lidocaine has been researched along with Injuries, Spinal Cord in 59 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 9.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 9.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| "Twenty-four spinal cord injury patients with neuropathic pain at or below the level of injury were randomized and completed a double-blind crossover trial of 5 mg/kg lidocaine and placebo infused over 30 min." | 9.11 | Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial. ( Bach, FW; Biering-Sørensen, F; Finnerup, NB; Jensen, TS; Johannesen, IL; Juhl, GI; Kristensen, AD; Sindrup, SH; Terkelsen, AJ, 2005) |
| "Lidocaine anal block significantly limits the autonomic dysreflexia response in susceptible patients undergoing anorectal procedures." | 9.11 | Lidocaine anal block limits autonomic dysreflexia during anorectal procedures in spinal cord injury: a randomized, double-blind, placebo-controlled trial. ( Cosman, BC; Vu, TT, 2005) |
| "Topical lidocaine did not significantly limit or prevent autonomic dysreflexia in susceptible patients." | 9.10 | Topical lidocaine does not limit autonomic dysreflexia during anorectal procedures in spinal cord injury: a prospective, double-blind study. ( Cosman, BC; Plowman, BK; Vu, TT, 2002) |
| "To investigate the effects of systemic administration of lidocaine on different components of neuropathic central pains by quantitative sensory testing." | 9.09 | Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study. ( Attal, N; Bouhassira, D; Brasseur, L; Dupuy, M; Gaudé, V; Guirimand, F; Parker, F, 2000) |
| "Bowel care is a potential trigger for autonomic dysreflexia (AD; paroxysmal hypertension elicited by sensory stimuli below the level of lesion)." | 6.94 | Clinical recommendations for use of lidocaine lubricant during bowel care after spinal cord injury prolong care routines and worsen autonomic dysreflexia: results from a randomised clinical trial. ( Claydon, VE; Inskip, JA; Lucci, VM; McGrath, MS; Sarveswaran, S; Willms, R, 2020) |
| "More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery." | 5.46 | Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. ( Aceves, M; Grau, JW; Hook, MA; Huang, YJ; Reynolds, JA; Strain, MM; Turtle, JD, 2017) |
| "To systematically review the evidence on the use of local analgesics, specifically lidocaine or bupivacaine, to prevent autonomic dysreflexia (AD) during iatrogenic procedures or bowel and bladder care routines in individuals with spinal cord injury (SCI)." | 5.41 | Are local analgesics effective in reducing autonomic dysreflexia in individuals with spinal cord injury? A systematic review. ( Gray, K; Krassioukov, AV; Krogh, K; McCracken, L; Sachdeva, R; Sheehan, W, 2023) |
| "This qualitative review found insufficient, heterogenous evidence and therefore no recommendation can be made for lidocaine infusion treatment in patients with chronic neuropathic pain due to spinal cord injury, peripheral nerve injury, diabetic neuropathy, postherpetic neuralgia, or complex regional pain syndrome type II." | 5.22 | Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. ( Argoff, CE; Bhullar, RK; Koutalianos, EP; Lee, JH; Leimer, EM, 2022) |
| "Sodium amobarbital decreased spontaneous pain by 73% (vs 46% with lidocaine) and normalized sensory abnormalities at or above the level of injury in 3 patients (as compared to just 1 patient with lidocaine), 2 of whom had transitional zone allodynia/hyperalgesia." | 5.14 | Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury. ( Bharatwal, B; Krassioukov, AV; Mailis-Gagnon, A; Yegneswaran, B, 2009) |
| "Ketamine but not lidocaine showed a significant analgesic effect in patients with neuropathic pain after spinal cord injury." | 5.11 | The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. ( Gordh, T; Karlsten, R; Kvarnström, A; Quiding, H, 2004) |
