Carotid Body; Humans; Lidocaine; Male; Respiratory Tract Diseases; W

1972
[Personal experience with a new type of mixed anesthesia in orthopedics and traumatology].
    Minerva anestesiologica, 1969, Volume: 35, Issue:10

    Topics: Adolescent; Adult; Aged; Diazepam; Female; Fracture Fixation; Humans; Lidocaine; Male; Middle Aged;

1969