lidocaine has been researched along with Injuries, Radiation in 6 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| "Radiation-induced oral mucositis was assessed according to the radiation therapy oncology group criteria." | 1.43 | [Effect of Kou Yan Qing Ke Li on the prevention and treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma]. ( Li, Z; Xudong, H; Yun, G; Zehui, F, 2016) |
| "The treatment of neuropathic pain is a medical challenge." | 1.40 | [Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain]. ( Chiarlone, R; Fogliardi, A; Intelligente, F; Irace, C; Lanzilotta, M; Lattanzi, S; Palomba, R; Provinciali, L; Storelli, E; Zampi, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Wang, Z | 1 |
| Shen, L | 1 |
| Li, X | 1 |
| Shu, X | 1 |
| Shan, B | 1 |
| Zhang, L | 1 |
| Gong, Y | 1 |
| Dong, Z | 1 |
| Provinciali, L | 1 |
| Lattanzi, S | 1 |
| Chiarlone, R | 1 |
| Fogliardi, A | 1 |
| Intelligente, F | 1 |
| Irace, C | 1 |
| Lanzilotta, M | 1 |
| Palomba, R | 1 |
| Storelli, E | 1 |
| Zampi, M | 1 |
| Yun, G | 1 |
| Li, Z | 1 |
| Zehui, F | 1 |
| Xudong, H | 1 |
| Khanal, B | 1 |
| Baliga, M | 1 |
| Uppal, N | 1 |
| Meredith, R | 1 |
| Salter, M | 1 |
| Kim, R | 1 |
| Spencer, S | 1 |
| Weppelmann, B | 1 |
| Rodu, B | 1 |
| Smith, J | 1 |
| Lee, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
3 trials available for lidocaine and Injuries, Radiation
| Article | Year |
|---|---|
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Chi-Square Distribution; Cranial Irr | 2010 |
Sucralfate for radiation mucositis: results of a double-blind randomized trial.
Topics: Anti-Ulcer Agents; Diphenhydramine; Double-Blind Method; Drug Therapy, Combination; Esophageal Neopl | 1997 |
3 other studies available for lidocaine and Injuries, Radiation
| Article | Year |
|---|---|
Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis.
Topics: Administration, Oral; Anesthetics, Local; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; | 2013 |
[Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain].
Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Blood Vessel Prosthesis Implantation; Br | 2014 |
[Effect of Kou Yan Qing Ke Li on the prevention and treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma].
Topics: Carcinoma; Humans; Lidocaine; Mouth Mucosa; Mouthwashes; Nasopharyngeal Carcinoma; Nasopharyngeal Ne | 2016 |