| "Twenty-four spinal cord injury patients with neuropathic pain at or below the level of injury were randomized and completed a double-blind crossover trial of 5 mg/kg lidocaine and placebo infused over 30 min." | 5.11 | Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial. ( Bach, FW; Biering-Sørensen, F; Finnerup, NB; Jensen, TS; Johannesen, IL; Juhl, GI; Kristensen, AD; Sindrup, SH; Terkelsen, AJ, 2005) |
| "Lidocaine anal block significantly limits the autonomic dysreflexia response in susceptible patients undergoing anorectal procedures." | 5.11 | Lidocaine anal block limits autonomic dysreflexia during anorectal procedures in spinal cord injury: a randomized, double-blind, placebo-controlled trial. ( Cosman, BC; Vu, TT, 2005) |
| "Topical lidocaine did not significantly limit or prevent autonomic dysreflexia in susceptible patients." | 5.10 | Topical lidocaine does not limit autonomic dysreflexia during anorectal procedures in spinal cord injury: a prospective, double-blind study. ( Cosman, BC; Plowman, BK; Vu, TT, 2002) |
| "To investigate the effects of systemic administration of lidocaine on different components of neuropathic central pains by quantitative sensory testing." | 5.09 | Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study. ( Attal, N; Bouhassira, D; Brasseur, L; Dupuy, M; Gaudé, V; Guirimand, F; Parker, F, 2000) |
| "In a double blind study, 21 patients with chronic spinal cord injury (SCI) pain underwent placement of a lumbar subarachnoid catheter and injection of placebo and lidocaine." | 5.07 | Diagnostic spinal anaesthesia in chronic spinal cord injury pain. ( Donovan, WH; Loubser, PG, 1991) |
| "To obtain objective evidence for the time to onset of action for intravesical lidocaine utilizing exaggerated sympathetic blood-pressure responsiveness in patients with spinal cord injuries (SCI)." | 3.96 | Onset of the action of intravesical lidocaine after spinal cord injury. ( Linsenmeyer, TA; Solinsky, R; Tam, K, 2020) |
| " Rats implanted subcutaneously with pellets or osmotic minipumps delivering morphine displayed time-related tactile allodynia and thermal hyperalgesia (i." | 3.71 | Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Suenaga, NM; Vanderah, TW, 2001) |
| "Bowel care is a potential trigger for autonomic dysreflexia (AD; paroxysmal hypertension elicited by sensory stimuli below the level of lesion)." | 2.94 | Clinical recommendations for use of lidocaine lubricant during bowel care after spinal cord injury prolong care routines and worsen autonomic dysreflexia: results from a randomised clinical trial. ( Claydon, VE; Inskip, JA; Lucci, VM; McGrath, MS; Sarveswaran, S; Willms, R, 2020) |
| "More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery." | 1.46 | Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. ( Aceves, M; Grau, JW; Hook, MA; Huang, YJ; Reynolds, JA; Strain, MM; Turtle, JD, 2017) |
| "The treatment of neuropathic pain is a medical challenge." | 1.40 | [Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain]. ( Chiarlone, R; Fogliardi, A; Intelligente, F; Irace, C; Lanzilotta, M; Lattanzi, S; Palomba, R; Provinciali, L; Storelli, E; Zampi, M, 2014) |
| "Paralytic ileus is a major concern in the acute phase of spinal cord injury." | 1.35 | Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. ( Audibert, G; Baumann, A; Klein, O; Mertes, PM, 2009) |
| "Chronic pain is common in patients with spinal cord injury (SCI)." | 1.33 | Pain management with interventional spine therapy in patients with spinal cord injury: a case series. ( Chiodo, A, 2005) |
| "The reduction of spasticity after administration of intrathecal fentanyl, 35 micrograms, and intrathecal lidocaine, 50 mg, was compared with preinjection spasticity levels in ten subjects with central nervous system disease or injury." | 1.28 | An objective comparison of intrathecal lidocaine versus fentanyl for the treatment of lower extremity spasticity. ( Chabal, C; Jacobson, L; Schwid, HA, 1991) |
