Page last updated: 2024-10-28

lidocaine and Infections, Respiratory

lidocaine has been researched along with Infections, Respiratory in 14 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"Lozenges containing lidocaine and cetylpyridinium chloride (CPC) are commonly used for the treatment of sore throat."9.27Efficacy of 8 mg lidocaine and 2 mg cetylpyridinium chloride (CPC) fixed-combination lozenges on sore throat pain intensity compared with 1 mg lidocaine and 2 mg CPC fixed-combination lozenges in subjects with sore throat due to upper respiratory tract in ( Donath, F; Furcha, R; Garreffa, S; Mallefet, P, 2018)
"The hexylresorcinol lozenge demonstrated superiority over placebo for primary and secondary efficacy variables including those related to throat soreness, sore throat relief and difficulty swallowing; the AMC/DCBA + lidocaine lozenge was also superior to placebo for secondary endpoints at various time points but did not reach significance for the primary efficacy variable."9.16Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection. ( Field, E; McNally, D; Shephard, A, 2012)
"Lozenges containing lidocaine and cetylpyridinium chloride (CPC) are commonly used for the treatment of sore throat."5.27Efficacy of 8 mg lidocaine and 2 mg cetylpyridinium chloride (CPC) fixed-combination lozenges on sore throat pain intensity compared with 1 mg lidocaine and 2 mg CPC fixed-combination lozenges in subjects with sore throat due to upper respiratory tract in ( Donath, F; Furcha, R; Garreffa, S; Mallefet, P, 2018)
"The hexylresorcinol lozenge demonstrated superiority over placebo for primary and secondary efficacy variables including those related to throat soreness, sore throat relief and difficulty swallowing; the AMC/DCBA + lidocaine lozenge was also superior to placebo for secondary endpoints at various time points but did not reach significance for the primary efficacy variable."5.16Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection. ( Field, E; McNally, D; Shephard, A, 2012)
"To evaluate the action of 2% lidocaine on the culture results of bronchial fluid in patients suspected of having lower respiratory tract infections."3.85Effect of Lidocaine 2% on Bacterial Culture of Bronchial Fluid. ( Ayatollahi, J; Fallah, T; Meybodi, FAA; Mokarianpour, T; Mongabadi, FD; Samet, M; Shahcheraghi, SH; Yazdi, MHA, 2017)
"Ertapenem is a new, structurally unique, parenteral beta-lactam antimicrobial agent that can be administered once daily."2.70Safety and local tolerability of intramuscularly administered ertapenem diluted in lidocaine: a prospective, randomized, double-blind study versus intramuscular ceftriaxone. ( Friedland, I; Jiang, Q; Legua, P; Lema, J; Moll, J; Woods, G, 2002)
"cephacetrile were respectively 14."2.64Cephacetrile, a new cephalosporin: in vitro, pharmacological and clinical evaluation. ( Bals, MG; Toma, E, 1975)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Samet, M1
Meybodi, FAA1
Mokarianpour, T1
Fallah, T1
Mongabadi, FD1
Ayatollahi, J1
Shahcheraghi, SH1
Yazdi, MHA1
Donath, F1
Mallefet, P1
Garreffa, S1
Furcha, R1
Dadure, C1
Sabourdin, N1
Veyckemans, F1
Babre, F1
Bourdaud, N1
Dahmani, S1
Queiroz, M1
Devys, JM1
Dubois, MC1
Kern, D1
Laffargue, A1
Laffon, M1
Lejus-Bourdeau, C1
Nouette-Gaulain, K1
Orliaguet, G1
Gayat, E1
Velly, L1
Salvi, N1
Sola, C1
Noitasaeng, P1
Vichitvejpaisal, P1
Kaosombatwattana, U1
Tassanee, J1
Suwannee, S1
Schebesta, K1
Güloglu, E1
Chiari, A1
Mayer, N1
Kimberger, O1
McNally, D1
Shephard, A1
Field, E1
Chandan, SS1
Faoagali, J1
Wainwright, CE1
Joshi, JH1
Wang, KP1
de Jongh, CA1
Newman, KA1
Wiernik, PH1
Schimpff, SC1
Hall, AP1
Fox, AJ1
Raphael, JH1
Nandwani, N1
Smith, G1
Peleg, R1
Binyamin, L1
Legua, P1
Lema, J1
Moll, J1
Jiang, Q1
Woods, G1
Friedland, I1
Bals, MG1
Toma, E1
Phillips, I1
Wanner, A1
Amikam, B1
Robinson, MJ1
Anandam, EJ1
Sackner, MA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Parallel Group, Single-dose Study of the Efficacy of Lidocaine 8 mg + Cetylpyridinium Chloride (CPC) 2 mg Fixed Combination Lozenges on Sore Throat Pain Intensity Compared to Lozenges Containing Lidocaine 1 mg and CPC 2 mg in S[NCT01265446]Phase 3250 participants (Actual)Interventional2010-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline Sore Throat Pain Intensity