| "Furthermore, autonomic hyperreflexia is completely established within 24 h after CST in the rat." | 1.28 | Chronic cervical spinal cord injury and autonomic hyperreflexia in rats. ( Osborn, JW; Schramm, LP; Taylor, RF, 1990) |
| " Dose-response curves were constructed evaluating the relationship between the duration of balloon inflation versus the percentage of animals with a sustained neurologic deficit." | 1.28 | Halothane, fentanyl/nitrous oxide, and spinal lidocaine protect against spinal cord injury in the rat. ( Cole, DJ; Drummond, JC; Shapiro, HM; Zivin, JA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (16.95) | 18.7374 |
| 1990's | 10 (16.95) | 18.2507 |
| 2000's | 19 (32.20) | 29.6817 |
| 2010's | 12 (20.34) | 24.3611 |
| 2020's | 8 (13.56) | 2.80 |
| Authors | Studies |
|---|---|
| Gray, K | 2 |
| Sheehan, W | 2 |
| Wecht, J | 1 |
| Linsenmeyer, TA | 2 |
| Sachdeva, R | 3 |
| Krassioukov, AV | 3 |
| Lucci, VM | 2 |
| McGrath, MS | 2 |
| Inskip, JA | 2 |
| Sarveswaran, S | 2 |
| Willms, R | 2 |
| Claydon, VE | 2 |
| Kalimullina, T | 1 |
| Pawar, K | 1 |
| Krassioukov, A | 1 |
| McCracken, L | 1 |
| Krogh, K | 1 |
| Lee, JH | 1 |
| Koutalianos, EP | 1 |
| Leimer, EM | 1 |
| Bhullar, RK | 1 |
| Argoff, CE | 1 |
| Solinsky, R | 1 |
| Tam, K | 1 |
| Davis, JA | 1 |
| Bopp, AC | 1 |
| Henwood, MK | 1 |
| Baine, RE | 1 |
| Cox, CC | 1 |
| Grau, JW | 3 |
| Krucoff, MO | 1 |
| Zhuang, K | 1 |
| MacLeod, D | 1 |
| Yin, A | 1 |
| Byun, YW | 1 |
| Manson, RJ | 1 |
| Turner, DA | 1 |
| Oliveira, L | 1 |
| Lebedev, MA | 1 |
| Chtompel, Y | 1 |
| Eghtesadi, M | 1 |
| Vargas-Schaffer, G | 1 |
| Zhang, Z | 1 |
| Chen, Y | 1 |
| Wang, E | 1 |
| Wu, L | 1 |
| Wang, R | 1 |
| Song, Z | 1 |
| Weng, Y | 1 |
| Sun, Z | 1 |
| Guo, Q | 1 |
| Li, Y | 1 |
| Sisti, MS | 1 |
| Nishida, F | 1 |
| Zanuzzi, CN | 1 |
| Laurella, SL | 1 |
| Cantet, RJC | 1 |
| Portiansky, EL | 1 |
| Broens, PM | 1 |
| Penninckx, FM | 1 |
| Ochoa, JB | 1 |
| Provinciali, L | 1 |
| Lattanzi, S | 1 |
| Chiarlone, R | 1 |
| Fogliardi, A | 1 |
| Intelligente, F | 1 |
| Irace, C | 1 |
| Lanzilotta, M | 1 |
| Palomba, R | 1 |
| Storelli, E | 1 |
| Zampi, M | 1 |
| Turtle, JD | 1 |
| Strain, MM | 1 |
| Aceves, M | 1 |
| Huang, YJ | 1 |
| Reynolds, JA | 1 |
| Hook, MA | 1 |
| Shafik, A | 1 |
| Shafik, AA | 1 |
| Shafik, IA | 1 |
| El Sibai, O | 1 |
| Furusawa, K | 1 |
| Sugiyama, H | 1 |
| Tokuhiro, A | 1 |
| Takahashi, M | 1 |
| Nakamura, T | 1 |
| Tajima, F | 1 |
| Baumann, A | 1 |
| Audibert, G | 1 |
| Klein, O | 1 |
| Mertes, PM | 1 |
| Mailis-Gagnon, A | 1 |
| Yegneswaran, B | 1 |
| Bharatwal, B | 1 |
| Aguilar, J | 1 |
| Humanes-Valera, D | 1 |
| Alonso-Calviño, E | 1 |
| Yague, JG | 1 |
| Moxon, KA | 1 |
| Oliviero, A | 1 |
| Foffani, G | 1 |
| Kumar, N | 2 |
| Patidar, SP | 1 |
| Joshi, D | 1 |
| Sun, N | 1 |
| Liu, XH | 1 |
| Du, JQ | 1 |
| Zhu, JX | 1 |
| Tang, JS | 1 |
| Li, Q | 1 |
| Hussain, AM | 1 |
| Khan, MA | 1 |
| Li, WJ | 1 |
| Li, SM | 1 |
| Ding, Y | 1 |
| He, B | 1 |
| Keegan, J | 1 |
| Dong, H | 1 |
| Ruan, JW | 1 |
| Zeng, YS | 1 |
| Crown, ED | 1 |
| Ferguson, AR | 1 |
| Joynes, RL | 2 |
| Parisod, E | 1 |
| Siddall, PJ | 1 |
| Viney, M | 1 |
| McClelland, JM | 1 |
| Cousins, MJ | 1 |
| BORS, E | 2 |
| ROSSIER, A | 1 |
| SULLIVAN, J | 1 |
| EADE, MN | 1 |
| Kvarnström, A | 1 |
| Karlsten, R | 1 |
| Quiding, H | 1 |
| Gordh, T | 1 |
| Finnerup, NB | 1 |
| Biering-Sørensen, F | 1 |
| Johannesen, IL | 1 |
| Terkelsen, AJ | 1 |
| Juhl, GI | 1 |
| Kristensen, AD | 1 |
| Sindrup, SH | 1 |
| Bach, FW | 1 |
| Jensen, TS | 1 |
| Cosman, BC | 2 |
| Vu, TT | 2 |
| Kumagai, H | 1 |
| Sugawara, Y | 1 |
| Isaka, M | 1 |
| Okada, K | 1 |
| Orihashi, K | 1 |
| Sueda, T | 1 |
| Chiodo, A | 1 |
| Bee, LA | 1 |
| Dickenson, AH | 1 |
| Young, EE | 1 |
| Baumbauer, KM | 1 |
| Hillyer, J | 1 |
| Shwiry, B | 1 |
| Joseph, S | 1 |
| Sullivan, CA | 1 |
| Gotta, AW | 1 |
| Kobrine, AI | 1 |
| Evans, DE | 1 |
| LeGrys, DC | 1 |
| Yaffe, LJ | 1 |
| Bradley, ME | 1 |
| Douglas, MJ | 1 |
| Bernards, CM | 1 |
| Kopacz, DJ | 1 |
| Michel, MZ | 1 |
| Vaidyanathan, S | 1 |
| Krishnan, KR | 1 |
| Soni, BM | 1 |
| Fraser, MH | 1 |
| Agrawal, SK | 1 |
| Fehlings, MG | 1 |
| Yokoyama, O | 1 |
| Ishiura, Y | 1 |
| Nakamura, Y | 1 |
| Kunimi, K | 1 |
| Mita, E | 1 |
| Namiki, M | 1 |
| Attal, N | 1 |
| Gaudé, V | 1 |
| Brasseur, L | 1 |
| Dupuy, M | 1 |
| Guirimand, F | 1 |
| Parker, F | 1 |
| Bouhassira, D | 1 |
| Lévecque, JP | 1 |
| Rouquette-Vincenti, I | 1 |
| Brinquin, L | 1 |
| Vanderah, TW | 1 |
| Suenaga, NM | 1 |
| Ossipov, MH | 1 |
| Malan, TP | 1 |
| Lai, J | 1 |
| Porreca, F | 1 |
| Ness, TJ | 1 |
| Castroman, P | 1 |
| Plowman, BK | 1 |
| Pitcher, GM | 1 |
| Henry, JL | 1 |
| Loubser, PG | 1 |
| Donovan, WH | 1 |
| Sugaya, K | 1 |
| Nishizawa, O | 1 |
| Noto, H | 1 |
| Suzuki, T | 1 |
| Tsukada, T | 1 |
| Kohama, T | 1 |
| Shimoda, N | 1 |
| Tsuchida, S | 1 |
| Chabal, C | 1 |
| Jacobson, L | 1 |
| Schwid, HA | 1 |
| Ceylan, S | 2 |
| Kalelioğlu, M | 1 |
| Aktürk, G | 1 |
| Aktürk, F | 1 |
| Osborn, JW | 1 |
| Taylor, RF | 1 |
| Schramm, LP | 1 |
| Cole, DJ | 1 |
| Shapiro, HM | 1 |
| Drummond, JC | 1 |
| Zivin, JA | 1 |
| Haghighi, SS | 1 |
| Chehrazi, BB | 1 |
| Higgins, RS | 1 |
| Remington, WJ | 1 |
| Wagner, FC | 1 |
| Adamson, DH | 1 |
| Noble, MI | 1 |
| Eisele, JR | 1 |
| Frankel, HL | 1 |
| Else, W | 1 |
| Guz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety of Intravenous Lidocaine Infusions for Chronic Neuropathic Pain[NCT01091935] | 70 participants (Actual) | Observational | 2009-06-30 | Completed | |||
| Intravenous Lidocaine for Preventing Painful Oxaliplatin-induced Peripheral Neuropathy (OIPN)[NCT03254394] | Phase 1/Phase 2 | 26 participants (Actual) | Interventional | 2017-09-15 | Completed | ||
| The Effect of Lidocaine to Prevent the Development of Chronic Post-Surgical Pain[NCT01619852] | 148 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Double Blind Trial Investigating the Role of Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients[NCT03847311] | Phase 2 | 40 participants (Anticipated) | Interventional | 2021-05-03 | Recruiting | ||
| Toward Personalized Treatment of Chronic Pain Using Transcranial Direct Current Stimulation Paired With Deep Learning[NCT05863494] | 40 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The cumulative dose of oxaliplatin received over the course (up to 12 cycles) of mFOLFOX6 treatment regimen. It corresponds to the absolute summed up quantity of Oxaliplatin administered to the patient over time. There is no range for this measure. Since this is a dose-limiting neuropathy prevention study, the higher value can be interpreted as better outcome. (NCT03254394)
Timeframe: 24 weeks
| Intervention | mg (Mean) |
|---|---|
| Placebo + FOLFOX | 1161.8 |
| Lidocaine + FOLFOX | 1294.8 |
"The intensity of cold pain and cold unpleasantness is evaluated separately, assessed daily on a 0-10 scale, upon holding a pre-cooled (~8°C) metal cylinder for 10 seconds. the area under the curve of cold pain and cold unpleasantness vs time is calculated per chemotherapy cycle (every two weeks) and serves as a primary outcome measure.~For intervention (lidocaine+FOLFOX) and control (placebo+FOLFOX) groups, the average of cold pain AUC and cold unpleasantness AUC over 7 cycles was calculated. The average AUCs over 7 cycles were compared between study arms.~The AUC is measured as a score on a 0-10 scale multiplied by 14 days and may range between 0 and 140. Higher AUC values represent more intense cold pain/unpleasantness." (NCT03254394)
Timeframe: 14 weeks