100 milimeter (mm) visual acuity score (left=no pain=0mm, right=worst possible pain=100mm) (NCT01265446)
Timeframe: Baseline and 2 hours post-dose

Interventionmm (Mean)
Lidocaine 8mg +CPC 2mg-27.4
Lidocaine 1mg + CPC 2mg-26.9

Change From Baseline Sore Throat Pain Intensity up to 240 mn Post-dose

100 milimeter (mm) visual acuity score (left=no pain=0mm, right=worst possible pain=100mm). It measures the highest pain level felt by the patient. (NCT01265446)
Timeframe: Baseline and 240 mn post-dose

Interventionmm (Mean)
Lidocaine 8mg +CPC 2mg-25.5
Lidocaine 1mg + CPC 2mg-29.1

Trials

7 trials available for lidocaine and Infections, Respiratory

ArticleYear
Efficacy of 8 mg lidocaine and 2 mg cetylpyridinium chloride (CPC) fixed-combination lozenges on sore throat pain intensity compared with 1 mg lidocaine and 2 mg CPC fixed-combination lozenges in subjects with sore throat due to upper respiratory tract in
    Trials, 2018, Dec-12, Volume: 19, Issue:1

    Topics: Administration, Oral; Adult; Anesthetics, Local; Anti-Infective Agents, Local; Cetylpyridinium; Doub

2018
Comparison of Spraying and Nebulized Lidocaine in Patients Undergoing Esophago-Gastro-Duodenoscopy: A Randomized Trial.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2016, Volume: 99, Issue:5

    Topics: Adult; Aged; Anesthetics, Local; Endoscopy, Digestive System; Female; Humans; Lidocaine; Male; Middl

2016
Topical lidocaine reduces the risk of perioperative airway complications in children with upper respiratory tract infections.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2010, Volume: 57, Issue:8

    Topics: Administration, Topical; Aging; Anesthesia; Anesthesia Recovery Period; Anesthetics, Local; Child; C

2010
Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2012, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Anti-Infective Agents, Local; Benzyl Alcohols; Cresols;

2012
Upper airway reactivity and upper respiratory tract infection: effect of nebulized lidocaine.
    British journal of anaesthesia, 1999, Volume: 82, Issue:6

    Topics: Adult; Airway Resistance; Ammonia; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Fo

1999
Safety and local tolerability of intramuscularly administered ertapenem diluted in lidocaine: a prospective, randomized, double-blind study versus intramuscular ceftriaxone.
    Clinical therapeutics, 2002, Volume: 24, Issue:3

    Topics: Aged; Anesthetics, Local; Anti-Bacterial Agents; beta-Lactams; Ceftriaxone; Cephalosporins; Double-B

2002
Cephacetrile, a new cephalosporin: in vitro, pharmacological and clinical evaluation.
    Infection, 1975, Volume: 3, Issue:3

    Topics: Bacteria; Cephacetrile; Cephalosporins; Clinical Trials as Topic; Drug Tolerance; Enterobacteriaceae

1975

Other Studies

7 other studies available for lidocaine and Infections, Respiratory

ArticleYear
Effect of Lidocaine 2% on Bacterial Culture of Bronchial Fluid.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017, Volume: 27, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cross

2017
Management of the child's airway under anaesthesia: The French guidelines.
    Anaesthesia, critical care & pain medicine, 2019, Volume: 38, Issue:6

    Topics: Administration, Topical; Airway Extubation; Airway Management; Algorithms; Child; Child, Preschool;

2019
Sensitivity of respiratory bacteria to lignocaine.
    Pathology, 2005, Volume: 37, Issue:4

    Topics: Anesthetics, Local; Animals; Bacteria; Candida albicans; Dose-Response Relationship, Drug; Haemophil

2005
A comparative evaluation of two fiberoptic bronchoscopy catheters: the plugged telescoping catheter versus the single sheathed nonplugged catheter.
    The American review of respiratory disease, 1982, Volume: 126, Issue:5

    Topics: Aerosols; Bronchoscopes; Catheterization; Fiber Optic Technology; Humans; Lidocaine; Neoplasms; Pros

1982
Practice tips. Treating persistent cough. Try a nebulized mixture of lidocaine and bupivacaine.
    Canadian family physician Medecin de famille canadien, 2002, Volume: 48

    Topics: Administration, Inhalation; Anesthetics, Local; Bupivacaine; Chronic Disease; Cough; Humans; Lidocai

2002
Postoperative respiratory-tract infection with Pseudomonas aeruginosa due to contaminated lignocaine jelly.
    Lancet (London, England), 1966, Apr-23, Volume: 1, Issue:7443

    Topics: Adult; Aged; Anesthesia, Endotracheal; Humans; Lidocaine; Male; Middle Aged; Postoperative Complicat

1966
Comparison between the bacteriologic flora of different segments of the airways. Examination by bedside bronchofiberscopy.
    Respiration; international review of thoracic diseases, 1973, Volume: 30, Issue:6

    Topics: Aged; Bronchi; Bronchoscopy; Fiber Optic Technology; Humans; Lidocaine; Lung Diseases; Middle Aged;

1973