| Intervention | score on a scale*days (Mean) | |
|---|---|---|
| pain AUC | unpleasantness AUC | |
| Lidocaine + FOLFOX | 9.5 | 25.4 |
| Placebo + FOLFOX | 16.4 | 33.1 |
Changes in Neuropathic Pain Symptom Inventory (NPSI) descriptors of neuropathic pain over time from baseline to cycle 3(6 weeks), cycle 6 (12 weeks), and the last follow-up (34-36 weeks). The total NPSI score ranges from 0 to 100; a higher NPSI total score represents a worse neuropathy outcome. The changes in scores from baseline are compared between study arms. (NCT03254394)
Timeframe: 6 weeks, 12 weeks, 34-36 weeks
| Intervention | score on a scale (Median) | ||
|---|---|---|---|
| 6 weeks visit | 12 weeks visit | last follow-up visit | |
| Lidocaine + FOLFOX | 0 | 0 | 13.5 |
| Placebo + FOLFOX | 0 | 0 | 3.0 |
"Change in CIPN (Chemotherapy-induced peripheral Neuropathy) score (on EORTC QLQ-CIPN20 tool ) from baseline to the Cycle 6 (12 weeks), and from baseline to last follow-up (34-36 weeks). EORTC QLQ-CIPN20 ranges from 0 (no symptoms) to 100 (worst symptoms). A higher score represents worse neuropathy. The changes in scores are compared between study arms.~EORTC QLQ-CIPN20 tool is a quality of life questionnaire (QLQ) from the European Organization for Research and Treatment of Cancer (EORTC) for evaluation of CIPN." (NCT03254394)
Timeframe: 12 weeks and 34-36 weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| 12 | 34-36 weeks | |
| Lidocaine + FOLFOX | 4 | 37.0 |
| Placebo + FOLFOX | 2 | 17.0 |
The participants development of chronic persistent pain 3 months after surgery as determined by character severity (yes/no). (NCT01619852)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Group L | 2 |
| .9% Normal Saline Placebo | 6 |
The amount of opioid analgesics consumed was converted to an equivalent dose of intravenous morphine. (NCT01619852)
Timeframe: 24 hours
| Intervention | equivalent dose of intravenous morphine (Median) |
|---|---|
| Group L | 34 |
| .9% Normal Saline Placebo | 39 |
Postoperative pain within the first 24 hours. Area under the numeric rating scale for pain versus time curve during the first 24 hours after surgery (score * hr). Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve during the first 24 hours ( score * hr). The pain scores were collected upon arrival to recovery area, 30 minutes, 1 hour and every 6 hours up to 24 hours following the procedure. Minimum score is 60, Maximum score is 170. A higher value indicates more pain. (NCT01619852)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Group L | 116 |
| .9% Normal Saline Placebo | 119 |
Quality of recovery (QoR-40 instrument) is a 40-item questionnaire that provides a global score and sub-scores across five dimensions: patient support, comfort, emotions, physical independence, and pain. Score range: 40 to 200. A score of 40 demonstrates poor recovery and a maximum score of 200 represents good recovery. The higher the score the better recovery after surgery. (NCT01619852)
Timeframe: 24 hours post operative
| Intervention | units on a scale (Median) |
|---|---|
| Lidocaine (Group L) | 158 |
| .9% Normal Saline Placebo | 169 |
The development of chronic pain 3 months after surgery determined by the Leads Assessment of Neuropathic Symptoms and Signs (LANSS) scale, a valid 7-item tool for identifying patients whose pain is dominated by neuropathic mechanisms. Each item is a binary response (yes or no) to the presence of symptoms (5 items) or clinical signs (2 items), range 0-24 points. A score ≥ 12, neuropathic mechanisms are likely to be contributing to the patient's pain. A score < 12 is unlikely to be contributing. McGill questionnaire (Sensory domain) - 11 descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe. The higher the score, greater the pain (range 0-33). McGill questionnaire (Motivational-affective) 4 affect descriptors rated on an intensity scale as 0=none, 1=mild, 2=moderate, 3=severe.The higher the score the greater the pain (range 0-12) Brief pain inventory - pain severity (0, no pain, 10 excruciating pain); Greater the score; greater the pain (range 0-10). (NCT01619852)
Timeframe: 3 months
| Intervention | units on a scale (Median) | |||
|---|---|---|---|---|
| S-LANNS | McGill Questionaire-Sensory Discrimation | McGill Questionaire-Motivational-affective | Brief Pain Inventory | |
| .9% Normal Saline Placebo | 3 | 3 | 0 | 1 |
| Group L | 3 | 4 | 0 | 1 |
2 reviews available for lidocaine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Are local analgesics effective in reducing autonomic dysreflexia in individuals with spinal cord injury? A systematic review.
Topics: Adult; Analgesics; Autonomic Dysreflexia; Bupivacaine; Humans; Lidocaine; Spinal Cord Injuries | 2023 |
Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review.
Topics: Adult; Chronic Pain; Diabetic Neuropathies; Humans; Lidocaine; Neuralgia; Peripheral Nerve Injuries; | 2022 |
10 trials available for lidocaine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Clinical recommendations for use of lidocaine lubricant during bowel care after spinal cord injury prolong care routines and worsen autonomic dysreflexia: results from a randomised clinical trial.
Topics: Adult; Autonomic Dysreflexia; Cross-Over Studies; Defecation; Double-Blind Method; Female; Humans; L | 2020 |
Percutaneous perineal electrostimulation induces erection: clinical significance in patients with spinal cord injury and erectile dysfunction.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Electric Stimulation; Erectile Dysfunction; Humans; | 2008 |
Topical anesthesia blunts the pressor response induced by bowel manipulation in subjects with cervical spinal cord injury.
Topics: Adolescent; Adult; Analysis of Variance; Anesthesia, Local; Autonomic Dysreflexia; Blood Pressure; D | 2009 |
Effects of intravenous sodium amobarbital vs lidocaine on pain and sensory abnormalities in patients with spinal cord injury.
Topics: Adult; Amobarbital; Anesthetics, Local; Female; Humans; Hypnotics and Sedatives; Injections, Intrave | 2009 |
The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Local; Cross-Over Studies; Double-Blind Method | 2004 |
Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial.
Topics: Adult; Aged; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections | 2005 |
Lidocaine anal block limits autonomic dysreflexia during anorectal procedures in spinal cord injury: a randomized, double-blind, placebo-controlled trial.
Topics: Anal Canal; Anesthetics, Local; Autonomic Dysreflexia; Blood Pressure; Double-Blind Method; Female; | 2005 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle A | 2000 |
Topical lidocaine does not limit autonomic dysreflexia during anorectal procedures in spinal cord injury: a prospective, double-blind study.
Topics: Administration, Topical; Anesthetics, Local; Autonomic Dysreflexia; Blood Pressure; Double-Blind Met | 2002 |
Diagnostic spinal anaesthesia in chronic spinal cord injury pain.
Topics: Adolescent; Adult; Anesthesia, Spinal; Chronic Disease; Dose-Response Relationship, Drug; Female; Hu | 1991 |
47 other studies available for lidocaine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Response to "Clinical recommendations for use of lidocaine lubricant during bowel care after spinal cord injury prolong care routines and worsen autonomic dysreflexia: results from a randomised clinical trial".
Topics: Autonomic Dysreflexia; Humans; Lidocaine; Lubricants; Spinal Cord Injuries | 2021 |
Response to "Clinical recommendations for use of lidocaine lubricant during bowel care after spinal cord injury prolong care routines and worsen autonomic dysreflexia: results from a randomized clinical trial" - the authors reply.
Topics: Autonomic Dysreflexia; Humans; Lidocaine; Lubricants; Spinal Cord; Spinal Cord Injuries | 2021 |
Rectal Application of Lidocaine Reduces the Severity of Autonomic Dysreflexia following Experimental Spinal Cord Injury.
Topics: Autonomic Dysreflexia; Blood Pressure; Humans; Lidocaine; Rectum; Spinal Cord; Spinal Cord Injuries | 2022 |
Onset of the action of intravesical lidocaine after spinal cord injury.
Topics: Adult; Autonomic Dysreflexia; Blood Pressure; Cohort Studies; Female; Humans; Lidocaine; Male; Middl | 2020 |
Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats.
Topics: Anesthetics, Local; Animals; Brain; Hemorrhage; Lidocaine; Locomotion; Pain; Pain Measurement; Rats; | 2020 |
A novel paraplegia model in awake behaving macaques.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Catheters, Indwelling; Epinephrine; Female; | 2017 |
A Case Report of Refractory Notalgia Paresthetica Treated with Lidocaine Infusions.
Topics: Anesthetics, Local; Epidural Abscess; Female; Humans; Infusions, Intravenous; Lidocaine; Middle Aged | 2017 |
Sufentanil Alleviates Intrathecal Lidocaine Induced Prolonged Sensory and Motor Impairments but not the Spinal Histological Injury in Rats.
Topics: Activating Transcription Factor 3; Analgesics, Opioid; Anesthetics, Local; Animals; Dyskinesia, Drug | 2018 |
Lidocaine protects neurons of the spinal cord in an excitotoxicity model.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Lidocai | 2019 |
Fecal continence revisited: the anal external sphincter continence reflex.
Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Anesthesia, Local; Anesthesia, Spinal; Anesthetics, Loca | 2013 |
[Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain].
Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Blood Vessel Prosthesis Implantation; Br | 2014 |
Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawl | 2017 |
Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury.
Topics: Adult; Aged; Female; Humans; Infusions, Intravenous; Intestinal Pseudo-Obstruction; Lidocaine; Male; | 2009 |
Spinal cord injury immediately changes the state of the brain.
Topics: Afferent Pathways; Analysis of Variance; Animals; Biophysics; Disease Models, Animal; Electric Stimu | 2010 |
Focal myelomalacia and syrinx formation after spinal anaesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Female; Humans; Lidocaine; Lumb | 2010 |
Rostroventral medulla-mediated biphasic modulation of the rat cardiosomatic motor reflex.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Local; Animals; Capsaicin; Dose-Response Relat | 2011 |
Pain management after traumatic spinal cord injury.
Topics: Adult; Analgesics; Anesthetics, Local; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; | 2012 |
Electro-acupuncture upregulates CGRP expression after rat spinal cord transection.
Topics: Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Cerebellum; Combined Modality Therapy; Co | 2012 |
Instrumental learning within the spinal cord. II. Evidence for central mediation.
Topics: Afferent Pathways; Animals; Central Nervous System; Conditioning, Psychological; Electroshock; Injec | 2002 |
Allodynia after acute intrathecal morphine administration in a patient with neuropathic pain after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthetics, Local; Clonidine; Humans; Injectio | 2003 |
Urological and neurological observations following anesthetic procedures of patients with spinal cord injuries. II. Cystometric and electromyographic effects of topical anesthesias.
Topics: Anesthesia, Local; Anesthetics; Electromyography; Humans; Lidocaine; Spinal Cord Injuries; Urinary B | 1962 |
RATIONALE OF ANESTHETIC PROCEDURES IN THE REHABILITATION OF PATIENTS WITH CORD BLADDER.
Topics: Anesthesia; Anesthesia, Conduction; Anesthetics; Autonomic Nervous System Diseases; Humans; Lidocain | 1964 |
PAROXYSMAL HYPERTENSION IN SPINAL CORD INJURIES (AUTONOMIC HYPERREFLEXIA).
Topics: Adolescent; Autonomic Dysreflexia; Autonomic Nervous System Diseases; Blushing; Bradycardia; Headach | 1964 |
Cold saline injection attenuates motor-evoked potential in the spinal cord by cortical electrical stimulation in the dog.
Topics: Animals; Aortic Aneurysm; Cold Temperature; Dogs; Electric Stimulation; Evoked Potentials, Motor; Li | 2005 |
Pain management with interventional spine therapy in patients with spinal cord injury: a case series.
Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Autonomic Dysreflexia; Chronic Disease; Disease | 2005 |
Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states.
Topics: Action Potentials; Afferent Pathways; Anesthetics, Local; Animals; Behavior, Animal; Brain Mapping; | 2007 |
Local anesthetic treatment significantly attenuates acute pain responding but does not prevent the neonatal injury-induced reduction in adult spinal behavioral plasticity.
Topics: Acute Disease; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Electroshock; Inject | 2007 |
A method of intubation for cervical spine injured patients.
Topics: Adult; Anesthesia, Endotracheal; Humans; Intubation, Intratracheal; Laryngeal Nerves; Lidocaine; Mal | 1983 |
Effect of intravenous lidocaine on experimental spinal cord injury.
Topics: Animals; Brain; Cats; Evoked Potentials, Somatosensory; Hemorrhage; Infusions, Parenteral; Lidocaine | 1984 |
Lidocaine in cord injury.
Topics: Humans; Lidocaine; Spinal Cord Injuries | 1984 |
Neurotoxicity of lidocaine--does it exist?
Topics: Adult; Anesthesia, Spinal; Animals; Humans; Lidocaine; Peripheral Nervous System Diseases; Sensation | 1995 |
Effect of needle puncture on morphine and lidocaine flux through the spinal meninges of the monkey in vitro. Implications for combined spinal-epidural anesthesia.
Topics: Anesthesia, Epidural; Anesthesia, Spinal; Animals; Female; Lidocaine; Macaca nemestrina; Male; Menin | 1994 |
Unusual complications of intermittent self-catheterisation in spinal cord injury patients.
Topics: Adult; Anesthetics, Local; Drug Hypersensitivity; Equipment Failure; Female; Humans; Lidocaine; Male | 1996 |
The effect of the sodium channel blocker QX-314 on recovery after acute spinal cord injury.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Female; Lidocaine; Rats; Rats, Wistar; Spinal C | 1997 |
Urodynamic effects of intravesical instillation of lidocaine in patients with overactive detrusor.
Topics: Administration, Intravesical; Adolescent; Adult; Aged; Aged, 80 and over; Cerebrovascular Disorders; | 1997 |
[Painful injection of propofol into a central vein].
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Catheterization, Central Venous; Chest Pain; Fe | 2000 |
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur | 2001 |
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur | 2001 |
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur | 2001 |
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur | 2001 |
Evidence for two populations of rat spinal dorsal horn neurons excited by urinary bladder distension.
Topics: Action Potentials; Analgesics, Opioid; Anesthetics, Local; Animals; Catheterization; Decerebrate Sta | 2001 |
Second phase of formalin-induced excitation of spinal dorsal horn neurons in spinalized rats is reversed by sciatic nerve block.
Topics: Action Potentials; Afferent Pathways; Anesthetics, Local; Animals; Lidocaine; Male; Nerve Block; Neu | 2002 |
[Experimental and clinical studies of urethral anesthesia on etiology and treatment of detrusor-sphincter dyssynergia].
Topics: Anesthesia, Local; Animals; Cats; Lidocaine; Muscle Contraction; Reflex; Spinal Cord Injuries; Ureth | 1991 |
An objective comparison of intrathecal lidocaine versus fentanyl for the treatment of lower extremity spasticity.
Topics: Adult; Aged; Fentanyl; Humans; Injections, Spinal; Knee Joint; Lidocaine; Male; Middle Aged; Muscle | 1991 |
Medical treatment of acute spinal cord injuries.
Topics: Acute Disease; Animals; Cats; Female; Lidocaine; Male; Naloxone; Spinal Cord Injuries; Thyrotropin-R | 1990 |
Chronic cervical spinal cord injury and autonomic hyperreflexia in rats.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Chronic Disease; Decerebrate State; Injections; L | 1990 |
Halothane, fentanyl/nitrous oxide, and spinal lidocaine protect against spinal cord injury in the rat.
Topics: Anesthesia, Inhalation; Anesthesia, Spinal; Animals; Fentanyl; Halothane; Lidocaine; Male; Nitrous O | 1989 |
Effect of lidocaine treatment on acute spinal cord injury.
Topics: Animals; Cats; Evoked Potentials, Somatosensory; Lidocaine; Neural Conduction; Reaction Time; Spinal | 1987 |
Continuous epidural anaesthesia in the community hospital.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesiology; Catheterization; Epinephrine; Female; | 1973 |
The role of the diaphragm in the sensation of holding the breath.
Topics: Adult; Apnea; Diaphragm; Electromyography; Female; Humans; Hypertrophy; Lidocaine; Male; Muscles; Ne | 1971 |